BR9612317A - Nucleotide analogues. - Google Patents

Nucleotide analogues.

Info

Publication number
BR9612317A
BR9612317A BR9612317-6A BR9612317A BR9612317A BR 9612317 A BR9612317 A BR 9612317A BR 9612317 A BR9612317 A BR 9612317A BR 9612317 A BR9612317 A BR 9612317A
Authority
BR
Brazil
Prior art keywords
nucleotide analogues
nucleotide
analogs
nucleotide analog
nucleotyde
Prior art date
Application number
BR9612317-6A
Other languages
Portuguese (pt)
Inventor
Murty N Arimilli
Norbert W Bischofberger
Robert J Jones
William A Lee
Ernest J Prisbe
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/581,147 external-priority patent/US5886179A/en
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of BR9612317A publication Critical patent/BR9612317A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative

Abstract

Patente de Invenção: <B>"ANáLOGOS NUCLEOTìDEOS"<D>. ésteres de nucleotídeos fosfonados caracterizados pela presença de um grupo éster ligado, o qual está ligado ao átomo de fósforo de um análogo nucleotídeo são aqui descritos. Os análogos compreedem um éster ligado que é hidrolisado in vivo para render uma análogo nucleotídeo fosfonato correspondente. Métodos e intermediários para suas sínteses e uso são descritos.Invention Patent: <B> "NUCLEOTYDE ANALOGS" <D>. phosphonated nucleotide esters characterized by the presence of a linked ester group, which is attached to the phosphorus atom of a nucleotide analog are described herein. The analogs comprise a bound ester which is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediaries for their synthesis and use are described.

BR9612317-6A 1995-12-29 1996-12-13 Nucleotide analogues. BR9612317A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US937595P 1995-12-29 1995-12-29
US937295P 1995-12-29 1995-12-29
US08/581,147 US5886179A (en) 1993-09-17 1995-12-29 Nucleotide analogs
PCT/US1996/020226 WO1997024361A1 (en) 1995-12-29 1996-12-13 Nucleotide analogs

Publications (1)

Publication Number Publication Date
BR9612317A true BR9612317A (en) 2000-10-31

Family

ID=27358844

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9612317-6A BR9612317A (en) 1995-12-29 1996-12-13 Nucleotide analogues.

Country Status (6)

Country Link
EP (1) EP0874858A1 (en)
AU (1) AU1427097A (en)
BR (1) BR9612317A (en)
CA (1) CA2239020A1 (en)
NZ (1) NZ325704A (en)
WO (1) WO1997024361A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ304734B6 (en) 2000-07-21 2014-09-10 Gilead Sciences, Inc. Process for preparing 9-[2-(phosphonomethoxy)propyl]adenine and 9-[2-(phosphonomethoxy)ethyl]adenine
CN102485229B (en) * 2010-12-02 2015-09-02 中国人民解放军军事医学科学院毒物药物研究所 antiviral drugs
CN103665043B (en) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 A kind of tenofovir prodrug and its application in medicine
CN103923124A (en) * 2013-01-15 2014-07-16 中国人民解放军军事医学科学院毒物药物研究所 Crystalline-state anti-hepatitis B virus drug

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8801729D0 (en) * 1988-05-06 1988-05-06 Astra Ab PURINE DERIVATIVES FOR USE IN THERAPY
EP0405748A1 (en) * 1989-05-30 1991-01-02 Beecham Group p.l.c. Phosphonoderivative of purine with antiviral activity
EP0481214B1 (en) * 1990-09-14 1998-06-24 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Prodrugs of phosphonates
AU691527B2 (en) * 1993-09-17 1998-05-21 Gilead Sciences, Inc. Nucleotide analogs

Also Published As

Publication number Publication date
AU1427097A (en) 1997-07-28
NZ325704A (en) 2000-02-28
EP0874858A1 (en) 1998-11-04
CA2239020A1 (en) 1997-07-10
WO1997024361A1 (en) 1997-07-10

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]