BR9907216A - Il-16 mutants, processes for their production and use - Google Patents

Il-16 mutants, processes for their production and use

Info

Publication number
BR9907216A
BR9907216A BR9907216-5A BR9907216A BR9907216A BR 9907216 A BR9907216 A BR 9907216A BR 9907216 A BR9907216 A BR 9907216A BR 9907216 A BR9907216 A BR 9907216A
Authority
BR
Brazil
Prior art keywords
mutants
production
processes
nucleic acid
amino acids
Prior art date
Application number
BR9907216-5A
Other languages
Portuguese (pt)
Inventor
Reinhard Kurth
Michael Baier
Albrecht Werner
Dorothee Ambrosius
Martin Lanzendoerfer
Original Assignee
Bundesrep Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bundesrep Deutschland filed Critical Bundesrep Deutschland
Publication of BR9907216A publication Critical patent/BR9907216A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5446—IL-16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Patente de Invenção: <B>"MUTANTES DE IL-16, PROCESSOS PARA SUA PRODUçãO E UTILIZAçãO DOS MESMOS"<D>. ácido nucléico que pode ser usado para expressar um mutante de IL-16 em uma célula hospedeira procariótica ou eucariótica, onde o ácido nucléico codifica um polipeptídeo com uma seq³ência de aminoácido começando com aminoácidos 1-5 e terminando com aminoácidos 93-107 da SEQID N°: 2, é apropriado para produção de mutantes de IL-16 com atividade aperfeiçoada.Invention Patent: <B> "MUTANTS OF IL-16, PROCESSES FOR THEIR PRODUCTION AND USE OF THE SAME" <D>. nucleic acid that can be used to express an IL-16 mutant in a prokaryotic or eukaryotic host cell, where the nucleic acid encodes a polypeptide with an amino acid sequence starting with amino acids 1-5 and ending with amino acids 93-107 of SEQID N °: 2, is suitable for production of IL-16 mutants with improved activity.

BR9907216-5A 1998-01-24 1999-01-22 Il-16 mutants, processes for their production and use BR9907216A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98101232 1998-01-24
PCT/EP1999/000428 WO1999037781A1 (en) 1998-01-24 1999-01-22 Mutants of il-16, processes for their production, and their use

Publications (1)

Publication Number Publication Date
BR9907216A true BR9907216A (en) 2000-10-24

Family

ID=8231307

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9907216-5A BR9907216A (en) 1998-01-24 1999-01-22 Il-16 mutants, processes for their production and use

Country Status (8)

Country Link
EP (1) EP1049782A1 (en)
JP (1) JP2002500889A (en)
AU (1) AU2424399A (en)
BR (1) BR9907216A (en)
CA (1) CA2320624A1 (en)
EA (1) EA200000769A1 (en)
MX (1) MXPA00006059A (en)
WO (1) WO1999037781A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6699466B1 (en) * 1999-08-05 2004-03-02 Research Corporation Technologies, Inc. IL-16 antagonist peptides and DNA encoding the peptides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994028134A1 (en) * 1993-05-21 1994-12-08 The Trustees Of Boston University Lymphocyte chemoattractant factor and uses thereof
WO1997023616A1 (en) * 1995-12-22 1997-07-03 BUNDESREPUBLIK DEUTSCHLAND, vertreten durch den BUNDESMINISTER FÜR GESUNDHEIT Polypeptides with interleukin 16 activity, process for the preparation and use thereof
DE19617202A1 (en) * 1996-04-30 1997-11-06 Boehringer Mannheim Gmbh Recombinant interleukin 16
US6444202B1 (en) * 1996-11-25 2002-09-03 Bundesrepublic Deutschland, Vertreten Durch Den Bundesminister Fur Gesundheit Processed polypeptides with IL-16 activity, processes for their production and their use

Also Published As

Publication number Publication date
JP2002500889A (en) 2002-01-15
EA200000769A1 (en) 2001-02-26
MXPA00006059A (en) 2003-08-01
EP1049782A1 (en) 2000-11-08
WO1999037781A1 (en) 1999-07-29
AU2424399A (en) 1999-08-09
CA2320624A1 (en) 1999-07-29

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1910 DE 14/08/2007.