BR9815580A - Vaccine composition, processes to generate an anti-idiotype response in a subject, to treat or prevent cancer, to treat or prevent an infectious disease, to prepare a first immunoglobulin molecule, and, first immunoglobulin molecule - Google Patents
Vaccine composition, processes to generate an anti-idiotype response in a subject, to treat or prevent cancer, to treat or prevent an infectious disease, to prepare a first immunoglobulin molecule, and, first immunoglobulin moleculeInfo
- Publication number
- BR9815580A BR9815580A BR9815580-6A BR9815580A BR9815580A BR 9815580 A BR9815580 A BR 9815580A BR 9815580 A BR9815580 A BR 9815580A BR 9815580 A BR9815580 A BR 9815580A
- Authority
- BR
- Brazil
- Prior art keywords
- treat
- prevent
- immunoglobulin molecule
- processes
- generate
- Prior art date
Links
- 108060003951 Immunoglobulin Proteins 0.000 title abstract 5
- 102000018358 immunoglobulin Human genes 0.000 title abstract 5
- 208000035473 Communicable disease Diseases 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 230000003302 anti-idiotype Effects 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 208000015181 infectious disease Diseases 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 229940072221 immunoglobulins Drugs 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
- C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
- C07K16/4266—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig against anti-tumor receptor Ig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/18—Kallidins; Bradykinins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
"COMPOSIçãO DE VACINA, PROCESSOS PARA GERAR UMA RESPOSTA DE ANTI-IDIóTIPO EM UM SUJEITO, PARA TRATAR OU PREVENIR CâNCER, PARA TRATAR OU PREVENIR UMA DOENçA INFECCIOSA, PARA PREPARAR UMA PRIMEIRA MOLéCULA DE IMUNOGLOBULINA, E, PRIMEIRA MOLéCULA DE IMUNOGLOBULINA". A invenção refere-se às moléculas de imunoglobulina modificada nas quais um ou mais resíduos de região variável que formam pontes de dissulfeto de intracadeias são substituídos por resíduos de aminoácido que não contêm grupos sulfidrila, de tal modo que não possa ser formada a ponte de dissulfeto de intracadeia. Tais moléculas de imunoglobulina apresentam uma capacidade aumentada de gerar uma resposta de anti-idiótipo. A invenção proporciona adicionalmente os processos para prevenção e tratamento de câncer e/ou de doenças infecciosas usando as imunoglobulinas modificadas da invenção."VACCINE COMPOSITION, PROCESSES TO GENERATE AN ANTI-IDIOTYPE RESPONSE IN A SUBJECT, TO TREAT OR PREVENT CANCER, TO TREAT OR PREVENT AN INFECTIOUS DISEASE, TO PREPARE A FIRST IMMUNOGLOBULINE MOLECULE, AND, IMMOLCULINE, AND IMMOLCULINE. The invention relates to modified immunoglobulin molecules in which one or more residues of variable region that form intrachain disulfide bridges are replaced by amino acid residues that do not contain sulfhydryl groups, so that the disulfide bridge cannot be formed of intrachain. Such immunoglobulin molecules have an increased ability to generate an anti-idiotype response. The invention further provides the processes for preventing and treating cancer and / or infectious diseases using the modified immunoglobulins of the invention.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6571697P | 1997-11-14 | 1997-11-14 | |
US8140398P | 1998-04-10 | 1998-04-10 | |
PCT/US1998/024303 WO1999025379A1 (en) | 1997-11-14 | 1998-11-13 | Modified antibodies with enhanced ability to elicit an anti-idiotype response |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9815580A true BR9815580A (en) | 2002-01-29 |
Family
ID=26745908
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9815580-6A BR9815580A (en) | 1997-11-14 | 1998-11-13 | Vaccine composition, processes to generate an anti-idiotype response in a subject, to treat or prevent cancer, to treat or prevent an infectious disease, to prepare a first immunoglobulin molecule, and, first immunoglobulin molecule |
BR9815289-0A BR9815289A (en) | 1997-11-14 | 1998-11-13 | Modified immunoglobulin, molecule, isolated nucleic acid, cell containing the same, recombinant non-human animal, pharmaceutical composition, vaccine composition, processes for identifying or measuring or detecting a cancer antigen, an antigen from an infectious disease agent, a ligand, and a receptor in a sample. to be tested, kits for detecting a cancer antigen, an infectious disease agent antigen, a cell receptor for an infectious disease agent, a ligand, and a cancer antigen, diagnostic processes or testing for the presence of or a predisposition for the development of a cancer by the increased presence of a cancer antigen, and for the presence of an infectious disease, treatment or prevention of a cancer by the presence of a cancer antigen, of an infectious disease typified by the presence of an antigen infectious disease agent, and a disease caused by an infectious disease agent that binds to a cell receptor, processes for modulating activity of a first member of a binding pair, process for producing a modified immunoglobulin, process for producing a modified immunoglobulin nucleic acid, and, isolated nucleic acid |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9815289-0A BR9815289A (en) | 1997-11-14 | 1998-11-13 | Modified immunoglobulin, molecule, isolated nucleic acid, cell containing the same, recombinant non-human animal, pharmaceutical composition, vaccine composition, processes for identifying or measuring or detecting a cancer antigen, an antigen from an infectious disease agent, a ligand, and a receptor in a sample. to be tested, kits for detecting a cancer antigen, an infectious disease agent antigen, a cell receptor for an infectious disease agent, a ligand, and a cancer antigen, diagnostic processes or testing for the presence of or a predisposition for the development of a cancer by the increased presence of a cancer antigen, and for the presence of an infectious disease, treatment or prevention of a cancer by the presence of a cancer antigen, of an infectious disease typified by the presence of an antigen infectious disease agent, and a disease caused by an infectious disease agent that binds to a cell receptor, processes for modulating activity of a first member of a binding pair, process for producing a modified immunoglobulin, process for producing a modified immunoglobulin nucleic acid, and, isolated nucleic acid |
Country Status (9)
Country | Link |
---|---|
EP (2) | EP1032420A4 (en) |
JP (2) | JP2002507544A (en) |
KR (2) | KR20010015817A (en) |
CN (2) | CN1327388A (en) |
AU (2) | AU763029B2 (en) |
BR (2) | BR9815580A (en) |
CA (2) | CA2310269A1 (en) |
IL (2) | IL136113A0 (en) |
WO (2) | WO1999025379A1 (en) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
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CA2350917A1 (en) * | 1998-11-13 | 2000-05-25 | Euro-Celtique, S.A. | Contraceptive antibody vaccines |
PT1092779E (en) * | 1999-10-11 | 2010-01-19 | Pasteur Institut | Lentiviral vectors for the preparation of immunotherapeutical compositions |
WO2001088159A2 (en) * | 2000-05-16 | 2001-11-22 | Euro-Celtique S.A. | Cd28 synthebody for the modulation of immune responses |
US7396917B2 (en) | 2000-12-05 | 2008-07-08 | Alexion Pharmaceuticals, Inc. | Rationally designed antibodies |
ATE414720T1 (en) | 2000-12-05 | 2008-12-15 | Alexion Pharma Inc | RATIONALLY DESIGNED ANTIBODIES |
GB0103174D0 (en) * | 2001-02-08 | 2001-03-28 | Smithkline Beecham Plc | Novel method of treatment |
WO2002078613A2 (en) * | 2001-04-02 | 2002-10-10 | Purdue Pharma L.P. | Immunoglobulin construct containing anti-mucin variable domain sequences for eliciting an anti-idiotype anti-tumor response |
AU2002365926A1 (en) * | 2001-10-25 | 2003-09-02 | Euro-Celtique S.A. | Compositions and methods directed to anthrax toxin |
EP1938834B1 (en) * | 2002-04-09 | 2012-04-25 | The Curators Of The University Of Missouri | Treatment of type 1 diabetes before and after expression of predisposition markers |
NZ571508A (en) | 2002-05-24 | 2010-05-28 | Schering Corp | Neutralizing human anti-IGFR antibody |
TWI323265B (en) | 2002-08-06 | 2010-04-11 | Glaxo Group Ltd | Antibodies |
CA2499300A1 (en) | 2002-10-31 | 2004-05-21 | Genentech, Inc. | Methods and compositions for increasing antibody production |
GB0306309D0 (en) | 2003-03-19 | 2003-04-23 | Glaxo Group Ltd | Method of treatment |
WO2005021595A1 (en) * | 2003-08-28 | 2005-03-10 | Euro-Celtique S.A. | Methods of antibody engineering using antibody display rules |
CN1938428A (en) | 2003-11-12 | 2007-03-28 | 先灵公司 | Plasmid system for multigene expression |
AR046639A1 (en) | 2003-11-21 | 2005-12-14 | Schering Corp | ANTI-IGFR1 ANTIBODY THERAPEUTIC COMBINATIONS |
CA2558813A1 (en) * | 2004-03-09 | 2005-09-15 | Kyoto University | Pharmaceutical composition comprising cxcr3 inhibitor |
ATE493442T1 (en) | 2004-12-03 | 2011-01-15 | Schering Corp | BIOLOGICAL MARKERS FOR PRE-SELECTION OF PATIENTS FOR ANTI-IGF1R THERAPY |
ZA200901165B (en) * | 2006-08-28 | 2010-06-30 | Kyowa Hakko Kirin Co Ltd | Antagonistic human light-specific human monoclonal antibodies |
GB0706070D0 (en) * | 2007-03-28 | 2007-05-09 | Scancell Ltd | Nucleic acids |
WO2009114585A1 (en) * | 2008-03-12 | 2009-09-17 | Imclone Llc | Anti-tyrp1 antibodies |
EP2799453B1 (en) * | 2009-04-29 | 2019-04-03 | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. | ERG2 monoclonal antibodies and their therapeutic use |
CN102816240B (en) * | 2011-03-08 | 2014-02-12 | 中国人民解放军第三军医大学第二附属医院 | Fusion protein and fusion protein expression vector thereof |
EP2714083A4 (en) * | 2011-05-27 | 2015-03-04 | Fox Chase Cancer Ct | Rationally-designed anti-mullerian inhibiting substance type ii receptor antibodies |
JP6121436B2 (en) * | 2011-11-23 | 2017-04-26 | バイオベン・3・リミテッドBioven 3 Limited | Recombinant proteins and their therapeutic uses |
JP5437525B1 (en) | 2012-12-28 | 2014-03-12 | 株式会社ナード研究所 | Tyrosine derivative and method for producing tyrosine derivative |
US20160206732A1 (en) * | 2013-05-14 | 2016-07-21 | Shanghai Hycharm Inc. | Epitope vaccine for low immunogenic protein and preparing method and usage thereof |
CN103275914B (en) * | 2013-06-03 | 2015-04-01 | 中国人民解放军军事医学科学院微生物流行病研究所 | Bacterial ghost presenting protective antigens and application thereof |
CN105263953B (en) * | 2014-01-15 | 2020-01-07 | 勃林格殷格翰动物保健美国有限公司 | Porcine parvovirus 5A, methods of use, and vaccines |
CA2949174A1 (en) * | 2014-05-19 | 2015-11-26 | Helsingin Yliopisto | Modified adenoviruses for cancer vaccines development |
CN105693859B (en) * | 2016-03-22 | 2019-06-21 | 苏州莱泰生物科技有限公司 | Anti-human G2A monoclonal antibody and the kit for detecting human macrophage G2A expression quantity |
CN111978382B (en) * | 2020-09-03 | 2022-03-04 | 吉林大学第一医院 | Preparation method and application of recombinant protein of Sporothrix globosum Gp70 |
CN112646029B (en) * | 2020-12-30 | 2022-07-29 | 深圳清华大学研究院 | Antibody of mature brain-derived neurotrophic factor, application thereof and diagnostic kit |
CN115856296B (en) * | 2022-12-16 | 2023-07-25 | 华北理工大学 | Monoclonal antibody for resisting shigella and application thereof in detection |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5688657A (en) * | 1988-03-31 | 1997-11-18 | International Bio-Immune Systems, Inc. | Monoclonal antibodies against human colon carcinoma-associated antigens and uses therefor |
ATE130765T1 (en) * | 1989-02-24 | 1995-12-15 | Univ California | GENETICALLY MODIFIED IMMUNOGLOBULINS. |
GB9019553D0 (en) * | 1990-09-07 | 1990-10-24 | Unilever Plc | Specific binding agents |
GB9109645D0 (en) * | 1991-05-03 | 1991-06-26 | Celltech Ltd | Recombinant antibodies |
GB9223084D0 (en) * | 1992-11-04 | 1992-12-16 | Imp Cancer Res Tech | Compounds to target cells |
JPH09503901A (en) * | 1992-11-16 | 1997-04-22 | キャンサー リサーチ ファンド オブ コントラ コスタ | Peptides and antisense peptides with broad neoplastic specificity |
WO1994014848A1 (en) * | 1992-12-24 | 1994-07-07 | The Regents Of The University Of California | Genetically engineered immunoglobulins |
WO1994014847A1 (en) * | 1992-12-24 | 1994-07-07 | The Regents Of The University Of California | Genetically engineered immunoglobulins |
US5476784A (en) * | 1993-04-06 | 1995-12-19 | Rice; Peter A. | Gonococcal anti-idiotypic antibodies and methods and compositions using them |
US5653977A (en) * | 1993-09-09 | 1997-08-05 | Uab Research Foundation | Anti-idiotypic antibody that mimics the GD2 antigen |
US5624904A (en) * | 1993-11-17 | 1997-04-29 | Massachusetts Institute Of Technology | Method for treating gram positive septicemia |
-
1998
- 1998-11-13 KR KR1020007005263A patent/KR20010015817A/en not_active Application Discontinuation
- 1998-11-13 CA CA002310269A patent/CA2310269A1/en not_active Abandoned
- 1998-11-13 WO PCT/US1998/024303 patent/WO1999025379A1/en not_active Application Discontinuation
- 1998-11-13 WO PCT/US1998/024302 patent/WO1999025378A1/en not_active Application Discontinuation
- 1998-11-13 BR BR9815580-6A patent/BR9815580A/en not_active IP Right Cessation
- 1998-11-13 IL IL13611398A patent/IL136113A0/en unknown
- 1998-11-13 KR KR1020007005264A patent/KR20010015818A/en not_active Application Discontinuation
- 1998-11-13 BR BR9815289-0A patent/BR9815289A/en not_active IP Right Cessation
- 1998-11-13 JP JP2000520812A patent/JP2002507544A/en active Pending
- 1998-11-13 CN CN98813119A patent/CN1327388A/en active Pending
- 1998-11-13 IL IL13611498A patent/IL136114A0/en unknown
- 1998-11-13 JP JP2000520811A patent/JP2001526021A/en active Pending
- 1998-11-13 AU AU14597/99A patent/AU763029B2/en not_active Ceased
- 1998-11-13 EP EP98958583A patent/EP1032420A4/en not_active Withdrawn
- 1998-11-13 CN CN98813117A patent/CN1294517A/en active Pending
- 1998-11-13 CA CA002309990A patent/CA2309990A1/en not_active Abandoned
- 1998-11-13 EP EP98958584A patent/EP1030684A4/en not_active Withdrawn
-
2003
- 2003-10-10 AU AU2003252902A patent/AU2003252902A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2001526021A (en) | 2001-12-18 |
IL136114A0 (en) | 2001-05-20 |
AU2003252902A1 (en) | 2003-11-06 |
EP1032420A4 (en) | 2004-09-15 |
AU1459899A (en) | 1999-06-07 |
IL136113A0 (en) | 2001-05-20 |
EP1030684A1 (en) | 2000-08-30 |
AU737457B2 (en) | 2001-08-23 |
CA2309990A1 (en) | 1999-05-27 |
EP1030684A4 (en) | 2004-09-15 |
CN1327388A (en) | 2001-12-19 |
WO1999025378A9 (en) | 1999-08-12 |
KR20010015817A (en) | 2001-02-26 |
AU763029B2 (en) | 2003-07-10 |
CA2310269A1 (en) | 1999-05-27 |
WO1999025378A1 (en) | 1999-05-27 |
CN1294517A (en) | 2001-05-09 |
JP2002507544A (en) | 2002-03-12 |
BR9815289A (en) | 2001-12-26 |
KR20010015818A (en) | 2001-02-26 |
AU1459799A (en) | 1999-06-07 |
WO1999025379A1 (en) | 1999-05-27 |
EP1032420A1 (en) | 2000-09-06 |
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Legal Events
Date | Code | Title | Description |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A E 8A ANUIDADES. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1890 DE 27/03/2007. |