BR9915938A - Pyrimidine derivatives replaced by aryl and heterocyclyl as anticoagulants - Google Patents
Pyrimidine derivatives replaced by aryl and heterocyclyl as anticoagulantsInfo
- Publication number
- BR9915938A BR9915938A BR9915938-4A BR9915938A BR9915938A BR 9915938 A BR9915938 A BR 9915938A BR 9915938 A BR9915938 A BR 9915938A BR 9915938 A BR9915938 A BR 9915938A
- Authority
- BR
- Brazil
- Prior art keywords
- anticoagulants
- heterocyclyl
- aryl
- pyrimidine derivatives
- derivatives replaced
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Separation Of Suspended Particles By Flocculating Agents (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Patente de Invenção: <B>"DERIVADOS DE PIRIMIDINIA SUBSTITUìDOS POR ARILA E HETEROCICLILA COMO ANTICOAGULANTES"<D>. Esta invenção é direcionada aos derivados de pirimidina substituída por arila e heterociclila selecionados das fórmulas (I), (II) e (III) em que Z , Z , R , R , R , R^ 4^, R^ 5^ e R^ 6^ são aqui definidos. Estes compostos são úteis como anticoagulantes.Invention Patent: <B> "PYRIMIDINY DERIVATIVES REPLACED BY ARYL AND HETEROCYCLYL AS ANTICOAGULANTS" <D>. This invention is directed to aryl and heterocyclyl-substituted pyrimidine derivatives selected from formulas (I), (II) and (III) where Z, Z, R, R, R, R ^ 4 ^, R ^ 5 ^ and R ^ 6 ^ are defined here. These compounds are useful as anticoagulants.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/205,498 US6127376A (en) | 1998-12-04 | 1998-12-04 | Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants |
PCT/US1999/028537 WO2000033844A1 (en) | 1998-12-04 | 1999-12-03 | Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9915938A true BR9915938A (en) | 2001-08-21 |
Family
ID=22762435
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9915938-4A BR9915938A (en) | 1998-12-04 | 1999-12-03 | Pyrimidine derivatives replaced by aryl and heterocyclyl as anticoagulants |
Country Status (26)
Country | Link |
---|---|
US (2) | US6127376A (en) |
EP (1) | EP1135131A4 (en) |
JP (1) | JP2002531506A (en) |
KR (1) | KR20010093799A (en) |
CN (1) | CN1329491A (en) |
AU (1) | AU760370B2 (en) |
BG (1) | BG105557A (en) |
BR (1) | BR9915938A (en) |
CA (1) | CA2354040A1 (en) |
CZ (1) | CZ20011932A3 (en) |
EE (1) | EE200100298A (en) |
HR (1) | HRP20010499A2 (en) |
HU (1) | HUP0104508A3 (en) |
IL (2) | IL143347A0 (en) |
LT (1) | LT4912B (en) |
LV (1) | LV12783B (en) |
MX (1) | MXPA01005656A (en) |
NO (1) | NO20012701L (en) |
NZ (1) | NZ512104A (en) |
PL (1) | PL348034A1 (en) |
RO (1) | RO120971B1 (en) |
RU (1) | RU2001118466A (en) |
SI (1) | SI20637A (en) |
SK (1) | SK7632001A3 (en) |
WO (1) | WO2000033844A1 (en) |
ZA (1) | ZA200104235B (en) |
Families Citing this family (45)
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WO1996028427A1 (en) | 1995-03-10 | 1996-09-19 | Berlex Laboratories, Inc. | Benzamidine derivatives their preparation and their use as anti-coagulants |
US6686364B2 (en) | 1997-12-08 | 2004-02-03 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
US6262088B1 (en) | 1998-11-19 | 2001-07-17 | Berlex Laboratories, Inc. | Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants |
US6350761B1 (en) | 1999-07-30 | 2002-02-26 | Berlex Laboratories, Inc. | Benzenamine derivatives as anti-coagulants |
US7129242B2 (en) | 2000-12-06 | 2006-10-31 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto |
US7122544B2 (en) | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
TWI329105B (en) * | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
AU2003217961B2 (en) | 2002-03-08 | 2008-02-28 | Signal Pharmaceuticals, Llc | Combination therapy for treating, preventing or managing proliferative disorders and cancers |
GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
DE60330466D1 (en) | 2002-07-29 | 2010-01-21 | Rigel Pharmaceuticals Inc | METHOD FOR THE TREATMENT OR PREVENTION OF AUTOIMMUNE DISEASES WITH 2,4-PYRIMIDINE-IAMINE COMPOUNDS |
BR0313255A (en) * | 2002-08-08 | 2005-07-12 | Amgen Inc | Compound, pharmaceutical composition, use of a compound and methods of making a medicament and preparing a compound |
PT1569912E (en) | 2002-12-03 | 2015-09-15 | Pharmacyclics Llc | 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors |
NZ545270A (en) | 2003-07-30 | 2010-04-30 | Rigel Pharmaceuticals Inc | 2,4-Pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases |
WO2005047268A2 (en) * | 2003-11-10 | 2005-05-26 | X-Ceptor Therapeutics, Inc. | Substituted pyrimidine compositions and methods of use |
ES2380550T3 (en) * | 2004-11-24 | 2012-05-16 | Rigel Pharmaceuticals, Inc. | Spiro-2,4-pyrimidinediamine compounds and their uses |
EP2161275A1 (en) | 2005-01-19 | 2010-03-10 | Rigel Pharmaceuticals, Inc. | Prodrugs of 2,4-pyrimidinediamine compounds and their uses |
US20060270694A1 (en) * | 2005-05-03 | 2006-11-30 | Rigel Pharmaceuticals, Inc. | JAK kinase inhibitors and their uses |
US8367682B2 (en) * | 2006-07-21 | 2013-02-05 | Novartis Ag | Pyrimidine derivatives and their use as pesticides |
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US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
EP2300013B1 (en) | 2008-05-21 | 2017-09-06 | Ariad Pharmaceuticals, Inc. | Phosphorous derivatives as kinase inhibitors |
US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
JP2011526299A (en) | 2008-06-27 | 2011-10-06 | アビラ セラピューティクス, インコーポレイテッド | Heteroaryl compounds and their use |
US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
US11351168B1 (en) | 2008-06-27 | 2022-06-07 | Celgene Car Llc | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
US8932842B2 (en) | 2009-02-11 | 2015-01-13 | Northwestern University | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition |
US8278084B2 (en) | 2009-02-11 | 2012-10-02 | Northwestern University | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition |
CA2760794C (en) | 2009-05-05 | 2017-07-25 | Dana Farber Cancer Institute | Egfr inhibitors and methods of treating disorders |
AU2011289604C1 (en) | 2010-08-10 | 2016-04-21 | Celgene Avilomics Research, Inc. | Besylate salt of a BTK inhibitor |
EP2635285B1 (en) | 2010-11-01 | 2017-05-03 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
NZ609957A (en) | 2010-11-01 | 2015-08-28 | Celgene Avilomics Res Inc | Heterocyclic compounds and uses thereof |
WO2012064706A1 (en) | 2010-11-10 | 2012-05-18 | Avila Therapeutics, Inc. | Mutant-selective egfr inhibitors and uses thereof |
JP5999177B2 (en) | 2011-05-04 | 2016-09-28 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Compound for inhibiting cell proliferation of EGFR-activated cancer |
AR088570A1 (en) | 2011-10-28 | 2014-06-18 | Celgene Avilomics Res Inc | METHODS TO TREAT AN ILLNESS OR DISORDER RELATED TO BRUTON TYROSINE KINASE |
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JP3565864B2 (en) * | 1996-09-12 | 2004-09-15 | シエーリング アクチエンゲゼルシヤフト | Benzamidine derivatives substituted by cyclic amino acids or cyclic hydroxy acid derivatives and their use as anti-pseudo-solids |
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EP0993448A1 (en) * | 1997-06-19 | 2000-04-19 | The Du Pont Merck Pharmaceutical Company | (AMIDINO)6-MEMBERED AROMATICS AS FACTOR Xa INHIBITORS |
CA2315070A1 (en) | 1997-12-17 | 1999-07-01 | Schering Aktiengesellschaft | Ortho-anthranilamide derivatives as anti-coagulants |
-
1998
- 1998-12-04 US US09/205,498 patent/US6127376A/en not_active Expired - Fee Related
-
1999
- 1999-12-03 AU AU31075/00A patent/AU760370B2/en not_active Ceased
- 1999-12-03 CZ CZ20011932A patent/CZ20011932A3/en unknown
- 1999-12-03 HU HU0104508A patent/HUP0104508A3/en unknown
- 1999-12-03 NZ NZ512104A patent/NZ512104A/en unknown
- 1999-12-03 EP EP99965087A patent/EP1135131A4/en not_active Withdrawn
- 1999-12-03 JP JP2000586336A patent/JP2002531506A/en active Pending
- 1999-12-03 RO ROA200100606A patent/RO120971B1/en unknown
- 1999-12-03 MX MXPA01005656A patent/MXPA01005656A/en not_active IP Right Cessation
- 1999-12-03 EE EEP200100298A patent/EE200100298A/en unknown
- 1999-12-03 KR KR1020017006934A patent/KR20010093799A/en not_active Application Discontinuation
- 1999-12-03 CA CA002354040A patent/CA2354040A1/en not_active Abandoned
- 1999-12-03 CN CN99814024A patent/CN1329491A/en active Pending
- 1999-12-03 PL PL99348034A patent/PL348034A1/en not_active Application Discontinuation
- 1999-12-03 RU RU2001118466/14A patent/RU2001118466A/en not_active Application Discontinuation
- 1999-12-03 BR BR9915938-4A patent/BR9915938A/en not_active IP Right Cessation
- 1999-12-03 IL IL14334799A patent/IL143347A0/en active IP Right Grant
- 1999-12-03 WO PCT/US1999/028537 patent/WO2000033844A1/en not_active Application Discontinuation
- 1999-12-03 SK SK763-2001A patent/SK7632001A3/en unknown
- 1999-12-03 SI SI9920090A patent/SI20637A/en not_active IP Right Cessation
-
2000
- 2000-03-30 US US09/539,812 patent/US6372751B1/en not_active Expired - Fee Related
-
2001
- 2001-05-23 ZA ZA200104235A patent/ZA200104235B/en unknown
- 2001-05-24 IL IL143347A patent/IL143347A/en not_active IP Right Cessation
- 2001-06-01 BG BG105557A patent/BG105557A/en unknown
- 2001-06-01 NO NO20012701A patent/NO20012701L/en not_active Application Discontinuation
- 2001-06-12 LT LT2001061A patent/LT4912B/en not_active IP Right Cessation
- 2001-07-04 HR HR20010499A patent/HRP20010499A2/en not_active Application Discontinuation
- 2001-07-04 LV LVP-01-100A patent/LV12783B/en unknown
Also Published As
Publication number | Publication date |
---|---|
EE200100298A (en) | 2002-12-16 |
US6127376A (en) | 2000-10-03 |
NO20012701D0 (en) | 2001-06-01 |
CN1329491A (en) | 2002-01-02 |
SK7632001A3 (en) | 2001-12-03 |
KR20010093799A (en) | 2001-10-29 |
PL348034A1 (en) | 2002-05-06 |
LT2001061A (en) | 2001-12-27 |
US6372751B1 (en) | 2002-04-16 |
CZ20011932A3 (en) | 2001-10-17 |
HUP0104508A2 (en) | 2002-05-29 |
JP2002531506A (en) | 2002-09-24 |
RO120971B1 (en) | 2006-10-30 |
IL143347A0 (en) | 2002-04-21 |
WO2000033844A1 (en) | 2000-06-15 |
SI20637A (en) | 2002-02-28 |
AU3107500A (en) | 2000-06-26 |
BG105557A (en) | 2001-12-29 |
NO20012701L (en) | 2001-07-25 |
EP1135131A4 (en) | 2002-01-02 |
NZ512104A (en) | 2003-10-31 |
LV12783B (en) | 2002-10-20 |
HRP20010499A2 (en) | 2003-04-30 |
HUP0104508A3 (en) | 2002-07-29 |
ZA200104235B (en) | 2002-08-23 |
EP1135131A1 (en) | 2001-09-26 |
IL143347A (en) | 2006-12-10 |
MXPA01005656A (en) | 2002-04-24 |
RU2001118466A (en) | 2003-04-20 |
AU760370B2 (en) | 2003-05-15 |
LV12783A (en) | 2002-01-20 |
CA2354040A1 (en) | 2000-06-15 |
LT4912B (en) | 2002-04-25 |
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