BR112022007203A2 - Compostos imunogênicos para tratamento de câncer adrenal - Google Patents
Compostos imunogênicos para tratamento de câncer adrenalInfo
- Publication number
- BR112022007203A2 BR112022007203A2 BR112022007203A BR112022007203A BR112022007203A2 BR 112022007203 A2 BR112022007203 A2 BR 112022007203A2 BR 112022007203 A BR112022007203 A BR 112022007203A BR 112022007203 A BR112022007203 A BR 112022007203A BR 112022007203 A2 BR112022007203 A2 BR 112022007203A2
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- adrenal cancer
- adrenal
- foxm1
- il13ra2
- Prior art date
Links
- 208000024447 adrenal gland neoplasm Diseases 0.000 title abstract 5
- 201000005188 adrenal gland cancer Diseases 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000002163 immunogen Effects 0.000 title abstract 2
- 102000007237 Forkhead Box Protein M1 Human genes 0.000 abstract 3
- 108010008599 Forkhead Box Protein M1 Proteins 0.000 abstract 3
- 101001003132 Homo sapiens Interleukin-13 receptor subunit alpha-2 Proteins 0.000 abstract 3
- 102100020793 Interleukin-13 receptor subunit alpha-2 Human genes 0.000 abstract 3
- 102000000763 Survivin Human genes 0.000 abstract 3
- 108010002687 Survivin Proteins 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 108010085418 Interleukin-13 Receptor alpha2 Subunit Proteins 0.000 abstract 1
- 102000007482 Interleukin-13 Receptor alpha2 Subunit Human genes 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001116—Receptors for cytokines
- A61K39/001119—Receptors for interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464416—Receptors for cytokines
- A61K39/464419—Receptors for interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
COMPOSTOS IMUNOGÊNICOS PARA TRATAMENTO DE CÂNCER ADRENAL. A presente invenção refere-se a imunoterapia baseada em antígeno direcionando o receptor alfa 2 de interleucina 13 (IL13RA2), BIRC5 e/ou FOXM1 para o tratamento de cânceres adrenais. Em particular, a presente invenção fornece o uso de um (poli)peptídeo compreendendo um epítopo de IL13RA2, BIRC5 e/ou FOXM1 ou uma variante de sequência dos mesmos para o tratamento de um câncer adrenal. Além disso, a presente invenção também fornece combinações do (poli)peptídeo compreendendo um epítopo de IL13RA2, BIRC5 e/ou FOXM1 ou uma variante de sequência dos mesmos com (poli)peptídeos compreendendo outros epítopos ou sequências variantes dos mesmos para tratamento de cânceres adrenais.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19306351 | 2019-10-16 | ||
| PCT/EP2020/079226 WO2021074389A1 (en) | 2019-10-16 | 2020-10-16 | Immunogenic compounds for treatment of adrenal cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022007203A2 true BR112022007203A2 (pt) | 2022-07-05 |
Family
ID=69055929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112022007203A BR112022007203A2 (pt) | 2019-10-16 | 2020-10-16 | Compostos imunogênicos para tratamento de câncer adrenal |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20230105457A1 (pt) |
| EP (1) | EP4045150A1 (pt) |
| BR (1) | BR112022007203A2 (pt) |
| MX (1) | MX2022004598A (pt) |
| WO (1) | WO2021074389A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3522915A2 (en) | 2016-10-07 | 2019-08-14 | Enterome S.A. | Immunogenic compounds for cancer therapy |
| CN117801069A (zh) | 2016-10-07 | 2024-04-02 | 恩特罗姆公司 | 用于癌症疗法的免疫原性化合物 |
| EP3522917A2 (en) | 2016-10-07 | 2019-08-14 | Enterome S.A. | Microbiota sequence variants of tumor-related antigenic epitopes |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3841091A1 (de) | 1988-12-07 | 1990-06-13 | Behringwerke Ag | Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung |
| EP0378881B1 (en) | 1989-01-17 | 1993-06-09 | ENIRICERCHE S.p.A. | Synthetic peptides and their use as universal carriers for the preparation of immunogenic conjugates suitable for the development of synthetic vaccines |
| IT1237764B (it) | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici. |
| IT1262896B (it) | 1992-03-06 | 1996-07-22 | Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini. | |
| GB9713156D0 (en) | 1997-06-20 | 1997-08-27 | Microbiological Res Authority | Vaccines |
| MY125387A (en) | 1999-03-19 | 2006-07-31 | Smithkline Beecham Biologicals S A | Vaccine |
| NO2119726T3 (pt) | 2008-05-14 | 2015-05-23 | ||
| EP2639299A1 (en) | 2012-03-16 | 2013-09-18 | Invectys | Universal cancer peptides derived from telomerase |
| US9428813B2 (en) * | 2012-03-26 | 2016-08-30 | The United States Of America, As Represented By The Secretary, Dept. Of Health & Human Services | DNA methylation analysis for the diagnosis, prognosis and treatment of adrenal neoplasms |
| US20190292601A1 (en) * | 2016-05-23 | 2019-09-26 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods of diagnosing cancer using cancer testis antigens |
| WO2019072871A2 (en) * | 2017-10-09 | 2019-04-18 | Enterome S.A. | MICROBIOTIC SEQUENCE VARIANTS OF ANTIGENIC EPITOPES ASSOCIATED WITH A TUMOR |
-
2020
- 2020-10-16 WO PCT/EP2020/079226 patent/WO2021074389A1/en unknown
- 2020-10-16 US US17/768,757 patent/US20230105457A1/en active Pending
- 2020-10-16 MX MX2022004598A patent/MX2022004598A/es unknown
- 2020-10-16 BR BR112022007203A patent/BR112022007203A2/pt unknown
- 2020-10-16 EP EP20793633.7A patent/EP4045150A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX2022004598A (es) | 2022-09-23 |
| WO2021074389A1 (en) | 2021-04-22 |
| US20230105457A1 (en) | 2023-04-06 |
| EP4045150A1 (en) | 2022-08-24 |
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