BR112022019539A2 - Comprimido compósito e método para preparar o comprimido compósito para administração oral - Google Patents

Comprimido compósito e método para preparar o comprimido compósito para administração oral

Info

Publication number
BR112022019539A2
BR112022019539A2 BR112022019539A BR112022019539A BR112022019539A2 BR 112022019539 A2 BR112022019539 A2 BR 112022019539A2 BR 112022019539 A BR112022019539 A BR 112022019539A BR 112022019539 A BR112022019539 A BR 112022019539A BR 112022019539 A2 BR112022019539 A2 BR 112022019539A2
Authority
BR
Brazil
Prior art keywords
composite tablet
preparing
oral administration
tablet
pharmaceutically acceptable
Prior art date
Application number
BR112022019539A
Other languages
English (en)
Inventor
Wook Tak Jin
Sik Kim Bo
Kwan Kwon Taek
Taek Im Ho
Il Kim Yong
Original Assignee
Hanmi Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd
Publication of BR112022019539A2 publication Critical patent/BR112022019539A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

COMPRIMIDO COMPÓSITO E MÉTODO PARA PREPARAR O COMPRIMIDO COMPÓSITO PARA ADMINISTRAÇÃO ORAL. De acordo com um aspecto, são fornecidos um comprimido compósito e um método para preparar o comprimido compósito, em que o comprimido compósito pode incluir uma primeira camada que inclui grânulos secos que incluem sitagliptina ou um sal farmaceuticamente aceitável da mesma, ou um hidrato da mesma, e dapagliflozina ou um sal farmaceuticamente aceitável da mesma, ou um hidrato da mesma, e uma segunda camada que inclui grânulos úmidos que incluem metformina ou um sal farmaceuticamente aceitável da mesma e dióxido de silício coloidal.
BR112022019539A 2020-03-30 2021-03-12 Comprimido compósito e método para preparar o comprimido compósito para administração oral BR112022019539A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020200038568A KR20210121599A (ko) 2020-03-30 2020-03-30 시타글립틴, 다파글리플로진, 및 메트포르민을 포함하는 경구용 복합정제
PCT/KR2021/003080 WO2021201461A1 (ko) 2020-03-30 2021-03-12 시타글립틴, 다파글리플로진, 및 메트포르민을 포함하는 경구용 복합정제

Publications (1)

Publication Number Publication Date
BR112022019539A2 true BR112022019539A2 (pt) 2022-11-16

Family

ID=77929083

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022019539A BR112022019539A2 (pt) 2020-03-30 2021-03-12 Comprimido compósito e método para preparar o comprimido compósito para administração oral

Country Status (9)

Country Link
US (1) US20230149314A1 (pt)
EP (1) EP4112047A4 (pt)
JP (1) JP2023519532A (pt)
KR (1) KR20210121599A (pt)
CN (1) CN115297847A (pt)
AU (1) AU2021249767A1 (pt)
BR (1) BR112022019539A2 (pt)
MX (1) MX2022012128A (pt)
WO (1) WO2021201461A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220007446A (ko) * 2020-07-10 2022-01-18 한미약품 주식회사 시타글립틴 및 다파글리플로진을 포함하는 복합제제 및 그 제조방법
EP4212150A1 (en) * 2022-01-13 2023-07-19 Sanovel Ilac Sanayi Ve Ticaret A.S. A bilayer tablet composition comprising amorphous dapagliflozin and metformin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20180109A1 (ar) * 2005-09-29 2019-01-30 Novartis Ag تركيبة جديدة
PT2498758T (pt) * 2009-11-13 2018-10-23 Astrazeneca Uk Ltd Formulações de comprimido bicamada
WO2013110085A1 (en) * 2012-01-20 2013-07-25 Handa Pharmaceuticals, Llc Oral dosage forms for delivering metformin and sitagliptin
KR20160111237A (ko) * 2015-03-16 2016-09-26 한미약품 주식회사 메트포르민 및 시타글립틴을 포함하는 경구용 복합제제
WO2018124497A1 (ko) * 2016-12-30 2018-07-05 한미약품 주식회사 다파글리플로진 l-프롤린과 항당뇨병제를 포함하는 약제학적 복합 제제
KR102369679B1 (ko) * 2017-09-29 2022-03-04 한미약품 주식회사 다파글리플로진 l-프롤린과 메트포르민을 포함하는 약제학적 복합제제
KR102204439B1 (ko) * 2018-05-14 2021-01-18 에이치케이이노엔 주식회사 Sglt-2 억제제 및 dpp-iv 억제제를 포함하는 약제학적 조성물

Also Published As

Publication number Publication date
EP4112047A4 (en) 2024-03-27
EP4112047A1 (en) 2023-01-04
CN115297847A (zh) 2022-11-04
MX2022012128A (es) 2022-10-18
JP2023519532A (ja) 2023-05-11
AU2021249767A1 (en) 2022-09-22
KR20210121599A (ko) 2021-10-08
WO2021201461A1 (ko) 2021-10-07
US20230149314A1 (en) 2023-05-18

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