BR9907683A - Pharmaceutical compositions in the form of nanoparticles, comprising lipid substances and amphiphilic substances and correlated preparation process - Google Patents

Pharmaceutical compositions in the form of nanoparticles, comprising lipid substances and amphiphilic substances and correlated preparation process

Info

Publication number
BR9907683A
BR9907683A BR9907683-7A BR9907683A BR9907683A BR 9907683 A BR9907683 A BR 9907683A BR 9907683 A BR9907683 A BR 9907683A BR 9907683 A BR9907683 A BR 9907683A
Authority
BR
Brazil
Prior art keywords
substances
nanoparticles
pharmaceutical compositions
correlated
preparation process
Prior art date
Application number
BR9907683-7A
Other languages
Portuguese (pt)
Inventor
Pierandrea Esposito
Italo Colombo
Nicoletta Coceani
Curto Maria Dorly Del
Fabio Carli
Original Assignee
Eurand Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eurand Int filed Critical Eurand Int
Publication of BR9907683A publication Critical patent/BR9907683A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

<B>"COMPOSIçõES FARMACêUTICAS NA FORMA DE NANOPARTìCULAS, COMPREENDENDO SUBSTâNCIAS LIPìDICAS E SUBSTâNCIAS ANFIFìLICAS E PROCESSO DE PREPARAçãO CORRELACIONADO"<D>. A presente invenção se refere à composições farmacêuticas na forma de nanopartículas, compreendendo um material compósito, consistindo de pelo menos uma substância lipídica e pelo menos uma substância anfifílica e um princípio farmaceuticamente ativo. As ditas composições, graças às propriedades de superfície e massa do dito material compósito, mostram um melhoramento na incorporação dos princípios ativos e aumento da biodisponibilidade dos princípios ativos fracamente absorvíveis.<B> "PHARMACEUTICAL COMPOSITIONS IN THE FORM OF NANOPARTICLES, UNDERSTANDING LIPID SUBSTANCES AND AMPHYPHYLIC SUBSTANCES AND CORRELATED PREPARATION PROCESS" <D>. The present invention relates to pharmaceutical compositions in the form of nanoparticles, comprising a composite material, consisting of at least one lipid substance and at least one amphiphilic substance and a pharmaceutically active principle. Said compositions, thanks to the surface and mass properties of said composite material, show an improvement in the incorporation of the active principles and an increase in the bioavailability of the weakly absorbable active principles.

BR9907683-7A 1998-02-06 1999-02-05 Pharmaceutical compositions in the form of nanoparticles, comprising lipid substances and amphiphilic substances and correlated preparation process BR9907683A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT98MI000234A IT1298575B1 (en) 1998-02-06 1998-02-06 PHARMACEUTICAL COMPOSITIONS IN THE FORM OF NANOPARTICLES INCLUDING LIPID SUBSTANCES AND ANTIPHILIC SUBSTANCES AND RELATED PROCESS OF
PCT/EP1999/000782 WO1999039700A1 (en) 1998-02-06 1999-02-05 Pharmaceutical compositions in form of nanoparticles comprising lipidic substances and amphiphilic substances and related preparation process

Publications (1)

Publication Number Publication Date
BR9907683A true BR9907683A (en) 2000-11-14

Family

ID=11378856

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9907683-7A BR9907683A (en) 1998-02-06 1999-02-05 Pharmaceutical compositions in the form of nanoparticles, comprising lipid substances and amphiphilic substances and correlated preparation process

Country Status (8)

Country Link
EP (1) EP1051160A1 (en)
JP (1) JP2002502813A (en)
KR (1) KR20010040726A (en)
AU (1) AU747129B2 (en)
BR (1) BR9907683A (en)
CA (1) CA2319565A1 (en)
IT (1) IT1298575B1 (en)
WO (1) WO1999039700A1 (en)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE251449T1 (en) 1999-06-14 2003-10-15 Cosmo Spa FLAVOR-MASKED ORAL PHARMACEUTICAL COMPOSITIONS WITH CONTROLLED DELIVERY
US8895064B2 (en) 1999-06-14 2014-11-25 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
US6309663B1 (en) * 1999-08-17 2001-10-30 Lipocine Inc. Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
WO2001012141A1 (en) 1999-08-18 2001-02-22 Kyowa Hakko Kogyo Co., Ltd. Hair growth stimulants
US6656504B1 (en) * 1999-09-09 2003-12-02 Elan Pharma International Ltd. Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions
CZ299726B6 (en) * 1999-11-01 2008-11-05 Composition for treatment of constipation and irritable bowel syndrome
EP1267946A4 (en) * 2000-02-28 2008-07-02 Genesegues Inc Nanocapsule encapsulation system and method
AU2001259671B2 (en) 2000-05-10 2004-06-24 Rtp Pharma Inc. Media milling
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
KR100508695B1 (en) * 2001-02-13 2005-08-17 한국과학기술연구원 Formulation for oral delivery of insulin and preparation method thereof
AU2002327179A1 (en) * 2001-06-07 2002-12-16 University Of Kentucky Research Foundation Nanoscintillation systems for aqueous-based liquid scintillation counting
KR100593861B1 (en) * 2001-09-24 2006-06-30 한국과학기술원 Method for preparing oral administration nanoparticles containing calcitonin
JP2005504090A (en) * 2001-09-26 2005-02-10 バクスター・インターナショナル・インコーポレイテッド Preparation of submicron size-nanoparticles by removal of dispersion and solvent or liquid phase
US20060003012A9 (en) * 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
ITMI20012599A1 (en) * 2001-12-11 2003-06-11 Cosmo Spa PHARMACEUTICAL COMPOSITIONS FOR THE ORAL ADMINISTRATION OF HEPARINE OR DERIVATIVES, USEFUL FOR THERAPY OF INFLAMMATORY DISEASES OF THE INT
US9308220B2 (en) 2001-12-11 2016-04-12 Cosmo Technologies Limited Pharmaceutical compositions for the oral administration of heparin or derivatives thereof
CA2470230C (en) * 2001-12-14 2012-01-24 Jagotec Ag Pharmaceutical formulation comprising cyclosporin and use thereof
SE0104421D0 (en) 2001-12-21 2001-12-21 Ponsus Pharma Ab New composition
KR100422763B1 (en) * 2002-01-17 2004-03-12 주식회사 태평양 Preparation of botanical nano-particles having excellent percutaneous absorption properties, and cosmetic and medical composition comprising the nano-particles
JP2003342196A (en) * 2002-05-31 2003-12-03 Mukku:Kk Composition for intravenous injection, method of production for the same and its preparation
ITMI20022323A1 (en) * 2002-10-31 2004-05-01 Maria Rosa Gasco PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF OPHTHALMIC DISEASES.
KR100507771B1 (en) * 2002-11-08 2005-08-17 한미약품 주식회사 A composition for oral administration of water-insoluble anti-cold drug and a preparation method thereof
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
KR20040084240A (en) * 2003-03-27 2004-10-06 (주) 코스메디 solid lipid nanoparticles, pharmaceutical compositions containing the solid lipid nanoparticles for delivering the active substance and preparing methods for theirof
US7438903B2 (en) 2003-06-06 2008-10-21 Nbty, Inc. Methods and compositions that enhance bioavailability of coenzyme-Q10
WO2005016386A1 (en) * 2003-08-19 2005-02-24 Meditech Research Limited Improved therapeutic protocols
AU2003303744A1 (en) * 2003-10-31 2005-06-17 Elan Pharma International Ltd. Novel nimesulide compositions
EP1691795A2 (en) * 2003-12-03 2006-08-23 LifeCycle Pharma A/S Pharmaceutical compositions comprising danazol
US7803366B2 (en) 2004-05-07 2010-09-28 Nbty, Inc. Methods and compositions that enhance bioavailability of coenzyme-Q10
EP1674077A1 (en) * 2004-12-27 2006-06-28 Université de Liège Mucoadhesive pharmaceutical compositions comprising chemoattractants
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
US8252326B2 (en) 2005-06-01 2012-08-28 Catalent Australia Pty Ltd. Self-microemulsifying dosage forms of low solubility active ingredients such as co-enzyme Q10
KR101106510B1 (en) 2006-05-30 2012-01-20 인타르시아 세라퓨틱스 인코포레이티드 Two-piece, internal-channel osmotic delivery system flow modulator
EP2086513B1 (en) * 2006-09-26 2016-09-07 Samyang Biopharmaceuticals Corporation Submicron nanoparticle of poorly water soluble camptothecin derivatives and process for preparation thereof
ES2402172T3 (en) 2007-04-23 2013-04-29 Intarcia Therapeutics, Inc Suspension formulation of insulinotropic peptides and uses thereof
CA2689978A1 (en) 2007-06-08 2008-12-18 Addrenex Pharmaceuticals, Inc. Extended release formulation and method of treating adrenergic dysregulation
EP2240155B1 (en) 2008-02-13 2012-06-06 Intarcia Therapeutics, Inc Devices, formulations, and methods for delivery of multiple beneficial agents
FR2943545B1 (en) * 2009-03-31 2011-06-03 Univ Claude Bernard Lyon SOLID LIPID NANOPARTICLES ENCAPSULATING MINOXIDIL AND AQUEOUS SUSPENSION CONTAINING SAME.
CN107638562B (en) 2009-09-28 2022-12-02 精达制药公司 Rapid establishment and/or termination of substantial steady-state drug delivery
FR2958150B1 (en) 2010-04-01 2012-06-15 Univ Claude Bernard Lyon ELASTIC ORTHODONTIC ELEMENTS TO RELEASE LOWLY SOLUBLE CHLORHEXIDINE IN SALIVA
CN102247320B (en) * 2010-05-21 2013-03-13 天津药物研究院 Etoposide long-circulating emulsion and preparation method thereof
BRPI1002601E2 (en) * 2010-06-01 2020-06-30 Embrapa Pesquisa Agropecuaria nanostructured composition for veterinary use for drug administration
CN101912363A (en) * 2010-07-29 2010-12-15 蔡海德 Dissolving ultrafiltration-spray drying-molecule dispersion coating-hydration palletizing-freeze drying method for preparing liposome combination medicine
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US10154964B2 (en) 2011-09-07 2018-12-18 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
BR112014012444B1 (en) 2011-11-23 2021-12-14 Therapeuticsmd, Inc A PHARMACEUTICAL COMPOSITION COMPRISING SOLUBILIZED ESTRADIOL, PROGESTERONE AND A SOLUBILIZING AGENT, AND USES THEREOF TO TREAT A MENOPAUSE-RELATED SYMPTOM IN A WOMAN
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
FR2995222B1 (en) * 2012-09-11 2016-05-20 Creathes ALTERNATIVE METHOD OF MICROENCAPSULATION OF ACTIVE PRINCIPLE
US9352047B2 (en) * 2012-11-14 2016-05-31 Abon Pharmaceuticals, Llc Oral transmucosal drug delivery system
CN102988285B (en) * 2012-12-13 2014-02-19 哈药集团技术中心 Docetaxel injection composition and preparation method thereof
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
CA2912578A1 (en) * 2013-06-20 2014-12-24 Glenmark Pharmaceuticals S.A. Nanoparticulate formulation comprising a trpa1 antagonist
EP2821077A1 (en) * 2013-07-04 2015-01-07 Praxis Biopharma Research Institute Lipid nanoparticles for wound healing
JP2017516768A (en) 2014-05-22 2017-06-22 セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． Natural combination hormone replacement therapy and therapy
ES2942619T3 (en) * 2014-06-11 2023-06-05 SpecGx LLC Spray-dried compositions with different dissolution profiles and procedures for their preparation
MX2016013693A (en) 2014-07-29 2017-10-31 Therapeuticsmd Inc Transdermal cream.
PT3174535T (en) * 2014-08-01 2019-05-27 Glenmark Pharmaceuticals Sa Nanoparticulate formulation comprising a mpges-1 inhibitor
CN111700877A (en) 2014-09-03 2020-09-25 吉倪塞思公司 Therapeutic nanoparticles and related compositions, methods and systems
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
US10925639B2 (en) 2015-06-03 2021-02-23 Intarcia Therapeutics, Inc. Implant placement and removal systems
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
EP3435977A4 (en) 2016-04-01 2019-10-16 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
BR112018073511A2 (en) 2016-05-16 2019-03-26 Intarcia Therapeutics, Inc. glucagon receptor selective polypeptides and methods of use
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
MX2019008006A (en) 2017-01-03 2019-08-29 Intarcia Therapeutics Inc Methods comprising continuous administration of a glp-1 receptor agonist and co-adminstration of a drug.
WO2021016134A1 (en) * 2019-07-19 2021-01-28 Spi Pharma, Inc. Preparation of lipophilic active ingredients

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3421468A1 (en) * 1984-06-08 1985-12-19 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim LIPID NANOPELLETS AS A CARRIER SYSTEM FOR MEDICINAL PRODUCTS FOR PERORAL USE
US5250236A (en) * 1991-08-05 1993-10-05 Gasco Maria R Method for producing solid lipid microspheres having a narrow size distribution
CA2091152C (en) * 1993-03-05 2005-05-03 Kirsten Westesen Solid lipid particles, particles of bioactive agents and methods for the manfuacture and use thereof

Also Published As

Publication number Publication date
KR20010040726A (en) 2001-05-15
JP2002502813A (en) 2002-01-29
WO1999039700A1 (en) 1999-08-12
AU747129B2 (en) 2002-05-09
AU2723899A (en) 1999-08-23
IT1298575B1 (en) 2000-01-12
EP1051160A1 (en) 2000-11-15
ITMI980234A1 (en) 1999-08-06
CA2319565A1 (en) 1999-08-12

Similar Documents

Publication Publication Date Title
BR9907683A (en) Pharmaceutical compositions in the form of nanoparticles, comprising lipid substances and amphiphilic substances and correlated preparation process
BRPI0009299B8 (en) mechanically stable pharmaceutical administration forms for oral administration, and, process for producing mechanically stable pharmaceutical administration forms.
ATE270544T1 (en) SEMI-SOLID MEDICINAL PREPARATION CONTAINING ISOTRETINOIN
BR0214469A (en) 17alpha-alkyl-17beta-oxystratrienes and intermediate products for their preparation, application of 17alpha-alkyl-17beta-oxystratrienes for the preparation of medicaments as well as pharmaceutical preparations
FR2824825B1 (en) NOVEL ALPHA-AMINOACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
BR9405798A (en) Methods for in vivo release of biological material and useful compositions thereof
CY1108166T1 (en) PHARMACEUTICAL FORM AND LONG-TERM GUIFFESENIN
EE200000791A (en) Novel acyl pseudopeptides, process for their preparation and pharmaceutical compositions containing them
MA28626B1 (en) CRYSTALLINE DELTA FORM OF IVABRADINE HYDROCHLORIDE, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
IT9022155A0 (en) PHARMACEUTICAL COMPOSITIONS IN THE FORM OF PARTICLES SUITABLE FOR THE CONTROLLED RELEASE OF PHARMACOLOGICALLY ACTIVE SUBSTANCES AND PROCEDURE FOR THEIR PREPARATION
NO20025621D0 (en) Sustained release pharmaceutical composition for parenteral administration of hydrophilic compounds
EE200200357A (en) Pharmaceutical compositions providing increased concentrations of the drug substance
DE69812936D1 (en) MEDICINAL PRODUCT IN THE FORM OF PARENENTERAL ADMINISTRATIVE LIPID MICROPARTICLE
BR0212052A (en) Preparation of prolonged release pharmaceutical composition
CY1112139T1 (en) A PHARMACEUTICAL COMPOSITION INCLUDING CRYSTALL RITONAVIR FORM II AND A PREPARATION THEREOF
BR0107899A (en) Process for producing an active ingredient preparation comprising ibuprofen, preparation of active ingredient, use thereof, pharmaceutical preparation, use thereof, process for producing solid dosage forms, and, solid dosage form
FR2803848B1 (en) NOVEL BENZENESULFONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
RU2001116085A (en) Phospholipid complexes of proanthocyanidin A2 as anti-atherosclerotic agents
BR9509517A (en) Liposomal composition Pharmaceutical composition and process for the preparation of liposomal compositions
NO331205B1 (en) Pharmaceutical composition as solid dosage form and method of preparation thereof
NO20012518D0 (en) Process for the preparation of drugs in solid administration form
FR2805259B1 (en) NOVEL N-MERCAPTOACYL AMINOACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2822153B1 (en) NOVEL INDENOINDOLONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
BR0013563A (en) Solid pharmaceutical preparation, use of a pharmaceutical preparation and process for the production of a pharmaceutical preparation
FR2821843B1 (en) NOVEL ISOINDOLOINDOLONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE 4A, 5A, 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1910 DE 14/08/2007.

B15K Others concerning applications: alteration of classification

Ipc: A61K 9/51 (2006.01), A61K 38/23 (2006.0