BR112023015219A2 - Derivados de 3h,4h,5h,6h,7h-pirimido [4,5-b][1,4]oxazina-4,6-diona como inibidores de trpa1 - Google Patents

Derivados de 3h,4h,5h,6h,7h-pirimido [4,5-b][1,4]oxazina-4,6-diona como inibidores de trpa1

Info

Publication number
BR112023015219A2
BR112023015219A2 BR112023015219A BR112023015219A BR112023015219A2 BR 112023015219 A2 BR112023015219 A2 BR 112023015219A2 BR 112023015219 A BR112023015219 A BR 112023015219A BR 112023015219 A BR112023015219 A BR 112023015219A BR 112023015219 A2 BR112023015219 A2 BR 112023015219A2
Authority
BR
Brazil
Prior art keywords
oxazine
dione
trpa1
inhibitors
trpa1 inhibitors
Prior art date
Application number
BR112023015219A
Other languages
English (en)
Inventor
Paul Christian Binder Florian
Thomas Fleck Martin
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of BR112023015219A2 publication Critical patent/BR112023015219A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)

Abstract

derivados de 3h,4h,5h,6h,7h-pirimido [4,5-b][1,4]oxazina-4,6-diona como inibidores de trpa1. a presente invenção fornece determinados derivados de 3h,4h,5h,6h,7h-pirimido[4,5-b][1,4]oxazina-4,6-diona que são inibidores do receptor do potencial de anquirina 1 transitório (trpa1) e são, portanto, úteis para o tratamento de doenças tratáveis por inibição de trpa1. também são fornecidas composições farmacêuticas que contêm os mesmos e processos para preparar os ditos compostos.
BR112023015219A 2021-04-14 2022-04-13 Derivados de 3h,4h,5h,6h,7h-pirimido [4,5-b][1,4]oxazina-4,6-diona como inibidores de trpa1 BR112023015219A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP21168440 2021-04-14
PCT/EP2022/059815 WO2022219012A1 (en) 2021-04-14 2022-04-13 3h,4h,5h,6h,7h-pyrimido[4,5-b][1,4]oxazine-4,6-dione derivatives as trpa1 inhibitors

Publications (1)

Publication Number Publication Date
BR112023015219A2 true BR112023015219A2 (pt) 2023-11-07

Family

ID=75539080

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023015219A BR112023015219A2 (pt) 2021-04-14 2022-04-13 Derivados de 3h,4h,5h,6h,7h-pirimido [4,5-b][1,4]oxazina-4,6-diona como inibidores de trpa1

Country Status (13)

Country Link
US (1) US11884681B2 (pt)
EP (1) EP4323368A1 (pt)
JP (1) JP2024511480A (pt)
KR (1) KR20230170933A (pt)
CN (1) CN117561264A (pt)
AU (1) AU2022258653A1 (pt)
BR (1) BR112023015219A2 (pt)
CA (1) CA3211048A1 (pt)
CL (1) CL2023002635A1 (pt)
IL (1) IL306086A (pt)
MX (1) MX2023011828A (pt)
TW (1) TW202309036A (pt)
WO (1) WO2022219012A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11891403B2 (en) 2020-06-29 2024-02-06 Boehringer Ingelheim International Gmbh Tetrazole derivatives as TRPA1 inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017060488A1 (en) 2015-10-09 2017-04-13 Almirall, S.A. New trpa1 antagonists
US11891403B2 (en) 2020-06-29 2024-02-06 Boehringer Ingelheim International Gmbh Tetrazole derivatives as TRPA1 inhibitors

Also Published As

Publication number Publication date
KR20230170933A (ko) 2023-12-19
TW202309036A (zh) 2023-03-01
CN117561264A (zh) 2024-02-13
AU2022258653A1 (en) 2023-08-17
CL2023002635A1 (es) 2024-03-15
EP4323368A1 (en) 2024-02-21
WO2022219012A1 (en) 2022-10-20
AU2022258653A9 (en) 2024-09-19
US11884681B2 (en) 2024-01-30
US20220340593A1 (en) 2022-10-27
MX2023011828A (es) 2023-10-13
CA3211048A1 (en) 2022-10-20
IL306086A (en) 2023-11-01
JP2024511480A (ja) 2024-03-13

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