BR9708684A - Process for the preparation of a compound - Google Patents

Process for the preparation of a compound

Info

Publication number
BR9708684A
BR9708684A BR9708684A BR9708684A BR9708684A BR 9708684 A BR9708684 A BR 9708684A BR 9708684 A BR9708684 A BR 9708684A BR 9708684 A BR9708684 A BR 9708684A BR 9708684 A BR9708684 A BR 9708684A
Authority
BR
Brazil
Prior art keywords
compound
preparation
phenyl
alkenyl
alkyl
Prior art date
Application number
BR9708684A
Other languages
Portuguese (pt)
Inventor
Ioannis Houpis
Audrey Molina
Ralph P Volante
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9612083.7A external-priority patent/GB9612083D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of BR9708684A publication Critical patent/BR9708684A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C07D213/34—Sulfur atoms to which a second hetero atom is attached
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE UM COMPOSTO" . Processo para a preparação de um composto de fórmula estrutural (1), em que R^ 1^ é alquila, alquenila, fenila ou fenila substituída, que consiste na adição de R^ 1^ a um intermediário (2), pelo tratamento de (2) com (R^ 1^)~ 3~M, seguido pela remoção redutiva do grupo sulfinila."PROCESS FOR THE PREPARATION OF A COMPOUND". Process for the preparation of a compound of structural formula (1), in which R ^ 1 ^ is alkyl, alkenyl, phenyl or substituted phenyl, consisting of the addition of R ^ 1 ^ to an intermediate (2), by treating ( 2) with (R ^ 1 ^) ~ 3 ~ M, followed by the reductive removal of the sulfinyl group.

BR9708684A 1996-04-17 1997-04-14 Process for the preparation of a compound BR9708684A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1568796P 1996-04-17 1996-04-17
GBGB9612083.7A GB9612083D0 (en) 1996-06-10 1996-06-10 Method of preparing phosphodiesterase IV inhibitors
PCT/US1997/006131 WO1997038976A1 (en) 1996-04-17 1997-04-14 Method of preparing phosphodiesterase iv inhibitors

Publications (1)

Publication Number Publication Date
BR9708684A true BR9708684A (en) 1999-08-03

Family

ID=26309476

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9708684A BR9708684A (en) 1996-04-17 1997-04-14 Process for the preparation of a compound

Country Status (10)

Country Link
EP (1) EP0898564A1 (en)
CN (1) CN1216532A (en)
AR (1) AR006550A1 (en)
AU (1) AU2459297A (en)
BR (1) BR9708684A (en)
CZ (1) CZ333298A3 (en)
EA (1) EA000877B1 (en)
SK (1) SK143198A3 (en)
TW (1) TW426669B (en)
WO (1) WO1997038976A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0931066B1 (en) * 1996-09-17 2002-05-15 Merck & Co., Inc. Method of preparing phosphodiesterase iv inhibitors
TW508353B (en) * 1996-09-17 2002-11-01 Merck & Co Inc Method of preparing phosphodiesterase IV inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW263495B (en) * 1992-12-23 1995-11-21 Celltech Ltd
GB9326173D0 (en) * 1993-12-22 1994-02-23 Celltech Ltd Chemical compounds and process

Also Published As

Publication number Publication date
CN1216532A (en) 1999-05-12
TW426669B (en) 2001-03-21
WO1997038976A1 (en) 1997-10-23
EA199800931A1 (en) 1999-04-29
AR006550A1 (en) 1999-09-08
AU2459297A (en) 1997-11-07
EA000877B1 (en) 2000-06-26
SK143198A3 (en) 1999-06-11
CZ333298A3 (en) 1999-03-17
EP0898564A1 (en) 1999-03-03

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]