BR9908723A - Compound, use of same, pharmaceutical composition, processes to modulate the activity of one or more ptpases or other molecules with phosphotyrosine recognition unit (s) in an individual in need of this control, to isolate a protein, to copulate a fluorescent molecule or radiation to a compound, to detect protein tyrosine phosphatase or other molecules, to quantify the amount of protein tyrosine phosphatase or other molecules, and, to determine the function of a given protein tyrosine phosphatase or protein tyrosine phosphatase group or said molecules . - Google Patents
Compound, use of same, pharmaceutical composition, processes to modulate the activity of one or more ptpases or other molecules with phosphotyrosine recognition unit (s) in an individual in need of this control, to isolate a protein, to copulate a fluorescent molecule or radiation to a compound, to detect protein tyrosine phosphatase or other molecules, to quantify the amount of protein tyrosine phosphatase or other molecules, and, to determine the function of a given protein tyrosine phosphatase or protein tyrosine phosphatase group or said molecules .Info
- Publication number
- BR9908723A BR9908723A BR9908723-5A BR9908723A BR9908723A BR 9908723 A BR9908723 A BR 9908723A BR 9908723 A BR9908723 A BR 9908723A BR 9908723 A BR9908723 A BR 9908723A
- Authority
- BR
- Brazil
- Prior art keywords
- molecules
- tyrosine phosphatase
- protein tyrosine
- protein
- compound
- Prior art date
Links
Abstract
"COMPOSTO, USO DO MESMO, COMPOSIçãO FARMACêUTICA, PROCESSOS PARA MODULAR A ATIVIDADE DE UMA OU MAIS PTPASES OU OUTRAS MOLéCULAS COM UNIDADE(S) DE RECONHECIMENTO DE FOSFOTIROSINA EM UM INDIVìDUO EM NECESSIDADE DESTE CONTROLE, PARA ISOLAR UMA PROTEìNA, PARA COPULAR UMA MOLéCULA FLUORESCENTE OU RADIOATIVA A UM COMPOSTO, PARA DETECTAR PROTEìNA-TIROSINA FOSFATASE OU OUTRAS MOLéCULAS, PARA QUANTIFICAR A QUANTIDADE DE PROTEìNA-TIROSINA FOSFATASES OU OUTRAS MOLéCULAS, E, PARA DETERMINAR A FUNçãO DE UMA DADA PROTEìNA-TIROSINA FOSFATASE OU GRUPO DE PROTEìNA-TIROSINA FOSFATASES OU REFERIDAS MOLéCULAS". A presente invenção provê novos compostos, novas composições, processos de seu uso e processos de sua fabricação, onde os compostos são inibidores farmacologicamente utilizáveis de proteína tirosina fosfatases (PTPases, PTPs) como PTP1B, TC-PTP, CD45, SHP-1, SHP-2, PTPa, PTPe, PTPm, PTP d, PTPs, PTPx, PTPb, PTPD1, PTPD2, PTPH1, PTP-MEG1, PTP-LAR e HePTP. Estes compostos são indicados no controle ou tratamento de uma ampla faixa de doenças como doenças autoimunes, inflamação aguda e crónica, osteoporose, várias formas de câncer e doenças malignas, e diabete tipo I e diabete tipo II."COMPOUND, USE OF THE SAME, PHARMACEUTICAL COMPOSITION, PROCESSES TO MODULATE THE ACTIVITY OF ONE OR MORE PTPASES OR OTHER MOLECULES WITH PHOSPHOTYROSOSINE RECOGNITION UNIT (S) IN AN INDIVIDUAL IN NEED OF THIS CONTROL, TO ISOLATE A PROTEIN, TO PROVIDE A PROTECTED PROTEIN. OR RADIOACTIVE TO A COMPOUND, TO DETECT PROTEIN-TYROSINE PHOSPHATASE OR OTHER MOLECULES, TO QUANTIFY THE AMOUNT OF PROTEIN-TYROSINE PHOSPHATASE OR OTHER MOLECULES, AND TO DETERMINE THE FUNCTION OF A DATA PROTEIN-TINE PROTECTION REFERRED TO MOLECULES ". The present invention provides new compounds, new compositions, processes of their use and processes of their manufacture, where the compounds are pharmacologically usable inhibitors of protein tyrosine phosphatases (PTPases, PTPs) such as PTP1B, TC-PTP, CD45, SHP-1, SHP -2, PTPa, PTPe, PTPm, PTP d, PTPs, PTPx, PTPb, PTPD1, PTPD2, PTPH1, PTP-MEG1, PTP-LAR and HePTP. These compounds are indicated for the control or treatment of a wide range of diseases such as autoimmune diseases, acute and chronic inflammation, osteoporosis, various forms of cancer and malignancies, and type I diabetes and type II diabetes.
Applications Claiming Priority (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK34498 | 1998-03-12 | ||
DK35098 | 1998-03-12 | ||
DK34698 | 1998-03-12 | ||
DK34898 | 1998-03-12 | ||
DK34798 | 1998-03-12 | ||
DK34598 | 1998-03-12 | ||
DK34398 | 1998-03-12 | ||
DK34298 | 1998-03-12 | ||
DK47398 | 1998-04-03 | ||
DK48098 | 1998-04-03 | ||
DK47298 | 1998-04-03 | ||
PCT/DK1999/000126 WO1999046237A1 (en) | 1998-03-12 | 1999-03-12 | Modulators of protein tyrosine phosphatases |
Publications (1)
Publication Number | Publication Date |
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BR9908723A true BR9908723A (en) | 2000-11-21 |
Family
ID=27581527
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9908723-5A BR9908723A (en) | 1998-03-12 | 1999-03-12 | Compound, use of same, pharmaceutical composition, processes to modulate the activity of one or more ptpases or other molecules with phosphotyrosine recognition unit (s) in an individual in need of this control, to isolate a protein, to copulate a fluorescent molecule or radiation to a compound, to detect protein tyrosine phosphatase or other molecules, to quantify the amount of protein tyrosine phosphatase or other molecules, and, to determine the function of a given protein tyrosine phosphatase or protein tyrosine phosphatase group or said molecules . |
Country Status (1)
Country | Link |
---|---|
BR (1) | BR9908723A (en) |
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1999
- 1999-03-12 BR BR9908723-5A patent/BR9908723A/en not_active IP Right Cessation
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