BR9816047A - Method of using neuroimmunophilins for selective neuronal radioprotection; improved method; use of neuroimmunophilin binders and manufactured article - Google Patents

Method of using neuroimmunophilins for selective neuronal radioprotection; improved method; use of neuroimmunophilin binders and manufactured article

Info

Publication number
BR9816047A
BR9816047A BR9816047-8A BR9816047A BR9816047A BR 9816047 A BR9816047 A BR 9816047A BR 9816047 A BR9816047 A BR 9816047A BR 9816047 A BR9816047 A BR 9816047A
Authority
BR
Brazil
Prior art keywords
manufactured article
neuroimmunophilins
neuroimmunophilin
radioprotection
binders
Prior art date
Application number
BR9816047-8A
Other languages
Portuguese (pt)
Inventor
Marcus Keep
Elmer Eskil
Original Assignee
Marcus Keep
Elmer Eskil
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marcus Keep, Elmer Eskil filed Critical Marcus Keep
Publication of BR9816047A publication Critical patent/BR9816047A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"MéTODO DE UTILIZAçãO DE NEUROIMUNOFIILINAS PARA RADIOPROTEçãO NEURONAL SELETIVA; MéTODO APERFEIçOADO; USO DE LIGANTES DE NEUROIMUNOFILINAS E ARTIGO FABRICADO". Um método e medicamentos para seletivamente proteger neurónios contra danos induzidos pela radiação ionizante, sem restrição a fonte De ofensa de radiação. Este método é particularmente util na proteção seletiva de neuronios normais, mas não para celulas de tumores cerebrais, contra os efeitos malígnos da radiação de ionizante."METHOD OF USE OF NEUROIMMUNOPHYLINES FOR SELECTIVE NEURONAL RADIO PROTECTION; PERFECT METHOD; USE OF NEUROIMMUNOPHYL LINERS AND MANUFACTURED ARTICLE". A method and drugs for selectively protecting neurons against damage induced by ionizing radiation without restriction to the source of radiation offense. This method is particularly useful in the selective protection of normal neurons, but not for brain tumor cells, against the ill effects of ionizing radiation.

BR9816047-8A 1998-09-23 1998-09-23 Method of using neuroimmunophilins for selective neuronal radioprotection; improved method; use of neuroimmunophilin binders and manufactured article BR9816047A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1998/020040 WO2000016794A1 (en) 1998-09-23 1998-09-23 Neuroimmunophilins for selective neuronal radioprotection

Publications (1)

Publication Number Publication Date
BR9816047A true BR9816047A (en) 2003-01-07

Family

ID=22267931

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9816047-8A BR9816047A (en) 1998-09-23 1998-09-23 Method of using neuroimmunophilins for selective neuronal radioprotection; improved method; use of neuroimmunophilin binders and manufactured article

Country Status (10)

Country Link
EP (1) EP1115412A4 (en)
JP (1) JP2002526453A (en)
CN (1) CN1322136A (en)
AP (1) AP2001002113A0 (en)
AU (1) AU766095B2 (en)
BR (1) BR9816047A (en)
CA (1) CA2345378A1 (en)
HK (1) HK1040617A1 (en)
IL (1) IL142120A0 (en)
WO (1) WO2000016794A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1330258T3 (en) * 2000-10-31 2006-05-22 Pharma Mar Sa Kahalalid F formulation
WO2005103255A1 (en) * 2004-03-25 2005-11-03 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Formylpeptide receptor (fpr) as a target for anti-malignant glioma therapy
JP2021525737A (en) 2018-05-30 2021-09-27 ザップ サージカル システムズ， インコーポレイテッド Radiosurgical neuromodulation near critical structures
CN118286388A (en) * 2024-04-12 2024-07-05 中国人民解放军军事科学院军事医学研究院 Application of cyclosporin in treating intestinal radiation injury

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE520730C2 (en) * 1995-01-20 2003-08-19 Eskil Elmer Treatment of brain ischemia and brain damage with a neuroprotective drug
JP3089350B2 (en) * 1995-11-20 2000-09-18 ギルフォード ファーマシューティカルズ インコーポレイテッド Inhibitors of cyclophilin rotamase activity

Also Published As

Publication number Publication date
AU766095B2 (en) 2003-10-09
AP2001002113A0 (en) 2001-06-30
JP2002526453A (en) 2002-08-20
IL142120A0 (en) 2002-03-10
AU9508198A (en) 2000-04-10
EP1115412A4 (en) 2004-12-15
WO2000016794A1 (en) 2000-03-30
EP1115412A1 (en) 2001-07-18
HK1040617A1 (en) 2002-06-21
CA2345378A1 (en) 2000-03-30
CN1322136A (en) 2001-11-14

Similar Documents

Publication Publication Date Title
NO952618L (en) Xerogels, their preparation process and their use
IL143901A0 (en) Use of cyclooxygenase-2- inhibitor, a matrix metallaproteinase inhibitor, an antineoplastic agent and optionally radiation as a combination treatment of neoplasia
BR0015110A (en) Methods of treating cell proliferative diseases, of treating a disorder associated with ksp kinesin activity, of ksp kinesin inhibition, of kps kinesin modulators and of screening compounds that bind ksp kinesin, and compounds
BR9603472A (en) Protector set and protection process suitable for use in communication device
BR9104565A (en) SYNTHETIC PSEUDOCERAMIDE, PROCESS TO SYNTHESIZE THE SAME, COMPOSITION AND PROCESS TO TREAT SKIN
BR9913752B1 (en) use of a tissue protection product and a process for tissue treatment.
IS1839B (en) Piperazine derivatives having analgesic effect, production and use
FI973522A0 (en) Aqueous, lecithin-based release agents and methods for their use
AU1221600A (en) Cardiac rhythm management device with detection and therapy for sudden syncopal events
ES2126887T3 (en) ARTIFICIAL TANNING COMPOSITIONS WITH IMPROVED STABILITY.
ATE221881T1 (en) TETRALIN COMPOUNDS WITH MULTI-DRUG RESISTANCE (MDR) ACTIVITY
SE9802208D0 (en) Novel compounds
EE03851B1 (en) Use of amines for the manufacture of a medicament for inhibiting the proliferation of tumor cells
BR9816047A (en) Method of using neuroimmunophilins for selective neuronal radioprotection; improved method; use of neuroimmunophilin binders and manufactured article
DE69920949D1 (en) ASCOMYCIN-CONTAINING TOPICAL PREPARATIONS
IL59378A (en) 1-allyltriazole derivatives,their preparation and their use as plant protecting agents
HUT74948A (en) Use of p antagonist for producing pharmaceutical compositions for treating acne, rosacea and/or pubic arythema
HUP0200969A3 (en) Use of saredutant and the pharmaceutically acceptable salts thereof to produce medicaments used to treat or prevent mood disorders, adjustment disorders os mixed anxiety-depression disorders
BR9100519A (en) COMPOUND, PHARMACEUTICAL COMPOSITION, METHOD FOR CHOLINESTERASE INHIBITION IN A MAMMAL AND METHOD TO IMPROVE MEMORY OR TREAT OR PREVENT ALZHEIMER'S DISEASE
AT378462B (en) DEVICE FOR THE EVEN DOSAGE, DISTRIBUTION AND APPLICATION OF LIQUID-FORMULATED PROTECTIVE SUBSTANCES, IN PARTICULAR SEEDING AGENTS
SE9802209D0 (en) Novel compounds
BR0208860A (en) Use of a cationic dextran derivative, method for protecting an individual against dose-limiting organ damage, and method for protecting an individual against renal damage
NO942230D0 (en) Substituted benzimidazoles, processes for their preparation and their use
WO1999045103A3 (en) Human spinal cord cell lines and methods of use therefor
ES456280A1 (en) Alpha-2,5,9-trimethyl-benzo(b)thiene(2,3-f)morphan and precursor thereof

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE COMO INVENCAO, DE ACORDO COM ARTIGO 8O DA LPI