BR112022008704A2 - Métodos e composições para uso de anticorpos de fator de crescimento em combinação com inibidores direcionados para quinase não tirosina - Google Patents

Métodos e composições para uso de anticorpos de fator de crescimento em combinação com inibidores direcionados para quinase não tirosina

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Publication number
BR112022008704A2
BR112022008704A2 BR112022008704A BR112022008704A BR112022008704A2 BR 112022008704 A2 BR112022008704 A2 BR 112022008704A2 BR 112022008704 A BR112022008704 A BR 112022008704A BR 112022008704 A BR112022008704 A BR 112022008704A BR 112022008704 A2 BR112022008704 A2 BR 112022008704A2
Authority
BR
Brazil
Prior art keywords
methods
combination
tyrosine kinase
compositions
growth factor
Prior art date
Application number
BR112022008704A
Other languages
English (en)
Portuguese (pt)
Inventor
D' Hondt Erik
Angel Molina-Vila Miguel
Original Assignee
In3Bio Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by In3Bio Ltd filed Critical In3Bio Ltd
Publication of BR112022008704A2 publication Critical patent/BR112022008704A2/pt

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    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K—PEPTIDES
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
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  • Oncology (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
BR112022008704A 2019-11-07 2020-11-06 Métodos e composições para uso de anticorpos de fator de crescimento em combinação com inibidores direcionados para quinase não tirosina BR112022008704A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962932131P 2019-11-07 2019-11-07
US202063094018P 2020-10-20 2020-10-20
PCT/IB2020/000969 WO2021090069A1 (en) 2019-11-07 2020-11-06 Methods and compositions for use of growth factor antibodies in combination with non-tyrosine targeting kinase inhibitors

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BR112022008704A2 true BR112022008704A2 (pt) 2022-07-19

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Country Link
US (1) US20220378891A1 (https=)
EP (1) EP4054619A1 (https=)
JP (1) JP2023500889A (https=)
KR (1) KR20220099990A (https=)
CN (1) CN115379851A (https=)
AU (1) AU2020378682A1 (https=)
BR (1) BR112022008704A2 (https=)
CA (1) CA3157334A1 (https=)
IL (1) IL292730A (https=)
MX (1) MX2022005306A (https=)
WO (1) WO2021090069A1 (https=)

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WO2017048702A1 (en) 2015-09-14 2017-03-23 Infinity Pharmaceuticals, Inc. Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
CN118984704A (zh) * 2022-02-18 2024-11-19 帕特恩电脑公司 治疗卵巢癌的药物组合和方法

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KR20190112263A (ko) * 2016-12-12 2019-10-04 멀티비르 인코포레이티드 암 및 감염성 질환의 치료 및 예방을 위한 바이러스 유전자 치료요법 및 면역 체크포인트 억제제를 포함하는 방법 및 조성물
WO2018175251A1 (en) * 2017-03-20 2018-09-27 Celcuity Llc Methods of measuring signaling pathway activity for selection of therapeutic agents
JP7751357B2 (ja) * 2017-07-18 2025-10-08 イン３バイオ・リミテッド 合成タンパク質およびその治療学的用途
KR102811888B1 (ko) * 2017-09-08 2025-05-27 에프. 호프만-라 로슈 아게 암의 진단 및 치료 방법

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CA3157334A1 (en) 2021-05-14
MX2022005306A (es) 2022-08-08
WO2021090069A1 (en) 2021-05-14
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US20220378891A1 (en) 2022-12-01

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