BR112021025507A2 - Sistemas e métodos para fabricar um dispositivo de rede vascular de microcanal e para semear um microcanal - Google Patents

Sistemas e métodos para fabricar um dispositivo de rede vascular de microcanal e para semear um microcanal

Info

Publication number
BR112021025507A2
BR112021025507A2 BR112021025507A BR112021025507A BR112021025507A2 BR 112021025507 A2 BR112021025507 A2 BR 112021025507A2 BR 112021025507 A BR112021025507 A BR 112021025507A BR 112021025507 A BR112021025507 A BR 112021025507A BR 112021025507 A2 BR112021025507 A2 BR 112021025507A2
Authority
BR
Brazil
Prior art keywords
microchannel
vascular network
network
network device
seeding
Prior art date
Application number
BR112021025507A
Other languages
English (en)
Portuguese (pt)
Inventor
Paul Spann Andrew
Batzaya BYAMBAA
Carly Comer
Craig Neville
P Vacanti Joseph
James Hancock Matthew
Tatevik Sahakyants
Tyler Lieberthal
Original Assignee
3D Biolabs Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3D Biolabs Llc filed Critical 3D Biolabs Llc
Publication of BR112021025507A2 publication Critical patent/BR112021025507A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/30—Auxiliary operations or equipment
    • B29C64/386—Data acquisition or data processing for additive manufacturing
    • B29C64/393—Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y50/00—Data acquisition or data processing for additive manufacturing
    • B33Y50/02—Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/20—Material Coatings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/00—3D culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2529/00—Culture process characterised by the use of electromagnetic stimulation
    • C12N2529/10—Stimulation by light
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Materials Engineering (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Computer Hardware Design (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Mechanical Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Prostheses (AREA)
  • Micromachines (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
BR112021025507A 2019-06-18 2020-06-18 Sistemas e métodos para fabricar um dispositivo de rede vascular de microcanal e para semear um microcanal BR112021025507A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962863165P 2019-06-18 2019-06-18
US201962863169P 2019-06-18 2019-06-18
PCT/US2020/038560 WO2020257539A1 (en) 2019-06-18 2020-06-18 Systems and methods for fabricating a microchannel vascular network device and seeding a microchannel

Publications (1)

Publication Number Publication Date
BR112021025507A2 true BR112021025507A2 (pt) 2022-04-26

Family

ID=71575801

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021025507A BR112021025507A2 (pt) 2019-06-18 2020-06-18 Sistemas e métodos para fabricar um dispositivo de rede vascular de microcanal e para semear um microcanal

Country Status (10)

Country Link
US (2) US12351827B2 (https=)
EP (1) EP3987003A1 (https=)
JP (1) JP2022536892A (https=)
KR (1) KR20220024635A (https=)
CN (1) CN114222819B (https=)
AU (1) AU2020294779B2 (https=)
BR (1) BR112021025507A2 (https=)
CA (1) CA3142179A1 (https=)
SG (1) SG11202113099QA (https=)
WO (1) WO2020257539A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119072541A (zh) 2022-04-22 2024-12-03 3D生物实验室公司 用于组织装置的液密箱以及具有所述组织装置的系统
WO2024073071A1 (en) * 2022-09-29 2024-04-04 The University Of Akron Chamber assembly for ex-vivo electroretinogram with filleted perfusion inlet and outlet
WO2026050767A2 (en) 2024-08-30 2026-03-05 3D Biolabs, Llc Systems and methods for fabricating hydrogels with intrinsic vascular channels for liver tissue engineering

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6176874B1 (en) 1993-10-18 2001-01-23 Masschusetts Institute Of Technology Vascularized tissue regeneration matrices formed by solid free form fabrication techniques
US7759113B2 (en) * 1999-04-30 2010-07-20 The General Hospital Corporation Fabrication of tissue lamina using microfabricated two-dimensional molds
US6772026B2 (en) * 2000-04-05 2004-08-03 Therics, Inc. System and method for rapidly customizing design, manufacture and/or selection of biomedical devices
ES2859575T3 (es) * 2007-04-12 2021-10-04 Massachusetts Gen Hospital Red vascular biomimética
WO2009042671A1 (en) * 2007-09-24 2009-04-02 The Board Of Trustees Of The University Of Illinois Three-dimensional microfabricated bioreactors with embedded capillary network
ES2672201T3 (es) 2008-07-16 2018-06-13 Children's Medical Center Corporation Dispositivo de imitación de órganos con microcanales y métodos de uso
CA2966623C (en) 2014-11-03 2024-02-20 The General Hospital Corporation Concentrating particles in a microfluidic device
KR101709312B1 (ko) 2015-03-11 2017-02-23 서강대학교산학협력단 하이드로젤 기반의 세포 공동-배양용 미세유체칩
WO2016154070A1 (en) 2015-03-20 2016-09-29 William Marsh Rice University Hypothermic 3d bioprinting of living tissues supported by perfusable vasculature
KR102530274B1 (ko) * 2015-07-06 2023-05-08 어드밴스드 솔루션즈 라이프 사이언스, 엘엘씨 혈관화된 시험관 관류 장치, 제조 방법 및 그 응용 방법
EP3359642A4 (en) 2015-10-06 2019-05-08 University of Pittsburgh- Of the Commonwealth System of Higher Education MICROFLUIDIC TISSUE DEVELOPMENT SYSTEMS
US11326138B2 (en) 2017-05-01 2022-05-10 University Of Kentucky Research Foundation Cell culture device and methods of use thereof

Also Published As

Publication number Publication date
KR20220024635A (ko) 2022-03-03
SG11202113099QA (en) 2021-12-30
AU2020294779B2 (en) 2026-02-19
JP2022536892A (ja) 2022-08-22
EP3987003A1 (en) 2022-04-27
US12351827B2 (en) 2025-07-08
WO2020257539A1 (en) 2020-12-24
CA3142179A1 (en) 2020-12-24
CN114222819B (zh) 2025-02-25
AU2020294779A1 (en) 2021-12-23
US20260009004A1 (en) 2026-01-08
US20210071145A1 (en) 2021-03-11
CN114222819A (zh) 2022-03-22

Similar Documents

Publication Publication Date Title
BR112021025507A2 (pt) Sistemas e métodos para fabricar um dispositivo de rede vascular de microcanal e para semear um microcanal
AR108457A1 (es) Longitud adaptativa de intervalo temporal de transmisión
BR112022014956A2 (pt) Segmentação de elementos de superfície e agrupamento de nós para dispositivos refletores inteligentes
MX2022015927A (es) Tarjeta de transacción con componentes electrónicos incorporados y procedimiento para su fabricación.
EP4362531A3 (en) Backhaul link connection information
EP4243301A3 (en) Base station controlled beam management
AR111353A1 (es) Transmisión de primeros datos de mensaje 3 (msg3) por una asignación dual
TW200802759A (en) Methods of forming a diamond micro-channel structure and resulting devices
EP3996421A3 (en) Connection failure reporting
AR109761A1 (es) Determinación de desplazamiento del esquema de modulación y codificación de información de control en la información de control de enlace ascendente por el canal físico compartido de enlace ascendente con intervalo de tiempo abreviado
AR056596A1 (es) Canal de senalizacion de eliminacion selectiva para un sistema de comunicacion inalambrico
BR112018002078A2 (pt) métodos e aparelho para protocolo de acesso de mídia de múltiplos canais
BR112019023297A2 (pt) Sinalização de quase colocalização de sub-banda cruzada
MX2018009813A (es) Coexistencia mejorada de sesiones tolerantes al retardo y sensibles al retardo.
BR112012016878A2 (pt) método e nós para programar recursos rádio em um sistema de comunicação sem fio empregando designação aprimorada de intervalo de tempo (efta).
BRPI0511585A (pt) rede de sensor sem fio
WO2007084147A3 (en) System for situational awareness
MX2022004154A (es) Dispositivo de visualizacion que incluye un soporte de modulo y metodo de fabricacion del soporte de modulo.
BRPI0414387A (pt) método de trocar mensagens entre uma primeira estação móvel e uma segunda estação móvel em um sistema que inclui uma rede sem fio e um usuário de roteamento acoplado a respectiva rede sem fio
MX2020002475A (es) Metodo de transmision de informacion y producto relacionado.
MX2010009986A (es) Transmisor en sistema de comunicación inalambrica con estructura piloto jerarquica.
MX2023001857A (es) Método de acceso a canal y aparato de comunicación.
UA91506C2 (ru) Распределенное резервирование ресурсов в беспроводной сети произвольной структуры
DE602007009039D1 (de) Anfängliche Verbindungsherstellung in einem drahtlosen Kommunikationssystem
MXPA04003872A (es) Metodo y sistema para transferencia permanente en un sistema de comunicacion de difusion.

Legal Events

Date Code Title Description
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]