BR112022009606A2 - Formulações, composições responsivas ao ph e métodos para imagear um tumor - Google Patents

Formulações, composições responsivas ao ph e métodos para imagear um tumor

Info

Publication number
BR112022009606A2
BR112022009606A2 BR112022009606A BR112022009606A BR112022009606A2 BR 112022009606 A2 BR112022009606 A2 BR 112022009606A2 BR 112022009606 A BR112022009606 A BR 112022009606A BR 112022009606 A BR112022009606 A BR 112022009606A BR 112022009606 A2 BR112022009606 A2 BR 112022009606A2
Authority
BR
Brazil
Prior art keywords
formulations
methods
imaging
tumor
responsive
Prior art date
Application number
BR112022009606A
Other languages
English (en)
Portuguese (pt)
Inventor
Zhao Tian
Jayalakshmi Yalia
A Hall Keith
Madajewski Brian
KAPLAN Hargita
Original Assignee
Onconano Medicine Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Onconano Medicine Inc filed Critical Onconano Medicine Inc
Publication of BR112022009606A2 publication Critical patent/BR112022009606A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10Esters
    • C08F220/34Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/005Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032Methine dyes, e.g. cyanine dyes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0063Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0076Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion
    • A61K49/0082Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion micelle, e.g. phospholipidic micelle and polymeric micelle
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10Esters
    • C08F220/38Esters containing sulfur
    • C08F220/382Esters containing sulfur and containing oxygen, e.g. 2-sulfoethyl (meth)acrylate
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F293/00Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • C08F293/005Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F299/00Macromolecular compounds obtained by interreacting polymers involving only carbon-to-carbon unsaturated bond reactions, in the absence of non-macromolecular monomers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2438/00Living radical polymerisation
    • C08F2438/01Atom Transfer Radical Polymerization [ATRP] or reverse ATRP
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/70Mechanisms involved in disease identification
    • G01N2800/7023(Hyper)proliferation
    • G01N2800/7028Cancer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Graft Or Block Polymers (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
BR112022009606A 2019-11-18 2020-11-17 Formulações, composições responsivas ao ph e métodos para imagear um tumor BR112022009606A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962937141P 2019-11-18 2019-11-18
PCT/US2020/060910 WO2021101905A1 (en) 2019-11-18 2020-11-17 Ph responsive compositions, formulations, and methods of imaging a tumor

Publications (1)

Publication Number Publication Date
BR112022009606A2 true BR112022009606A2 (pt) 2022-08-16

Family

ID=75980983

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022009606A BR112022009606A2 (pt) 2019-11-18 2020-11-17 Formulações, composições responsivas ao ph e métodos para imagear um tumor

Country Status (11)

Country Link
US (1) US20230025280A1 (https=)
EP (1) EP4061428A4 (https=)
JP (1) JP7752110B2 (https=)
KR (1) KR20220149906A (https=)
CN (1) CN115279422B (https=)
AU (1) AU2020387279B2 (https=)
BR (1) BR112022009606A2 (https=)
CA (1) CA3158471A1 (https=)
IL (1) IL293101A (https=)
MX (1) MX2022005996A (https=)
WO (1) WO2021101905A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202113178QA (en) * 2019-05-28 2021-12-30 Univ Texas pH RESPONSIVE COMPOSITIONS AND USES THEREOF
WO2025129124A1 (en) * 2023-12-15 2025-06-19 The Board Of Regents Of The University Of Texas System Stimuli-responsive sting-activating polymer compositions and methods of use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE345780T1 (de) * 2001-07-13 2006-12-15 Nanocarrier Co Ltd Lyophilisierende zusammensetzung von wirkstoff- verkapselnder polymer-mizelle und verfahren zu ihrer herstellung
CN103002921A (zh) * 2010-05-14 2013-03-27 马林克罗特有限公司 用于联合的光学成像和治疗的功能性交联纳米结构
DE102010022110A1 (de) * 2010-05-31 2011-12-01 LMU Universität München Department Chemie Cyaninfarbstoffe als Kontrastmittel zur Unterstützung der Augenchirurgie
US9511152B2 (en) * 2012-04-05 2016-12-06 The Board Of Regents Of The University Of Texas System Multicolored pH-activatable fluorescence nanoplatform
AU2015269068A1 (en) * 2014-06-06 2016-12-22 The Board Of Regents Of The University Of Texas System Library of pH responsive polymers and nanoprobes thereof
CN104758247B (zh) * 2015-04-22 2017-11-14 广东工业大学 一种pH响应聚合物混合胶束及其应用
CA3016457A1 (en) * 2016-03-02 2017-09-08 The Board Of Regents Of The University Of Texas System Sting activating nanovaccine for immunotherapy
JP6984909B2 (ja) * 2016-12-23 2021-12-22 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 活性ベースのプローブ化合物、組成物、および使用方法
US20200333357A1 (en) * 2017-11-13 2020-10-22 The Board Of Regents Of The University Of Texas System Novel tfeb pathway agonists for metabolic diseases and ageing
CN108721649B (zh) * 2018-06-26 2021-12-07 武汉凯德维斯生物技术有限公司 一种肿瘤靶向近红外荧光显像剂的设计、合成及应用
SG11202113178QA (en) * 2019-05-28 2021-12-30 Univ Texas pH RESPONSIVE COMPOSITIONS AND USES THEREOF

Also Published As

Publication number Publication date
MX2022005996A (es) 2022-10-27
US20230025280A1 (en) 2023-01-26
AU2020387279A1 (en) 2022-06-02
JP7752110B2 (ja) 2025-10-09
EP4061428A4 (en) 2023-12-20
EP4061428A1 (en) 2022-09-28
CN115279422A (zh) 2022-11-01
WO2021101905A1 (en) 2021-05-27
IL293101A (en) 2022-07-01
JP2023502998A (ja) 2023-01-26
AU2020387279B2 (en) 2026-04-09
CA3158471A1 (en) 2021-05-27
KR20220149906A (ko) 2022-11-09
CN115279422B (zh) 2024-03-29

Similar Documents

Publication Publication Date Title
MX2021014443A (es) Inhibidores del dominio asociado mejorador de la transcripcion (tead) y usos de los mismos.
AR122785A2 (es) Inhibidores de kras g12c y métodos para su uso
BR112021024224A2 (pt) Inibidores de tead e usos dos mesmos
ZA202202097B (en) Amino pyrimidine ssao inhibitors
DK4015003T5 (da) Forbedret antistof-oligonukleotid-konjugat
CL2017003103A1 (es) Compuestos de heteroarilo para la inhibición de cinasa
MX2023002507A (es) Inhibidores de cd73.
EA201991700A1 (ru) Селективные ингибиторы jak1
MX2022005256A (es) Inhibidores de cd73.
MX2022014457A (es) Formulaciones de inmunoconjugado anti-cd79b estables.
SG11201906435SA (en) Pyrimidine compound and pharmaceutical use thereof
EA202190633A1 (ru) Лекарственные формы для применения в педиатрии, способы получения и применения
AU2016380190A8 (en) Deuterated compounds for treating cancer and related diseases and conditions, and compositions and methods thereof
CY1125433T1 (el) Αντιπολλαπλασιαστικες ενωσεις και χρησεις αυτων
MX392700B (es) Inhibidores de antígeno de la membrana específico para la próstata (psma) quelados.
MX2022007626A (es) Combinaciones.
MX2021007201A (es) Producto estable con esta?o para el cuidado oral.
IL288856A (en) Compositions, kits, methods and uses for preventing microbial growth
BR112022009606A2 (pt) Formulações, composições responsivas ao ph e métodos para imagear um tumor
WO2017095950A3 (en) Compounds for treating proliferative diseases
WO2019109067A3 (en) Creatine prodrugs, compositions and methods of use thereof
MA53603A (fr) Procédés de modulation de la cytotoxicité à médiation cellulaire dépendante des anticorps
PH12020551206A1 (en) Farber disease markers and uses thereof
MX379649B (es) Derivados de azetidina para formacion de imágenes de tau.
CO2021003295A2 (es) (r)-5-carbamoilpiridin-3-il-2-metil-4-(3-(trifluorometoxi)bencil)piperazin-1-carboxilato cristalino, composiciones y sus métodos de uso