BR9915406A - Device and method for the analysis of a biological sample - Google Patents

Device and method for the analysis of a biological sample

Info

Publication number
BR9915406A
BR9915406A BR9915406-4A BR9915406A BR9915406A BR 9915406 A BR9915406 A BR 9915406A BR 9915406 A BR9915406 A BR 9915406A BR 9915406 A BR9915406 A BR 9915406A
Authority
BR
Brazil
Prior art keywords
fluid
microspheres
biological sample
sample
analyzed
Prior art date
Application number
BR9915406-4A
Other languages
Portuguese (pt)
Inventor
Peter Lea
Original Assignee
Umedik Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA002254223A external-priority patent/CA2254223A1/en
Application filed by Umedik Inc filed Critical Umedik Inc
Publication of BR9915406A publication Critical patent/BR9915406A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5002—Partitioning blood components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/045—Connecting closures to device or container whereby the whole cover is slidable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/168—Specific optical properties, e.g. reflective coatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

Patente de Invenção: <B>"DISPOSITIVO E MéTODO PARA A ANáLISE DE UMA AMOSTRA BIOLóGICA"<D>. Um dispositivo para a separação de um fluido de uma amostra biológica, quando a amostra tiver um componente de fluido e não de fluido. O dispositivo é um dispositivo de ponto de atendimento, através do qual dados podem ser eletronicamente coletados e eletronicamente transmitidos para uma avaliação posterior. Um método para a separação de fluido de uma amostra biológica é provido, onde o método compreende a etapa de colocação de amostra de fluido em contato de fluido com as microesferas, de modo que o componente de fluido se mova por uma ação capilar entre as microesferas ao longo de canais capilares formados pelos espaços entre as esferas e deixando, por exemplo, uma fração celular para trás. No dispositivo da presente invenção, a etapa de separação do fluido pode ser combinada com outras técnicas de ensaio para detecção e/ou medição de um ou mais analisados, os quais podem estar presentes na amostra de fluido, tais como imunoensaios e ensaios cromotográficos. Estas podem ser, ainda, combinadas com grupos de microesferas, para uso na etapa de detecção de analisado, bem como na etapa de separação, onde as microesferas atuam como rótulos para o analisado ou como uma fonte de rótulo para o analisado.Invention Patent: <B> "DEVICE AND METHOD FOR THE ANALYSIS OF A BIOLOGICAL SAMPLE" <D>. A device for separating a fluid from a biological sample, when the sample has a fluid component and not a fluid component. The device is a point of care device, through which data can be electronically collected and electronically transmitted for further evaluation. A method for separating fluid from a biological sample is provided, where the method comprises the step of placing the fluid sample in fluid contact with the microspheres, so that the fluid component moves by a capillary action between the microspheres along capillary channels formed by the spaces between the spheres and leaving, for example, a cellular fraction behind. In the device of the present invention, the fluid separation step can be combined with other assay techniques for detecting and / or measuring one or more analyzed, which may be present in the fluid sample, such as immunoassays and chromotographic assays. These can also be combined with groups of microspheres, for use in the analyte detection step, as well as in the separation step, where the microspheres act as labels for the analyzed or as a label source for the analyzed.

BR9915406-4A 1998-11-16 1999-11-12 Device and method for the analysis of a biological sample BR9915406A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CA002254223A CA2254223A1 (en) 1998-11-16 1998-11-16 Device and method for analyzing a biologic sample
US09/335,732 US6403384B1 (en) 1998-11-16 1999-06-18 Device and method for analyzing a biologic sample
PCT/CA1999/001079 WO2000029847A2 (en) 1998-11-16 1999-11-12 Device and method for analyzing a biologic sample

Publications (1)

Publication Number Publication Date
BR9915406A true BR9915406A (en) 2001-07-24

Family

ID=25680640

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9915406-4A BR9915406A (en) 1998-11-16 1999-11-12 Device and method for the analysis of a biological sample

Country Status (6)

Country Link
EP (1) EP1131632A2 (en)
JP (1) JP4544498B2 (en)
AU (1) AU1144000A (en)
BR (1) BR9915406A (en)
TW (1) TW468046B (en)
WO (1) WO2000029847A2 (en)

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EP1224465B1 (en) 1999-09-27 2005-12-21 Clifford L. Librach Detection of hla-g
US6989891B2 (en) 2001-11-08 2006-01-24 Optiscan Biomedical Corporation Device and method for in vitro determination of analyte concentrations within body fluids
DE10354806A1 (en) * 2003-11-21 2005-06-02 Boehringer Ingelheim Microparts Gmbh sample carrier
US20050266398A1 (en) * 2004-06-01 2005-12-01 Peter Lea Method and device for rapid detection and quantitation of macro and micro matrices
US8936755B2 (en) 2005-03-02 2015-01-20 Optiscan Biomedical Corporation Bodily fluid composition analyzer with disposable cassette
US20060194325A1 (en) 2005-02-14 2006-08-31 Gable Jennifer H Fluid handling cassette with a fluid control interface
US9561001B2 (en) 2005-10-06 2017-02-07 Optiscan Biomedical Corporation Fluid handling cassette system for body fluid analyzer
US8731638B2 (en) 2009-07-20 2014-05-20 Optiscan Biomedical Corporation Adjustable connector and dead space reduction
US9091676B2 (en) 2010-06-09 2015-07-28 Optiscan Biomedical Corp. Systems and methods for measuring multiple analytes in a sample
US9554742B2 (en) 2009-07-20 2017-01-31 Optiscan Biomedical Corporation Fluid analysis system
WO2013006716A1 (en) 2011-07-06 2013-01-10 Optiscan Biomedical Corporation Sample cell for fluid analysis system
CN103917870B (en) * 2011-11-16 2016-04-13 贝克顿·迪金森公司 For detecting the method and system of the analysis thing in sample
US9678065B2 (en) 2013-01-11 2017-06-13 Becton, Dickinson And Company Low-cost point-of-care assay device
CN113477149B (en) 2013-11-06 2023-09-12 贝克顿·迪金森公司 Microfluidic devices and methods of making and using the same
BR112016010721B1 (en) 2013-11-13 2021-06-01 Becton, Dickinson And Company METHOD AND SYSTEM OF ANALYSIS OF A SAMPLE FOR AN ANALYTE
WO2016060793A1 (en) 2014-10-14 2016-04-21 Becton, Dickinson And Company Blood sample management using open cell foam
EP3939506A3 (en) 2014-10-14 2022-04-13 Becton, Dickinson and Company Blood sample management using open cell foam
AU2016229837B2 (en) 2015-03-10 2018-05-24 Becton, Dickinson And Company Biological fluid micro-sample management device
US10578606B2 (en) 2015-09-01 2020-03-03 Becton, Dickinson And Company Depth filtration device for separating specimen phases
CN111433350B (en) * 2017-11-30 2023-11-14 烟台澳斯邦生物工程有限公司 Method, system and filtration unit for separating particles from biological samples
KR102074150B1 (en) * 2018-04-11 2020-02-06 바디텍메드(주) System and method for changing reaction characteristic information of plurality of diagnosis cartridge set

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Also Published As

Publication number Publication date
JP2002530648A (en) 2002-09-17
JP4544498B2 (en) 2010-09-15
TW468046B (en) 2001-12-11
EP1131632A2 (en) 2001-09-12
AU1144000A (en) 2000-06-05
WO2000029847A2 (en) 2000-05-25
WO2000029847A3 (en) 2000-09-08

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]