BR112023014818A2 - USE OF EXOGENOUS KETONE ESTERS TO INDUCE WEIGHT LOSS IN MAMMALS - Google Patents

USE OF EXOGENOUS KETONE ESTERS TO INDUCE WEIGHT LOSS IN MAMMALS

Info

Publication number
BR112023014818A2
BR112023014818A2 BR112023014818A BR112023014818A BR112023014818A2 BR 112023014818 A2 BR112023014818 A2 BR 112023014818A2 BR 112023014818 A BR112023014818 A BR 112023014818A BR 112023014818 A BR112023014818 A BR 112023014818A BR 112023014818 A2 BR112023014818 A2 BR 112023014818A2
Authority
BR
Brazil
Prior art keywords
weight loss
mammals
induce weight
ketone esters
exogenous ketone
Prior art date
Application number
BR112023014818A
Other languages
Portuguese (pt)
Inventor
J Stubbs Brianna
c newman John
Original Assignee
Buck Inst Res Aging
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Buck Inst Res Aging filed Critical Buck Inst Res Aging
Publication of BR112023014818A2 publication Critical patent/BR112023014818A2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/121—Ketones acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Botany (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicinal Preparation (AREA)

Abstract

uso de ésteres de cetona exógena para induzir perda de peso em mamíferos . em várias modalidades, método e composições são providos para induzir perda de peso em um mamífero. em certas modalidades, os métodos envolvem a administração a um mamífero de uma quantidade eficaz de compostos ß-hidroxiéster de ácido graxo e/ou um ou mais ésteres de butanodiol.use of exogenous ketone esters to induce weight loss in mammals. In various embodiments, method and compositions are provided for inducing weight loss in a mammal. In certain embodiments, the methods involve administering to a mammal an effective amount of fatty acid ß-hydroxyester compounds and/or one or more butanediol esters.

BR112023014818A 2021-01-26 2022-01-24 USE OF EXOGENOUS KETONE ESTERS TO INDUCE WEIGHT LOSS IN MAMMALS BR112023014818A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163141754P 2021-01-26 2021-01-26
PCT/US2022/013533 WO2022164755A1 (en) 2021-01-26 2022-01-24 Use of exogenous ketone esters to induce weight loss in mammals

Publications (1)

Publication Number Publication Date
BR112023014818A2 true BR112023014818A2 (en) 2023-10-03

Family

ID=82653822

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112023014818A BR112023014818A2 (en) 2021-01-26 2022-01-24 USE OF EXOGENOUS KETONE ESTERS TO INDUCE WEIGHT LOSS IN MAMMALS

Country Status (10)

Country Link
US (1) US20240122890A1 (en)
EP (1) EP4284358A1 (en)
JP (1) JP2024504424A (en)
KR (1) KR20230136627A (en)
AU (1) AU2022212793A1 (en)
BR (1) BR112023014818A2 (en)
CA (1) CA3206310A1 (en)
IL (1) IL304762A (en)
MX (1) MX2023008675A (en)
WO (1) WO2022164755A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023212091A1 (en) * 2022-04-29 2023-11-02 Buck Institute For Research On Aging Novel ketone ester compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102638807B1 (en) * 2016-06-07 2024-02-21 더 제이. 데이비드 글래드스톤 인스티튜트, 어 테스터멘터리 트러스트 이스타빌리쉬드 언더 더 윌 오브 제이. 데이비드 글래드스톤 Medium chain fatty acid esters of beta-hydroxybutyrate and butanediol and compositions and methods for using same
WO2019147503A1 (en) * 2018-01-25 2019-08-01 Buck Institute For Research On Aging Synthesis of 3-hydroxybutyryl 3-hydroxybutyrate and related compounds

Also Published As

Publication number Publication date
EP4284358A1 (en) 2023-12-06
AU2022212793A1 (en) 2023-08-10
JP2024504424A (en) 2024-01-31
KR20230136627A (en) 2023-09-26
WO2022164755A1 (en) 2022-08-04
US20240122890A1 (en) 2024-04-18
CA3206310A1 (en) 2022-08-04
AU2022212793A9 (en) 2024-09-19
MX2023008675A (en) 2023-08-02
IL304762A (en) 2023-09-01

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