BR112022021380A2 - MESSENGER RNA NANOPARTICLES FOR TREATMENT - Google Patents
MESSENGER RNA NANOPARTICLES FOR TREATMENTInfo
- Publication number
- BR112022021380A2 BR112022021380A2 BR112022021380A BR112022021380A BR112022021380A2 BR 112022021380 A2 BR112022021380 A2 BR 112022021380A2 BR 112022021380 A BR112022021380 A BR 112022021380A BR 112022021380 A BR112022021380 A BR 112022021380A BR 112022021380 A2 BR112022021380 A2 BR 112022021380A2
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- messenger rna
- messenger
- nanoparticles
- rna nanoparticles
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
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- C07K—PEPTIDES
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Abstract
NANOPARTÍCULAS DE RNA MENSAGEIRO PARA TRATAMENTO. O presente documento fornece exemplos de nanopartículas de tratamento de RNA mensageiro e métodos de uso dos mesmos para tratar um paciente. Uma nanopartícula de tratamento de RNA mensageiro pode incluir um ou mais RNAs mensageiros codificando um antígeno específico de tumor e um agente imunomodulador; e uma molécula de veículo de liberação encapsulando os referidos um ou mais RNAs mensageiros.MESSENGER RNA NANOPARTICLES FOR TREATMENT. The present document provides examples of messenger RNA treatment nanoparticles and methods of using the same to treat a patient. A messenger RNA treatment nanoparticle can include one or more messenger RNAs encoding a tumor-specific antigen and an immunomodulatory agent; and a delivery vehicle molecule encapsulating said one or more messenger RNAs.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063014074P | 2020-04-22 | 2020-04-22 | |
PCT/US2021/028312 WO2021216647A1 (en) | 2020-04-22 | 2021-04-21 | Mrna treatment nanoparticles |
Publications (1)
Publication Number | Publication Date |
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BR112022021380A2 true BR112022021380A2 (en) | 2022-12-06 |
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ID=78270002
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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BR112022021380A BR112022021380A2 (en) | 2020-04-22 | 2021-04-21 | MESSENGER RNA NANOPARTICLES FOR TREATMENT |
Country Status (12)
Country | Link |
---|---|
US (1) | US11879126B2 (en) |
EP (1) | EP4139044A1 (en) |
JP (1) | JP2023523150A (en) |
KR (1) | KR20230005241A (en) |
CN (1) | CN115956003A (en) |
AU (1) | AU2021259571A1 (en) |
BR (1) | BR112022021380A2 (en) |
CA (1) | CA3174267A1 (en) |
IL (1) | IL297161A (en) |
MX (1) | MX2022012854A (en) |
TW (1) | TW202206083A (en) |
WO (1) | WO2021216647A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2024038407A1 (en) * | 2022-08-19 | 2024-02-22 | Seqirus Inc. | Lipid nanoparticle comprising a dna-binding protein |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
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US20040096835A1 (en) * | 2002-11-19 | 2004-05-20 | Isis Pharmaceuticals Inc. | Modulation of TNFSF14 expression |
WO2012024658A2 (en) * | 2010-08-20 | 2012-02-23 | IntegenX, Inc. | Integrated analysis system |
US10258698B2 (en) * | 2013-03-14 | 2019-04-16 | Modernatx, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
WO2017193084A1 (en) * | 2016-05-06 | 2017-11-09 | Exicure, Inc. | Tlr9-targeted spherical nucleic acids having potent antitumor activity |
GB201612520D0 (en) * | 2016-07-19 | 2016-08-31 | F-Star Beta Ltd | Binding molecules |
BR112019008369A2 (en) * | 2016-10-26 | 2019-10-01 | Modernatx Inc | messenger ribonucleic acids to enhance immune responses and methods for using them |
EP3691662A4 (en) * | 2017-10-06 | 2021-05-12 | The University of Chicago | Screening of t lymphocytes for cancer-specific antigens |
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