BR112022025334A2 - Derivado de insulina degludeca, método de preparação do mesmo, e uso do mesmo - Google Patents
Derivado de insulina degludeca, método de preparação do mesmo, e uso do mesmoInfo
- Publication number
- BR112022025334A2 BR112022025334A2 BR112022025334A BR112022025334A BR112022025334A2 BR 112022025334 A2 BR112022025334 A2 BR 112022025334A2 BR 112022025334 A BR112022025334 A BR 112022025334A BR 112022025334 A BR112022025334 A BR 112022025334A BR 112022025334 A2 BR112022025334 A2 BR 112022025334A2
- Authority
- BR
- Brazil
- Prior art keywords
- present
- fusion protein
- same
- protein
- insulin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
- C12N9/506—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses derived from RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/22—Cysteine endopeptidases (3.4.22)
- C12Y304/22044—Nuclear-inclusion-a endopeptidase (3.4.22.44)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010524886.5A CN113773398B (zh) | 2020-06-10 | 2020-06-10 | 一种德谷胰岛素衍生物及其应用 |
PCT/CN2021/099493 WO2021249505A1 (zh) | 2020-06-10 | 2021-06-10 | 一种德谷胰岛素衍生物及其制备方法和应用 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022025334A2 true BR112022025334A2 (pt) | 2023-03-07 |
Family
ID=78834815
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022025334A BR112022025334A2 (pt) | 2020-06-10 | 2021-06-10 | Derivado de insulina degludeca, método de preparação do mesmo, e uso do mesmo |
Country Status (6)
Country | Link |
---|---|
US (1) | US20230127875A1 (zh) |
EP (1) | EP4166573A1 (zh) |
JP (1) | JP2023531168A (zh) |
CN (2) | CN113773398B (zh) |
BR (1) | BR112022025334A2 (zh) |
WO (1) | WO2021249505A1 (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116425884B (zh) * | 2023-03-09 | 2024-04-26 | 北京惠之衡生物科技有限公司 | 一种德谷胰岛素的纯化及制备方法 |
CN117782730A (zh) * | 2023-12-27 | 2024-03-29 | 亿帆医药(上海)有限公司 | 德谷胰岛素中大肠杆菌菌体蛋白残留的检测试剂和方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK134189D0 (da) * | 1989-03-20 | 1989-03-20 | Nordisk Gentofte | Insulinforbindelser |
CN102504022A (zh) * | 2011-11-30 | 2012-06-20 | 苏州元基生物技术有限公司 | 含有保护赖氨酸的胰岛素原及使用其制备胰岛素的方法 |
AU2012350586B2 (en) * | 2011-12-15 | 2017-02-02 | Jiangsu Hengrui Medicine Co., Ltd. | Human insulin analogue and acylated derivative thereof |
CN102628072B (zh) * | 2012-03-20 | 2013-12-04 | 甘李药业股份有限公司 | 一种胰岛素的制备方法 |
CN104619726B (zh) * | 2012-03-23 | 2018-05-18 | 苏州鲲鹏生物技术有限公司 | 由超折叠绿色荧光蛋白构成的融合蛋白及其用途 |
CN105820233B (zh) * | 2015-01-04 | 2021-06-15 | 甘李药业股份有限公司 | 一种胰岛素衍生物的制备方法 |
CN104892749B (zh) * | 2015-06-16 | 2019-02-05 | 珠海联邦制药股份有限公司 | 一种德谷胰岛素结晶的制备方法及应用 |
CN109295067B (zh) * | 2018-10-26 | 2020-12-29 | 吉林惠升生物制药有限公司 | 一种密码子优化的德谷胰岛素前体基因及其表达方法 |
CN111718417B (zh) * | 2019-03-19 | 2022-10-14 | 宁波鲲鹏生物科技有限公司 | 含有荧光蛋白片段的融合蛋白及其用途 |
-
2020
- 2020-06-10 CN CN202010524886.5A patent/CN113773398B/zh active Active
-
2021
- 2021-06-10 EP EP21821084.7A patent/EP4166573A1/en not_active Withdrawn
- 2021-06-10 US US18/000,986 patent/US20230127875A1/en active Pending
- 2021-06-10 BR BR112022025334A patent/BR112022025334A2/pt unknown
- 2021-06-10 WO PCT/CN2021/099493 patent/WO2021249505A1/zh unknown
- 2021-06-10 JP JP2022576376A patent/JP2023531168A/ja active Pending
- 2021-06-10 CN CN202180041116.8A patent/CN115708413A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2023531168A (ja) | 2023-07-21 |
CN115708413A (zh) | 2023-02-21 |
WO2021249505A1 (zh) | 2021-12-16 |
EP4166573A1 (en) | 2023-04-19 |
US20230127875A1 (en) | 2023-04-27 |
CN113773398B (zh) | 2023-05-23 |
CN113773398A (zh) | 2021-12-10 |
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