BR112022026068A2 - Processo para a preparação de cloridrato de remifentanila - Google Patents

Processo para a preparação de cloridrato de remifentanila

Info

Publication number
BR112022026068A2
BR112022026068A2 BR112022026068A BR112022026068A BR112022026068A2 BR 112022026068 A2 BR112022026068 A2 BR 112022026068A2 BR 112022026068 A BR112022026068 A BR 112022026068A BR 112022026068 A BR112022026068 A BR 112022026068A BR 112022026068 A2 BR112022026068 A2 BR 112022026068A2
Authority
BR
Brazil
Prior art keywords
remifentanil
preparation
hcl
hydrodrate
preparing
Prior art date
Application number
BR112022026068A
Other languages
English (en)
Inventor
Andrews Susan
archer Nicolas
Original Assignee
Macfarlan Smith Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Macfarlan Smith Ltd filed Critical Macfarlan Smith Ltd
Publication of BR112022026068A2 publication Critical patent/BR112022026068A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)

Abstract

PROCESSO PARA A PREPARAÇÃO DE CLORIDRATO DE REMIFENTANILA. A presente invenção fornece um processo para a preparação de cloridrato de remifentanila com um perfil de impureza melhorado.
BR112022026068A 2020-07-02 2021-07-02 Processo para a preparação de cloridrato de remifentanila BR112022026068A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB2010168.9A GB202010168D0 (en) 2020-07-02 2020-07-02 Process for preparing remifentanil hydrochloride
PCT/GB2021/051680 WO2022003364A1 (en) 2020-07-02 2021-07-02 Process for preparing remifentanil hydrochloride

Publications (1)

Publication Number Publication Date
BR112022026068A2 true BR112022026068A2 (pt) 2023-01-17

Family

ID=72050377

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022026068A BR112022026068A2 (pt) 2020-07-02 2021-07-02 Processo para a preparação de cloridrato de remifentanila

Country Status (9)

Country Link
US (1) US20230312472A1 (pt)
EP (1) EP4175945A1 (pt)
JP (1) JP2023530847A (pt)
KR (1) KR20230058595A (pt)
CN (1) CN115996909A (pt)
BR (1) BR112022026068A2 (pt)
CA (1) CA3179839A1 (pt)
GB (1) GB202010168D0 (pt)
WO (1) WO2022003364A1 (pt)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5019583A (en) * 1989-02-15 1991-05-28 Glaxo Inc. N-phenyl-N-(4-piperidinyl)amides useful as analgesics
EP1867635A1 (en) * 2006-06-15 2007-12-19 Kern Pharma, S.L. Process for preparing remifentanil, intermediates thereof, use of said intermediates and processes for their preparation
SI3643704T1 (sl) * 2018-10-26 2021-04-30 Hameln Pharma Gmbh Novi intermediati za pripravo remifentanil hidroklorida

Also Published As

Publication number Publication date
CN115996909A (zh) 2023-04-21
EP4175945A1 (en) 2023-05-10
KR20230058595A (ko) 2023-05-03
CA3179839A1 (en) 2022-01-06
US20230312472A1 (en) 2023-10-05
WO2022003364A1 (en) 2022-01-06
GB202010168D0 (en) 2020-08-19
JP2023530847A (ja) 2023-07-20

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]