BR9912176A - Epìtopos de célula auxiliar t artificial como estimuladores imunes para imunógenos de peptìdeo sintéticos incluindo peptìdeos de lhrh imunogênicos - Google Patents
Epìtopos de célula auxiliar t artificial como estimuladores imunes para imunógenos de peptìdeo sintéticos incluindo peptìdeos de lhrh imunogênicosInfo
- Publication number
- BR9912176A BR9912176A BR9912176-0A BR9912176A BR9912176A BR 9912176 A BR9912176 A BR 9912176A BR 9912176 A BR9912176 A BR 9912176A BR 9912176 A BR9912176 A BR 9912176A
- Authority
- BR
- Brazil
- Prior art keywords
- artificial
- peptide immunogens
- synthetic peptide
- auxiliary cell
- cell epitopes
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 230000002163 immunogen Effects 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 101000904173 Homo sapiens Progonadoliberin-1 Proteins 0.000 abstract 3
- 102100024028 Progonadoliberin-1 Human genes 0.000 abstract 3
- 101000996723 Sus scrofa Gonadotropin-releasing hormone receptor Proteins 0.000 abstract 3
- XLXSAKCOAKORKW-UHFFFAOYSA-N gonadorelin Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 XLXSAKCOAKORKW-UHFFFAOYSA-N 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000002443 helper t lymphocyte Anatomy 0.000 abstract 1
- 230000005847 immunogenicity Effects 0.000 abstract 1
- 230000003308 immunostimulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18422—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18711—Rubulavirus, e.g. mumps virus, parainfluenza 2,4
- C12N2760/18722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Reproductive Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gynecology & Obstetrics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"EPìTOPOS DE CéLULA AUXILIAR T ARTIFICIAL COMO ESTIMULADORES IMUNES PARA IMUNóGENOS DE PEPTìDEO SINTéTICOS INCLUINDO PEPTìDEOS DE LHRH IMUNOGêNICOS". A presente invenção refere-se a novos imunógenos de peptídeo para eliciar anticorpos para LHRH compreendendo epítopos de célula auxiliar T artificiais (epítopos de Th) projetados para prover ótima imunogenicidade. Os epítopos de Th artificiais estão covalentemente ligados a LHRH e opcionalmente a uma seq³ência imunoestimuladora.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/100,414 US6025468A (en) | 1998-06-20 | 1998-06-20 | Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens including immunogenic LHRH peptides |
PCT/US1999/013960 WO1999066952A1 (en) | 1998-06-20 | 1999-06-21 | Artificial t helper cell epitopes as immune stimulators for synthetic peptide immunogens including immunogenic lhrh peptides |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9912176A true BR9912176A (pt) | 2002-11-05 |
Family
ID=22279642
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9912176-0A BR9912176A (pt) | 1998-06-20 | 1999-06-21 | Epìtopos de célula auxiliar t artificial como estimuladores imunes para imunógenos de peptìdeo sintéticos incluindo peptìdeos de lhrh imunogênicos |
Country Status (10)
Country | Link |
---|---|
US (3) | US6025468A (pt) |
EP (1) | EP1087787A1 (pt) |
JP (2) | JP2003504302A (pt) |
CN (1) | CN1315869A (pt) |
AU (1) | AU764961B2 (pt) |
BR (1) | BR9912176A (pt) |
CA (1) | CA2330249A1 (pt) |
MX (1) | MXPA00011298A (pt) |
TW (1) | TWI225069B (pt) |
WO (1) | WO1999066952A1 (pt) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI229679B (en) * | 1998-06-20 | 2005-03-21 | United Biomedical Inc | Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens |
TWI227241B (en) * | 1998-06-20 | 2005-02-01 | United Biomedical Inc | IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate |
US6025468A (en) * | 1998-06-20 | 2000-02-15 | United Biomedical, Inc. | Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens including immunogenic LHRH peptides |
ES2284287T3 (es) * | 1998-10-16 | 2007-11-01 | Glaxosmithkline Biologicals S.A. | Sistemas adyuvantes y vacunas. |
US8241274B2 (en) | 2000-01-19 | 2012-08-14 | Medtronic, Inc. | Method for guiding a medical device |
US6783761B2 (en) | 2000-05-05 | 2004-08-31 | Aphton Corporation | Chimeric peptide immunogens |
US20030232055A1 (en) * | 2000-07-31 | 2003-12-18 | Ruslan Medzhitov | Innate immune system-directed vaccines |
US6780969B2 (en) * | 2000-12-22 | 2004-08-24 | United Biomedical, Inc. | Synthetic peptide composition as immunogens for prevention of urinary tract infection |
US20030175287A1 (en) * | 2001-01-03 | 2003-09-18 | Yale University | Innate immune system-directed vaccines |
US6906169B2 (en) * | 2001-05-25 | 2005-06-14 | United Biomedical, Inc. | Immunogenic peptide composition comprising measles virus Fprotein Thelper cell epitope (MUFThl-16) and N-terminus of β-amyloid peptide |
US8088388B2 (en) * | 2002-02-14 | 2012-01-03 | United Biomedical, Inc. | Stabilized synthetic immunogen delivery system |
US20040202673A1 (en) * | 2003-04-08 | 2004-10-14 | Jen-Pin Huang | Constructs of branched synthetic peptide immunogens with artificial T helper cell epitopes coupled to B cell epitopes |
EP2161037A3 (en) | 2003-04-22 | 2010-05-26 | Ipsen Pharma | Camptothecin-Somatostatin conjugates |
US8637047B2 (en) * | 2003-10-30 | 2014-01-28 | Boehringer Ingelheim Vetmedica, Inc. | Erysipelothrix rhusiopathiae-haemophilus parasuis vaccine and methods of using the same |
AU2005282231B2 (en) * | 2004-09-10 | 2011-03-10 | The Council Of The Queensland Institute Of Medical Research (Qimr) | Truncated LHRH formulations |
MX2007002930A (es) * | 2004-09-10 | 2007-10-15 | Queensland Inst Med Res | Formulaciones de lhrh truncadas. |
US8697846B2 (en) * | 2007-08-15 | 2014-04-15 | Emory University | Methods of making monoclonal antibodies using fusion-peptide epitope adoptive transfer (F-PEAT) technology |
US9932372B2 (en) | 2010-07-08 | 2018-04-03 | United Biomedical, Inc. | Designer peptide-based PCV2 vaccine |
CN101991848B (zh) * | 2010-11-10 | 2013-03-27 | 中国农业科学院上海兽医研究所 | 猪瘟合成肽疫苗及其应用 |
EP2797625B1 (en) * | 2011-12-30 | 2022-05-11 | United Biomedical, Inc. | Synthetic peptide-based marker vaccine and diagnostic system for effective control of porcine reproductive and respiratory syndrome (prrs) |
US9102752B2 (en) * | 2013-03-15 | 2015-08-11 | United Biomedical, Inc. | Peptide vaccine for prevention and immunotherapy of dementia of the Alzheimer's type |
AU2014401765A1 (en) * | 2014-07-25 | 2017-01-12 | United Biomedical, Inc. | Immunogenic LHRH composition and use thereof in pigs |
CN107449924B (zh) * | 2017-10-12 | 2019-03-19 | 华派生物工程集团有限公司 | 一种鸡免疫去势效果的判定方法 |
BR112020022443A2 (pt) * | 2018-05-04 | 2021-02-09 | Ubi Ip Holdings | epitopos de células t auxiliares promíscuos artificiais que facilitam a produção de anticorpos alvejados com resposta inflamatória de células t limitada |
JP7505788B2 (ja) * | 2018-10-01 | 2024-06-25 | ユナイテッド ニューロサイエンス | C9orf72に由来するジペプチドリピートタンパク質に対して指向化されたペプチド免疫原コンストラクト |
JP2022515934A (ja) * | 2018-12-31 | 2022-02-22 | ユナイテッド ニューロサイエンス リミテッド | カルシトニン遺伝子関連ペプチド(cgrp)を標的とするペプチド免疫原ならびに片頭痛の治療及び予防のためのそれらの配合物 |
WO2021150910A1 (en) * | 2020-01-23 | 2021-07-29 | Ubi Ip Holdings | Peptide immunogens targeting pituitary adenylate cyclase-activating peptide (pacap) and formulations thereof for prevention and treatment of migraine |
CN112879446A (zh) * | 2021-01-13 | 2021-06-01 | 刘兵 | 一种带有气压清洁机构的轴承装配台 |
CN112759636B (zh) * | 2021-01-21 | 2022-05-31 | 浙江辉肽生命健康科技有限公司 | 具有氨基酸结构eslkgvdpkflr的生物活性肽及其制备方法和应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0399001B1 (en) * | 1988-02-01 | 1994-07-27 | Praxis Biologics, Inc. | T-cell epitope as carriers molecule for conjugate vaccines |
US5023077A (en) * | 1989-01-24 | 1991-06-11 | Aphton Corporation | Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease |
IT1237764B (it) * | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici. |
DE69431114T2 (de) * | 1993-04-27 | 2003-03-13 | United Biomedical, Inc. | Immunogene lhrh peptidkonstrukion und synthetische, universale immunstimulatoren als impfstoffe |
US5759551A (en) * | 1993-04-27 | 1998-06-02 | United Biomedical, Inc. | Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines |
EP0725838A4 (en) * | 1993-10-26 | 1997-02-26 | United Biomedical Inc | STRUCTURED SYNTHETIC ANTIGAN BANKS AS DIAGNOSTICS, VACCINE AND THERAPEUTIC AGENTS |
US6025468A (en) * | 1998-06-20 | 2000-02-15 | United Biomedical, Inc. | Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens including immunogenic LHRH peptides |
TWI229679B (en) * | 1998-06-20 | 2005-03-21 | United Biomedical Inc | Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens |
-
1998
- 1998-06-20 US US09/100,414 patent/US6025468A/en not_active Expired - Lifetime
-
1999
- 1999-04-16 TW TW088106135A patent/TWI225069B/zh active
- 1999-04-30 US US09/303,323 patent/US6228987B1/en not_active Expired - Lifetime
- 1999-06-21 CA CA002330249A patent/CA2330249A1/en not_active Abandoned
- 1999-06-21 AU AU45803/99A patent/AU764961B2/en not_active Expired
- 1999-06-21 MX MXPA00011298A patent/MXPA00011298A/es unknown
- 1999-06-21 BR BR9912176-0A patent/BR9912176A/pt not_active IP Right Cessation
- 1999-06-21 CN CN99806646A patent/CN1315869A/zh active Pending
- 1999-06-21 WO PCT/US1999/013960 patent/WO1999066952A1/en not_active Application Discontinuation
- 1999-06-21 JP JP2000555638A patent/JP2003504302A/ja active Pending
- 1999-06-21 EP EP99928819A patent/EP1087787A1/en not_active Withdrawn
-
2001
- 2001-01-25 US US09/770,014 patent/US6559282B1/en not_active Expired - Lifetime
-
2005
- 2005-01-07 JP JP2005002994A patent/JP2005162761A/ja not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
CN1315869A (zh) | 2001-10-03 |
US6559282B1 (en) | 2003-05-06 |
CA2330249A1 (en) | 1999-12-29 |
US6025468A (en) | 2000-02-15 |
JP2005162761A (ja) | 2005-06-23 |
AU764961B2 (en) | 2003-09-04 |
EP1087787A1 (en) | 2001-04-04 |
AU4580399A (en) | 2000-01-10 |
JP2003504302A (ja) | 2003-02-04 |
WO1999066952A1 (en) | 1999-12-29 |
MXPA00011298A (es) | 2003-03-12 |
TWI225069B (en) | 2004-12-11 |
US6228987B1 (en) | 2001-05-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8O, 9O E 10O ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 1999 DE 28/04/2009. |