BR112022012789A2 - Homólogo de proteína, quito-oligossacarídeo, composição farmacêutica, método de tratamento ou prevenção, ácido nucleico sintético ou recombinante e uso de um homólogo de proteína - Google Patents

Homólogo de proteína, quito-oligossacarídeo, composição farmacêutica, método de tratamento ou prevenção, ácido nucleico sintético ou recombinante e uso de um homólogo de proteína

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Publication number
BR112022012789A2
BR112022012789A2 BR112022012789A BR112022012789A BR112022012789A2 BR 112022012789 A2 BR112022012789 A2 BR 112022012789A2 BR 112022012789 A BR112022012789 A BR 112022012789A BR 112022012789 A BR112022012789 A BR 112022012789A BR 112022012789 A2 BR112022012789 A2 BR 112022012789A2
Authority
BR
Brazil
Prior art keywords
protein homolog
oligosaccharide
present
provides
chito
Prior art date
Application number
BR112022012789A
Other languages
English (en)
Inventor
Saiyed Taslimarif
Brijalal Patel Paresh
Ravindran Balachandran
Panda Santosh
Original Assignee
Centre For Cellular And Molecular Platforms
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre For Cellular And Molecular Platforms filed Critical Centre For Cellular And Molecular Platforms
Publication of BR112022012789A2 publication Critical patent/BR112022012789A2/pt

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1767Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • A61K31/722Chitin, chitosan
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43536Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
    • C07K14/4354Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms from nematodes
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/00272-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Genetics & Genomics (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

HOMÓLOGO DE PROTEÍNA, QUITO-OLIGOSSACARÍDEO, COMPOSIÇÃO FARMACÊUTICA, MÉTODO DE TRATAMENTO OU PREVENÇÃO, ÁCIDO NUCLEICO SINTÉTICO OU RECOMBINANTE E USO DE UM HOMÓLOGO DE PROTEÍNA. A presente invenção proporciona moléculas terapêuticas para combater sepse. A presente invenção proporciona proteínas capazes de aprimorar a sobrevivência através de imunomodulação em pós-septicemia em mamíferos e oligossacarídeos, capazes de imunomodular inflamação em um mamífero. A presente invenção proporciona homólogo de proteínas de HSP70 humano derivado a partir de nematoide Setaria digitata e suas formas recombinantes e oligossacarídeos e o papel das mesmas em imunomodular a resposta inflamatória em um mamífero. A presente invenção também proporciona uma composição que compreende proteínas terapêuticas e/ou profiláticas e moléculas de oligossacarídeo para imunomodulação em sepse; e método para tratar e/ou evitar sepse, MODS (síndrome de disfunção de múltiplos órgãos) ou choque séptico em um mamífero.
BR112022012789A 2019-12-26 2020-12-26 Homólogo de proteína, quito-oligossacarídeo, composição farmacêutica, método de tratamento ou prevenção, ácido nucleico sintético ou recombinante e uso de um homólogo de proteína BR112022012789A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201941053971 2019-12-26
PCT/IB2020/062459 WO2021130729A1 (en) 2019-12-26 2020-12-26 Therapeutic molecules for combating sepsis

Publications (1)

Publication Number Publication Date
BR112022012789A2 true BR112022012789A2 (pt) 2022-09-20

Family

ID=76574046

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022012789A BR112022012789A2 (pt) 2019-12-26 2020-12-26 Homólogo de proteína, quito-oligossacarídeo, composição farmacêutica, método de tratamento ou prevenção, ácido nucleico sintético ou recombinante e uso de um homólogo de proteína

Country Status (6)

Country Link
US (1) US20230105103A1 (pt)
EP (1) EP4081223A4 (pt)
KR (1) KR20220132542A (pt)
AU (1) AU2020415493A1 (pt)
BR (1) BR112022012789A2 (pt)
WO (1) WO2021130729A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022185286A1 (en) * 2021-03-05 2022-09-09 Centre For Cellular And Molecular Platforms Therapeutic and/or prophylactic anti-viral agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1261264A (en) * 1984-11-29 1989-09-26 Shigeo Suzuki Immunopotentiating agents and method
JPS62138496A (ja) * 1985-12-11 1987-06-22 Ihara Chem Ind Co Ltd キチンオリゴマ−の製造方法
US20020198139A1 (en) * 2001-05-17 2002-12-26 Deutschman Clifford S. Method of preventing acute pulmonary cell injury

Also Published As

Publication number Publication date
EP4081223A1 (en) 2022-11-02
EP4081223A4 (en) 2024-03-27
KR20220132542A (ko) 2022-09-30
WO2021130729A1 (en) 2021-07-01
US20230105103A1 (en) 2023-04-06
AU2020415493A1 (en) 2022-08-18

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