BR9909805A - Certain endothelin converting enzyme thiol inhibitors - Google Patents

Certain endothelin converting enzyme thiol inhibitors

Info

Publication number
BR9909805A
BR9909805A BR9909805-9A BR9909805A BR9909805A BR 9909805 A BR9909805 A BR 9909805A BR 9909805 A BR9909805 A BR 9909805A BR 9909805 A BR9909805 A BR 9909805A
Authority
BR
Brazil
Prior art keywords
converting enzyme
endothelin converting
inhibitors
certain
thiol inhibitors
Prior art date
Application number
BR9909805-9A
Other languages
Portuguese (pt)
Inventor
Stephane De Lombaert
Cynthia Anne Fink
Fariborz Firooznia
Denton Wade Hoyer
Arco Yingecheu Jeng
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR9909805A publication Critical patent/BR9909805A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Patente de Invenção: <B>"CERTOS INIBIDORES DE TIOL DE ENZIMA DE CONVERSãO DE ENDOTELINA"<D>. Revelados como inibidores de enzima de conversão de endotelina são os compostos da fórmula em que as variáveis têm os significados como definidos aqui mais acima.Invention Patent: <B> "CERTAIN ENDOTHELIN CONVERSION ENZYME TYPE INHIBITORS" <D>. Revealed as endothelin converting enzyme inhibitors are the compounds of the formula in which the variables have the meanings as defined here above.

BR9909805-9A 1998-04-23 1999-04-21 Certain endothelin converting enzyme thiol inhibitors BR9909805A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6526598A 1998-04-23 1998-04-23
PCT/EP1999/002690 WO1999055726A1 (en) 1998-04-23 1999-04-21 Certain thiol inhibitors of endothelin-converting enzyme

Publications (1)

Publication Number Publication Date
BR9909805A true BR9909805A (en) 2000-12-26

Family

ID=22061502

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9909805-9A BR9909805A (en) 1998-04-23 1999-04-21 Certain endothelin converting enzyme thiol inhibitors

Country Status (16)

Country Link
EP (1) EP1073674A1 (en)
JP (1) JP4350306B2 (en)
KR (1) KR20010034816A (en)
CN (1) CN1297453A (en)
AU (1) AU3819999A (en)
BR (1) BR9909805A (en)
CA (1) CA2323691A1 (en)
HU (1) HUP0101640A3 (en)
ID (1) ID26822A (en)
IL (1) IL138246A0 (en)
NO (1) NO20005293L (en)
PL (1) PL343594A1 (en)
RU (1) RU2000129510A (en)
SK (1) SK15812000A3 (en)
WO (1) WO1999055726A1 (en)
ZA (1) ZA200004680B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6423727B1 (en) 1998-04-23 2002-07-23 Novartis Ag Certain thiol inhibitors of endothelin-converting enzyme
US6426354B1 (en) 1998-04-23 2002-07-30 Novartis Ag Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme
AU2001254776A1 (en) * 2000-04-06 2001-10-23 Novartis Ag Organic compounds
US6777443B2 (en) * 2001-05-15 2004-08-17 Novartis Ag Dipeptide derivatives
CN1304415C (en) * 2001-09-21 2007-03-14 诺瓦提斯公司 Pyrane derivatives as both ACE- and NEP- inhibitors
TWI259079B (en) 2002-02-08 2006-08-01 Merck & Co Inc N-biphenyl(substituted methyl)aminocycloalkanecarboxamide derivatives
EP1476419B1 (en) 2002-02-08 2006-02-01 Merck & Co., Inc. N-biphenylmethyl aminocycloalkanecarboxamide derivatives
EP2161254B1 (en) 2002-03-05 2014-08-13 Sumitomo Chemical Company, Limited Intermediate for preparing a biaryl compound
CA2510811A1 (en) * 2002-12-20 2004-07-08 Bayer Healthcare Ag Use of substituted 2,5-diamidoindoles for the treatment of urological diseases
US7262184B2 (en) 2003-09-26 2007-08-28 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US7452875B2 (en) 2003-09-26 2008-11-18 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US7427611B2 (en) 2003-09-26 2008-09-23 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl)-cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
ATE406899T1 (en) * 2004-01-12 2008-09-15 Solvay Pharm Bv NEUTRAL ENDOPEPTIDASE (NEP) AND HUMAN SOLUBLE ENDOPEPTIDASE (HSEP) INHIBITORS FOR THE PROPHYLAXIS AND TREATMENT OF NEURODEGENERATIVE DISEASES
JP4047365B2 (en) 2006-01-11 2008-02-13 生化学工業株式会社 Cycloalkanecarboxamide derivative and method for producing the same
JP3975226B2 (en) 2006-01-11 2007-09-12 生化学工業株式会社 Cycloalkylcarbonylamino acid derivative and process for producing the same
EP2036920B1 (en) 2006-01-11 2011-05-18 Seikagaku Corporation Cycloalkylcarbonylamino acid ester derivative and process for producing the same
EP2234608A2 (en) 2007-12-11 2010-10-06 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties
CN104725279B (en) * 2015-02-12 2018-03-02 威海迪素制药有限公司 A kind of preparation method of N Boc biphenylalanine derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9407933A (en) * 1993-11-01 1996-11-26 Japat Ltd Endothelin receptor antagonists
PT655461E (en) * 1993-11-16 2000-11-30 Novartis Ag CYCLE DERIVATIVES OF AMINO ACIDS
FR2745571B1 (en) * 1996-03-04 1998-06-19 Inst Nat Sante Rech Med NOVEL SULFUR DERIVATIVES COMPRISING AN AMIDE BINDING, THEIR PREPARATION PROCESS, THEIR USE AS MEDICAMENTS, AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
ZA200004680B (en) 2001-04-25
NO20005293D0 (en) 2000-10-20
EP1073674A1 (en) 2001-02-07
AU3819999A (en) 1999-11-16
HUP0101640A3 (en) 2002-10-28
CN1297453A (en) 2001-05-30
IL138246A0 (en) 2001-10-31
ID26822A (en) 2001-02-15
SK15812000A3 (en) 2001-03-12
JP4350306B2 (en) 2009-10-21
CA2323691A1 (en) 1999-11-04
WO1999055726A1 (en) 1999-11-04
NO20005293L (en) 2000-12-18
RU2000129510A (en) 2002-11-10
HUP0101640A2 (en) 2001-09-28
KR20010034816A (en) 2001-04-25
PL343594A1 (en) 2001-08-27
JP2002513032A (en) 2002-05-08

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5O,6O, 7O E 8O ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007.