BR112022001554A2 - Copolímero de polioxazolina, uso do copolímero, produto médico biocompatível e processo de preparação de copolímeros - Google Patents
Copolímero de polioxazolina, uso do copolímero, produto médico biocompatível e processo de preparação de copolímerosInfo
- Publication number
- BR112022001554A2 BR112022001554A2 BR112022001554A BR112022001554A BR112022001554A2 BR 112022001554 A2 BR112022001554 A2 BR 112022001554A2 BR 112022001554 A BR112022001554 A BR 112022001554A BR 112022001554 A BR112022001554 A BR 112022001554A BR 112022001554 A2 BR112022001554 A2 BR 112022001554A2
- Authority
- BR
- Brazil
- Prior art keywords
- copolymer
- pox
- polyoxazoline
- calcium
- present
- Prior art date
Links
- 229920001577 copolymer Polymers 0.000 title abstract 9
- 229920000765 poly(2-oxazolines) Polymers 0.000 title abstract 3
- 229940127554 medical product Drugs 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 210000000988 bone and bone Anatomy 0.000 abstract 3
- 239000000017 hydrogel Substances 0.000 abstract 3
- 125000003504 2-oxazolinyl group Chemical group O1C(=NCC1)* 0.000 abstract 2
- 239000011575 calcium Substances 0.000 abstract 2
- 229910052791 calcium Inorganic materials 0.000 abstract 2
- 229940122361 Bisphosphonate Drugs 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical group [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000004888 barrier function Effects 0.000 abstract 1
- 150000004663 bisphosphonates Chemical group 0.000 abstract 1
- 229910001424 calcium ion Inorganic materials 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- 239000003292 glue Substances 0.000 abstract 1
- 239000007943 implant Substances 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 239000002105 nanoparticle Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 230000002441 reversible effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/02—Polyamines
- C08G73/0233—Polyamines derived from (poly)oxazolines, (poly)oxazines or having pendant acyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Materials For Medical Uses (AREA)
- Biological Depolymerization Polymers (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Abstract
copolímero de polioxazolina, uso do copolímero, produto médico biocompatível e processo de preparação de copolímeros. a presente invenção refere-se a um copolímero de polioxazolina (pox) que compreende pelo menos 20 unidades de oxazolina, incluindo pelo menos quatro unidades de oxazolina não terminais que contêm um grupo de ligação de cálcio selecionado a partir de bisfosfonato, citrato, ácido etilenodiaminotetra-acético (edta) e suas combinações. os copolímeros de pox de acordo com a presente invenção exibem afinidade muito alta para íons de cálcio e são capazes de formar hidrogéis devido à retícula reversível com íons de ca2+. os copolímeros de pox oferecem a importante vantagem de serem bioabsorvíveis. a afinidade de cálcio, a biodegradabilidade e as características de hidrogel do copolímero de pox podem ser facilmente definidas, já que o pox pode ser facilmente derivado ao longo de toda a cadeia principal polimérica e não apenas nos grupos terminais. os copolímeros de pox de acordo com a presente invenção podem ser adequadamente aplicados em uma série de aplicações biomédicas, tais como membranas de barreira, emplastros, redes, fitas, dispositivos de fixação de ossos, implantes ósseos, hidrogéis (injetáveis), cola para fixação de ossos e nanopartículas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19189100 | 2019-07-30 | ||
| PCT/EP2020/071317 WO2021018922A1 (en) | 2019-07-30 | 2020-07-28 | Polyoxazoline copolymer comprising calcium binding groups |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022001554A2 true BR112022001554A2 (pt) | 2022-03-22 |
Family
ID=67513382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112022001554A BR112022001554A2 (pt) | 2019-07-30 | 2020-07-28 | Copolímero de polioxazolina, uso do copolímero, produto médico biocompatível e processo de preparação de copolímeros |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11999822B2 (pt) |
| EP (1) | EP4004085A1 (pt) |
| JP (1) | JP2022542504A (pt) |
| BR (1) | BR112022001554A2 (pt) |
| WO (1) | WO2021018922A1 (pt) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6436386B1 (en) * | 2000-11-14 | 2002-08-20 | Shearwater Corporation | Hydroxyapatite-targeting poly (ethylene glycol) and related polymers |
| US7829074B2 (en) | 2001-10-18 | 2010-11-09 | Nektar Therapeutics | Hydroxypatite-targeting poly(ethylene glycol) and related polymers |
| US20080182823A1 (en) * | 2007-01-26 | 2008-07-31 | Hidesmasa Katsumi | Polymer-linked-biophosphonate inhalant formulations and methods for using the same |
| WO2013103297A1 (en) * | 2012-01-02 | 2013-07-11 | Universiteit Gent | Polyoxazoline polymers and methods for their preparation, conjugates of these polymers and medical uses thereof |
| WO2014150513A2 (en) * | 2013-03-15 | 2014-09-25 | Basf Se | A polyoxazoline chelating agent |
-
2020
- 2020-07-28 EP EP20746974.3A patent/EP4004085A1/en active Pending
- 2020-07-28 JP JP2022502464A patent/JP2022542504A/ja active Pending
- 2020-07-28 BR BR112022001554A patent/BR112022001554A2/pt not_active Application Discontinuation
- 2020-07-28 WO PCT/EP2020/071317 patent/WO2021018922A1/en unknown
-
2022
- 2022-01-27 US US17/586,428 patent/US11999822B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN114206988A (zh) | 2022-03-18 |
| US11999822B2 (en) | 2024-06-04 |
| EP4004085A1 (en) | 2022-06-01 |
| WO2021018922A1 (en) | 2021-02-04 |
| JP2022542504A (ja) | 2022-10-04 |
| US20220153930A1 (en) | 2022-05-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |