BR112022026601A2 - Processos para preparação de um composto opticamente ativo, incluindo 1,1,3-trimetil-4-aminoindano, e complexos de cobalto assimétrico, de hidreto e de alquila - Google Patents

Processos para preparação de um composto opticamente ativo, incluindo 1,1,3-trimetil-4-aminoindano, e complexos de cobalto assimétrico, de hidreto e de alquila

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Publication number
BR112022026601A2
BR112022026601A2 BR112022026601A BR112022026601A BR112022026601A2 BR 112022026601 A2 BR112022026601 A2 BR 112022026601A2 BR 112022026601 A BR112022026601 A BR 112022026601A BR 112022026601 A BR112022026601 A BR 112022026601A BR 112022026601 A2 BR112022026601 A2 BR 112022026601A2
Authority
BR
Brazil
Prior art keywords
optically active
active compound
asymmetrical
trimethyl
preparing
Prior art date
Application number
BR112022026601A
Other languages
English (en)
Inventor
Mpaka Lutete Leopold
Hagiya Koji
Original Assignee
Sumitomo Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co filed Critical Sumitomo Chemical Co
Publication of BR112022026601A2 publication Critical patent/BR112022026601A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/06—Cobalt compounds
    • C07F15/065—Cobalt compounds without a metal-carbon linkage
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/86—Separation
    • C07C209/88—Separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/57—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems of the carbon skeleton
    • C07C211/60—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems of the carbon skeleton containing a ring other than a six-membered aromatic ring forming part of at least one of the condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/07—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/08—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms with acylated ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/06—Cobalt compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCESSOS PARA PREPARAÇÃO DE UM COMPOSTO OPTICAMENTE ATIVO, INCLUINDO 1,1,3-TRIMETIL-4- AMINOINDANO, E COMPLEXOS DE COBALTO ASSIMÉTRICO, DE HIDRETO E DE ALQUILA. A presente invenção se refere ao fornecimento de um outro processo mais eficaz para preparação de um certo composto opticamente ativo incluindo uma 1-acetil-2,2,4-trimetil-1,2,3,4-tetra-hidroquinolina opticamente ativa. A presente invenção forneceu um processo para um composto opticamente ativo representado pela Fórmula (3) (na qual R5 representa um átomo de hidrogênio etc., R6 e R7, cada um, independentemente, representam um átomo de hidrogênio, etc., R8 representa um grupo C1-C6 alquila, e R9, R10 e R11, cada um, independentemente representam um átomo de hidrogênio, etc. O átomo de carbono com um símbolo asterisco "*" representa um átomo de carbono assimétrico), que compreende uma reação de um composto representado pela Fórmula (2) (na qual R5, R6, R7, R8, R9, R10, e R11 apresentam os mesmos significados que acima) com hidrogênio na presença de complexo de conalto assimétrico.
BR112022026601A 2020-07-17 2021-07-06 Processos para preparação de um composto opticamente ativo, incluindo 1,1,3-trimetil-4-aminoindano, e complexos de cobalto assimétrico, de hidreto e de alquila BR112022026601A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2020122762 2020-07-17
PCT/JP2021/025489 WO2022014414A1 (ja) 2020-07-17 2021-07-06 光学活性な化合物の製造方法

Publications (1)

Publication Number Publication Date
BR112022026601A2 true BR112022026601A2 (pt) 2023-01-24

Family

ID=79554611

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022026601A BR112022026601A2 (pt) 2020-07-17 2021-07-06 Processos para preparação de um composto opticamente ativo, incluindo 1,1,3-trimetil-4-aminoindano, e complexos de cobalto assimétrico, de hidreto e de alquila

Country Status (10)

Country Link
US (1) US20230257408A1 (pt)
EP (1) EP4186882A4 (pt)
JP (1) JPWO2022014414A1 (pt)
KR (1) KR20230041010A (pt)
CN (1) CN115836041B (pt)
AU (1) AU2021308138A1 (pt)
BR (1) BR112022026601A2 (pt)
CA (1) CA3186051A1 (pt)
IL (1) IL299590A (pt)
WO (1) WO2022014414A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114773263B (zh) * 2022-05-16 2023-09-05 江苏百康德医药科技有限公司 (r)-2,2,4-三甲基-1,2,3,4-四氢喹啉的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0654464A1 (en) * 1993-10-22 1995-05-24 Shell Internationale Researchmaatschappij B.V. Processes for the preparation of pesticides and intermediates
US5521317A (en) 1993-10-22 1996-05-28 American Cyanamid Co. Processes for the preparation of pesticides and intermediates
JP2012025735A (ja) * 2010-06-24 2012-02-09 Sumitomo Chemical Co Ltd 植物病害防除組成物及び植物病害防除方法
TW201329067A (zh) * 2011-12-08 2013-07-16 Amgen Inc 作為ｇｋａ活化劑之脲化合物
DK3103789T3 (en) 2014-02-07 2019-01-28 Sumitomo Chemical Co METHOD FOR PREPARING (R) -1,1,3-TRIMETHYL-4-AMINOINDAN
US9796678B2 (en) * 2014-03-18 2017-10-24 Sumitomo Chemical Company, Limited Method for manufacturing optically active compound
JP2018039757A (ja) * 2016-09-08 2018-03-15 日産化学工業株式会社 イミダゾール誘導体の製造方法

Also Published As

Publication number Publication date
EP4186882A4 (en) 2024-10-16
JPWO2022014414A1 (pt) 2022-01-20
CA3186051A1 (en) 2022-01-20
KR20230041010A (ko) 2023-03-23
AU2021308138A1 (en) 2023-02-23
CN115836041B (zh) 2024-09-17
EP4186882A1 (en) 2023-05-31
CN115836041A (zh) 2023-03-21
WO2022014414A1 (ja) 2022-01-20
IL299590A (en) 2023-03-01
US20230257408A1 (en) 2023-08-17

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