BR9610012A - Processes for monitoring an analyte's concentration and intensifying the transdermal flow rate of an active permeant in a selected area on an individual's body, for applying a tattoo to a selected area of the skin and for reducing a time delay in the diffusion of an analyte of an individual's blood and the evaporation of the interstitial fluid and its vapor pressure - Google Patents

Processes for monitoring an analyte's concentration and intensifying the transdermal flow rate of an active permeant in a selected area on an individual's body, for applying a tattoo to a selected area of the skin and for reducing a time delay in the diffusion of an analyte of an individual's blood and the evaporation of the interstitial fluid and its vapor pressure

Info

Publication number
BR9610012A
BR9610012A BR9610012-5A BR9610012A BR9610012A BR 9610012 A BR9610012 A BR 9610012A BR 9610012 A BR9610012 A BR 9610012A BR 9610012 A BR9610012 A BR 9610012A
Authority
BR
Brazil
Prior art keywords
individual
analyte
selected area
peleur
tattoo
Prior art date
Application number
BR9610012-5A
Other languages
Portuguese (pt)
Inventor
Jonathan A Eppstein
Michael R Hatch
Difei Yang
Original Assignee
Spectrx Inc E Altea Technologi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spectrx Inc E Altea Technologi filed Critical Spectrx Inc E Altea Technologi
Publication of BR9610012A publication Critical patent/BR9610012A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/3203—Fluid jet cutting instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00137—Details of operation mode
    • A61B2017/00154—Details of operation mode pulsed
    • A61B2017/00172—Pulse trains, bursts, intermittent continuous operation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00761—Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00765—Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452—Skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452—Skin
    • A61B2018/0047—Upper parts of the skin, e.g. skin peeling or treatment of wrinkles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Optics & Photonics (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Surgical Instruments (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Laser Surgery Devices (AREA)

Abstract

"PROCESSOS PARA MONITORAR A CONCENTRAçãO DE UM ANALISADO E INTENSIFICAR O ìNDICE DE FLUXO TRANSDéRMICO DE UM PERMEANTE ATIVO EM UMA áREA SELECIONADA NO CORPO DE UM INDìVìDUO, PARA APLICAR UMA TATUAGEM A UMA áREA SELECIONADA DA PELE E PARA REDUZIR UM RETARDAMENTO TEMPORAL NA DIFUSãO DE UM ANALISADO DO SANGUE DE UM INDIVìDUO E A EVAPORAçãO DO FLUIDO E A SUA PRESSãO DE VAPOR". Um processo de melhorar a permeabilidade da pele (120, 274) a um analisado para fins diagnósticos, ou a um medicamento para fins terapêuticos, é descrito utilizando-se a microporação e energia opcionalmente sónica e um intensificador químico. Se selecionada, a energia sónica pode ser modulada por meio de modulação de frequência, modulação de amplitude, modulação de fase e/ou combinações destas. A microporação é realizada por (a) remoção do extrato córneo (274) mediante aquecimento rápido localizado de água, tal que a água seja vaporizada, assim erodindo as células; (b) punção do extrato córneo (274) com uma microlanceta calibrada para formar um microporo de até cerca de 1000 um de diâmetro; (c) remoção do extrato córneo (274), mediante focalização de um feixe de energia sónica firmemente focalizado no extrato córneo (274); (d) hidraulicamente puncional o extrato córneo (274) com um jato de fluido de alta pressão, para formar um microporo de até cerca de 1000 um de diâmetro; ou (e) puncionar o extrato córneo (274) com pulsos curtos de eletricidade, para formar um microporo de até cerca de 1000 um de diâmetro."PROCESSES FOR MONITORING THE CONCENTRATION OF AN ANALYZE AND INTENSIFYING THE TRANSDERMAL FLOW INDEX OF AN ACTIVE PERMEANT IN A SELECTED AREA IN THE BODY OF AN INDIVIDUAL, TO APPLY A TATTOO TO A SELECTED TEMPLE OF THE PELEUR OF THE PELEUR AND DURING THE PELEUR OF THE PELEUR OF THE PELEUR AND DARKNESS. AN INDIVIDUAL'S BLOOD ANALYZE AND THE FLUID EVAPORATION AND ITS STEAM PRESSURE ". A process of improving skin permeability (120, 274) to an analyte for diagnostic purposes, or to a drug for therapeutic purposes, is described using microporation and optionally sonic energy and a chemical intensifier. If selected, sonic energy can be modulated by means of frequency modulation, amplitude modulation, phase modulation and / or combinations of these. Microporation is performed by (a) removing the horny extract (274) by means of rapid localized heating of water, such that the water is vaporized, thus eroding the cells; (b) puncture of the horny extract (274) with a microlancet calibrated to form a micropore up to about 1000 µm in diameter; (c) removal of the horny extract (274), by focusing a beam of sonic energy firmly focused on the horny extract (274); (d) hydraulically punctional the horny extract (274) with a jet of high pressure fluid, to form a micropore up to about 1000 µm in diameter; or (e) puncturing the horny extract (274) with short pulses of electricity, to form a micropore up to about 1000 µm in diameter.

BR9610012-5A 1995-08-29 1996-08-29 Processes for monitoring an analyte's concentration and intensifying the transdermal flow rate of an active permeant in a selected area on an individual's body, for applying a tattoo to a selected area of the skin and for reducing a time delay in the diffusion of an analyte of an individual's blood and the evaporation of the interstitial fluid and its vapor pressure BR9610012A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52054795A 1995-08-29 1995-08-29
US804395P 1995-10-30 1995-10-30
PCT/US1996/013865 WO1997007734A1 (en) 1995-08-29 1996-08-29 Microporation of human skin for drug delivery and monitoring applications

Publications (1)

Publication Number Publication Date
BR9610012A true BR9610012A (en) 1999-12-21

Family

ID=26677684

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9610012-5A BR9610012A (en) 1995-08-29 1996-08-29 Processes for monitoring an analyte's concentration and intensifying the transdermal flow rate of an active permeant in a selected area on an individual's body, for applying a tattoo to a selected area of the skin and for reducing a time delay in the diffusion of an analyte of an individual's blood and the evaporation of the interstitial fluid and its vapor pressure

Country Status (14)

Country Link
EP (1) EP0858285A4 (en)
JP (2) JP3899427B2 (en)
CN (1) CN1174713C (en)
AU (1) AU707065B2 (en)
BR (1) BR9610012A (en)
CA (1) CA2199002C (en)
ES (1) ES2536459T3 (en)
GB (1) GB2307414B (en)
HK (1) HK1009321A1 (en)
IL (1) IL123379A (en)
NO (1) NO334437B1 (en)
PT (1) PT1563788E (en)
TR (1) TR199800347T1 (en)
WO (1) WO1997007734A1 (en)

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