BR0312648A - Process for preparing certain pyrrole triazine compounds - Google Patents

Process for preparing certain pyrrole triazine compounds

Info

Publication number
BR0312648A
BR0312648A BR0312648-0A BR0312648A BR0312648A BR 0312648 A BR0312648 A BR 0312648A BR 0312648 A BR0312648 A BR 0312648A BR 0312648 A BR0312648 A BR 0312648A
Authority
BR
Brazil
Prior art keywords
compounds
formula
preparing certain
triazine compounds
useful
Prior art date
Application number
BR0312648-0A
Other languages
Portuguese (pt)
Inventor
Rajeev Bhide
Junying Fan
Luca Parlanti
Stephanie Barbosa
Ligang Qian
Zhen-Wei Cai
Francis S Gibson
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BR0312648A publication Critical patent/BR0312648A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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Abstract

"PROCESSO PARA PREPARAçãO DE COMPOSTOS PIRROLO TRIAZINA, COMPOSIçãO E USO DOS MESMOS". A presente invenção refere-se a um processo para preparação de certos compostos pirroltriazina da fórmula (I) e seus sais farmaceuticamente aceitáveis. Os compostos de fórmula (I) inibem a atividade tirosina cinase de receptores de fator de crescimento tais como VEGFR-2 e FGFR-1, pelo que tornando-os úteis como agentes anticâncer. Os compostos de fórmula I também são úteis para o tratamento de outras doenças associadas com caminhos de transdução de sinal operando através de receptores de fator de crescimento."PROCESS FOR PREPARATION OF TRIAZINE PIRROLO COMPOUNDS, COMPOSITION AND USE OF THE SAME". The present invention relates to a process for preparing certain pyrroltriazine compounds of formula (I) and their pharmaceutically acceptable salts. The compounds of formula (I) inhibit the growth factor receptor tyrosine kinase activity such as VEGFR-2 and FGFR-1, making them useful as anticancer agents. The compounds of formula I are also useful for treating other diseases associated with signal transduction pathways operating through growth factor receptors.

BR0312648-0A 2002-07-19 2003-07-21 Process for preparing certain pyrrole triazine compounds BR0312648A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US39725602P 2002-07-19 2002-07-19
US44721303P 2003-02-13 2003-02-13
US10/622,280 US6933386B2 (en) 2002-07-19 2003-07-18 Process for preparing certain pyrrolotriazine compounds
PCT/US2003/022755 WO2004009542A2 (en) 2002-07-19 2003-07-21 Process for preparing certain pyrrolotriazine compounds

Publications (1)

Publication Number Publication Date
BR0312648A true BR0312648A (en) 2005-08-02

Family

ID=30773518

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0312648-0A BR0312648A (en) 2002-07-19 2003-07-21 Process for preparing certain pyrrole triazine compounds

Country Status (12)

Country Link
US (1) US6933386B2 (en)
EP (1) EP1554281A4 (en)
JP (1) JP2006502120A (en)
CN (1) CN1665817A (en)
AU (1) AU2003256645A1 (en)
BR (1) BR0312648A (en)
CA (1) CA2492861A1 (en)
IL (1) IL165985A0 (en)
MX (1) MXPA05000344A (en)
PL (1) PL375316A1 (en)
TW (1) TWI272271B (en)
WO (1) WO2004009542A2 (en)

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CN102603718B (en) * 2012-02-08 2014-01-29 武汉凯斯瑞科技有限公司 Synthesis method of cediranib
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