BR112022016212A2 - Método para detectar tumor ovariano maligno, e, uso de um anticorpo - Google Patents
Método para detectar tumor ovariano maligno, e, uso de um anticorpoInfo
- Publication number
- BR112022016212A2 BR112022016212A2 BR112022016212A BR112022016212A BR112022016212A2 BR 112022016212 A2 BR112022016212 A2 BR 112022016212A2 BR 112022016212 A BR112022016212 A BR 112022016212A BR 112022016212 A BR112022016212 A BR 112022016212A BR 112022016212 A2 BR112022016212 A2 BR 112022016212A2
- Authority
- BR
- Brazil
- Prior art keywords
- ovarian tumors
- antibody
- malignant ovarian
- distinct
- tfpi2
- Prior art date
Links
- 206010033128 Ovarian cancer Diseases 0.000 title abstract 5
- 206010004433 Benign ovarian tumour Diseases 0.000 abstract 3
- 101000835083 Homo sapiens Tissue factor pathway inhibitor 2 Proteins 0.000 abstract 3
- 102100026134 Tissue factor pathway inhibitor 2 Human genes 0.000 abstract 3
- 201000008016 ovarian benign neoplasm Diseases 0.000 abstract 3
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 208000004548 serous cystadenocarcinoma Diseases 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57449—Specifically defined cancers of ovaries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4703—Regulators; Modulating activity
- G01N2333/4704—Inhibitors; Supressors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
- G01N2333/8114—Kunitz type inhibitors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Hospice & Palliative Care (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
MÉTODO PARA DETECTAR TUMOR OVARIANO MALIGNO, E, USO DE UM ANTICORPO. A presente invenção aborda o problema de prover um método para detectar tumores ovarianos malignos distintamente de tumores ovarianos benignos e um reagente que pode ser usado no método. Este método para detectar tumores ovarianos malignos (excluindo carcinoma seroso de alto grau) distintamente de tumores ovarianos benignos é distinguido pela quantidade de TFPI2 em uma amostra originária de um paciente ser medida. Além disso, um anticorpo que reconhece especificamente o polipeptídeo de processamento de TFPI2 e TFPI2 intacto é incluído em um reagente para detectar tumores ovarianos malignos (excluindo carcinoma seroso de alto grau) distintamente de tumores ovarianos benignos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2020030210 | 2020-02-26 | ||
PCT/JP2021/004736 WO2021172000A1 (ja) | 2020-02-26 | 2021-02-09 | 卵巣悪性腫瘍の検出方法及び検出試薬 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022016212A2 true BR112022016212A2 (pt) | 2022-10-04 |
Family
ID=77490489
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022016212A BR112022016212A2 (pt) | 2020-02-26 | 2021-02-09 | Método para detectar tumor ovariano maligno, e, uso de um anticorpo |
Country Status (8)
Country | Link |
---|---|
US (1) | US20230122642A1 (pt) |
EP (1) | EP4113119A4 (pt) |
JP (1) | JPWO2021172000A1 (pt) |
CN (1) | CN115151821A (pt) |
AU (1) | AU2021227181A1 (pt) |
BR (1) | BR112022016212A2 (pt) |
CA (1) | CA3172404A1 (pt) |
WO (1) | WO2021172000A1 (pt) |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003068054A2 (en) * | 2002-02-13 | 2003-08-21 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health Services | Identification of ovarian cancer tumor markers and therapeutic targets |
WO2004108896A2 (en) * | 2003-06-03 | 2004-12-16 | The Board Of Trustees Of The University Of Arkansas | Gene expression profiling of uterine serous papillary carcinomas and ovarian serous papillary tumors |
ATE557277T1 (de) * | 2003-09-24 | 2012-05-15 | Oncotherapy Science Inc | Verfahren zur diagnose von endometriose mittels tfpi-2 protein |
WO2011102461A1 (ja) | 2010-02-22 | 2011-08-25 | 公立大学法人横浜市立大学 | 卵巣明細胞腺癌に特異的に発現しているタンパク質とその応用 |
JP5906447B2 (ja) * | 2011-01-13 | 2016-04-20 | 国立研究開発法人産業技術総合研究所 | 上皮性卵巣癌鑑別マーカー |
JP6074676B2 (ja) * | 2011-08-19 | 2017-02-08 | 公立大学法人横浜市立大学 | 組織因子経路阻害因子2(tfpi2)測定による卵巣明細胞腺癌の検査方法および検査薬 |
CN107001437B (zh) * | 2014-11-27 | 2021-10-29 | 公立大学法人横滨市立大学 | 卵巢透明细胞腺癌的检查方法及检查药 |
JP6760562B2 (ja) * | 2016-09-30 | 2020-09-23 | 公立大学法人横浜市立大学 | 卵巣明細胞癌患者の予後を予測するための情報提供方法 |
EP3657170A1 (en) * | 2018-11-20 | 2020-05-27 | Philipps-Universität Marburg | Method for the early detection and diagnosis of primary and relapsed ovarian carcinoma (oc) |
-
2021
- 2021-02-09 BR BR112022016212A patent/BR112022016212A2/pt unknown
- 2021-02-09 JP JP2022503238A patent/JPWO2021172000A1/ja active Pending
- 2021-02-09 AU AU2021227181A patent/AU2021227181A1/en active Pending
- 2021-02-09 WO PCT/JP2021/004736 patent/WO2021172000A1/ja unknown
- 2021-02-09 US US17/802,354 patent/US20230122642A1/en active Pending
- 2021-02-09 CA CA3172404A patent/CA3172404A1/en active Pending
- 2021-02-09 EP EP21760051.9A patent/EP4113119A4/en active Pending
- 2021-02-09 CN CN202180016885.2A patent/CN115151821A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
EP4113119A1 (en) | 2023-01-04 |
AU2021227181A1 (en) | 2022-09-22 |
WO2021172000A1 (ja) | 2021-09-02 |
US20230122642A1 (en) | 2023-04-20 |
CA3172404A1 (en) | 2021-09-02 |
CN115151821A (zh) | 2022-10-04 |
JPWO2021172000A1 (pt) | 2021-09-02 |
EP4113119A4 (en) | 2024-03-06 |
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