BR9904696A - Process and intermediates for the preparation of nicotinamide derivatives - Google Patents

Process and intermediates for the preparation of nicotinamide derivatives

Info

Publication number
BR9904696A
BR9904696A BR9904696-2A BR9904696A BR9904696A BR 9904696 A BR9904696 A BR 9904696A BR 9904696 A BR9904696 A BR 9904696A BR 9904696 A BR9904696 A BR 9904696A
Authority
BR
Brazil
Prior art keywords
compound
formula
preparation
reacting
prepared
Prior art date
Application number
BR9904696-2A
Other languages
Portuguese (pt)
Inventor
Jerry Anthony Murry
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR9904696A publication Critical patent/BR9904696A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Patente de Invenção: <B>"PROCESSO E INTERMEDIáRIOS PARA A PREPARAçãO DE DERIVADOS DE NICOTINAMIDA"<D>. Um processo para a preparação de um composto da fórmula o qual inclui fazer reagir um composto da fórmula IV com uma base de carbonato num solvente alcoólico. O composto de fórmula IV é preparado pela reação de um composto com a fórmula III com um reagente de Grignard de metila num solvente inerte. O Composto de fórmula III é preparado fazendo reagir um composto com a fórmula II com um anidrido acético e uma amina como base num solvente clorado. O composto de fórmula II é preparado fazendo reagir um composto com a fórmula I com um álcool num meio ácido, para formar um grupo éster. A invenção inclui também os novos compostos das fórmulas no qual R é alquila(C~ 1~-C~ 6~), eInvention Patent: <B> "PROCESS AND INTERMEDIARIES FOR THE PREPARATION OF NICOTINAMIDE DERIVATIVES" <D>. A process for the preparation of a compound of the formula which includes reacting a compound of the formula IV with a carbonate base in an alcoholic solvent. The compound of formula IV is prepared by reacting a compound of formula III with a methyl Grignard reagent in an inert solvent. The compound of formula III is prepared by reacting a compound of formula II with an acetic anhydride and an amine as a base in a chlorinated solvent. The compound of formula II is prepared by reacting a compound of formula I with an alcohol in an acidic medium, to form an ester group. The invention also includes the new compounds of the formulas in which R is alkyl (C ~ 1 ~ -C ~ 6 ~), and

BR9904696-2A 1998-10-21 1999-10-20 Process and intermediates for the preparation of nicotinamide derivatives BR9904696A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10512098P 1998-10-21 1998-10-21

Publications (1)

Publication Number Publication Date
BR9904696A true BR9904696A (en) 2000-08-08

Family

ID=22304138

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9904696-2A BR9904696A (en) 1998-10-21 1999-10-20 Process and intermediates for the preparation of nicotinamide derivatives

Country Status (10)

Country Link
JP (1) JP2000128835A (en)
KR (1) KR20000029190A (en)
AR (1) AR020919A1 (en)
AU (1) AU5595399A (en)
BR (1) BR9904696A (en)
CA (1) CA2286646A1 (en)
HU (1) HU9903736D0 (en)
IL (1) IL132405A0 (en)
PL (1) PL336111A1 (en)
ZA (1) ZA996624B (en)

Also Published As

Publication number Publication date
AU5595399A (en) 2000-05-04
KR20000029190A (en) 2000-05-25
HU9903736D0 (en) 1999-12-28
PL336111A1 (en) 2000-04-25
JP2000128835A (en) 2000-05-09
CA2286646A1 (en) 2000-04-21
IL132405A0 (en) 2001-03-19
ZA996624B (en) 2001-04-20
AR020919A1 (en) 2002-06-05

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]