BR112023023793A2 - Peptídeo natriurético tipo b modificado - Google Patents
Peptídeo natriurético tipo b modificadoInfo
- Publication number
- BR112023023793A2 BR112023023793A2 BR112023023793A BR112023023793A BR112023023793A2 BR 112023023793 A2 BR112023023793 A2 BR 112023023793A2 BR 112023023793 A BR112023023793 A BR 112023023793A BR 112023023793 A BR112023023793 A BR 112023023793A BR 112023023793 A2 BR112023023793 A2 BR 112023023793A2
- Authority
- BR
- Brazil
- Prior art keywords
- bnp
- modified
- natriuretic
- nucleic acid
- individual
- Prior art date
Links
- 101800000407 Brain natriuretic peptide 32 Proteins 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 239000002934 diuretic Substances 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 230000002883 vasorelaxation effect Effects 0.000 abstract 3
- 239000013598 vector Substances 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 230000001882 diuretic effect Effects 0.000 abstract 2
- 230000001452 natriuretic effect Effects 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
peptídeo natriurético tipo b modificado. trata-se de um peptídeo natriurético tipo b modificado (bnp) que compreende um polímero ligado covalentemente compreendendo aminoácidos, onde o polímero inibe a degradação e/ou eliminação do bnp em um indivíduo, e onde o bnp modificado retém atividade vasorrelaxante. moléculas de ácido nucleico que codificam o bnp modificado acima descrito, assim como vetores compreendendo as moléculas de ácido nucleico e células compreendendo o vetor. também são fornecidos métodos de tratamento de um indivíduo que sofre ou é diagnosticado com uma doença, distúrbio ou condição médica que pode ser tratada com um natriurético, diurético ou vasorrelaxante. os métodos compreendem a administração do bnp modificado acima ao indivíduo. é ainda fornecido um método de preparação do bnp modificado acima descrito. adicionalmente é fornecido o uso do bnp modificado acima descrito, do ácido nucleico acima descrito, do vetor acima descrito e/ou da célula acima descrita para a fabricação de um medicamento para o tratamento de uma doença, distúrbio ou condição médica que pode ser tratada com natriurético, diurético ou vasorrelaxante.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163188743P | 2021-05-14 | 2021-05-14 | |
| PCT/US2022/029436 WO2022241310A1 (en) | 2021-05-14 | 2022-05-16 | Modified b-type natriuretic peptide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112023023793A2 true BR112023023793A2 (pt) | 2024-01-30 |
Family
ID=84028518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112023023793A BR112023023793A2 (pt) | 2021-05-14 | 2022-05-16 | Peptídeo natriurético tipo b modificado |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20240199716A1 (pt) |
| EP (1) | EP4337668A1 (pt) |
| JP (1) | JP2024517967A (pt) |
| CN (1) | CN117957237A (pt) |
| AU (1) | AU2022272733A1 (pt) |
| BR (1) | BR112023023793A2 (pt) |
| CA (1) | CA3218973A1 (pt) |
| WO (1) | WO2022241310A1 (pt) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1729795B1 (en) * | 2004-02-09 | 2016-02-03 | Human Genome Sciences, Inc. | Albumin fusion proteins |
-
2022
- 2022-05-16 CN CN202280047467.4A patent/CN117957237A/zh active Pending
- 2022-05-16 AU AU2022272733A patent/AU2022272733A1/en active Pending
- 2022-05-16 BR BR112023023793A patent/BR112023023793A2/pt unknown
- 2022-05-16 EP EP22808476.0A patent/EP4337668A1/en active Pending
- 2022-05-16 JP JP2023570371A patent/JP2024517967A/ja active Pending
- 2022-05-16 CA CA3218973A patent/CA3218973A1/en active Pending
- 2022-05-16 WO PCT/US2022/029436 patent/WO2022241310A1/en active Application Filing
-
2023
- 2023-11-14 US US18/509,195 patent/US20240199716A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP4337668A1 (en) | 2024-03-20 |
| CN117957237A (zh) | 2024-04-30 |
| US20240199716A1 (en) | 2024-06-20 |
| JP2024517967A (ja) | 2024-04-23 |
| WO2022241310A1 (en) | 2022-11-17 |
| AU2022272733A1 (en) | 2023-11-30 |
| CA3218973A1 (en) | 2022-11-17 |
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