BR112022005226A2 - Carboxilatos bicíclicos como moduladores de tranportadores e usos dos mesmos - Google Patents
Carboxilatos bicíclicos como moduladores de tranportadores e usos dos mesmosInfo
- Publication number
- BR112022005226A2 BR112022005226A2 BR112022005226A BR112022005226A BR112022005226A2 BR 112022005226 A2 BR112022005226 A2 BR 112022005226A2 BR 112022005226 A BR112022005226 A BR 112022005226A BR 112022005226 A BR112022005226 A BR 112022005226A BR 112022005226 A2 BR112022005226 A2 BR 112022005226A2
- Authority
- BR
- Brazil
- Prior art keywords
- modulators
- bicyclic
- treatment
- carboxylates
- compounds
- Prior art date
Links
- -1 Bicyclic carboxylates Chemical class 0.000 title abstract 3
- 102000017298 Monocarboxylate transporters Human genes 0.000 abstract 2
- 108050005244 Monocarboxylate transporters Proteins 0.000 abstract 2
- 108010078791 Carrier Proteins Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000001613 neoplastic effect Effects 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000004962 physiological condition Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
carboxilatos bicíclicos como moduladores de tranportadores e usos dos mesmos. a presente invenção em geral se refere ao campo de moduladores de transportador, por exemplo, inibidores de transportador de monocarboxilato, e mais particularmente aos novos compostos de carboxilato enona bicíclicos, a síntese e uso destes compostos e suas composições farmacêuticas, por exemplo, no tratamento, modulação e/ou prevenção de condições fisiológicas associadas com a atividade de transportador de monocarboxilato tal como no tratamento de câncer e outros distúrbios neoplásticos, rejeição de transplante de tecido ou órgão.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962905606P | 2019-09-25 | 2019-09-25 | |
| PCT/US2020/052413 WO2021061929A1 (en) | 2019-09-25 | 2020-09-24 | Bicyclic carboxylates as modulators of transporters and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022005226A2 true BR112022005226A2 (pt) | 2022-06-14 |
Family
ID=75166130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112022005226A BR112022005226A2 (pt) | 2019-09-25 | 2020-09-24 | Carboxilatos bicíclicos como moduladores de tranportadores e usos dos mesmos |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20220281888A1 (pt) |
| EP (1) | EP4034112A4 (pt) |
| JP (1) | JP2022550314A (pt) |
| KR (1) | KR20220101078A (pt) |
| CN (1) | CN114615980A (pt) |
| AU (1) | AU2020356491A1 (pt) |
| BR (1) | BR112022005226A2 (pt) |
| CA (1) | CA3149987A1 (pt) |
| IL (1) | IL290990A (pt) |
| MX (1) | MX2022003611A (pt) |
| TW (1) | TW202126661A (pt) |
| WO (1) | WO2021061929A1 (pt) |
| ZA (1) | ZA202202619B (pt) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010089580A1 (en) * | 2009-02-06 | 2010-08-12 | Astrazeneca Ab | Use of a mct1 inhibitor in the treatment of cancers expressing mct1 over mct4 |
| WO2013109972A2 (en) * | 2012-01-20 | 2013-07-25 | Regents Of The University Of Minnesota | Therapeutic compounds |
| US20160115146A1 (en) * | 2013-06-07 | 2016-04-28 | Universite Catholique De Louvain | 3-carboxy substituted coumarin derivatives with a potential utility for the treatment of cancer diseases |
| WO2016081464A1 (en) * | 2014-11-17 | 2016-05-26 | Nirogyone Therapeutics, Inc. | Monocarboxylate transport modulators and uses thereof |
| CA2974697A1 (en) * | 2015-01-22 | 2016-07-28 | The Scripps Research Institute | Pyrimidine-2,4-(1h,3h)-dione derivatives and pharmaceutical compositions thereof and their use as inhibitors of monocarboxylate transporters |
| SG11202009586WA (en) * | 2018-03-30 | 2020-10-29 | Nirogy Therapeutics Inc | Bicyclic enone carboxylates as modulators of transporters and uses thereof |
-
2020
- 2020-09-24 KR KR1020227013269A patent/KR20220101078A/ko unknown
- 2020-09-24 EP EP20869741.7A patent/EP4034112A4/en not_active Withdrawn
- 2020-09-24 JP JP2022518941A patent/JP2022550314A/ja active Pending
- 2020-09-24 BR BR112022005226A patent/BR112022005226A2/pt not_active Application Discontinuation
- 2020-09-24 MX MX2022003611A patent/MX2022003611A/es unknown
- 2020-09-24 US US17/638,088 patent/US20220281888A1/en active Pending
- 2020-09-24 AU AU2020356491A patent/AU2020356491A1/en active Pending
- 2020-09-24 WO PCT/US2020/052413 patent/WO2021061929A1/en active Application Filing
- 2020-09-24 CA CA3149987A patent/CA3149987A1/en active Pending
- 2020-09-24 CN CN202080067502.XA patent/CN114615980A/zh active Pending
- 2020-09-25 TW TW109133360A patent/TW202126661A/zh unknown
-
2022
- 2022-02-28 IL IL290990A patent/IL290990A/en unknown
- 2022-03-03 ZA ZA2022/02619A patent/ZA202202619B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20220281888A1 (en) | 2022-09-08 |
| CA3149987A1 (en) | 2021-04-01 |
| AU2020356491A1 (en) | 2022-03-31 |
| ZA202202619B (en) | 2023-12-20 |
| KR20220101078A (ko) | 2022-07-19 |
| EP4034112A1 (en) | 2022-08-03 |
| JP2022550314A (ja) | 2022-12-01 |
| MX2022003611A (es) | 2022-04-20 |
| IL290990A (en) | 2022-05-01 |
| TW202126661A (zh) | 2021-07-16 |
| WO2021061929A1 (en) | 2021-04-01 |
| CN114615980A (zh) | 2022-06-10 |
| EP4034112A4 (en) | 2023-07-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |