BR9810500A - System and apparatus for the transfer of nucleic acid in vivo into the cells of multicellular eukaryotic organisms - Google Patents
System and apparatus for the transfer of nucleic acid in vivo into the cells of multicellular eukaryotic organismsInfo
- Publication number
- BR9810500A BR9810500A BR9810500-0A BR9810500A BR9810500A BR 9810500 A BR9810500 A BR 9810500A BR 9810500 A BR9810500 A BR 9810500A BR 9810500 A BR9810500 A BR 9810500A
- Authority
- BR
- Brazil
- Prior art keywords
- cells
- nucleic acid
- vivo
- transfer
- devices
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
"SISTEMA E APARELHO PARA A TRANSFERêNCIA DE áCIDO NUCLéICO IN VIVO PARA O INTERIOR DE CéLULAS DE ORGANISMOS EUCARIóTICOS PLURICELULARES". Esta invenção refere-se a sistemas e aparelhos que proporcionam um aumento notável da transferência, in vivo, para o interior de células, particularmente células de músculos e células de tumor, de vetores de ácidos nucléicos utilizando-se campos elétricos fracos, de modo a incrementar a eficiência desse tipo de transferências. Os aparelhos da invenção são projetados para proporcionar um gradiente de voltagem ótimo para incrementar a migração de vetores de ácido nucléico para o interior de células, sem danificar as células ou o tecido. Esses aparelhos caracterizam-se por disposições únicas de eletrodos, e por limites de potência únicos definidos por ajustes de voltagem máxima."SYSTEM AND APPARATUS FOR THE TRANSFER OF NUCLEIC ACID IN VIVO TO THE INTERIOR OF CELLS OF PLURICELLULAR EUCHARIOTIC ORGANISMS". This invention relates to systems and devices that provide a notable increase in the transfer, in vivo, into cells, particularly muscle cells and tumor cells, of nucleic acid vectors using weak electric fields in order to increase the efficiency of such transfers. The devices of the invention are designed to provide an optimal voltage gradient to increase the migration of nucleic acid vectors into cells, without damaging cells or tissue. These devices are characterized by unique electrode arrangements, and unique power limits defined by maximum voltage adjustments.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9708232A FR2765241B1 (en) | 1997-06-30 | 1997-06-30 | IMPROVEMENT OF NUCLEIC ACID TRANSFER IN CELLS OF PLURICELLULAR EUKARYOTIC ORGANISMS AND COMBINATION FOR CARRYING OUT THE METHOD |
FR9708233A FR2765242B1 (en) | 1997-06-30 | 1997-06-30 | IMPROVEMENT OF THE TRANSFER OF NUCLEIC ACID IN THE STRIKE MUSCLE AND COMBINATION ALLOWING THE IMPLEMENTATION OF THE PROCESS |
US6748897P | 1997-12-01 | 1997-12-01 | |
US6748797P | 1997-12-01 | 1997-12-01 | |
US8385898P | 1998-05-01 | 1998-05-01 | |
PCT/EP1998/003976 WO1999001175A1 (en) | 1997-06-30 | 1998-06-30 | Device for optimized electrotransfer of nucleic acid vectors to tissues in vivo |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9810500A true BR9810500A (en) | 2000-09-05 |
Family
ID=27515625
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9810500-0A BR9810500A (en) | 1997-06-30 | 1998-06-30 | System and apparatus for the transfer of nucleic acid in vivo into the cells of multicellular eukaryotic organisms |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0993318A1 (en) |
JP (1) | JP2002515816A (en) |
KR (1) | KR20010014298A (en) |
CN (1) | CN1261812A (en) |
AU (1) | AU8730798A (en) |
BR (1) | BR9810500A (en) |
CA (1) | CA2295029A1 (en) |
IL (1) | IL133709A0 (en) |
NO (1) | NO996540L (en) |
PL (1) | PL337617A1 (en) |
WO (1) | WO1999001175A1 (en) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2753379B1 (en) | 1996-09-13 | 1998-10-30 | Rhone Poulenc Rorer Sa | METHOD OF TREATING AMYOTROPHIC SIDE SCLEROSIS |
US6261281B1 (en) | 1997-04-03 | 2001-07-17 | Electrofect As | Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells |
WO2000045823A1 (en) * | 1999-02-08 | 2000-08-10 | Chiron Corporation | Electrically-mediated enhancement of dna vaccine immunity and efficacy in vivo |
ES2368419T3 (en) | 2000-03-13 | 2011-11-17 | Cornell Research Foundation, Inc. | BLOCK OF MIGRATION OF LEUCOCITS AND INFLAMMATION BY INTERFERENCE WITH CD99 / HEC2. |
JP2003531149A (en) | 2000-04-13 | 2003-10-21 | ザ・ロツクフエラー・ユニバーシテイ | Enhancement of antibody-derived immune response |
CA2409603A1 (en) | 2000-05-22 | 2001-11-29 | Merck & Company, Inc. | System and method for assessing the performance of a pharmaceutical agent delivery system |
DE60144198D1 (en) | 2000-12-28 | 2011-04-21 | Wyeth Llc | RECOMBINANT PROTECTION PROTEIN FROM STREPTOCOCCUS PNEUMONIAE |
DE60234475D1 (en) | 2001-03-02 | 2009-12-31 | Univ Rockefeller | RECOMBINANT HYBRID ALLERGENIC CONSTRUCTS WITH REDUCED ALLERGENITY, MAINTAINING THE IMMUNOGENICITY OF NATURAL ALLERGEN |
US20020198567A1 (en) * | 2001-06-07 | 2002-12-26 | Yona Keisari | Electro-endocytotic therapy as a treatment modality of cancer |
MX339524B (en) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Novel immunogenic compositions for the prevention and treatment of meningococcal disease. |
US20050154434A1 (en) | 2002-03-07 | 2005-07-14 | Adam Simon | Clinical syringe with electrical stimulation aspects |
EP2316922B1 (en) | 2002-05-24 | 2013-05-22 | Merck Sharp & Dohme Corp. | Neutralizing human anti-IGFR antibody |
US7785608B2 (en) | 2002-08-30 | 2010-08-31 | Wyeth Holdings Corporation | Immunogenic compositions for the prevention and treatment of meningococcal disease |
EP1759714A1 (en) * | 2005-09-02 | 2007-03-07 | Bioalliance Pharma | Electrotransfer of nucleic acid into tissue cells |
PT1933937E (en) * | 2005-10-03 | 2015-04-23 | Novocure Ltd | Optimizing characteristics of an electric field to increase the field's effect on proliferating cells |
JP4961137B2 (en) * | 2005-12-14 | 2012-06-27 | 久光製薬株式会社 | Device for iontophoresis |
EP2530090A3 (en) | 2006-10-19 | 2013-01-23 | CSL Limited | Anti-IL-13R alpha 1 antibodies and their uses thereof |
ES2658239T3 (en) | 2006-10-19 | 2018-03-08 | Csl Limited | Interleukin-13 alpha 1 receptor high affinity antibody antagonists |
AR064642A1 (en) | 2006-12-22 | 2009-04-15 | Wyeth Corp | POLINUCLEOTIDE VECTOR THAT INCLUDES IT RECOMBINATING CELL THAT UNDERSTANDS THE VECTOR POLYPEPTIDE, ANTIBODY, COMPOSITION THAT UNDERSTANDS THE POLINUCLEOTIDE, VECTOR, RECOMBINATING CELL POLYPEPTIDE OR ANTIBODY, USE OF THE COMPOSITION AND A COMPOSITION AND A METHOD |
US8246176B2 (en) | 2007-03-06 | 2012-08-21 | Sanyo Electric Co., Ltd. | Projection display device having an operation section for displacing a lens |
US8093043B2 (en) | 2008-06-04 | 2012-01-10 | New York University | β-TrCP1, β-TrCP2 and RSK1 or RSK2 inhibitors and methods for sensitizing target cells to apoptosis |
JP5774480B2 (en) * | 2008-07-18 | 2015-09-09 | マックスサイト インコーポレーティッド | Method for optimizing electroporation |
MX2011004755A (en) | 2008-11-05 | 2011-10-10 | Wyeth Llc | Multicomponent immunogenic composition for the prevention of beta-hemolytic streptococcal (bhs) disease. |
EP2608805B1 (en) | 2010-08-23 | 2017-07-05 | Wyeth LLC | STABLE FORMULATIONS OF NEISSERIA MENINGITIDIS rLP2086 ANTIGENS |
JP5976652B2 (en) | 2010-09-10 | 2016-08-24 | ワイス・エルエルシー | Non-lipidated variant of Neisseria meningitidis ORF2086 antigen |
SA115360586B1 (en) | 2012-03-09 | 2017-04-12 | فايزر انك | Neisseria meningitidis compositions and methods thereof |
CA2960030C (en) | 2012-03-09 | 2020-02-25 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
WO2014107739A1 (en) | 2013-01-07 | 2014-07-10 | Eleven Biotherapeutics, Inc. | Antibodies against pcsk9 |
WO2014136064A2 (en) | 2013-03-08 | 2014-09-12 | Pfizer Inc. | Immunogenic fusion polypeptides |
CA2923129C (en) | 2013-09-08 | 2020-06-09 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
BR112017017460A2 (en) | 2015-02-19 | 2018-04-10 | Pfizer Inc. | neisseria meningitidis compositions and methods thereof |
SG10202111092UA (en) | 2017-01-31 | 2021-11-29 | Pfizer | Neisseria meningitidis compositions and methods thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9317380D0 (en) * | 1993-08-20 | 1993-10-06 | Therexsys Ltd | Transfection process |
US5641680A (en) * | 1994-11-14 | 1997-06-24 | Zhao; Xi | Gene transfer apparatus and method for using the same |
AU6855796A (en) * | 1995-08-29 | 1997-03-19 | Cbr Laboratories, Inc. | In vivo electroporation of cells |
-
1998
- 1998-06-30 PL PL98337617A patent/PL337617A1/en not_active Application Discontinuation
- 1998-06-30 AU AU87307/98A patent/AU8730798A/en not_active Abandoned
- 1998-06-30 WO PCT/EP1998/003976 patent/WO1999001175A1/en not_active Application Discontinuation
- 1998-06-30 EP EP98938676A patent/EP0993318A1/en not_active Ceased
- 1998-06-30 IL IL13370998A patent/IL133709A0/en unknown
- 1998-06-30 JP JP50807599A patent/JP2002515816A/en active Pending
- 1998-06-30 BR BR9810500-0A patent/BR9810500A/en not_active IP Right Cessation
- 1998-06-30 CN CN98806793A patent/CN1261812A/en active Pending
- 1998-06-30 KR KR1019997012430A patent/KR20010014298A/en not_active Application Discontinuation
- 1998-06-30 CA CA002295029A patent/CA2295029A1/en not_active Abandoned
-
1999
- 1999-12-29 NO NO996540A patent/NO996540L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2002515816A (en) | 2002-05-28 |
NO996540L (en) | 2000-02-03 |
EP0993318A1 (en) | 2000-04-19 |
NO996540D0 (en) | 1999-12-29 |
AU8730798A (en) | 1999-01-25 |
CN1261812A (en) | 2000-08-02 |
WO1999001175A1 (en) | 1999-01-14 |
CA2295029A1 (en) | 1999-01-14 |
PL337617A1 (en) | 2000-08-28 |
IL133709A0 (en) | 2001-04-30 |
KR20010014298A (en) | 2001-02-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TC | Change of name | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1889 DE 20/03/2007. |