BR9713195A - Método de aperfeiçoamento da produção de biomassa ou de um produto desejado de uma célula. - Google Patents

Método de aperfeiçoamento da produção de biomassa ou de um produto desejado de uma célula.

Info

Publication number
BR9713195A
BR9713195A BR9713195-4A BR9713195A BR9713195A BR 9713195 A BR9713195 A BR 9713195A BR 9713195 A BR9713195 A BR 9713195A BR 9713195 A BR9713195 A BR 9713195A
Authority
BR
Brazil
Prior art keywords
sub
cell
atpase
biomass
desired product
Prior art date
Application number
BR9713195-4A
Other languages
English (en)
Inventor
Peter Ruhdal Jensen
Jacky Leendert Snoep
Hans Victor Westerhoff
Original Assignee
Peter Ruhdal Jensen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Peter Ruhdal Jensen filed Critical Peter Ruhdal Jensen
Publication of BR9713195A publication Critical patent/BR9713195A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Physical Deposition Of Substances That Are Components Of Semiconductor Devices (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Patente de Invenção:<B>"MéTODO DE APERFEIçOAMENTO DA PRODUçãO DE BIOMASSA OU DE UM PRODUTO DESEJADO A PARTIR DE UMA CéLULA"<D>. A produção de biomassa ou de um produto desejado a partir de uma célula pode ser aperfeiçoada por indução da conversão de ATP para ADP sem efeitos primários sobre outros metabólitos ou funções celulares, o que se consegue por expressão de uma atividade ATPase não-acoplada, na referida célula e incubando a célula com um substrato adequado para produzir a referida biomassa ou produto. Isto é convenientemente realizado expressando-se na referida célula a parte solúvel (F~1~) de H^ +^-ATPase (tipo F~ 0~F~ 1~) ligada à membrana ou de uma parte de F1 apresentando atividade ATPase. O organismo do qual a ATPase F~ 1~ ou partes deste é derivado, ou em que a ATPase F~ 1~ ou partes deste é expressada, pode ser selecionado dentre organismos procariontes e eucariontes. Em particular, o DNA codificando F~ 1~ ou uma parte desta pode ser derivado de bactérias e microorganismos eucarióticos, tais como leveduras, outros fungos e linhas de células ou organismos superiores e pode ser selecionado do grupo que consiste do gene que codifica a subunidade <225> de F~ 1~ ou de uma parte desta e de várias combinações do gene ou parte com os genes que codificam as outras subunidades de F~ 1~ ou partes deste. O método pode ser usado, inter alia, para otimizar a formação da biomassa ou de um produto desejado por uma célula, expressando diferentes níveis de atividade ATPase não-acoplada na célula, incubando a célula em um substrato adequado, medindo a velocidade de conversão do substrato em biomassa ou o produto desejado em cada nível de expressão ATPase, e escolhendo um nível de expressão ATPase ao qual a velocidade de conversão é otimizada.
BR9713195-4A 1996-09-06 1997-09-08 Método de aperfeiçoamento da produção de biomassa ou de um produto desejado de uma célula. BR9713195A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK96396 1996-09-06
PCT/DK1997/000373 WO1998010089A1 (en) 1996-09-06 1997-09-08 A method of improving the production of biomass or a desired product from a cell

Publications (1)

Publication Number Publication Date
BR9713195A true BR9713195A (pt) 1999-12-21

Family

ID=8099475

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9713195-4A BR9713195A (pt) 1996-09-06 1997-09-08 Método de aperfeiçoamento da produção de biomassa ou de um produto desejado de uma célula.

Country Status (9)

Country Link
US (3) US6511836B1 (pt)
EP (1) EP0939830B1 (pt)
JP (1) JP2000514309A (pt)
AT (1) ATE419371T1 (pt)
AU (1) AU723380B2 (pt)
BR (1) BR9713195A (pt)
DE (1) DE69739188D1 (pt)
DK (1) DK0939830T3 (pt)
WO (1) WO1998010089A1 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU723380B2 (en) * 1996-09-06 2000-08-24 Peter Ruhdal Jensen A method of improving the production of biomass or a desired product from a cell
WO2000001799A2 (en) * 1998-07-03 2000-01-13 Chr. Hansen A/S Method of preventing bacteriophage infection of bacterial cultures
ES2345965T3 (es) 1998-07-03 2010-10-06 Chr. Hansen A/S Metodo de prevencion de infeccion bacteriofaga de cultivos bacterianos.
EP1097216B1 (en) 1998-07-10 2006-05-03 Fluxome Sciences AS Metabolically engineered microbial cell with an altered metabolite production
US6790950B2 (en) * 1999-04-09 2004-09-14 Pharmacia & Upjohn Company Anti-bacterial vaccine compositions
WO2002002747A2 (en) * 2000-07-05 2002-01-10 Danmarks Tekniske Universitet Method of improving biomass yield of lactic acid bacterial cultures
AU2003287625A1 (en) 2002-11-06 2004-06-03 University Of Florida Materials and methods for the efficient production of acetate and other products
US20070181253A1 (en) * 2006-02-03 2007-08-09 Ming Xu Image receiver media and printing process
US20120198588A1 (en) * 2009-03-23 2012-08-02 Basf Plant Science Company Gmbh Transgenic plants with altered redox mechanisms and increased yield
CN102459566B (zh) * 2009-06-26 2014-12-17 阿彻丹尼尔斯米德兰德公司 过表达atp降解酶的重组酿酒酵母菌株中乙醇产量的提高和生物质积累的减少
US9682132B2 (en) 2010-01-26 2017-06-20 Banyan Biomarkers, Inc Compositions and methods relating to argininosucccinate synthetase
RU2012102470A (ru) * 2012-01-25 2013-07-27 Общество С Ограниченной Ответственностью "Изобиотех" Способ повышения эффективности синтеза целевых продуктов культурами клеток
US9885062B2 (en) * 2012-12-20 2018-02-06 Archer-Daniels-Midland Company Ethanol yield with reduction of biomass accumulation in the recombinant strain of Saccharomyces cerevisiae overexpressing alkaline phosphate
JP7376208B2 (ja) * 2017-10-25 2023-11-08 アレーロ セラピューティクス ビーヴイ 抗原特異的製剤の投与による免疫疾患の治療
CN112899328B (zh) * 2021-04-23 2023-06-02 南京同凯兆业生物技术有限责任公司 一种利用酵母全细胞催化合成三磷酸腺苷的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL80510A0 (en) 1985-11-08 1987-02-27 Genetics Inst Improved yeast strains
CA2047028A1 (en) * 1990-07-18 1992-01-19 Myra B. Kurtz Gene encoding candida albicans plasma membrane h+atpase
US5330754A (en) 1992-06-29 1994-07-19 Archana Kapoor Membrane-associated immunogens of mycobacteria
ATE187603T1 (de) * 1993-09-24 2000-01-15 Dsm Nv Verbesserung der herstellung von gas und alkohol von hefestämmen
AU723380B2 (en) * 1996-09-06 2000-08-24 Peter Ruhdal Jensen A method of improving the production of biomass or a desired product from a cell

Also Published As

Publication number Publication date
US20060094078A1 (en) 2006-05-04
ATE419371T1 (de) 2009-01-15
JP2000514309A (ja) 2000-10-31
DE69739188D1 (de) 2009-02-12
US7250280B2 (en) 2007-07-31
WO1998010089A1 (en) 1998-03-12
DK0939830T3 (da) 2009-04-06
EP0939830B1 (en) 2008-12-31
US6511836B1 (en) 2003-01-28
EP0939830A1 (en) 1999-09-08
AU723380B2 (en) 2000-08-24
US20030180832A1 (en) 2003-09-25
AU4113597A (en) 1998-03-26

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Legal Events

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: OPINAMOS PELO INDEFERIMENTO DO PEDIDO EM LIDE COM BASE NO ART. 24 DA LPI.

B12B Appeal against refusal [chapter 12.2 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 16A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2238 DE 26/11/2013.