BR112020020959A2 - USE OF PHENYLAMIDINE 4-SUBSTITUTED COMPOUNDS TO CONTROL RUST DISEASES IN VEGETABLES - Google Patents

Abstract

use of 4-substituted phenylamidine compounds to control rust diseases in vegetables. the present invention discloses the use of 4-substituted phenylamidine of the compounds of the formula (i), la-r7-r4-n-r2-n-r3-r1-r6-r5 formula (i) to control or prevent unwanted phytopathogenic fungi, particularly, by the pathogens of rust diseases in agricultural and / or horticultural crops, where, r1 to r7, a and l have the meanings defined in the description. the present invention has also disclosed a method to control or prevent unwanted phytopathogenic fungi, in particular, by pathogens of rust diseases in agricultural and / or horticultural crops, using 4-substituted phenylamidine compounds of formula (i).

Description

“USE OF PHENYLAMIDINE 4-SUBSTITUTED COMPOUNDS TO CONTROL RUST DISEASES IN VEGETABLES”

FIELD OF THE INVENTION

[0001] The present invention relates to the use of a 4-substituted phenylamidine compound of Formula (I) to control or prevent phytopathogenic fungi in agricultural and / or horticultural crops. More particularly, the present invention relates to a method for controlling or preventing diseases caused by phytopathogenic fungi, in particular rust pathogens, in agricultural and / or horticultural crops, using a 4-substituted phenylamidine compound of Formula (I).

BACKGROUND OF THE INVENTION

[0002] The control of crop damage caused by phytopathogenic microorganisms is extremely important to achieve high efficiency in crops. For example, damage caused by diseases in ornamental plants, vegetables, fields, cereals and fruits can cause a significant reduction in productivity and thus result in increased costs for the consumer. There are many commercially available products to control this damage. There remains a need for new compounds that are more effective, less expensive, less toxic, environmentally safer and / or have different modes of action. Certain phenylamidine derivatives are disclosed in published material as microbicidically active ingredients in pesticides.

[0003] For example, the documents, WO2000046184, WO2003093224, WO2007031526, WO2008110314, WO2014119617,

WO2015025962, WO2015121802, WO2017067839, WO2017067837 WO2017102635, WO2018091430, WO2018108998 disclose the use of phenylamidine derivatives as fungicides, either alone or as part of a composition.

[0004] In addition, rust diseases are a serious concern in plants, in particular soybean plants, caused by pathogenic basidiomycete fungi Phakopsora pachyrhizi and Phakopsora meibomiae for plants. Countless published materials demonstrate a moderate increase in yield with the application of fungicides. However, there is a need for a treatment method that demonstrates better yields, along with preventive treatment and / or curative capabilities, in the treatment of soy oxidation. The fungicidal activity of known fungicidal compounds, especially against rust pathogens, in particular soybean rust, is not satisfactory.

[0005] The effectiveness of the phenylamine derivatives described in the prior art is good, but often leaves something to be desired. Therefore, it is always of great interest in agriculture to use new pesticide compounds to prevent and / or control the development of microorganisms, such as fungal or bacterial pathogens or pests resistant to known active ingredients. Therefore, it is of great interest to use new compounds that are more active than those already known, in order to decrease the amounts of active compound to be used, while maintaining an efficiency at least equivalent to the already known compounds.

[0006] Now we have found a new family of compounds that have the effects or advantages mentioned above. A new family of compounds, namely, derivatives of phenylamidine, in which the phenyl ring is replaced according to the invention, thus allowing an unexpected and significantly superior activity against unwanted microorganisms, such as fungi or pathogenic bacteria or pests.

SUMMARY OF THE INVENTION

[0007] The present invention relates to the use of a 4-substituted phenylamidine compound of Formula (I), Formula (I) in which the definition of the substituents is defined in the detailed description.

[0008] In one embodiment, the present invention provides a method to control or prevent infestation of useful plants by phytopathogenic fungi, in particular, by pathogens of rust diseases, in agricultural and / or horticultural crops, using a compound of Formula ( I).

[0009] In another embodiment, the present invention provides a method for controlling or preventing phytopathogenic fungi, in particular, by pathogens of rust diseases, in agricultural and / or horticultural crops using a compound of Formula (I), which comprises a Step of applying effective dosages of a compound of Formula (I) in quantities ranging from 1 g to 5 kg per hectare of agricultural and / or horticultural crops.

DETAILED DESCRIPTION OF THE INVENTION

[0010] The term "alkyl", used alone or in compound words such as "alkylthio" or "haloalkyl", includes straight or branched chain alkyl, such as methyl, ethyl, n-propyl, i-propyl, or the different butyl, pentyl or hexyl isomers.

[0011] The term "alkenyl" includes straight or branched chain alkenes, such as ethenyl, 1-propenyl, 2-propenyl, and the different isomers of butenyl, pentenyl and hexenyl. "Alkenyl" also includes polyenes, such as 1,2-propadienyl and 2,4-hexadienyl.

[0012] The term "alkynyl" includes straight or branched chain alkynes such as ethynyl, 1-propynyl, 2-propynyl and the different isomers of butynyl, pentynyl and hexynyl. "Alquinyl" can also include fractions consisting of multiple triple bonds, such as 2,5-hexadynyl.

[0013] The term "cyclic alkyl" or "cycloalkyl" includes, for example, cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl. Cyclic alkenyl includes, for example, cyclopropenyl, cyclobutenyl, cyclopentenyl and cyclohexenyl. Cyclic alkynyl refers similarly to pentynyl, hexynyl, heptinyl and cyclic octinyl.

[0014] The term "aryl", as used here, is a group containing a carbon based aromatic group, including, but not limited to, phenyl, naphthalene, biphenyl, anthracene and the like. The aryl group can be substituted or unsubstituted. In addition, the aryl group can be a single ring structure or comprise multiple ring structures that are ring structures fused or linked by means of one or more bridge groups, such as a carbon-carbon bond.

carbon.

[0015] The term "hetero", in connection with the rings, refers to a ring in which at least one atom of the ring is not carbon and which may contain from 1 to 4 heteroatoms selected regardless of the group consisting of nitrogen, oxygen and sulfur, provided that each ring contains no more than 4 nitrogens, no more than 2 oxygen and no more than 2 sulfur.

[0016] The term "heterocyclyl" means a cyclic ring system in which at least one atom of the ring is not carbon and which may contain heteroatoms selected independently from the group comprising nitrogen, oxygen, sulfur, phosphorus, boron, etc. and one or more carbon atoms are optionally substituted by C (= O), C (= S), S (O) m and SiR′2.

[0017] The term "heterocyclyl" can further be classified as "non-aromatic heterocycle" and "heterocycle or aromatic heteroaryl".

[0018] The term "non-aromatic heterocycle" includes a monocyclic or polycyclic heterocycle, fused or unfused, of three to fifteen members, preferably three to twelve members, saturated or totally or partially unsaturated (spiro, fused, bridged , not fused), in which the heteroatom is selected from the group of oxygen, nitrogen and sulfur; and if the ring contains more than one oxygen atom, they are not directly adjacent;

[0019] Examples of non-aromatic heterocycle include, but are not limited to, oxetanil, oxiranil, aziridinyl, thiiranil, azetidinyl, thiethanil, dithiethanil, diazetidinyl, 2-tetrahydrofuranyl, 3-tetrahydrofuranil, 2-

tetrahydrothienil, 3-tetrahydrothienil, 2-pyrrolidinyl, 3-pyrrolidinyl, 3-isoxazolidinyl, 4-isoxazolidinyl, 5-isoxazolidinyl, 3-isothiazolidinyl, 4-isothiazolidinyl, 2-tetrahydropyranyl, 4-tetrahidrir This definition also applies to heterocyclyl as part of a compound substituent, for example, heterocyclylalkyl (heterocyclic radicals including an alkyl moiety as defined above), etc., unless specifically defined elsewhere.

[0020] The term "heteroaryl", as used here, is a group containing a system of monocyclic or polycyclic unsaturated rings, fused or not, of three to fifteen members, preferably three to twelve members, more preferably five or 6 members, containing heteroatoms selected from the group of oxygen, nitrogen, sulfur, phosphorus, boron, etc .; one or more carbon atoms are optionally substituted by C (= O), C (= S), S (O) m and SiR′2.

Examples of 5-membered heteroaryl groups include, but are not limited to, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-pyrrolyl, 3-pyrrolyl, 3-isoxazolyl, 4-isoxazolyl, 5- isoxazolyl, 3-isothiazolyl, 4-isothiazolyl, 5-isothiazolyl, 3-pyrazolyl, 4-pyrazolyl, 5-pyrazolyl, 2-oxazolyl, 4-oxazolyl, 5-oxazolyl, 2-thiazolyl, 4-thiazolyl, 5-thiazolyl, 5-thiazolyl, 5 2-imidazolyl, 4-imidazolyl, 1,2,4-oxadiazol-3-yl, 1,2,4-oxadiazol-5-yl, 1,2,4-thiadiazol-3-yl, 1,2,4- thiadiazol-5-yl, 1,2,4-triazol-3-yl, 1,3,4-oxadiazol-2-yl, 1,3,4-thiadiazol-2-yl, 1,3,4-triazole- 2-yl, 1-pyrrolyl, 1-pyrazolyl, 1,2,4-triazol-1-yl, 1-imidazolyl, 1,2,3-triazol-1-yl, 1,3,4-triazole-1- useful and the like.

[0022] Examples of 6-membered heteroaryl groups include, but are not limited to, 2-pyridinyl, 3-pyridinyl, 4-pyridinyl, 3-pyridazinyl, 4-pyridazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 2- pyrazinyl, 1,2,5-triazin-2-yl, 1,2,4-triazin-3-yl, 1,2,4,5-tetrazin-3-yl and the like.

Examples of 5-membered benzofused heteroaryl include, but are not limited to, indol-1-yl, indol-2-yl, indol-3-yl, indol-4-yl, indol-5-yl, indol-6- useful, indol-7-yl, benzimidazol-1-yl, benzimidazol-2-yl, benzimidazol-4-yl, benzimidazol-5-yl, indazol-1-yl, indazol-3-yl, indazol-4-yl, indazol-5-yl, indazol-6-yl, indazol-7-yl, indazol-2-yl, 1-benzofuran-2-yl, 1-benzofuran-3-yl, 1-benzofuran-4-yl, l- benzofuran-5-yl, 1-benzofuran-6-yl, l-benzofuran-7-yl, l-benzothiophene-2-yl, l-benzothiophene-3-yl, l-benzothiophene-4-yl, 1-benzothiophene- 5-yl, 1-benzothiophene-6-yl, 1-benzothiophene-7-yl, 1,3-benzothiazol-2-yl, 1,3-benzothiazol-4-yl, 1,3-benzothiazol-5-yl, 1,3-benzothiazol-6-yl, 1,3-benzothiazol-7-yl, 1,3-benzoxazol-2-yl, 1,3-benzoxazol-4-yl, 1,3-benzoxazol-5-yl, 1,3-benzoxazol-6-yl, 1,3-benzoxazol-7-yl and the like.

[0024] Examples of 6-membered benzofused heteroaryl include, but are not limited to, quinolin-2-yl, quinolin-3-yl, quinolin-4-yl, quinolin-5-yl, quinolin-6-yl, quinolin-7- yl, quinolin-8-yl, isoquinolin-1-yl, isoquinolin-3-yl, isoquinolin-4-yl, isoquinolin-5-yl, isoquinolin-6-yl, isoquinolin-7-yl, isoquinolin-8-yl and similar.

[0025] The term "aralkyl" refers to aryl hydrocarbon radicals that include an alkyl moiety as defined above. Examples include benzyl, phenylethyl and 6-naphthylhexyl. As used here, the term "aralkenyl"

refers to aryl hydrocarbon radicals that include an alkenyl moiety, as defined above, and an aryl moiety, as defined above. Examples include styryl, 3- (benzyl) prop-2-enyl and 6-naphthylhex-2-enyl.

[0026] The term "alkoxy" includes, for example, methoxy, ethoxy, n-propyloxy, isopropyloxy and the different isomers butoxy, pentoxy and hexyloxy.

The term "Alkylthio" includes branched or straight chain alkylthio moieties, such as methylthio, ethylthio and the different propylthio, butylthio, pentylthio and hexylthio isomers.

[0028] The term "halogen", used alone or in compound words, such as "haloalkyl", includes fluorine, chlorine, bromine or iodine. In addition, when used in compound words like "haloalkyl", said alkyl can be partially or completely replaced with halogen atoms that can be the same or different. Examples of "haloalkyl" include chloromethyl, bromomethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chlorofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl, 1-chloroethyl, 1-bromoethyl, 2-fluoroethyl, 2-fluoroethyl, 2-fluoroethyl, 2-fluoroethyl, 2-fluoroethyl, 2-fluoroethyl, 2-fluoroethyl, 2-fluoroethyl , 2,2-trifluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro-2,2-difluoroethyl, 2,2-dichloro-2-fluoroethyl, 2,2,2-trichloroethyl, pentafluoroethyl, 1,1-dichloro -2,2,2-trifluoroethyl, and 1,1,1-trifluoroprop-2-yl. This definition also applies to haloalkyl as part of a compound substituent, for example, haloalkylaminoalkyl, etc., unless specifically defined elsewhere.

[0029] The terms "haloalkenyl", "haloalkynyl" are defined in an analogous manner, except that, instead of alkyl groups, alkenyl and alkynyl groups are present as a part of the substituent.

[0030] The total number of carbon atoms in a substituent group is indicated by the prefix "Ci-Cj", where i and j are numbers from 1 to 21. For example, C1-C3 alkoxy designates methoxy by means of propoxy. In the previous descriptions, when a compound of Formula (I) consists of one or more heterocyclic rings, all substituents are attached to those rings through any carbon or nitrogen available by substituting a hydrogen in said carbon or nitrogen.

[0031] When a compound is replaced by a substituent with a subscript indicating that the number of said substituents may exceed 1, said substituents (when they exceed 1) are independently selected from the group of defined substituents. In addition, when the subscript indicates a range, for example, (R) i-j, then the number of substituents can be selected from the integers between i and j, inclusive.

[0032] When a group contains a substituent that may be hydrogen, for example, R1 or R2, then, when this substituent is taken as hydrogen, it is recognized that this is equivalent to said unsubstituted group.

[0033] In view of the above, the present invention describes the use of a 4-substituted phenylamidine compound of Formula (I)

Formula (I) where, R1 is selected from the group consisting of hydrogen, CN, SR ″, S (O) nR ″, OR ″, C1-C12-alkyl, C1-C12-alkoxy, C1-C12- alkylthio, C2-C12-alkenyl, C2-C12-alkynyl, C1-C12-haloalkyl, C2-C12-haloalkenyl, C1-C12-haloalkoxy, C1-C12-haloalkylthio, C3-C8-cycloalkyl, C4-C8-cycloalkenyl C5-C8-cycloalkynyl; wherein one or more carbon atoms in the cyclic ring system can be replaced by hetero atoms selected from the group consisting of N, O, and S (O) n; R2 and R3 are independently selected from the group consisting of hydrogen, CN, S (O) nR ″, OR ′, (C = O) -R ″, C1-C12-alkyl, C2-C12-alkenyl, C2- C12-alkynyl, C1-C12-haloalkyl, C2-C12-haloalkenyl, C2-C12-haloalkynyl, C3-C8-cycloalkyl, C4-C8-cycloalkenyl, C5- C8-cycloalkynyl, C6-C18-aryl and C7-C19- aralkyl; wherein one or more carbon atoms in the cyclic ring system can be replaced by hetero atoms selected from the group consisting of N, O, and S (O) n; or R1 and R2, R2 and R3 or R1 and R3 together with the atoms to which they are attached, or together with other atoms selected from the group consisting of C, N, O, S and which optionally include from 1 to 3 members of the ring selected from the group consisting of C (= O),

C (= S), S (O) m and SiR′2 can form a four to seven-membered ring, which in turn can be replaced by one or more groups selected from the group consisting of X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN and CONR′2; each group of R1, R2, and R3 can optionally be substituted by one or more groups selected from the group consisting of X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN and CONR′2; R4, R5, R6 and R7 are independently selected from the group consisting of hydrogen, X, CN, SCN, SF5, S (O) nR ″, SiR′3, OR ″, NR′R ″, (C = O ) -R ″, CR′═NR ″, C1- C12-alkyl, C2-C12-alkenyl, C2-C12-alkynyl, C1-C12-haloalkyl, C2-C12-haloalkenyl, C2-C12-haloalkynyl, C1- C12 -haloalkoxy, C1-C12-haloalkylthio, C3-C8-cycloalkyl, C4-C8-cycloalkenyl, C5-C8-cycloalkynyl, C3-C8-cycloalkyloxy, C3-C8-cycloalkylthio, C6-C18-aryl and C7- C19-aral ; wherein one or more carbon atoms in the cyclic ring system can be replaced by hetero atoms selected from the group consisting of N, O, and S (O) n; and all the groups mentioned above can optionally be replaced by one or more groups selected from the group consisting of X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN and CONR′2 ; or R4 and R7 or R5 and R6 together with the atom to which they are attached or together with other atoms selected from the group consisting of C, N, O, S and which optionally include from 1 to 3 ring members selected from of the group consisting of C (= O), C (= S), S (O) me

SiR′2 can form a four to seven-membered ring, which in turn can be replaced by one or more groups selected from the group consisting of X, R ′, OR ′, SR ′, NR′2, SiR ′ 3, COOR ′, CN and CONR ′; each group of R4, R5, R6 and R7 can optionally be replaced by one or more groups selected from the group consisting of X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN and CONR′2; L represents CR8R9 or NR10; R8 and R9 are independently selected from the group consisting of hydrogen, X, CN, SCN, S (O) nR ″, OS (O) nR ″, SiR′3, OSiR′3, NR′R ″, NR ′ S (O) nR ″, (C = O) -R ″, CR ′ = NR ″, C1-C12-alkyl, C2-C12-alkenyl, C2-C12-alkynyl, C1-C12-alkoxy, C2-C12- alkenyloxy, C2-C12-alkynyloxy, C1-C12-haloalkyl, C2-C12-haloalkenyl, C2-C12-haloalkynyl, C1-C12-haloalkoxy, C1-C12-haloalkylthio, C3-C8-cycloalkyl, C4-C8-cycle C5-C8-cycloalkynyl, C3-C8-cycloalkyloxy, C3-C8-cycloalkylthio, C6-C18-aryl and C7-C19-aralkyl; wherein one or more carbon atoms in the cyclic ring system can be replaced by hetero atoms selected from the group consisting of N, O, or S (O) n; and all the groups mentioned above can optionally be replaced by one or more groups selected from the group consisting of X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN and CONR′2 ; or R8 and R9 together with the atom to which they are attached or together with other atoms selected from the group consisting of C, N, O, S and which optionally include from 1 to 3 ring members selected from the group consisting of in C (= O), C (= S), S (O) m and SiR′2 can form a three to seven membered ring, which in turn can be replaced by one or more groups selected from the group consisting of in X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN and CONR′2; or R8 and R9 together with the atom to which they are attached can form a group of = C (R′R ′ ″), = S, = NR ′ ″; R10 is selected from the group consisting of hydrogen, CN, SCN, S (O) nR ″, SiR′3, NR′R ″, (C = O) -R ″, CR ′ = NR ″, C1-C12 -alkyl, C2-C12-alkenyl, C2-C12-alkynyl, C1-C12-haloalkyl, C2-C12-haloalkenyl, C2-C12-haloalkynyl, C3-C8-cycloalkyl, C4-C8-cycloalkenyl, C5- C8-cycloalkynyl , C6-C18-aryl and C7-C19-aralkyl; wherein one or more carbon atoms in the cyclic ring system can be replaced by hetero atoms selected from the group consisting of N, O, and S (O) n; and all the groups mentioned above can be replaced by one or more groups selected from the group consisting of X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN and CONR′2; A is selected from the group consisting of fused or non-fused C6-C18-aryl and C5-C18-heteroaryl; wherein one or more heteroatoms selected from N, O, S and one or more carbon atoms are optionally substituted by C (= O), C (= S), S (O) m and SiR′2; and which is optionally substituted by one or more groups of R11; R11 is selected from the group consisting of hydrogen, X, CN, SCN, SF5, R ″, OR ′ ′, NO2, NR′′2, SiR′3, (C = O) -R ″, S (O ) nR ″, OS (O) nR ″, NR′S (O) nR ″, OSiR′3, C1-C8-alkyl-S (O) nR ″, C1-C8-alkyl- (C = O) -R ″, CR ′ = NR ″,

S (O) nC6-C18-aryl, S (O) nC7-C19-aralkyl, S (O) nC7-C19-alkaryl, C1-C12-alkyl, C2-C12-alkenyl, C2-C12-alkynyl, C1- C12-haloalkyl, C2-C12-haloalkenyl, C2-C12-haloalkyl, C1-C12-alkoxy, C1-C12-alkylthio, C1-C12-holoalkoxy, C1-C12-haloalkylthio, C3-12-cycloalkyl, C4- C8- cycloalkenyl, C5-C8-cycloalkyl, C3-C8-cycloalkyloxy, C3-C8-cycloalkylthio, C7-C19-aralkyl, C5-C12-bicyclic alkyl and C7-C12-bicyclic alkenyl; wherein one or more carbon atoms in the cyclic ring system can be replaced by hetero atoms selected from the group consisting of N, O, and S (O) n; and all the groups mentioned above can be replaced by one or more groups selected from the group consisting of X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN and CONR′2; each group of R8, R9 and R10 can be optionally substituted by one or more groups selected from the group consisting of X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN and CONR 'two; X represents halogen; R ′ is selected from the group consisting of hydrogen, straight or branched chain C1-C12-alkyl and C3-10-cyclic alkyl; where each group of R ′ is optionally substituted by one or more X; R ″ is selected from the group consisting of hydrogen, NR′2, OR ′, straight or branched C1-C12-alkyl, C1-C12-haloalkyl, C3-C8-cyclic alkyl; where each group of R ″ is optionally substituted by one or more groups selected from the group consisting of X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN and

CONR′2; and C6-C18-aryl which is optionally substituted by one or more R ′; R ′ ″ is selected from the group consisting of hydrogen, R ″, CN, OR ′, (C = O) -R ′, COOR ′, CONR′2, C1- C12-straight or branched chain alkyl, C2 -C12- alkenyl, C2-C12-alkynyl, C3-C8-cyclic alkyl, C4-C8-cyclic alkenyl, C5-C8-cyclic alkynyl, C6-C18-aryl and C7-C19-aralkyl; wherein one or more carbon atoms in the cyclic ring system can be replaced by hetero atoms selected from the group consisting of N, O, or S (O) n; and all the groups mentioned above can be replaced by one or more groups selected from the group consisting of X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN and CONR′2; or R ′ and R ′ ″ together with the atom to which they are attached or together with other atoms selected from the group consisting of C, N, O, S and which optionally include from 1 to 3 ring members selected from the group consisting of C (= O), C (= S), S (O) m and SiR′2 can form a ring of three to six members, which in turn can be replaced by one or more X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN, or CONR′2; m and n represent integers, where n = 0, 1 or 2; and m = 1 or 2; and its salts, structural isomers / isomers, stereoisomers, diastereoisomers, enantiomers, tautomers or agronomically acceptable N-oxides.

[0034] According to one embodiment, R1 is selected from hydrogen, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-

alkylthio, C1-C6-haloalkyl or C3-C8-cycloalkyl.

[0035] According to a preferred embodiment, R1 is selected from hydrogen, C1-C6-alkyl or C3-C5-cycloalkyl.

[0036] According to one embodiment, R2 and R3 are independently selected from C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-alkoxy, C1-C6-alkylthio, C1- C6-haloalkyl or C3-C8-cycloalkyl.

[0037] According to another embodiment, R1 and R2, R2 and R3 or R1 and R3 together with the atoms to which they are attached, or together with other atoms selected from the group consisting of C, N, O, S and which optionally include from 1 to 3 ring members selected from the group consisting of C (= O), C (= S), S (O) m and SiR′2 can form a four to seven member non-aromatic ring, which in turn can be replaced by one or more X, R ′, OR ′, SR ′ and CN.

[0038] According to a preferred embodiment, R1 and R2, R2 and R3 or R1 and R3 together with the atoms to which they are attached form a cyclic ring system selected from azetidine, pyrrolidine, imidazolidine, oxazolidine, piperidine, morpholine , thiomorpholine, piperazine, 1-methylpiperazine, 1-methylpyrrolidine, 1-methylpiperidine or 3-methyl-1,3-thiazinane.

[0039] According to one embodiment, R4 and R5 are independently selected from X, CN, S (O) nR ″, NR′R ″, (C = O) -R ″, CR ′ = NR ″, C1 -C6-alkyl, C2-C6-alkenyl, C1- C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkylthio, C3-C8-cycloalkyl or C3-C8-cycloalkylthio.

[0040] According to one embodiment, R6 and R7 are independently selected from hydrogen, X,

CN, S (O) nR ″, NR′R ″, (C = O) -R ″, CR ′ = NR ″, C1-C6-alkyl, C2-C6-alkenyl, C1-C6-haloalkyl, C1-C6 -alkoxy, C1-C6-haloalkylthio, C3-C8-cycloalkyl or C3-C8-cycloalkylthio.

[0041] According to another embodiment, R4 and R7 or R5 and R6 together with the atom to which they are attached or together with other atoms selected from the group consisting of C, N, O, S and which optionally include from 1 up to 3 ring members selected from the group consisting of C (= O), C (= S), S (O) m and SiR′2 can form a four to seven member ring, which in turn can be replaced one or more X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN, or CONR′2; and where each group of R4, R5, R6 and R7 can be optionally substituted by one or more groups selected from the group consisting of X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN, or CONR′2.

[0042] According to one embodiment, R8 and R9 are independently selected from hydrogen, X, CN, S (O) nR ″, NR′R ″, (C = O) -R ″, CR ′ = NR ″ , C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-4-alkylthio, C1- C6-haloalkylthio, C3-C8-cycloalkyl, C3-C8-cycloalkoxy or C3 - C8-cycloalkylthio.

[0043] According to another embodiment, R8 and R9 together with the atom to which they are attached or together with other atoms selected from the group consisting of C, N, O, S can form a ring of three to six members, which in turn can be replaced by one or more X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN, or CONR′2.

[0044] According to one embodiment, R10 is selected from hydrogen X, CN, SCN, SF5, R ″, NO2, NR′′2, SiR′3, (C = O) -R ″, S (O ) nR ″, C1-C8-alkyl-S (O) nR ″, C1-C6-alkyl- (C = O) -

R ″, CR ′ = NR ″, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-haloalkyl, C2-C6-haloalkenyl, C1-C12-alkoxy, C1-C12-alkylthio, C1-C12-holoalkoxy , C1-C12-haloalkylthio, C3-C8-cycloalkyl, C4-C8-cycloalkenyl, C3-C8-cycloalkyloxy or C3-C8-cycloalkylthio.

[0045] In another embodiment, two R11s together with the atom to which they are attached or together with other atoms selected from the group consisting of C, N, O, S and which optionally include from 1 to 3 ring members selected from from the group consisting of C (= O), C (= S), S (O) m and SiR′2 can form a four to ten membered ring, which in turn can be replaced by one or more X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN, or CONR′2.

[0046] In one embodiment, A is selected from phenyl, naphthalenyl, furyl, thienyl, pyrrolyl, isoxazolyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrazolyl, oxazolyl, imidazolyl, oxadiazolyl, triazolyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, indolyl, benzimidazolyl, indazolyl, benzofuranyl, benzothiophenol, benzothiazolyl, benzoxazolyl, quinolinyl, isoquinolinyl, quinazolinyl or cinnolinyl; wherein each ring system is optionally replaced by one or more R10.

[0047] In a preferred embodiment, A is selected from phenyl, naphthalenyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyridinyl, pyridazinyl, pyrimidinyl or pyrazinyl; wherein each ring system is optionally replaced by one or more R10.

[0048] Another realization provides the use of the compound of Formula (I) and its compositions, to control or prevent phytopathogenic fungi, in particular, by the pathogens of rust diseases, in agricultural and / or horticultural crops.

[0049] A preferred embodiment provides the use of compounds of Formula (I), and their compositions, to control plant diseases: the species Puccinia (rust) in various plants, selected, among others, from P. triticina ( brown or leaf rust), P. striiformis (yellow or stripe rust), Puccinia melanocephala (sugar cane rust), P. hordei (dwarf rust), P. graminis (black or stem rust) or P. recondita (brown or leaf rust) in cereals selected from wheat, barley or rye, and the species Phakopsoraceae in various plants, particularly Phakopsora pachyrhizi and P. meibomiae (soybean rust) in soybeans.

[0050] Another preferred embodiment provides the use of the compound of Formula (I), and its compositions, to control and / or prevent phytopathogenic fungi, in particular, pathogens of rust diseases, such as Phakopsora pachyrhizi, Phakopsora meibomiae in cultures agricultural and / or horticultural products.

[0051] Another preferred embodiment provides the use of the compound of Formula (I), and its compositions, which are particularly suitable for controlling and / or preventing diseases of agricultural crops, such as cereals, corn, soybeans and other legumes; fruit and fruit trees; walnuts and walnut trees; citrus fruit and citrus trees; any vegetable plants; oil plants; coffee, tea and other vegetables and ornamentals.

[0052] Any of the compounds, according to the invention, can also exist in one or more geometric forms of isomers, depending on the number of double bonds in the compound. Thus, the invention also refers to all geometric isomers and their racemic or scalemic mixtures (the term "scalemic" denotes a mixture of enantiomers in different proportions), and to mixtures of all possible stereoisomers, in all proportions. Diastereoisomers and / or optical isomers can be separated according to methods which are known per se to one skilled in the art.

[0053] Any of the compounds according to the invention can also exist in one or more geometric isomeric forms, depending on the number of double bonds in the compound. Thus, the invention relates equally to all geometric isomers and to all possible mixtures, in all proportions. Geometric isomers can be separated according to general methods, which are known per se to one skilled in the art.

[0054] Any of the compounds, according to the invention, can also exist in one or more amorphous or isomorphic or polymorphic forms, depending on their preparation, purification, storage and various other influencing factors. Thus, the invention relates to all possible amorphous, isomorphic and polymorphic forms, in all proportions. Amorphous, isomorphic and polymorphic forms can be prepared and / or separated and / or purified according to general methods, which are known per se to one skilled in the art.

[0055] The compounds of Formula (I) are prepared according to the schemes or examples disclosed in PCT patent applications WO2018069841 and WO2018069842; whose disclosure is incorporated in this document as a reference.

[0056] In one embodiment, the present invention provides the use of a composition to control unwanted phytopathogenic fungi, in particular, pathogens of rust diseases, which comprise at least one compound of Formula (I) and one or more inert vehicles. The inert vehicle also comprises auxiliaries, solvents, diluents, surfactants and / or extenders and the like suitable for agriculture.

[0057] In another embodiment, the present invention provides the use of a composition to control unwanted phytopathogenic fungi, in particular, pathogens of rust diseases, which comprise at least one compound of Formula (I) and / or one or more compatible active compounds selected from fungicides, bactericides, acaricides, insecticides, nematicides, herbicides, biopesticides, plant growth regulators, antibiotics, fertilizers and / or their mixtures.

[0058] The concentration of the compounds of Formula (I) in said composition ranges from 1 to 90% by weight relative to the total weight of the composition, preferably from 5% to 50% by weight relative to the total weight of the composition.

[0059] The present invention provides a method for controlling unwanted fungi, in particular, by rust disease pathogens, wherein the compounds of Formula (I) are applied to fungi, in particular, rust disease pathogens, and / or its habitat.

[0060] The present invention further provides a method for protecting seeds against unwanted fungi using seeds treated with at least one compound of Formula (I).

[0061] The compounds of Formula (I) can be used for curative or protective control of phytopathogenic fungi. The invention, therefore, also relates to curative and protective methods to control phytopathogenic fungi by using the inventive active ingredients of Formula (I) or their compositions, which are applied to the seed, plant or parts of the plant, the fruit or the soil on which plants grow.

[0062] The compounds of Formula (I) can be used in crop protection, with agricultural crops being cereals, corn, rice, soybeans and other legumes, fruits and fruit trees; walnuts and walnut trees; citrus fruit and citrus trees; any vegetables, cucurbits, oilseeds, tobacco, coffee, tea, cocoa, sugar beet, sugar cane, cotton, potatoes, tomatoes, onions, peppers and other vegetables and ornamentals.

[0063] According to the invention, a vehicle is a natural or synthetic, organic or inorganic substance with which the active ingredients are mixed or combined for better applicability, particularly for its application in plants or parts of plants or seeds. Vehicles, which can be solid or liquid, are generally inert and must be suitable for use in agriculture.

[0064] Useful solid vehicles include, for example, ammonium salts and flours of natural rocks, such as kaolin, clays, talc, chalk, quartz, atapulgite, montmorillonite or diatomaceous earth, and synthetic rock flours, such as finely divided silica , alumina and silicates; solid vehicles useful for granules include, for example, crushed and fractionated natural rocks, such as calcite, marble,

pumice, sepiolite and dolomite, as well as synthetic granules of inorganic and organic flours, and granules of organic material, such as paper, sawdust, coconut husks, corn cobs and tobacco stalks; useful emulsifiers and / or foaming agents include, for example, nonionic and anionic emulsifiers, such as polyoxyethylene fatty acid esters, polyoxyethylene fatty alcohol ethers, for example, alkylaryl polyglycol ethers, alkylsulfonates, alkyl sulfates, arylsulfonates and also protein hydrolysates; suitable dispersants are non-ionic and / or ionic substances, for example, from the classes of alcohol ethers-POE and / or -POP, acid esters and / or POP POE, alkylaryl ethers and / or POP POE, adducts and / or fat of POP POE, POE derivatives and / or POP-polyol, POE and / or POP-sorbitan or sugar adducts, alkyl or aryl sulfates, alkyl or aryl sulfonates and alkyl or aryl phosphates or the corresponding PO-ether adducts. In addition, suitable oligo- or polymers are, for example, those derived from vinyl monomers, acrylic acid, EO and / or PO alone or in combination with, for example, (poly) alcohols or (poly) amines. It is also possible to use lignin and its derivatives of sulfonic acid, unmodified and modified celluloses, aromatic and / or aliphatic sulfonic acids and also its adducts with formaldehyde.

[0065] The active ingredients can be applied as such or converted to usual formulations, or in the form of their formulations, or in the forms of use prepared from them, such as ready-to-use solutions, emulsions, water or oil based suspensions, powders, wettable powders, pastes, soluble powders, soluble tablets, powders, soluble granules, dispersion granules, suspoemulsion concentrates, natural products impregnated with the active ingredient, synthetic substances impregnated with the active ingredient, fertilizers and also microencapsulations in polymeric substances. The application is carried out in the usual way, for example, wetting, spraying, atomizing, in nursery boxes, dispersing, piling, foaming, spreading and the like. It is also possible to implant the active ingredients using the ultra low volume method or inject the preparation of the active ingredient or the active ingredient itself into the soil. It is also possible to treat the seed of plants.

[0066] The active ingredients can also be converted into nanoformulation with the intention of further improving water solubility, thermal stability, bioavailability, sensory attributes and physiological performance.

[0067] In addition, the choice of type of formulation will depend on the specific use.

[0068] The mentioned formulations can be prepared in a known manner, for example, by mixing the active ingredients with at least one extender, solvent or diluent, emulsifier, dispersing and / or binder agent or fixing agent, humectant, water repellent , if appropriate, drying agents and UV stabilizers, and, if appropriate, dyes and pigments, defoamers, preservatives, secondary thickeners, adhesives, usual gibberellins and also other processing aids.

[0069] The present invention does not only include formulations that are already ready for use and can be applied with a suitable device on the plant or seed, but also commercial concentrates that must be diluted with water before use.

[0070] The auxiliaries used can be those substances that are suitable for giving particular properties to the composition itself and / or to the preparations derived therefrom (for example, spray liquids, seed coating), such as certain technical properties and / or also properties particular biological conditions. Typical auxiliaries include extenders, solvents and vehicles.

[0071] Suitable extenders are, for example, water, polar and non-polar organic chemical liquids, for example, from the aromatic and non-aromatic hydrocarbon classes (such as paraffins, alkylbenzenes, alkylnaphthalenes, chlorobenzenes), alcohols and polyols (which can optionally also be substituted, etherified and / or esterified), ketones (such as acetone, cyclohexanone), esters (including fats and oils) and (poly) ethers, unsubstituted and substituted amines, amides, lactams (such as N-alkylpyrrolidones) and lactones, sulfones and sulfoxides (such as dimethyl sulfoxide).

[0072] Liquefied gaseous extenders or carriers are gaseous liquids at standard temperature and standard pressure, for example, aerosol propellants such as halohydrocarbons, or butane, propane, nitrogen and carbon dioxide.

[0073] In the formulations it is possible to use adhesion agents such as carboxymethylcellulose, natural and synthetic polymers in the form of powders, granules or latices, such as gum arabic, polyvinyl alcohol and polyvinyl acetate, or else natural phospholipids, such as cephalins and lecithins, and synthetic phospholipids . Other additives can be minerals, vegetable oils and methylated seed oils.

[0074] If the extender used is water, it is also possible to use, for example, organic solvents as auxiliary solvents. Essentially, useful liquid solvents are aromatics, such as xylene, toluene or alkylnaphthalenes, chlorinated aromatics or chlorinated aliphatic hydrocarbons, such as chlorobenzenes, chloroethylenes or methylene chloride, aliphatic hydrocarbons, such as cyclohexane or paraffins, for example, oil fractions, alcohols like butanol or glycol and its ethers and esters, ketones, such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, strongly polar solvents, such as dimethylformamide and dimethyl sulfoxide, or else water.

[0075] Compositions comprising the compounds of Formula (I) may additionally comprise other components, for example, surfactants. Suitable surfactants are emulsifiers and / or foams, dispersants or wetting agents with ionic or non-ionic properties, or mixtures of these surfactants. Examples of these are salts of polyacrylic acid, salts of lignosulfonic acid, salts of phenolsulfonic acid or naphthalenesulfonic acid, polycondensates of ethylene oxide with fatty alcohols or fatty acids or fatty amines, substituted phenols (preferably alkylphenols or arylphenols), the salts of sulfosuccinic esters, derived from taurine (preferably alkyl taurates), phosphoric esters of alcohols or polyethoxylated phenols, fatty esters of polyols, and those derived from compounds containing sulphates, sulphonates and phosphates, for example, alkyl alkyl polyglycol ethers, alkylsulphonates alkyl sulfates, aryl sulfonates, protein hydrolysates, lignosulfite residual liquids and methyl cellulose. The presence of a surfactant is necessary if one of the active ingredients and / or one of the inert vehicles is not soluble in water and when the application is carried out in water. The proportion of surfactants is between 5 and 40% by weight of the inventive composition.

[0076] It is possible to use dyes such as inorganic pigments, for example, iron oxide, titanium oxide and Prussian blue, and organic dyes such as alizarin dyes, metallic azo and phthalocyanine dyes and trace nutrients such as iron salts, manganese, boron, copper, cobalt, molybdenum and zinc.

[0077] Other additives can be perfumes, minerals or vegetables, optionally modified oils, waxes and nutrients (including trace nutrients), such as iron, manganese, boron, copper, cobalt, molybdenum and zinc salts.

[0078] Other additional components can be stabilizers, such as cold stabilizers, preservatives, antioxidants, light stabilizers or other agents that improve chemical and / or physical stability.

[0079] If applicable, other additional components may also be present, for example, protective colloids, binders, adhesives, thickeners, thixotropic substances, penetrants, stabilizers, sequestering agents, complex builders. In general, the active ingredients can be combined with any solid or liquid additive commonly used for formulation purposes.

[0080] The formulations generally contain between 0.05 and 99% by weight, 0.01 and 98% by weight, preferably between 0.1 and 95% by weight, more preferably between 0.5 and 90% of active ingredient, and even more preferably between 10 and 70 % by weight.

[0081] The formulations described above can be used to control unwanted fungi, in which the compositions comprising the compounds of Formula (I) are applied to the fungi and / or in their habitat.

[0082] The compounds of Formula (I), or their salts, N-oxides, metal complexes, stereoisomers or polymorphs, according to this invention, can be used as such or in formulations or with known mixing partners, in order to improve the spectrum of activity or to prevent the development of resistance. Suitable suitable mixing components include, for example, known fungicides, insecticides, acaricides, nematicides, biopesticides and bactericides. It is also possible to mix with other known active ingredients, such as herbicides, or with fertilizers and growth regulators, sapheners and / or semi-chemicals.

[0083] Examples for such chemical ingredients are presented here in a non-limiting way. Some of them are specified here by their common names, with those that are known and described, for example, in The Pesticide Manual, 17th Edition, or can be searched on the internet (for example, at www.alanwood.net/pesticides). Others are described by their systematic name following the IUPAC nomenclature rules.

[0084] The present invention also relates to the use of a combination comprising at least one compound of Formula

(I) and at least one other active substance as a pesticide selected from the group of fungicides, insecticides, nematicides, acaricides, biopesticides, herbicides, protectors, plant growth regulators, antibiotics, fertilizers and nutrients. The active substances as pesticides reported in WO2015185485, pages 36-43, and WO2017093019, pages 42-56, can be used in conjunction with the compound (s) of Formula (I). The combination components are selected from compounds (A) to (O) or active ingredients with unknown or undetermined mode of action as disclosed in PCT applications WO2018069841 and WO2018069842.

[0085] The active substances referred to as component 2 are known, their preparation and their activity, for example, against harmful fungi (see: http://www.alanwood.net/pesticides/); these substances are commercially available. The compounds described by the IUPAC nomenclature, their preparation and their pesticidal activity are also known (see: Can. J. Plant Sci. 48 (6), 587-94, 1968; EP141317; EP152031; EP226917; EP243970; EP256503; EP428941; ; EP532022; EP1028125; EP1035122; EP1201648; EP1122244, JP2002316902, DE19650197, DE10021412, DE102005009458; US3296272; US3325503; WO9846608; WO9914187; WO9924413; WO9927783; WO0029404; WO0046148; WO0065913; WO0154501; WO 0156358; WO0222583; WO0240431; WO0310149; WO0311853; WO0314103; WO0316286; WO0353145; WO0361388; WO0366609; WO0374491; WO0449804; WO0483193; WO05120234; WO05123689; WO05123690; WO0563721; WO0587772; WO0587772; WO06588;

WO2007006670; WO201177514; WO13047749; WO10069882; WO13047441; WO0316303; WO0990181; WO13007767; WO1310862; WO13127704; WO13024009; WO13024010; WO13047441; WO13162072; WO13092224 and WO11135833.

[0086] The present invention further provides for the use of agrochemical mixtures comprising at least one compound of Formula (I) (component 1) and at least one other active substance useful for plant protection, for example, selected from from groups A) to O) (component 2), in particular another fungicide, for example, one or more fungicides from groups A) to K), as described above and, if desired, a suitable solid solvent or vehicle. In addition, controlling or preventing harmful fungi with a mixture of the compound (s) of Formula (I) and at least one fungicide from groups A) to K), as described above, is advantageous than controlling or preventing these fungi with individual compound (s) of Formula (I) or individual fungicides from groups A) to K).

[0087] The compounds of Formula (I) may be used to treat several fungal pathogens. Examples of fungal disease pathogens that can be treated according to the invention include:

[0088] Ustilaginales such as Ustilaginoidea virens, Ustilago nuda, Ustilago tritici, Ustilago zeae, ferrugens, for example, those caused by Pucciniales such as Cerotelium fici, Chrysomyxa arctostaphili, Coleosporium ipomoeae, Hemileia vastatrix, Pucia, Puccinia, Puccinia, Puccinia , Puccinia sorghi, Puccinia hordei, Puccinia striiformis f.sp. Hordei, Puccinia striiformis f.sp. Secalis, Pucciniastrum corili, or

Uredinales such as Cronartium ribicola, Gymnosporangium juniperi-viginianae, Melampsora medusae, Phakopsora pachyrhizi, Phragmidium mucronatum, Physopella ampelosidis, Tranzschelia discolor and Uromyces viciae-fabae; and other rot and diseases such as those caused by the species Cryptococcus, Exobasidium vexans, Marasmiellus inoderma, the species Mycena, Sphacelotheca reiliana, Typhula ishikariensis, Urocystis agropiri, ltersonilia perplexans, Corticium invisum, Laetisaria fuciforis, Solanis, cucumormis, Waitea, dahliae, Entilomella microspora, Neovossia moliniae and Tilletia caries. Blastocladiomycetes, such as Physoderma maydis. Mucoromycetes, such as Choanephora cucurbitarum .; the Mucor species; and Rhizopus arrhizus.

[0089] In one embodiment, diseases caused by pathogens of rust disease, for example, Gymnosporangium species, for example, Gymnosporangium sabinae; Hemileia species, for example, Hemileia vastatrix; Phakopsora species, for example, Phakopsora pachyrhizi or Phakopsora meibomiae; Puccinia species, for example, Puccinia recondita, Puccinia graminis or Puccinia striiformis; Uromyces species, for example, Uromyces appendiculatus.

[0090] In particular, Cronartium ribicola (rust on white pine blister); Gymnosporangium juniperi- virginianae (cedar-apple rust); Hemilea vastatrix (coffee rust); Phakopsora meibomiae and P. pachyrhizi (soybean rust); Puccinia coronata (crown rust of oats and ryegrass); Puccinia graminis (Kentucky stalk and bluegrass rust, or black grain rust);

Puccinia hemerocallidis (rust Dailily); Puccinia persistens subspecies trithycin (wheat rust or 'brown or red rust'); Puccinia sorghi (rust on corn); Puccinia striiformis ('Yellow rust' in cereals); Uromyces appendiculatus (bean rust); Uromyces phaseoli (bean rust); Puccinia melanocephala (brown rust on sugar cane); Puccinia kuehnii ('orange rust' in sugar cane).

[0091] The plants that can be treated according to the invention include the following: cotton, flax, grapevine, fruits, vegetables, such as Rosaceae species, (for example, pome trees such as apples, pears, apricots, cherries, almonds and peaches), Ribesioidae species, Juglandaceae species, Betulaceae species, Anacardiaceae species, Fagaceae species, Moraceae species, Oleaceae species, Actinidaceae species, Lauraceae species, Musaceae species (for example, banana plants and banana), Rubiaceae species (for example, coffee), Theaceae species, Sterculiceae species, Rutaceae species (for example, lemons, oranges and grapefruits); Vitaceae species (for example, grapes); the Solanaceae species (for example, tomatoes, peppers), the Liliaceae species, the Asteraceae species (for example, lettuce), the Umbelliferae species, the Cruciferae species, the Chenopodiaceae species, the Cucurbitaceae species (the cucumber), the species Alliaceae (for example, leeks, onions), Papilionaceae species (for example, peas); important crop plants, such as Poaceae / Gramineae species (eg maize, grass, cereals such as wheat, rye, rice, barley, oats, millet and triticale), Asteraceae species (eg sunflowers), Brassicaceae species (eg white and red cabbage, broccoli, cauliflower, brussels sprouts, pak choi, kohlrabi, radish and rapeseed, mustard, horseradish and watercress), Fabacae species (eg beans, peanuts) , the Papilionaceae species (for example, soybeans), the Solanaceae species (for example, potatoes), the Chenopodiaceae species (for example, sugar beet, fodder beet, chard, beet); Malvaceae (for example, cotton); useful plants and ornamental plants for gardens and wooded areas; and the genetically modified varieties of each of these plants.

[0092] In one embodiment, the present invention provides the use of the compound of Formula (I) to control or prevent pathogenic rust diseases selected from Cronartium ribicola (white pine rust); Gymnosporangium juniperi-virginianae (cedar apple rust); Hemilea vastatrix (coffee rust); Phakopsora meibomiae and P. pachyrhizi (soybean rust); Puccinia coronata (rust of oats and ryegrass); Puccinia graminis (Kentucky wheat and grass stem rust or black grain rust); Puccinia hemerocallidis (rust Dailily); Puccinia persistens subspecies trithycin (wheat rust or 'brown or red rust'); Puccinia sorghi (rust on corn); Puccinia striiformis (‘yellow rust’ on cereals); Uromyces appendiculatus (bean rust); Uromyces phaseoli (bean rust); Puccinia melanocephala (‘brown rust’ on sugar cane) or Puccinia kuehnii (‘orange rust’ on sugar cane).

[0093] More preference is given to the control of the following diseases of soy: Fungal diseases in leaves, stems, fruits and seeds caused, for example, by rust (Phakopsora pachyrhizi, Phakopsora meibomiae).

[0094] All plants and parts of plants can be treated according to the invention. Plants are understood here to mean all plants and plant populations, such as desired and unwanted wild plants or harvest plants (including naturally occurring harvest plants). Harvesting plants can be plants that can be obtained by conventional breeding and optimization methods, or by biotechnological and genetic engineering methods, or combinations of these methods, including transgenic plants and including plant cultivars that are both protected and not protected by breeder's rights. Plant parts are understood to mean all plant parts and organs above and below ground, such as buds, leaves, flowers and roots, examples of which include leaves, needles, stems, stems, flowers, bodies of fruits, fruits and seeds, and also roots, tubers and rhizomes. The parts of the plant also include the material harvested and the material of vegetative and generative propagation, for example, cuttings, tubers, rhizomes, grafts and seeds.

[0095] The compound of Formula (I) and its compositions, respectively, can be used to improve the health of a plant. The invention also relates to a method for improving plant health by treating a plant, its propagating material and / or the place where the plant is growing, or will grow, with an effective amount of the compounds of Formula (I) and compositions, respectively.

[0096] The term "plant health" (plant health) should be understood as a condition of the plant and / or its products that is determined by various indicators, alone or in combination with each other, such as yield (eg increased biomass) and / or increased content of valuable ingredients), plant vigor (for example, better plant growth and / or greener leaves ("greening effect")), quality (for example, better content or composition of certain ingredients) and tolerance to abiotic and / or biotic stress. The indicators identified above for a plant's health status may be interdependent or may result from each other.

[0097] The compound (s) of Formula I may be present in different crystal modifications whose biological activity may differ. They are also the subject of the present invention.

[0098] The compound (s) of Formula I are used as such, or in the form of compositions, for the treatment of fungi or plants, plant propagation materials such as seeds, soil, surfaces, materials or rooms, to be protected against fungal attacks with an effective fungicidal amount of the active substances. The application can be carried out before and after plant infection, plant propagation materials, such as seeds, soil, surfaces, materials or rooms by fungi.

[0099] Plant propagation materials may be treated with the compound (s) of Formula (I) as such, or a composition comprising at least one compound of Formula (I) prophylactically during or before planting or transplant.

[0100] The invention also relates to agrochemical compositions comprising an auxiliary and at least one compound of Formula (I).

[0101] An agrochemical composition comprises an effective fungicidal amount of a Formula I compound. The term "effective amount" indicates an amount of the Formula I compound, or compound (s), sufficient to control harmful fungi in plants. or protection of materials and does not result in substantial damage to the treated plants. This amount can vary over a wide range and depends on several factors, such as the species of fungi to be controlled, the plant or cultivated material treated, the climatic conditions and the specific compound of Formula I used.

[0102] The compounds of Formula I, their oxides and salts, can be converted into usual types of agrochemical compositions, for example, solutions, emulsions, suspensions, powders, pastes, granules, presses, capsules and their mixtures. Examples for types of composition are suspensions (for example, SC, OD, FS), emulsifiable concentrates (for example, EC), emulsions (for example, EW, EO, ES, ME), capsules (for example, CS, ZC ), wettable pastes, lozenges, powders or powders (for example, WP, SP, WS, DP, DS), tablets (for example, BR, TB, DT), granules (for example, WG, SG, GR, FG, GG, MG), insecticidal articles (for example, LN), as well as gel formulations for the treatment of plant propagation materials, such as seeds (for example, GF). These and other types of compositions are defined in the Catalog of pesticide formulation types and international coding system (Technical Catalog of Pesticide Formulations and International Coding System), Technical Monograph No. 2, 6th Edition, May 2008, CropLife International.

[0103] The compositions are prepared in a known manner, as described by Mollet and Grubemann in Formulation technology, Wiley VCH, Weinheim, 2001; or by Knowles in New developments in crop protection product formulation (Agrow Reports DS243, T&F Informa, London, 2005).

[0104] Suitable auxiliaries are solvents, liquid vehicles, solid vehicles or fillers, surfactants, dispersants, emulsifiers, humidifiers, adjuvants, solubilizers, penetration enhancers, protective colloids, adhesives, thickeners, humectants, repellents, attractions, food, compatibilizers, bactericides, antifreeze agents, antifoaming agents, dyes, adherents and binders.

[0105] Suitable liquid solvents and vehicles are water and organic solvents, such as fractions of medium to high boiling mineral oil, for example, kerosene, diesel oil; vegetable or animal oils; aliphatic, cyclic and aromatic hydrocarbons, for example, toluene, paraffin, tetrahydronaphthalene, alkylated naphthalene; alcohols, for example, ethanol, propanol, butanol, benzyl alcohol, cyclohexanol; glycols; DMSO; ketones, for example, cyclohexanone; esters, for example, lactates, carbonates, fatty acid esters, gamma-butyrolactone; fatty acids; phosphonates; amines; amides, for example, N-methyl pyrrolidone, dimethyl fatty acid amides, and mixtures thereof.

[0106] Suitable solid vehicles or fillers are mineral soils, for example, silicates, silica gels, talc, kaolin, limestone, lime, chalk, clays, dolomite, diatomaceous earth, bentonite, calcium sulfate, magnesium sulfate, magnesium oxide; polysaccharides, for example, cellulose, starch; fertilizers, for example, ammonium sulfate, ammonium phosphate, ammonium nitrate, ureas; products of plant origin, for example, cereal bran, tree bark bran, wood bran, nutshell bran and mixtures thereof.

[0107] Suitable surfactants are surfactant compounds, such as anionic, cationic, non-ionic and amphoteric surfactants, block polymers, polyelectrolytes and their mixtures. Such surfactants can be used as emulsifiers, dispersants, solubilizers, humidifiers, penetration enhancers, protective colloids or adjuvants. Examples of surfactants are listed by McCutcheon in Vol.1: Emulsifiers & Detergents, McCutcheon's Directories, Glen Rock, USA, 2008 (international edition or North American edition).

[0108] Suitable anionic surfactants are alkaline, alkaline earth or ammonium salts of sulfonates, sulfates, phosphates, carboxylates and mixtures thereof. Examples of sulfonates are alkylaryl sulphonates, diphenyl sulphonates, alpha-olefin sulphonates, lignin sulphonates, fatty acid sulphonates and oils, ethoxylated alkyl phenol sulphonates, alkoxylated aryl phenyl sulphonates, condensed naphthalene sulphonates and dodyl sulphide sulphides. , naphthalene sulfonates and alkyl naphthalenes, sulfosuccinates or sulfosuccinates. Examples of sulfates are fatty acid and oil sulfates, ethoxylated alkylphenols, alcohols, ethoxylated alcohols or fatty acid esters. Examples of phosphates are phosphate esters. Examples of carboxylates are alkyl carboxylates and carboxylated alcohol or alkylphenol ethoxylates.

[0109] Suitable non-ionic surfactants are alkoxylates, N-substituted fatty acid amides, amine oxides, esters, sugar-based surfactants, polymeric surfactants and mixtures thereof. Examples of alkoxylates are compounds such as alcohols, alkylphenols, amines, amides, arylphenols, fatty acids or fatty acid esters that have been alkoxylated with 1 to 50 equivalents. Ethylene oxide and / or propylene oxide, preferably ethylene oxide, can be used for alkoxylation. Examples of N-substituted fatty acid amides are fatty acid glucamides or fatty acid alkanolamides. Examples of esters are fatty acid esters, glycerol esters or monoglycerides. Examples of sugar-based surfactants are sorbitans, ethoxylated sorbitans, sucrose and glucose esters or alkyl polyglucosides. Examples of polymeric surfactants are homo or copolymers of vinyl pyrrolidone, vinyl alcohols or vinyl acetate.

[0110] Suitable cationic surfactants are quaternary surfactants, for example, quaternary ammonium compounds with one or two hydrophobic groups or salts of long chain primary amines. Suitable amphoteric surfactants are alkylbetains and imidazolines. Suitable block polymers are block polymers of type A-B or A-B-A which comprise blocks of polyethylene oxide and polypropylene oxide, or of type A-B-C which comprise alkanol, polyethylene oxide and polypropylene oxide.

[0111] Suitable polyelectrolytes are polyacids or polybases. Examples of polyacids are alkaline salts of polyacrylic acid polymers or a polyacid comb. Examples of polybases are polyvinyl amines or polyethylene amines.

[0112] Suitable adjuvants are compounds that have negligible or even non-existent pesticidal activity and that improve the biological performance of Formula I compounds on the target. Examples are surfactants, mineral or vegetable oils and other auxiliaries. Other examples are listed by Knowles in Adjuvants and additives (Adjuvants and additives), Agrow Reports DS256, T&F Informa United Kingdom, 2006, chapter 5.

[0113] Suitable thickeners are polysaccharides (eg, xanthan gum, carboxymethyl cellulose), inorganic clays (organically modified or unmodified), polycarboxylates and silicates.

[0114] Suitable bactericides are derived from bronopol and isothiazolinone, such as alkylisothiazolinones and benzisothiazolinones.

[0115] Suitable antifreeze agents are ethylene glycol, propylene glycol, urea and glycerin. Suitable antifoam agents are silicones, long-chain alcohols and fatty acid salts. Suitable dyes (for example,

red, blue or green) are pigments with low water solubility and water-soluble dyes. Examples are inorganic dyes (for example, iron oxide, titanium oxide, iron hexacyanoferrate) and organic dyes (for example, alizarin, azo and phthalocyanine dyes).

[0116] Suitable adherents or binders are polyvinylpyrrolidones, polyvinylacetates, polyvinyl alcohols, polyacrylates, biological or synthetic waxes and cellulose ethers.

[0117] Examples for types of composition and their preparation are: i) Water-soluble concentrates (SL, LS) 10-60% by weight of a compound of Formula I and 5-15% by weight of wetting agent (eg alcohol alkoxylates) are dissolved in water and / or in a water-soluble solvent (for example, alcohols) at 100% by weight. The active substance dissolves by dilution with water. ii) Dispersible concentrates (DC) 5-25 wt% of a compound of Formula I and 1-10 wt% of dispersant (eg polyvinylpyrrolidone) are dissolved in 100% by weight organic solvent (eg cyclohexanone) . Dilution with water produces a dispersion. iii) Emulsifiable concentrates (EC) 15-70% by weight of a compound of Formula I and 5-10% by weight of emulsifiers (for example, calcium dodecylbenzenessulfonate and castor oil ethoxylate) are dissolved in a water-insoluble organic solvent (for example, aromatic hydrocarbonate) at 100% by weight.

Dilution with water produces an emulsion. iv) Emulsions (EW, EO, ES) 5-40% by weight of a compound of Formula I and 1-10% by weight of emulsifiers (eg calcium dodecylbenzenessulfonate and castor oil ethoxylate) are dissolved in 20- 40% by weight of water-insoluble organic solvent (eg aromatic hydrocarbonate). This mixture is introduced into the water at 100% by weight by means of an emulsifying machine and transformed into a homogeneous emulsion.

Dilution with water produces an emulsion. v) Suspensions (SC, OD, FS) In a stirred ball mill, 20-60% by weight of a compound of Formula I are crushed with the addition of 2- 10% by weight of dispersants and wetting agents (for example, lignosulfonate sodium and alcohol ethoxylate), 0.1-2% by weight of thickener (eg xanthan gum) and 100% by weight water to produce a fine suspension of the active substance.

Dilution in water gives a stable suspension of the active substance.

For an FS-type composition up to 40% by weight, binder (eg polyvinyl alcohol) is added. vi) Water-dispersible granules and water-soluble granules (WG, SG) 50-80% by weight of a compound of Formula I are finely ground with the addition of dispersants and wetting agents (eg sodium lignosulfonate and alcohol ethoxylate ) at 100% by weight and prepared as water-dispersible or water-soluble granules using technical devices (eg extrusion, spray tower, fluidized bed). Dilution in water produces a stable dispersion or solution of the active substance. vii) Water-dispersible powders and water-soluble powders (WP, SP, WS) 50-80% by weight of a compound of Formula I are ground in a rotor-stator mill with the addition of 1-5% by weight of dispersants (e.g., sodium lignosulfonate), 1-3% by weight of wetting agents (e.g., alcohol ethoxylate) and 100% by weight solid vehicle (e.g., silica gel).

Dilution in water produces a stable dispersion or solution of the active substance. viii) Gel (GW, GF) In a stirred ball mill, 5-25% by weight of a compound of Formula I are crushed with the addition of 3-10% by weight of dispersants (eg sodium lignosulfonate), 1 -5% by weight of thickener (eg carboxymethylcellulose) and 100% by weight water to give a fine suspension of the active substance.

Dilution in water produces a stable suspension of the active substance. ix) Microemulsion (ME) 5-20% by weight of a compound of Formula I are added to 5-30% by weight of organic solvent mixture (for example, fatty acid dimethylamide and cyclohexanone), 10-25% by weight weight of surfactant mixture (eg alcohol ethoxylate and arylphenol ethoxylate) and 100% water. This mixture is stirred for 1 hour to spontaneously produce a thermodynamically stable microemulsion. x) Microcapsules (CS) An oily phase comprising 5-50% by weight of a compound of Formula I, 0-40% by weight of water-insoluble organic solvent (eg aromatic hydrocarbonate), 2-15% by weight Acrylic monomers (for example, methyl methacrylate, methacrylic acid and a di or triacrylate) are dispersed in an aqueous solution of a protective colloid (for example, polyvinyl alcohol). The radical polymerization results in the formation of poly (meth) acrylate microcapsules.

Alternatively, an oil phase comprising 5-50% by weight of a compound of Formula I, according to the invention, 0-40% by weight of water-insoluble organic solvent (for example, aromatic hydrocarbonate), and a monomer of isocyanates (eg, diphenylmethane-4,4'-diisocyanate) are dispersed in an aqueous solution of a protective colloid (eg, polyvinyl alcohol). The addition of a polyamine (eg, hexamethylenediamine) results in the formation of polyurea microcapsules.

Monomers are equivalent to 1-10% by weight.

The weight% refers to the total composition of CS. xi) Sprinkle powders (DP, DS) 1-10% by weight of a compound of Formula I are finely ground and mixed intimately with the solid vehicle (e.g. finely divided kaolin) at 100% by weight. xii) Granules (GR, FG)

0.5-30% by weight of a compound of Formula I are finely ground and combined with the solid vehicle (e.g., silicate) to 100% by weight. Granulation is obtained by extrusion, spray drying or fluidized bed. xiii) Ultra low volume (UL) liquids 1-50% by weight of a compound of Formula I are dissolved in an organic solvent (for example, aromatic hydrocarbonate) at 100% by weight.

[0118] The types of compositions i) to xiii) can optionally comprise additional auxiliaries, such as

0.1-1% by weight of bactericides, 5-15% by weight of antifreeze agents, 0.1-1% by weight of anti-foaming agents, and 0.1-1% by weight of colorants.

[0119] Agrochemical compositions generally comprise between 0.01 and 95%, preferably between 0.1 and 90%, and particularly between 0.5 and 75% by weight of the active ingredient (ia).

[0120] The active ingredients (ia) are used in a purity of 90% to 100%, preferably between 95% to 100% (according to the NMR spectrum).

[0121] For the purpose of treating plant propagation materials, particularly seeds, solutions are generally used for the treatment of seeds (LS), suspoemulsions (SE), fluid concentrates (FS), dry treatment powders (DS), water-dispersible powders for slurry treatment (WS), water-soluble powders (SS),

emulsions (ES), emulsifiable concentrates (EC) and gels (GF). The compositions in question provide, after dilution of two to ten times, concentrations of the active substance from 0.01 to 60% by weight, and preferably from 0.1 to 40%, in ready-to-use preparations.

[0122] The application can be carried out before or during sowing. The methods of application of the Formula I compound (s), their combinations and compositions, respectively, plant propagation material, especially seeds, include fertilization, coating, granulation, dusting, and immersion, as well as methods of groove application. Preferably, the compound (s) of Formula I, their combinations and compositions, respectively, are applied to the propagation material of the plant by a method that does not allow germination to be induced, for example, by fertilization, granulation , seed coating and sprinkling.

[0123] When used in phytosanitary protection, the amounts of active substances applied are, depending on the type of effect desired, from 0.001 to 2 kg per ha, preferably from 0.005 to 2 kg per ha, more preferably from 0.05 to 0.9 kg per ha , and particularly from 0.1 to 0.75 kg per ha.

[0124] In the treatment of plant propagation materials, such as seeds, for example, by sprinkling, coating or moistening the seeds, the amounts of active substance generally required are 0.1 to 1000 g, preferably 1 to 1000 g, more preferably from 1 to 100 g and more preferably from 5 to 100 g, per 100 kg of plant propagating material (preferably seeds).

[0125] When used to protect stored materials or products, the amount of active substance applied depends on the type of application area and the desired effect. The amounts usually applied in the protection of materials are 0.001 g to 2 kg, preferably 0.005 g to 1 kg, of active substance per cubic meter of treated material.

[0126] Various types of oils, moist, adjuvants, fertilizers or micronutrients and other pesticides (for example, herbicides, insecticides, fungicides, growth regulators, protectors, biopesticides) can be added to the active substances or compositions that comprise them as pre -mixing or, if appropriate, until just before use (mixing the tank). These agents can be mixed with the compositions according to the invention in a weight ratio of 1: 100 to 100: 1, preferably 1:10 to 10: 1.

[0127] A pesticide is generally a chemical or biological agent (as an active ingredient pesticide, compound, composition, virus, bacterium, antimicrobial or disinfectant) that, by its effect, stops, disables, kills or weakens pests. Target pests can include insects, plant pathogens, weeds, mollusks, birds, mammals, fish, nematodes (worms) and microbes that destroy properties, cause discomfort, spread disease or are disease vectors. The term pesticides also includes plant growth regulators that change the expected rate of growth, flowering or the rate of reproduction of plants; defoliants that cause leaves or other leaves to fall on a plant, usually to facilitate harvesting; desiccants that promote the drying of living tissue, such as unwanted plant tops; plant activators that activate plant physiology to defend against certain pests; protectors that reduce the unwanted herbicidal action of pesticides on crop plants; and plant growth promoters that affect plant physiology to increase growth, biomass, yield, or any other quality parameter of a crop plant's harvestable assets.

[0128] Biopesticides have been defined as a form of pesticides based on microorganisms (bacteria, fungi, viruses, nematodes etc.) or natural products (compounds, such as metabolites, proteins or extracts from biological sources or other natural sources) (Agência de US Environmental Protection: http://www.epa.gov/pesticides/biopesticides/). Biopesticides are generally created through the growth and concentration of natural organisms and / or their metabolites, including bacteria and other microbes, fungi, viruses, nematodes, proteins, etc. These are often considered to be important components of integrated pest management (IPM) programs.

[0129] Biopesticides fall into two main classes: microbial pesticides and biochemicals:

1. Microbial pesticides consist of bacteria, fungi or viruses (and generally include metabolites produced by bacteria and fungi). Entomopathogenic nematodes are also classified as microbial pesticides, even though they are multicellular.

2. Biochemical pesticides are natural substances that control pests or provide other uses for crop protection, as defined below, but are relatively non-toxic to mammals.

[0130] The user applies the composition according to the invention normally from a pre-dosing device, a backpack sprayer, a spray tank, a spray plane or an irrigation system. Usually, the agrochemical composition is made with water, buffer, and / or other auxiliaries for the concentration of the desired application, and this is how the ready-to-use spray liquid or the agrochemical composition according to the invention is obtained. Generally, 20 to 2000 liters are applied, preferably 50 to 400 liters, per hectare of agricultural useful area, of the spray liquid ready to use.

[0131] The present invention further relates to a composition for controlling unwanted microorganisms that comprises at least one of the compounds of Formula (I) and one or more inert vehicles. The inert vehicle also comprises auxiliaries, solvents, diluents, surfactants and / or extenders and the like suitable for agriculture.

[0132] The present invention also relates to a composition to control unwanted fungi, which comprises at least one of the compounds of Formula (I) and / or one or more compatible active compounds selected from fungicides, bactericides, acaricides, insecticides , nematicides, herbicides, biopesticides, plant growth regulators, antibiotics, fertilizers and / or their mixtures.

[0133] Generally, a compound of the present invention is used in the form of a composition (e.g., formulation) containing a vehicle. A compound of the invention and its compositions can be used in various ways, such as aerosol dispenser, capsule suspension, cold fogging concentrate, dusting powder, emulsifiable concentrate, water emulsion oil, oil emulsion water, granules encapsulated, fine granules, fluid concentrate for seed treatment, gas (under pressure), gas-generating product, granules, hot mist concentrate, macrogranules, microgranules, oil dispersible powders, oil miscible fluid concentrate, oil miscible liquid , paste, vegetable stick, dry seed treatment powder, pesticide coated seed, soluble concentrate, soluble powder, seed treatment solution, suspension concentrate (fluid concentrate), ultra low volume liquid (ULV), volume suspension ultra low (ULV), water-dispersible granules or tablets, water-dispersible powder for treating sludge, water-soluble granules or tablets, soluble powder and m water for treating seeds and wettable powder.

[0134] A formulation generally comprises a liquid or solid carrier and, optionally, one or more usual formulation auxiliaries, which can be solid or liquid auxiliaries, for example, non-epoxidized or epoxidized vegetable oils (eg coconut oil, oil rapeseed oil or soy oil), defoamers, for example silicone oil, preservatives, clays, inorganic compounds,

viscosity regulators, surfactants, binding and / or adhesion agents. The composition can also comprise a fertilizer, a micronutrient donor or other preparations that influence plant growth, in addition to comprising a combination containing the compound of the invention with one or more other biologically active agents, such as bactericides, fungicides, nematicides , plant activators, mites and insecticides.

[0135] Thus, the present invention also provides a composition comprising a compound of the invention and an agronomic vehicle and, optionally, one or more usual formulation aids.

[0136] The compositions are prepared in a manner known per se in the absence of auxiliaries, for example, by crushing, sifting and / or compressing a solid compound of the present invention and in the presence of at least one auxiliary, for example, by intimately mixing and / or by grinding the compound of the present invention with the auxiliary (auxiliaries). In the case of the solid compounds of the invention, the grinding / grinding of the compounds is to guarantee a specific particle size. These processes for preparing the compositions and using the compounds of the invention for the preparation of these compositions are also the subject of the invention.

[0137] As a rule, the compositions comprise from 0.1 to 99%, especially from 0.1 to 95%, of the compound according to the present invention and from 1 to 99.9%, especially from 5 to

99.9%, of at least one solid or liquid vehicle, being possible, as a rule, from 0 to 25%, especially from 0.1 to

20%, of the composition are surfactants (% in each case means weight percentage). While concentrated compositions tend to be preferred for commercial products, as a rule, the end consumer uses diluted compositions that have substantially lower concentrations of the active ingredient.

[0138] Examples of foliar formulation types for premix compositions are: GR: EW granules: emulsions, oil in water WP: wettable powders ME: microemulsion WG: dispersible granules SC: aqueous suspension concentrate (powders) SG: granules soluble in CS: suspension of aqueous water capsule SL: soluble concentrates OD: suspension concentrate based on oil; and EC: SE concentrate: aqueous suspo-emulsion. emulsifiable

[0139] While examples of types of seed treatment formulation for premix compositions are: WS: wettable powders for FS: Concentrated suspension seed treatment sludge LS: solution for WG: dispersible granules in treatment of water seeds, and ES: emulsions for CS: capsule suspension aqueous seed treatment

[0140] Examples of suitable formulation types for tank mix compositions are solutions, diluted emulsions, suspensions or a mixture thereof, and powders.

[0141] As with the nature of the formulations, the application methods, such as foliar, moistening, spraying, atomization, dusting, spreading, coating or pouring, are chosen according to the intended objectives and the prevailing circumstances.

[0142] Tank mix compositions are generally prepared by diluting one or more premix compositions containing different pesticides and, optionally, other auxiliaries with a solvent (for example, water). Suitable vehicles and adjuvants can be solid or liquid, and are the substances normally used in formulation technology, for example, natural or regenerated mineral substances, solvents, dispersants, wetting agents, adhesives, thickeners, binders or fertilizers.

[0143] Generally, a tank mix formulation for foliar or soil application comprises 0.1 to 20%, especially 0.1 to 15%, of the desired ingredients and

99.9 to 80%, especially 99.9 to 85%, of a solid or liquid auxiliary (including, for example, a solvent such as water), where the auxiliaries can be a surfactant in an amount of 0 to 20%, especially 0.1 to 15 %, based on the tank mix formulation. Typically, a premix formulation for foliar application comprises from 0.1 to 99.9%, especially 1 to 95%, of the desired ingredients, and from 99.9 to 0.1%, especially from 99 to 5%, of a solid or liquid adjuvant. (including, for example, a solvent such as water), where auxiliaries can be a surfactant in an amount of 0 to 50%, especially 0.5 to 40%, based on the premix formulation.

[0144] Typically, a tank mix formulation for application in seed treatment comprises from 0.25 to 80%, especially from 1 to 75%, of the desired ingredients and 99.75 to 20%, especially 99 to 25%, of a solid auxiliary or liquid (including, for example, a solvent such as water), where the auxiliaries can be a surfactant in an amount of 0 to 40%, especially 0.5 to 30%, based on the tank mix formulation.

[0145] Normally, a premix formulation for application in seed treatment comprises from 0.5 to

99.9%, especially 1 to 95%, of the desired ingredients and 99.5 to 0.1%, especially 99 to 5%, of a solid or liquid adjuvant (including, for example, a solvent such as water), where auxiliaries can be used a surfactant in an amount of 0 to 50%, especially 0.5 to 40%, based on the premix formulation; while commercial products will preferably be formulated as concentrates (for example, premix composition (formulation)), the end user will normally employ diluted formulations (for example, tank mix composition).

[0146] The preferred premix formulations for seed treatment are concentrated in aqueous suspension. The formulation can be applied to seeds using conventional treatment techniques and machines, such as fluidized bed techniques, roller mill method, rotostatic seed tractors and drum liners. Other methods, such as the spouting bed, may also be useful. The seeds can be pre-sized before coating. After coating, the seeds are normally dried and then transferred to a sizing machine. Such procedures are known in the art. The compounds of the present invention are particularly suitable for use in soil and seed treatment applications.

[0147] In general, the premixed compositions of the invention contain from 0.5 to 99.9, especially from 1 to 95, advantageously from 1 to 50% by weight of the desired ingredients, and from 99.5 to

0.1, especially from 99 to 5%, by weight of a solid or liquid adjuvant (including, for example, a solvent such as water), where auxiliaries (or adjuvants) can be a surfactant in an amount of 0 to 50, especially of

0.5 to 40% by weight based on the mass of the pre-mix formulation.

[0148] A compound of Formula (I) in a preferred embodiment, independent of any other embodiments, is in the form of a treatment (or protection) composition of the propagating material of the plant, wherein said protective composition of the propagating material of the plant may additionally comprise a coloring agent. The protective composition or mixture for plant propagation material may also comprise at least one polymer from water-soluble and water-dispersible film-forming polymers that improve the adhesion of active ingredients to the propagation material of treated plants, the polymer generally has an average molecular weight of at least 10,000 to about 100,000.

[0149] Examples of application methods for the compounds of the invention and their compositions, which are the methods of pest control in agriculture, are spraying, atomization, dusting, brushing, fertilizing, spreading or pouring, which must be selected according to the intended objectives of the prevailing circumstances.

[0150] One method of application in agriculture is the application on the foliage of plants (foliar application), being possible to select the frequency and the application rate to combine the danger of infestation with the pest or fungi in question. Alternatively, the active ingredient can reach plants through the root system (systemic action), applying the compound to the plant site, for example, applying a liquid composition of the compound to the soil (by immersion) or by applying a solid form of the compound in the form of granules to the soil (application to the soil). In the case of paddy rice plants, these granules can be measured in the flooded paddy field. The application of the compounds of the present invention to the soil is a preferred method of application.

[0151] Typical application rates per hectare are generally 1 to 2000 gr of the active ingredient per hectare, in particular 10 to 1000 gr / ha, preferably 10 to 600 gr / ha, such as 50 to 300 gr / ha.

[0152] In one embodiment, the present invention provides a method to control or prevent phytopathogenic fungi in particular, by pathogens of rust diseases in agricultural and / or horticultural crops using said compound of Formula (I), which consists of applying dosages compounds in amounts ranging from agricultural and / or horticultural crops.

[0153] The compounds of the invention and their compositions are also suitable for the protection of plant propagating material, for example seeds, such as fruits, tubers or grains or nursery plants, against pests of the aforementioned type. The propagation material can be treated with the compost before planting, for example, the seeds can be treated before sowing. Alternatively, the compound can be applied to the seeds of the grains (coating), soaking the grains in a liquid composition or applying a layer of a solid composition. It is also possible to apply the compositions when the propagation material is planted at the application site, for example, in the seed groove during drilling. These treatment methods for plant propagation material, and the plant propagation material so treated, are other subjects of the invention. Typical treatment rates depended on the plant and the pests / fungi to be controlled and are generally between 1 to 200 gr per 100 kg of seeds, preferably between 5 to 150 gr per 100 kg of seeds, and as between 10 to 100 gr per 100 kg of seeds. The application of the compounds of the present invention to seeds is a preferred method of application.

[0154] The rate of application of the formulations usable according to the invention can vary within a relatively wide range. It is guided by the specific content of the active ingredients in the formulations and the seeds. Application rates for each single active ingredient are generally between 0.001 and 15 gr per kilogram of seed, preferably between 0.01 and 5 gr per kilogram of seed.

[0155] When using the compounds of Formula (I) as fungicides, application rates can vary within a relatively wide range, depending on the type of application. The application rate of the active ingredients of the invention is:

[0156] In the case of treatment of plant parts, for example, leaves: from 0.1 to 10,000 gr / ha, preferably from 10 to 1000 gr / ha, more preferably from 30 to 300 gr / ha (in the case of water application or dripping, it is even possible to reduce the application rate, especially when using inert substrates, such as rock wool or perlite);

[0157] In the case of seed treatment: from 0.1 to 200 gr per 100 kg of seed, preferably from 1 to 150 gr per 100 kg of seed, more preferably from 2.5 to 25 gr per 100 kg of seed, even more preferably from 2.5 to

12.5 gr per 100 kg of seed;

[0158] In the case of soil treatment: from 0.1 to 10,000 gr / ha, preferably from 1 to 5000 gr / ha.

[0159] The term seed covers seeds and plant propagules of all kinds, including, but not limited to, true seeds, pieces of seeds, sprouts, grains, bulbs, fruits, tubers, grains, rhizomes, cuttings, cut sprouts and the like and in a preferred embodiment means true seeds.

[0160] The present invention also comprises seeds coated or treated with or containing a compound of Formula (I). The term "coated or treated with and / or containing" generally means that the active ingredient is mostly on the seed surface at the time of application, although a greater or lesser part of the ingredient may penetrate the seed material, depending on the application method. In one embodiment, the present invention provides a plant propagation material adhered to it with a compound of Formula (I). In addition, a composition is available which comprises a plant propagating material treated with a compound of Formula (I).

[0161] Seed treatment comprises all suitable seed treatment techniques known in the art, such as seed treatment, coating, spraying, soaking and granulating. The application of the seed treatment of the compound of Formula (I), which is a preferred method of application, can be carried out by any known methods, such as spraying or sprinkling the seeds before or during the sowing / planting of the seeds.

[0162] These application rates are for example only and are not limiting for the purposes of the invention.

[0163] The compounds of the present invention were illustrated in Table 1, which shows the compounds of Formula (I) Formula (I)

[0164] The compounds of Formula (I) are prepared according to the schemes or examples disclosed in PCT patent applications WO2018069841 and WO2018069842; whose disclosure is incorporated in this document as a reference. Table: 1

Sir

Sir

Compound name Compound name No.

At the.

N '- (2,5-dimethyl-4- N' - (2-chloro-4- (phenylamino) phenyl) -N- (ethyl (phenyl) amino) -5- 1 404 ethyl-N-methylphenyl) -N -ethyl-N- methylformimidamide methylformimidamide N '- (2,5-dimethyl-4- N- (5-chloro-4- (methyl (phenyl) amino) fe ((((ethyl (methyl) amino) methyl 2 405 nil) -N-ethyl-N- no) amino) -2-methylphenyl) -N- methylformimidamide phenylacetamide N '- (2-chloro-5-methyl- N' - (2-chloro-4 - ((2- 4- ( phenylamino) phenyl) - ((difluoromethyl) thio) phenyl) 3 406 N-ethyl-N-amino) -5-methylphenyl) -N-methylformimidamide ethyl-N-methylformimidamide N '- (2-chloro-5-methyl- N '- (2-chloro-4 - ((2- 4- ((difluoromethyl) thio) phenyl) 4 (methyl (phenyl) amino) fe 407 (methyl) amino) -5-nyl) -N-ethyl-N- methylphenyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-4- (ethyl (3-N' - (4-benzyl-2,5-methoxyphenyl) amino) -5- 5 dimethylphenyl) -N -ethyl- 408 methylphenyl) -N-ethyl-N- N-methylformimidamide methylformimidamide N '- (2-chloro-4 - ((3-N' - (2,5-dimethyl-4- (N- (difluoromethoxy)) - 4-phenylmethylsulfonamide 6 409 fluorophenyl) amino) -5-) phenyl) -N-ethyl-N-methylphenyl) -N-ethyl-N-methylformimidam going methylformimidamide

Sir

Sir

Compound name Compound name No.

At the.

N '- (2,5-dimethyl-4- (methyl (2-methyl-4- N' - (2-chloro-4- (N- (3- (perfluoropropan-2-methoxyphenyl) methylsulfonami 7 410 yl) phenyl ) amino) phenyl) da) -5-methylphenyl) -N-ethyl- -N-ethyl-N- N-methylformimidamide methylformimidamide N '- (4 - ((4- N' - (4 - ((3-chlorophenyl) (methyl) ami (difluoromethoxy) -4- 8 no) -2,5- 411 fluorophenyl) amino) -2,5-dimethylphenyl) -N-ethyl-dimethylphenyl) -N-ethyl-N-N-methylformimidamide methylformimidamide N ' - (4 - ((3- N '- (2-chloro-4 - ((3-chlorophenyl) (methyl) ami (difluoromethoxy) -4- 9 no) -2,5- 412 fluorophenyl) (methyl) amino) - dimethylphenyl) -N-ethyl- 5-methylphenyl) -N-ethyl-N- N-methylformimidamide methylformimidamide N '- (4 - ((3,4- N' - (4 - ((3-dichlorophenyl) (methyl) a (difluoromethoxy) -4-10 min) -2,5- 413 fluorophenyl) (methyl) amino) -dimethylphenyl) -N-ethyl-2,5-dimethylphenyl) -N-ethyl- N-methylformimidamide N-methylformimidamide N ' - (2-chloro-5-methyl- N '- (4 - ((2,5- 4- (methyl (3,4,5-dimethylphenyl) amino) -2,5-11 trifluorophenyl) amino) 414 dimethylphenyl) -N-ethyl-N- phenyl) -N-ethyl-N- methylformimidamide methylformimidamide

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N '- (2-chloro-5-methyl- N' - (2-chloro-4 - ((2,5- 4- (methyl (m-dimethylphenyl) amino) -5-12 tolyl) amino) phenyl) - N- 415 methylphenyl) -N-ethyl-N- ethyl-N- methylformimidamide methylformimidamide N '- (2-chloro-4 - ((3,4- N- (5-chloro-4-dichlorophenyl) (methyl) a ( ((ethyl (methyl) amino) methyl 13 mino) -5-methylphenyl) - 416 no) amino) -2-methylphenyl) -N- N-ethyl-N- (2-chlorophenyl) propionamide methylformimidamide N '- (2- chloro-4 - (((3-N-ethyl-N '- (5-fluoro-4 - (((4-methoxyphenyl) (methyl) am methoxyphenyl) amino) -2- 14 ino) -5-methylphenyl) -N- 417 methylphenyl) -N- ethyl-N- methylformimidamide methylformimidamide N-ethyl-N '- (4- N-ethyl-N' - (5-fluoro-4 - ((4- (methoxy (phenyl) methyl) - methoxyphenyl) (methyl) amino) - 15 418 2,5-dimethylphenyl) -N- 2-methylphenyl) -N- methylformimidamide methylformimidamide N '- (2-chloro-5-methyl- N' - (2-chloro-4- (2 -fluoro-6- 4- (methyl (4- (trifluoromethyl) benzyl) - 16 (trifluoromethyl) phenyl 419 5-methylphenyl) -N-ethyl-N-) amino) phenyl) -N-ethyl-methylformimidamide N-methylformimidamide N '- (2-chloro-5-methyl- N' - (2-cyclopropyl-4- (2- 4- (methyl (p-fluorobenzyl) -5- 17 tolyl) amino) phenyl) -N- 420 methylphenyl) -N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide

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N '- (2-chloro-4 - ((2-methoxyphenyl) (methyl) am N' - (2-cyclopropyl-5-methyl-18 ino) -5-methylphenyl) -N- 421 4- (4-methylbenzyl ) phenyl) -N- ethyl-N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-5-methyl-N' - (4- (2-chlorobenzyl) -2- 4- (N-cyclopropyl-5 -methylphenyl) - 19 phenylmethylsulfonamide 422 N-ethyl-N-) phenyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-4 - ((2- N' - (2-cyclopropyl-5-methyl - chlorophenyl) (methyl) ami 4- (3- 20 no) -5-methylphenyl) -N- 423 (trifluoromethoxy) benzyl) ethyl-N- enyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (2 -chloro-4 - (((4- N- (5-chloro-4-chlorophenyl) (methyl) ami ((((ethyl (methyl) amino) methyl 21 no) -5-methyl phenyl) -N- 424 no) amino) -2-methylphenyl) -N- ethyl-N- (2-fluorophenyl-methylformimidamide) propionamide N '- (2-chloro-4- (N- (4- N' - (2-chloro-4 - ((4-fluoro -3- (1,1,2,2-methoxyphenyl) (methyl) am tetrafluoroethoxy) phenyl) met 22 ino) -5-methylphenyl) -N-425 ylsulfonamide) -5-ethyl-N-methylphenyl) -N-ethyl -N- methylformimidamide methylformimidamide N '- (4- (3,5- N-ethyl-N' - (2-fluoro-4- (4- dicl orobenzyl) -2,5-methylbenzyl) -5- 23 426 dimethylphenyl) -N-ethyl- (trifluoromethyl) phenyl) -N- N-methylformimidamide methylformimidamide

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N '- (4- (4- N' - (4- (2-chlorobenzyl) -2-bromobenzyl) -2,5-fluoro-5- 24 427 dimethylphenyl) -N-ethyl- (trifluoromethyl) phenyl) -N - N-methylformimidamide ethyl-N-methylformimidamide N '- (4- (3,4- N-ethyl-N' - (2-fluoro-4- (2-dichlorobenzyl) -2,5-fluorobenzyl) -5- 25 428 dimethylphenyl) -N-ethyl- (trifluoromethyl) phenyl) -N- N-methylformimidamide methylformimidamide N '- (2,5-dimethyl-4- (3- N-ethyl-N' - (2-fluoro-4- ( 2-methylbenzyl) phenyl) -N- methylbenzyl) -5- 26 429 ethyl-N- (trifluoromethyl) phenyl) -N- methylformimidamide methylformimidamide N '- (4- (4- N' - (4- (3-chlorobenzyl) -2- chlorobenzyl) -2,5- fluoro-5- 27 430 dimethylphenyl) -N-ethyl- (trifluoromethyl) phenyl) -N- N-methylformimidamide ethyl-N-methylformimidamide N '- (2,5-dimethyl-4 - (4- N-ethyl-N '- (2-fluoro-4- (3- (methylthio) benzyl) phen fluorobenzyl) -5- 28 431 yl) -N-ethyl-N- (trifluoromethyl) phenyl) -N - methylformimidamide methylformimidamide N '- (2-chloro-4 - ((4-methoxy-3-N-ethyl-N' - (2-fluoro-4- (3-methylphenyl) (methyl) ami methylbenzyl) -5- 29 432 no) -5-methylphenyl) -N- (trifluoromethyl) phenyl) -N- ethyl-N-methylfor mimidamide methylformimidamide

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N '- (2-chloro-4 - ((3,4-N-ethyl-N' - (2-fluoro-5-dimethoxyphenyl) (methyl) (trifluoromethyl) -4- (3- 30 amino) -5- methylphenyl) - 433 (trifluoromethyl) benzyl) fe N-ethyl-N-nyl) -N-methylformimidamide methylformimidamide N '- (2-chloro-4 - ((3,5- N-ethyl-N' - (2-fluoro -4- (3-dimethoxyphenyl) (methyl) (trifluoromethoxy) benzyl) - 31 amino) -5-methylphenyl) - 434 5- (trifluoromethyl) phenyl) - N-ethyl-N- N-methylformimidamide methylformimidamide N '- (5 -chloro-4- (cyano (5- N '- (2,5-dimethyl-4- (4-fluoro-2-methylbenzyl) phenyl) -N- 32 435 methylphenyl) methyl) -2-ethyl-N-methylphenyl ) -N-ethyl-N-methylformimidamide methylformimidamide N '- (4- (3-methyl 2- (2-chloro-4-chlorobenzyl) -2,5- ((((ethyl (methyl) amino) methyl 33 436 dimethylphenyl) -N-ethyl- (amino) -5-methylphenyl) -2- N-methylformimidamide (3-chlorophenyl) acetate N '- (2,5-dimethyl-4- (4- N' - (4- (1- (4-bromophenyl)) - (methylsulfonyl) benzyl 34 437 5-chloro-2-methylphenyl) -N- o) phenyl) -N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide N '- (2,5-dimethyl -4- N '- (2,5-dimethyl-4 - ((3- (methyl (m- (1,1,2,2- 35 tolyl) amino) phenyl) -N - 438 tetrafluoroethoxy) phenyl) ami ethyl-N- no) phenyl) -N-ethyl-N-methylformimidamide methylformimidamide

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N-ethyl-N '- (4 - ((3- N' - (2,5-dimethyl-4-methoxyphenyl) (methyl) am (methyl (3- (1,1,2,2- 36 ino) - 2,5- 439 tetrafluoroethoxy) phenyl) ami dimethylphenyl) -N- no) phenyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (2,5-dimethyl-4- N-ethyl-N' - (4- ((2-fluoro-5- (methyl (p-methylphenyl) amino) -2,5- 37 tolyl) amino) phenyl) -N- 440 dimethylphenyl) -N- ethyl-N-methylformimidamide methylformimidamide N-ethyl-N ' - (4 - ((4- N-ethyl-N '- (5-fluoro-4 - (((2-methoxyphenyl) (methyl) am fluorophenyl) amino) -2- 38 ino) -2,5- 441 methylphenyl) -N- dimethylphenyl) -N- methylformimidamide methylformimidamide N-ethyl-N '- (4 - ((3-N-ethyl-N' - (4 - (((2-fluoro-5-methoxyphenyl) amino) - methylphenyl) ( methyl) amino) - 39 442 2,5-dimethylphenyl) -N- 2,5-dimethylphenyl) -N- methylformimidamide methylformimidamide N '- (2-chloro-4 - ((2-fluoro- N' - (2,5 -dimethyl-4- (m-5-tolylamino) phenyl) -N- 40 443 methylphenyl) (methyl) amino) - ethyl-N- 5-methylphenyl) -N-ethyl-N-methylformimidamide methylformimidamide N-ethyl-N ' - (4 - ((4- N-ethyl-N '- (5-fluoro-2-methylphenyl) (methyl) ami methyl-4- 41 no) -2,5- 444 (phenylamino) fen il) -N- dimethylphenyl) -N- methylformimidamide methylformimidamide

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N '- (4- (3- N' - (4 - ((2-bromobenzyl) -2-chloro-chlorophenyl) amino) -5- 42 445 5-methylphenyl) -N-ethyl-fluoro-2-methylphenyl) -N- N-methylformimidamide ethyl-N-methylformimidamide N '- (4- (3- N' - (4 - ((4- (tert-bromobenzyl) -2,5-butyl) phenyl) amino) -5- 43 446 dimethylphenyl) -N-ethyl-fluoro-2-methylphenyl) -N- N-methylformimidamide ethyl-N-methylformimidamide N-ethyl-N '- (4- (2- N-ethyl-N' - (5-fluoro- 2- fluorobenzyl) -2,5-methyl-4- (m- 44 447 dimethylphenyl) -N-tolylamino) phenyl) -N- methylformimidamide methylformimidamide N '- (2-chloro-4- (2- N- (5- chloro-4-fluorobenzyl) -5- ((((ethyl (methyl) amino) methyl 45 448 methylphenyl) -N-ethyl-N- no) amino) -2-methylphenyl) -N- methylformimidamide phenylpropionamide N '- (2- chloro-4- (2- N- (5-chloro-4-chlorobenzyl) -5- ((((ethyl (methyl) amino) methyl 46 449 methylphenyl) -N-ethyl-N- no) amino) -2-methylphenyl ) -N- methylformimidamide (3-methoxyphenyl) acetamide N '- (4- (2- N' - (2-chloro-4 - (((4-fluoro-chlorobenzyl) -2,5- 3-methoxyphenyl) amino) - 5- 47 450 dimethylphenyl) -N-ethyl-methylphenyl) -N-ethyl-N-N-methylformimidamide methylformimidamide N ' - (2,5-dimethyl-4- (4-N-ethyl-N '- (4 - ((4-fluoro-3- (methylsulfinyl) benzyl methoxyphenyl) amino) -2,5- 48 451 o) phenyl) -N-ethyl-N- dimethylphenyl) -N- methylformimidamide methylformimidamide

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N '- (4 - ((4- (tert- N-ethyl-N' - (4 - ((4-fluoro-3-butyl) phenyl) (methyl) am methoxyphenyl) (methyl) amino) - 49 ino) -2,5- 452 2,5-dimethylphenyl) -N- dimethylphenyl) -N-ethyl-methylformimidamide N-methylformimidamide N '- (4 - ((4- (tert- N' - (4 - ((2-butyl ) phenyl) amino) - ((difluoromethyl) thio) phenyl) 50 2,5-dimethylphenyl) -N- 453 amino) -2,5-dimethylphenyl) - ethyl-N-N-ethyl-N-methylformimidamide methylformimidamide N'- (4 - ((2- N '- (4 - ((2-chlorophenyl) amino) - ((difluoromethyl) thio) phenyl) 51 2,5-dimethylphenyl) -N- 454 (methyl) amino) -2,5 - ethyl-N-dimethylphenyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (4 - ((2- N' - (2-chloro-4 - (((4-fluoro-chlorophenyl) (methyl) ami 3- 52 no) -2,5- 455 methoxyphenyl) (methyl) amino) - dimethylphenyl) -N-ethyl-5-methylphenyl) -N-ethyl-N- N-methylformimidamide methylformimidamide N '- (2-chloro-4- ( (2- N '- (2-bromo-6-fluoro-3-chlorophenyl) amino) -5-methyl-4- 53 456 methylphenyl) -N-ethyl-N- (phenylamino) phenyl) -N-ethyl-methylformimidamide N-methylformimidamide N '- (2-chloro-5-methyl-4 - ((5-N' - (2-chloro-4- (3,4-oxo-5,6,7,8-dichlorobenzyl) -5 - 54 457 tetrahydronaphthalene-2-methylphenyl) -N-ethyl-N-yl) amino) phenyl) -N-ethyl-N-methylformimidamide methylformimidamide

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N '- (2-chloro-4- (3,5- N' - (2-chloro-5-methyl-4 - ((1-dichlorobenzyl) -5-methylindoline-5- 55 458 methylphenyl) -N-ethyl -N- yl) amino) phenyl) -N-ethyl-N- methylformimidamide methylformimidamide 2- (2-chloro-5-ethyl-4- N '- (4- (4- ((((ethyl (methyl) amino) methyl) bromobenzyl) -2-chloro-56 459 no) amino) phenyl) -2- (3- 5-methylphenyl) -N-ethyl-fluorophenyl) -N, N-N-methylformimidamide dimethylpropanamide 2- (2-chloro-4- N '- (2,5-dimethyl-4- (2- ((((ethyl (methyl) amino) methyl (methylthio) benzyl) phen 57 460 no) amino) -5-methylphenyl) -2-yl) -N- ethyl-N- (3-fluorophenyl) -N, N-methylformimidamide dimethylpropanamide 2- (2-chloro-4- N '- (2,5-dimethyl-4- (2- (((ethyl (methyl) amino) methyl) (methylsulfinyl) benzyl 58 461 no) amino) -5-methylphenyl) -2- o) phenyl) -N-ethyl-N- (5-fluoro-2-methylphenyl) - methylformimidamide N, N-dimethylacetamide N '- (2 , 5-dimethyl-4- (2- N '- (5-chloro-4 - (((4-chloro-3- (methylsulfonyl) benzyl fluorophenyl) (cyano) methyl) - 59 462 o) phenyl) -N-ethyl -N- 2-methylphenyl) -N-ethyl-N- methylformimidamide methylformimidamide N-ethyl-N '- (4 - ((2-fluorophenyl) (methyl) am N' - (2,5-difluor o-4- (2- 60 ino) -2,5- 463 fluorobenzyl) phenyl) -N- dimethylphenyl) -N- ethyl-N-methylformimidamide methylformimidamide

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N '- (2-chloro-4 - ((2-fluorophenyl) (methyl) am N' - (4- (3-chlorobenzyl) -2,5- 61 ino) -5-methylphenyl) -N- 464 difluorophenyl) -N-ethyl-N- ethyl-N-methylformimidamide methylformimidamide N-ethyl-N '- (4 - ((3-fluorophenyl) (methyl) am N' - (2,5-difluoro-4- (3- 62 ino ) -2,5- 465 methylbenzyl) phenyl) -N-ethyl-dimethylphenyl) -N- N-methylformimidamide methylformimidamide N-ethyl-N '- (4 - (((4-fluorophenyl) (methyl) am N' - (2 , 5-difluoro-4- (4- 63 ino) -2,5- 466 methylbenzyl) phenyl) -N-ethyl-dimethylphenyl) -N- N-methylformimidamide methylformimidamide N '- (4- (2,5- N' - (4- (2-chlorobenzyl) -5- dimethylbenzyl) -2,5- 64 467 cyano-2-methylphenyl) -N-dimethylphenyl) -N-ethyl-ethyl-N-methylformimidamide N-methylformimidamide N '- (4 - (3-bromo-2- N '- (5-cyano-4- (2-fluorobenzyl) -2,5-fluorobenzyl) -2- 65 468 dimethylphenyl) -N-ethyl-methylphenyl) -N-ethyl-N - N-methylformimidamide methylformimidamide N '- (4- (3-chloro-4- N' - (5-cyano-2-methyl-4- (2-fluorobenzyl) -2,5- 66 469 methylbenzyl) phenyl) -N -ethyl-dimethylphenyl) -N-ethyl- N-methylformimidamide N-methylformimidamide

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N-ethyl-N '- (4- (3- N' - (4- (3-chlorobenzyl) -5-fluorobenzyl) -2,5- 67 470 cyano-2-methylphenyl) -N-dimethylphenyl) -N- ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-4- (3- N' - (5-cyano-4- (3-fluorobenzyl) -5-fluorobenzyl) -2- 68 471 methylphenyl) -N-ethyl -N- methylphenyl) -N-ethyl-N- methylformimidamide methylformimidamide N '- (2,5-dimethyl-4- N' - (5-cyano-2-methyl-4- (3- ((methylimino) (phenyl) m 69 472 methylbenzyl) phenyl) -N-ethyl-ethyl) phenyl) -N-ethyl-N- N-methylformimidamide methylformimidamide N '- (2,5-dimethyl-4- (2- N' - (5-cyano- 2-methyl-4- (4-methylbenzyl) phenyl) -N- 70 473 methylbenzyl) phenyl) -N-ethyl-ethyl-N- N-methylformimidamide methylformimidamide N '- (2,5-dimethyl-4- (2- N '- (4- (2-chlorobenzyl) -2,5-phenyl-1,3-dithiolan-2- 71 474 difluorophenyl) -N-ethyl-N-yl) phenyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (4 - ((4-chlorophenyl) amino) - N' - (2,5-difluoro-4- (2-72 2,5-dimethylphenyl) -N- 475 methylbenzyl) phenyl) -N-ethyl- ethyl-N- N-methylformimidamide methylformimidamide N-ethyl-N '- (4 - ((4- N' - (5-chloro-4- (2-fluorophenyl) amino) - chlorobenzyl) -2- 73 476 2,5-dimethylphenyl) -N-methylphenyl) -N-ethyl-N-methylformimidamide methylformimidamide

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N- (4- (3-chloro-4- N '- (5-chloro-4- (2-fluorobenzyl) -2,5-fluorobenzyl) -2- 74 477 dimethylphenyl) -1- methylphenyl) -N-ethyl -N- morpholinomethimine methylformimidamide N- (4- (3-chloro-4-fluorobenzyl) -2,5- N '- (5-chloro-2-methyl-4- (2-75 dimethylphenyl) -1- 478 methylbenzyl) phenyl) -N-ethyl- (piperidin-1- N-methylformimidamide yl) metanimine N- (4- (3-bromo-2- N '- (5-chloro-4- (3-fluorobenzyl) -2,5- chlorobenzyl) -2- 76 479 dimethylphenyl) -1- methylphenyl) -N-ethyl-N-morpholinomethimine methylformimidamide N- (4- (3-bromo-2- N '- (5-chloro-4- (3-fluorobenzyl) -2,5- fluorobenzyl) -2- 77 dimethylphenyl) -1- 480 methylphenyl) -N-ethyl-N- (piperidin-1-methylformimidamide yl) metanimine N- (2-chloro-4- (3- N'- (5-chloro-2-methyl-4- (3-fluorobenzyl) -5- 78 481 methylbenzyl) phenyl) -N-ethyl-methylphenyl) -1- N-methylformimidamide morpholinometanimine N- (2-chloro-4- (3 - fluorobenzyl) -5- N '- (5-chloro-2-methyl-4- (4- 79 methylphenyl) -1- 482 methylbenzyl) phenyl) -N-ethyl- (piperidin-1- N-methylformimidamide yl) metanimine

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N- (2-chloro-4- (2- N '- (4- (2-chlorobenzyl) -2-chlorobenzyl) -5-cyclopropyl-5- 80 483 methylphenyl) -1- (trifluoromethyl) phenyl) -N- morpholinomethimine ethyl-N-methylformimidamide N-ethyl-N '- (4 - ((2- N' - (2-cyclopropyl-4- (3-methoxyphenyl) amino) - methylbenzyl) -5- 81 484 2,5-dimethylphenyl ) -N- (trifluoromethyl) phenyl) -N- methylformimidamide ethyl-N-methylformimidamide N-ethyl-N '- (4 - ((3- N' - (2-cyclopropyl-4- (4-fluorophenyl) amino) - methylbenzyl) -5- 82 485 2,5-dimethylphenyl) -N- (trifluoromethyl) phenyl) -N- methylformimidamide ethyl-N-methylformimidamide N '- (2-chloro-4 - ((2- N' - (4- (3-chlorobenzyl) -2-fluorophenyl) amino) -5-cyclopropyl-5- 83 486 methylphenyl) -N-ethyl-N- (trifluoromethyl) phenyl) -N-methylformimidamide ethyl-N-methylformimidamide N '- (2- chloro-4 - (((3-N '- (2-cyclopropyl-4- (3-chlorophenyl) amino) -5-fluorobenzyl) -5- 84 487 methylphenyl) -N-ethyl-N- (trifluoromethyl) phenyl) - N- methylformimidamide ethyl-N-methylformimidamide N '- (2,5-dimethyl-4 - ((5-oxo- N- (3-chlorophenyl) - 5,6,7,8- N, 2,5-trimethyl- 4- 85 488 tetrahydronaphthalene-2- ((morpholinomethi leno) to yl) amino) phenyl) -N-ethyl-N-mino) aniline methylformimidamide N '- (2-chloro-4 - (((3-N-ethyl-N' - (5-fluoro-2-chlorophenyl) (methyl) ami methyl-4- 86 no) -5-methylphenyl) -N- 489 (methyl (phenyl) amino) phenyl) -ethyl-N-N-methylformimidamide methylformimidamide

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N- (3-chlorophenyl) - N '- (4 - ((4- (tert-N, 2,5-trimethyl-4-butyl) phenyl) (methyl) amino) - 87 ((piperidin-1- 490 5 -fluoro-2-methylphenyl) -N-ylmethylene) amino) anil ethyl-N-methylformimidamide ina N '- (4 - ((3-N-ethyl-N' - (5-fluoro-2-chlorophenyl) (methyl) ami methyl-4- (methyl (m-88 no) -2,5- 491 tolyl) amino) phenyl) -N- dimethylphenyl) -N- methylformimidamide cyanoformimidamide N-allyl-N '- (4 - ((3- N '- (2-cyclopropyl-4- (2-chlorophenyl) (methyl) ami methylbenzyl) -5- 89 no) -2,5- 492 (trifluoromethyl) phenyl) -N-dimethylphenyl) -N- ethyl-N-methylformimidamide methylformimidamide N '- (4 - ((3-chlorophenyl) (methyl) ami N' - (2,5-difluoro-4- (3-no) -2,5- 90 493 fluorobenzyl) phenyl) -N- dimethylphenyl) -N- ethyl-N-methylformimidamide isopropyl-N- methylformimidamide N '- (4 - ((2- N' - (2-chloro-4- (cyano (3-bromophenyl) amino) - (trifluoromethyl) phenyl) methyl 91 2,5-dimethylphenyl) -N- 494 l) -5-methylphenyl) -N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide

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N '- (4 - ((3-N-ethyl-N-methyl-N' - (5-chlorophenyl) amino) - methyl-4- (2-methylbenzyl) -2- 92 2,5-dimethylphenyl) -N - 495 (methylsulfonyl) phenyl) formyl ethyl-N-midamide methylformimidamide N-ethyl-N '- (4 - (((4-N-ethyl-N-methyl-N' - - (5-methoxyphenyl) amino) - methyl-4 - (4-methylbenzyl) -2- 93 496 2,5-dimethylphenyl) -N- (methylsulfonyl) phenyl) formi methylformimidamide midamide N '- (2-chloro-5-methyl- N' - (4- (3-chlorobenzyl ) -5- 4- (3-methyl-2- 94 methylbenzyl) phenyl) -N- 497 (methylsulfonyl) phenyl) -N- ethyl-N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-5- methyl- N-ethyl-N '- (4- (3- 4- (4-fluorobenzyl) -5-methyl-2- 95 methylbenzyl) phenyl) -N- 498 (methylsulfonyl) phenyl) -N- ethyl-N- methylformimidamide methylformimidamide N '- (2,5-dimethyl-4-N-ethyl-N-methyl-N' - (5- ((2-methyl-4- (3-methylbenzyl) -2- 96 (trifluoromethyl) phenyl 499 (methylsulfonyl) phenyl) formi) amino) phenyl) -N-ethyl-midamide N-methylformimidamide N '- (2,5-dimethyl-4- N-ethyl-N' - (4- (2- (methyl (2- fluorobenzyl) -5-methyl-2- 97 (trifluoromethyl) phenyl 500 (methylsulfonyl) phenyl) -N-) amino) phenyl) -Ne til-methylformimidamide N-methylformimidamide

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N-ethyl-N '- (4- (3- N' - (4- (2-chlorobenzyl) -5-methoxybenzyl) -2,5-methyl-2- 98 501 dimethylphenyl) -N- (methylsulfonyl) phenyl) -N- methylformimidamide ethyl-N-methylformimidamide N-ethyl-N-methyl-N '- (5- N' - (2,5-dimethyl-4- (3-methyl-2- (methylsulfonyl) -4- (trifluoromethyl ) benzyl 99 502 (3-lo) phenyl) -N-ethyl-N- (trifluoromethyl) benzyl) fe methylformimidamide nil) formimidamide N-ethyl-N-methyl-N '- (5- N' - (4- (3 - methyl-2- (methylsulfonyl) -4- cyanobenzyl) -2,5- 100 503 (3-dimethylphenyl) -N-ethyl- (trifluoromethoxy) benzyl) f N-methylformimidamide enyl) formimidamide N '- (4- (4 - N '- (2-chloro-4 - ((2-fluoro-cyanobenzyl) -2,5- 5-methylphenyl) amino) -5- 101 504 dimethylphenyl) -N-ethyl-methylphenyl) -N-ethyl-N - N-methylformimidamide methylformimidamide N '- (2,5-dimethyl-4- (3-N' - (2,5-dimethyl-4 - ((1-nitrobenzyl) phenyl) -N- methylindoline-5- 102 505 ethyl -N- yl) amino) phenyl) -N-ethyl-N- methylformimidamide methylformimidamide 2- (4-chloro-3-fluorophenyl) - N '- (2,5-dimethyl-4- (2- 2- (2- chloro-4-nitrobenzyl) phenyl) -N- 103 506 ((((ethyl (methyl) amino) methyl ethyl-N- no) amino) -5-methylphenyl) - methylformimidamide N, N-dimethylpropanamide

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Compound name Compound name No.

No. 2- (4-chloro-3-fluorophenyl) - N '- (2,5-dimethyl-4- (3- 2- (2-chloro-5-ethyl-4- (trifluoromethoxy) benz 104 507 (( (ethyl (methyl) amino) methyl yl) phenyl) -N-ethyl-N- no) amino) phenyl) -N, N-methylformimidamide dimethylpropanamide N-ethyl-N '- (4- (3- 2- (5- chloro-4-fluoro-5- ((((ethyl (methyl) amino) methyl (trifluoromethyl) benzyl 105 508 no) amino) -2-methylphenyl) -2- lo) -2,5- (3-fluorophenyl) -N , N-dimethylphenyl) -N- dimethylacetamide methylformimidamide N '- (2,5-dimethyl-4- (2- 2- (5-chloro-4-methyl-5- (((ethyl (methyl) amino) methyl 106 ( trifluoromethyl) benzi 509 no) amino) -2-methylphenyl) -2- lo) phenyl) -N-ethyl-N- (3-fluorophenyl) -N, N-methylformimidamide dimethylpropanamide N-ethyl-N '- (4- ( 4- N '- (2-chloro-4- (1- (3-methoxybenzyl) -2,5-fluorophenyl) vinyl) -5- 107 510 dimethylphenyl) -N-methylphenyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (2,5-dimethyl-4- N' - (2,5-dichloro-4 - ((2,3- ((4-dihydro-1H-inden-4- 108 (trifluoromethyl) phenyl 511 yl) amino) phenyl) -N-ethyl-N-) amino) phenyl) -N-ethyl-methylformimidamide N-methylformimidamide

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N '- (2,5-dimethyl-4- ((3- N' - (4 - ((2,3-dihydro-1H- (trifluoromethoxy) pheni inden-4-yl) amino) -2,5-109 512 l) amino) phenyl) -N- dimethylphenyl) -N-ethyl-N- ethyl-N-methylformimidamide methylformimidamide N '- (2,5-dimethyl-4 N' - (2-chloro-4 - ((2 , 3- (methyl (4-dihydro-1H-inden-4- 110 (trifluoromethyl) phenyl 513 yl) amino) -5-methylphenyl) -N-) amino) phenyl) -N-ethyl-ethyl-N-methylformimidamide N -methylformimidamide N '- (2,5-dimethyl-4- (methyl (3-N' - (2,5-dichloro-4 - ((2,3- (trifluoromethoxy) pheni dihydro-1H-inden-4- 111 514 l) amino) phenyl) -N-yl) (methyl) amino) phenyl) -N- ethyl-N-ethyl-N-methylformimidamide methylformimidamide N '- (2,5-dimethyl-4- N' - (4- ((2,3-dihydro-1H- ((3-inden-4-yl) (methyl) amino) - 112 (methylthio) phenyl) amino 515 2,5-dimethylphenyl) -N-ethyl-) phenyl) -N -ethyl-N- N-methylformimidamide methylformimidamide N '- (4 - ((2- N' - (4- (cyano (3-bromophenyl) (methyl) ami (trifluoromethyl) phenyl) methyl 113 no) -2,5- 516 l) -2,5-dimethylphenyl) -N, N-dimethylphenyl) -N-ethyl-dimethylformimidamide N-methylformimidamide

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N- (4- (2- N '- (4- (cyano (3-fluorobenzyl) -2,5- (trifluoromethyl) phenyl) methyl 114 517 dimethylphenyl) -1- 1) -2,5-dimethylphenyl) -N - morpholinomethimine ethyl-N-methylformimidamide N- (4- (4- N '- (2-chloro-5-methyl-4- (N-fluorobenzyl) -2,5-phenylethylsulfonamide) phenyl 115 518 dimethylphenyl) -1-) -N-ethyl-N- morpholinomethimine methylformimidamide N-ethyl-N '- (4- (4- N' - (2-chloro-4- (N- (3-fluorobenzyl) -2,5-methoxyphenyl) ethylsulfonamid 116 519 dimethylphenyl) -N- a) -5-methylphenyl) -N-ethyl-N-methylformimidamide methylformimidamide N- (4- (2- N '- (2-chloro-5-methyl-4 - (((1-fluorobenzyl) - 2,5- methyl-1,2,3,4- 117 dimethylphenyl) -1- 520 tetrahydroquinolin-6- (piperidin-1-yl) amino) phenyl) -N-ethyl-N- yl) metanimine methylformimidamide N- ( 4- (2-chlorobenzyl) - N-ethyl-N '- (2-fluoro-5- 2,5-dimethylphenyl) -1- methyl-4- 118 521 (piperidin-1- (phenylamino) phenyl) -N- il) metanimine methylformimidamide N- (4- (4- N '- (2-chloro-4- (N- (4-fluorobenzyl) -2,5-methoxyphenyl) methylsulfonami 119 dimethylphenyl) -1- 522 da) -5- methylphenyl) -N-ethyl- (piperidin-1- N-methylformimidamide il) metanimine

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N '- (4- (2- N-ethyl-N' - (2-fluoro-4 - (((2-fluorobenzyl) -2,5-methoxyphenyl) amino) -5-120 dimethylphenyl) -N- 523 methylphenyl) -N- methoxy-N- methylformimidamide methylformimidamide N '- (4- (2- N' - (2-chloro-5-methyl-4-chlorobenzyl) -2,5- (methyl (5-oxo-5,6, 7.8- 121 dimethylphenyl) -N- 524 tetrahydronaphthalene-2-methoxy-N-yl) amino) phenyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-5-methyl-4- (methyl (6-methyl-5-oxo- N- (4- (2-chlorobenzyl) - 5,6,7,8-2 122 2,5-dimethylphenyl) -1- 525 tetrahydronaphthalene-2-morpholinomethimine yl) amino) phenyl) -N-ethyl-N-methylformimidamide N-cyano-N '- (4- (2- N-ethyl-N' - (4- (methoxy (o-fluorobenzyl) -2,5-tolyl) methyl) -2, 5- 123 526 dimethylphenyl) formimid dimethylphenyl) -N- amide methylformimidamide N '- (2-chloro-5-methyl-4- N' - (4- (2- ((5,6,7,8-chlorobenzyl) - 2.5 - 124 527 tetrahydronaphthalene-1-dimethylphenyl) -N-yl) amino) phenyl) -N-ethyl-N-cyanoformimidamide methylformimidamide N '- (4- (2- N' - (2,5-dimethyl-4 - fluorobenzyl) -2,5- ((5,6,7,8- 125 dimethylphenyl) -N- 528 tetrahydronaphthalene-1-isopropylformi midamid il) amino) phenyl) -N-ethyl-N- a methylformimidamide

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N '- (4- (2- N' - (2,5-dimethyl-4- (3-chlorobenzyl) -2,5- (trifluoromethyl) benzyl) fe 126 dimethylphenyl) -N- 529 nil) -N, N - N '- (4- (1- (4-bromophenyl) - N' - (2-chloro-4- (4- 2,2,2-trifluoro-1-cyanobenzyl) -5- 127 530 hydroxyethyl isopropylformimidamide ) -2-chloro-5-methylphenyl) -N-ethyl-N-methylphenyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (4- (1- (4-bromophenyl) - N' - (2-chlorine -4- (4- 2,2,2-trifluoro-1-methoxybenzyl) -5- 128 531 ((trimethylsilyl) oxy) ethyl) - methylphenyl) -N-ethyl-N-2-chloro-5-methylphenyl) - N- methylformimidamide ethyl-N-methylformimidamide N '- (2-chloro-4- (3- N' - (2-chloro-4- (methoxy (o-methoxybenzyl) -5-tolyl) methyl) -5- 129 532 methylphenyl) -N-ethyl-N-methylphenyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-5-methyl- N' - (4 - ((4- 4- (3- bromophenyl) ( methylimino) met 130 nitrobenzyl) phenyl) -N- 533 yl) -2-chloro-5-methylphenyl) - ethyl-N- N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-4- (3- N '- (2-chloro-4 - ((4-cyanobenzyl) -5-chlorophenyl) (methoxy) methyl) - 131 534 methylphenyl) -N -ethyl-N- 5-methylphenyl) -N-ethyl-N-methylformimidamide methylformimidamide

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N-ethyl-N '- (4 - ((2- N-ethyl-N' - (4 - (((2-methoxyphenyl) (methyl) am fluorophenyl) amino) -5- 132 ino) -2,5- 535 methyl-2-dimethylphenyl) -N- (methylsulfonyl) phenyl) -N- methylformimidamide methylformimidamide N '- (2,5-dimethyl-4- N' - (2-chloro-4 - ((4- (methyl (3- chlorophenyl) (methylimino) met 133 (methylthio) phenyl) amino 536 yl) -5-methylphenyl) -N-ethyl-) phenyl) -N-ethyl-N- N-methylformimidamide methylformimidamide N '- (2-chloro-5- methyl- N-ethyl-N-methyl-N '- (5- 4 - ((3-methyl-2- (methylsulfonyl) -4- 134 (methylthio) phenyl) amino 537 (p-) phenyl) -N-ethyl -N- tolylamino) phenyl) formimide methylformimidamide N '- (2-chloro-5-methyl- N' - (4 - ((4- (tert- 4- (m-butyl) phenyl) amino) -5- 135 tolylamino) phenyl) -N- 538 methyl-2-ethyl-N- (methylsulfonyl) phenyl) -N-methylformimidamide ethyl-N-methylformimidamide N '- (2-chloro-4 - ((3-N-ethyl-N' - (2-fluoro-4 - ((2-methoxyphenyl) amino) -5-fluorophenyl) amino) -5- 136 539 methylphenyl) -N-ethyl-N-methylphenyl) -N- methylformimidamide methylformimidamide N '- (2- chloro-5-methyl- N-ethyl-N '- (2-fluoro-4 - ((2- 4- (o-methoxyphenyl) (methyl) amino) - 137 toli lamino) phenyl) -N- 540 5-methylphenyl) -N- ethyl-N-methylformimidamide methylformimidamide

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N '- (2-chloro-4 - ((4-N-ethyl-N' - (2-fluoro-4 - ((2-chlorophenyl) amino) -5-fluorophenyl) (methyl) amino) - 138 541 methylphenyl ) -N-ethyl-N- 5-methylphenyl) -N- methylformimidamide methylformimidamide N '- (2,5-dimethyl-4- (o-N' - (2-chloro-4- (N- (4-tolylamino) phenyl) -N- methoxyphenyl) ethylsulfonamid 139 542 ethyl-N- a) -5-methylphenyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-4 - ((4- N- (5-chlorine -4- methoxyphenyl) amino) -5- ((((ethyl (methyl) amino) methyl 140 543 methylphenyl) -N-ethyl-N- no) amino) -2-methylphenyl) -N- methylformimidamide (4-methoxyphenyl) acetamide N '- (2-chloro-5-methyl- N-ethyl-N' - (2-fluoro-5- 4- (methyl (o-methyl-4- 141 tolyl) amino) phenyl) -N- 544 (methyl (phenyl) amino) phenyl) - ethyl-N- N-methylformimidamide methylformimidamide N '- (4 - ((2- N' - (2-chloro-4- (ethyl (2-bromophenyl) amino) -2-methoxyphenyl) amino) -5- 142 chloro-5-methylphenyl) - 545 methylphenyl) -N-ethyl-N- N-ethyl-N-methylformimidamide methylformimidamide N '- (4 - ((2- N' - (2-chloro-4 - (N- (2-bromophenyl) (methyl) ami methoxyphenyl) methylsulfonami 143 no) -2-chloro-5- 546 da) -5-methylphenyl ) -N-ethyl-methylphenyl) -N-ethyl-N- N-methylformimidamide methylformimidamide

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N '- (2,5-dimethyl-4- N- (5-chloro-4- (methyl (o- ((((ethyl (methyl) amino) methyl 144 tolyl) amino) phenyl) -N- 547 no) amino ) -2-methylphenyl) -N- ethyl-N- (2-methoxyphenyl) acetamide methylformimidamide N '- (2-chloro-4 - ((2- N' - (4 - ((2-methoxyphenyl) amino) -5 - bromophenyl) (methylimino) met 145 548 methylphenyl) -N-ethyl-N- yl) -2,5-dimethylphenyl) -N- methylformimidamide ethyl-N-methylformimidamide N '- (2-chloro-5-methyl- N' - (2-chloro-5-methyl-4- 4 - ((2- ((methylimino) (phenyl) methyl) 146 (trifluoromethyl) phenyl 549 phenyl) -N-ethyl-N-) amino) phenyl) -N- ethyl-methylformimidamide N-methylformimidamide N '- (2-chloro-5-methyl- N' - (4 - ((2- 4- (methyl (2-bromophenyl) (methoxy) methyl) - 147 (trifluoromethyl) phenyl 550 2 , 5-dimethylphenyl) -N-ethyl-) amino) phenyl) -N-ethyl- N-methylformimidamide N-methylformimidamide N '- (2-chloro-5-methyl- N-ethyl-N-methyl-N' - ( 5- 4 - ((4-methyl-2- (methylsulfonyl) -4- 148 (trifluoromethyl) phenyl 551 (phenylamino) phenyl) formimid) amino) phenyl) -N-ethyl-amide N-methylformimidamide N-ethyl-N ' - (4 - ((3- N '- (2-chloro-4 - (((3-methoxyphenyl) amino) -5-fluorophenyl) amino) -5- 149 552 methyl-2-methylphenyl) -N-ethyl-N- (methylsulfonyl) phenyl) -N- methylformimidamide methylformimidamide

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N-ethyl-N '- (4 - ((2- N' - (2-chloro-4 - (((4-fluorophenyl) (methyl) amino) - fluorophenyl) amino) -5- 150 553 5-methyl-2 - methylphenyl) -N-ethyl-N- (methylsulfonyl) phenyl) -N- methylformimidamide methylformimidamide N '- (2-chloro-4 - ((3-N-ethyl-N-methyl-N' - (5-fluorophenyl) (methyl) am methyl-4- (methyl (p-151 ino) -5-methylphenyl) -N- 554 tolyl) amino) -2-ethyl-N- (methylsulfonyl) phenyl) formi methylformimidamide N '- (2- chloro-4 - ((4-N '- (4 - ((2-fluorophenyl) (methyl) am chlorophenyl) amino) -2- 152 ino) -5-methylphenyl) -N- 555 fluoro-5-ethyl-N - (trifluoromethyl) phenyl) -N- methylformimidamide ethyl-N-methylformimidamide N '- (4 - (((3-N' - (4-benzyl-2-chlorophenyl) amino) -2-chloro-5-methylphenyl) - 153 556 fluoro-5- N-ethyl-N- (trifluoromethyl) phenyl) -N- methylformimidamide ethyl-N-methylformimidamide N '- (2-chloro-5-methyl- N' - (4 - ((4- 4- ( 2-chlorophenyl) amino) -2- 154 nitrobenzyl) phenyl) -N- 557 fluoro-5-ethyl-N- (trifluoromethyl) phenyl) -N-methylformimidamide ethyl-N-methylformimidamide N-ethyl-N-methyl-N ' - (5- N '- (2-chloro-4- (4-methyl-4-fluorobenzyl) -5- 155 558 (methyl ( phenyl) amino) -2-methylphenyl) -N-ethyl-N- (methylsulfonyl) phenyl) formi methylformimidamide midamide

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N '- (2-chloro-5-methyl- N' - (4 - ((2- 4- (4-chlorophenyl) (methyl) amino) - ((trifluoromethyl) thio) 156 559 2-fluoro-5-benzyl ) phenyl) -N- (trifluoromethyl) phenyl) -N- ethyl-N- ethyl-N-methylformimidamide methylformimidamide N '- (4 - ((3- N' - (2-chloro-4- (3-chlorophenyl)) methyl) amino) - chlorobenzyl) -5- 157 560 2-fluoro-5-methylphenyl) -N-ethyl-N- (trifluoromethyl) phenyl) -N-methylformimidamide ethyl-N-methylformimidamide N '- (4 - ((4 - N '- (2-chloro-4- (4-chlorophenyl) (methyl) amino) - chlorobenzyl) -5- 158 561 2-fluoro-5-methylphenyl) -N-ethyl-N- (trifluoromethyl) phenyl) - N- methylformimidamide ethyl-N-methylformimidamide N '- (2-chloro-5-methyl- N' - (2,5-dichloro-4- 4- (3- (cyano (3-fluoro-4- 159 (trifluoromethyl) benzi 562 methylphenyl) methyl) phenyl) -N- lo) phenyl) -N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide N '- (4- (2-fluorobenzyl) -2,5- N' - (2, 5-dichloro-4- 160 dimethylphenyl) -N- 563 (phenylamino) phenyl) -N-ethyl-isopropyl-N- N-methylformimidamide methylformimidamide

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N '- (4- (2-chlorobenzyl) -2,5- N' - (2,5-dichloro-4- (p-161 dimethylphenyl) -N- 564 tolylamino) phenyl) -N-ethyl-isopropyl-N - N-methylformimidamide methylformimidamide N-allyl-N '- (4- (2- N' - (2,5-dichloro-4 - (((2-fluorobenzyl) -2,5- 162 565 chlorophenyl) amino) phenyl) - N- dimethylphenyl) -N- ethyl-N-methylformimidamide methylformimidamide N-allyl-N '- (4- (2- N' - (2,5-dichloro-4 - ((4-chlorobenzyl) -2,5- 163 566 chlorophenyl) amino) phenyl) -N- dimethylphenyl) -N- ethyl-N-methylformimidamide methylformimidamide N- (4- (2- N '- (2,5-dichloro-4 - ((4-fluorobenzyl) -2, 5- chlorophenyl) (methyl) amino) fe 164 dimethylphenyl) -1- 567 nil) -N-ethyl-N-thiomorpholinometanimin methylformimidamide a N- (4- (2-chlorobenzyl) - N '- (2,5-dichloro- 4 - ((4- 2,5-dimethylphenyl) -1- chlorophenyl) (ethyl) amino) phen 165 568 thiomorpholinomethanimin il) -N-ethyl-N- to methylformimidamide N- (cyclopropylmethyl) - N '- (2.5 -dichloro-4- N '- (4- (2- (methyl (phenyl) amino) phenyl) - 166 fluorobenzyl) -2,5- 569 N-ethyl-N-dimethylphenyl) -N- methylformimidamide methylformimidamide

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N- (cyclopropylmethyl) - N '- (4- (2- N' - (2,5-dichloro-4 - ((3-fluorobenzyl) -2,5-methoxyphenyl) (methyl) amino) f 167 570 dimethylphenyl) -N- enyl) -N-ethyl-N- isopropylformimidamid methylformimidamide to N '- (4- (2-chlorobenzyl) -2,5- N' - (2,5-dichloro-4 - ((2-dimethylphenyl) - N- chlorophenyl) (methyl) amino) fe 168 571 (cyclopropylmethyl) -N- nyl) -N-ethyl-N-isopropylformimidamid methylformimidamide N '- (4- (2-chlorobenzyl) -2,5- N' - ( 2,5-dichloro-4 - ((3-dimethylphenyl) -N-methoxyphenyl) amino) phenyl) - 169 572 cyano-N- N-ethyl-N- (cyanomethyl) formimide methylformimidamide N-cyano-N- N- ethyl-N '- (5-fluoro-4 - ((4- (cyanomethyl) -N' - (4-fluorophenyl) amino) -2- 170 (2-fluorobenzyl) -2,5- 573 methylphenyl) -N- dimethylphenyl) formimid methylformimidamide amide N '- (2,5-dimethyl-4- (4- N-ethyl-N' - (5-fluoro-4 - ((2- ((trifluoromethyl) thio) methoxyphenyl) amino) -2 - 171 benzyl) phenyl) -N- 574 methylphenyl) -N- ethyl-N-methylformimidamide methylformimidamide

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N-ethyl-N '- (5-fluoro-2- N' - (2,5-dimethyl-4- (2-methyl-4 - ((2- (trifluoromethyl) benzyl 172 575 ((trifluoromethyl) thio) phenyl lo) phenyl) -N-ethyl-N-) amino) phenyl) -N- methylformimidamide methylformimidamide N '- (2,5-dimethyl-4- (4- N' - (4 - ((4- (trifluoromethyl) benzi chlorophenyl) (methyl) amino) - 173 576 lo) phenyl) -N-ethyl-N-5-fluoro-2-methylphenyl) -N-methylformimidamide ethyl-N-methylformimidamide N '- (2,5-dimethyl-4- N-ethyl-N '- (5-fluoro-4 - ((4- ((3-fluorophenyl) (methyl) amino) - 174 (trifluoromethyl) phenyl 577 2-methylphenyl) -N-) amino) phenyl) -N -ethyl-methylformimidamide N-methylformimidamide N '- (2-chloro-5-methyl- N' - (4 - ((4- 4 - ((3-chlorophenyl) amino) -5- 175 (trifluoromethyl) phenyl 578 fluoro- 2-methylphenyl) -N-) amino) phenyl) -N-ethyl-ethyl-N-methylformimidamide N-methylformimidamide N '- (2-chloro-5-methyl- N-ethyl-N' - (5-fluoro-4 - (((2- 4- (methyl (3-methoxyphenyl) (methyl) amino) - 176 (trifluoromethyl) phenyl 579 2-methylphenyl) -N-) amino) phenyl) -N-ethyl-methylformimidamide N-methylformimidamide N'- (2,5-dimethyl-4-N-ethyl-N '- (2-fluoro-4 - ((3- (methyl (3-fluorophen nil) amino) -5- 177 (trifluoromethyl) phenyl 580 methylphenyl) -N-) amino) phenyl) -N-ethyl-methylformimidamide N-methylformimidamide

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N '- (2-chloro-4- (4- N-ethyl-N' - (2-fluoro-4 - ((4-chloro-3-fluorophenyl) amino) -5- 178 fluorobenzyl) -5- 581 methylphenyl ) -N- methylphenyl) -N-ethyl-N- methylformimidamide methylformimidamide N '- (4- (3,5- N-ethyl-N' - (2-fluoro-4 - ((3- bis (trifluoromethyl) be methoxyphenyl ) amino) -5- 179 nzyl) -2-chloro-5- 582 methylphenyl) -N-methylphenyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-5-methyl- N-ethyl-N '- (2-fluoro-4 - ((3- 4- (4-methyl-3-fluorophenyl) (methyl) amino) - 180 (trifluoromethyl) benzi 583 5-methylphenyl) -N- lo) phenyl) -N- ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-4- (3-fluoro-5- N-ethyl-N' - (2-fluoro-4 - ((4- (trifluoromethyl) benzi fluorophenyl) (methyl) amino) - 181 584 lo) -5-methylphenyl) -N- 5-methylphenyl) -N- ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-4- (2- N-ethyl-N' - (2 -fluoro-4 - ((3-chloro-4-methoxyphenyl) (methyl) amino) - 182 fluorobenzyl) -5- 585 5-methylphenyl) -N-methylphenyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- ( 2-chloro-4- (2- N '- (4 - ((4- (tert-cyanobenzyl) -5-butyl) phenyl) amin o) -2- 183 586 methylphenyl) -N-ethyl-N-fluoro-5-methylphenyl) -N-methylformimidamide ethyl-N-methylformimidamide

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N '- (2-chloro-5-methyl- N' - (4 - ((4- (tert- 4- (4-butyl) phenyl) amino) -2- 184 (trifluoromethyl) benzi 587 chloro-5-methylphenyl ) -N- lo) phenyl) -N-ethyl-N- ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-5-methyl- N' - (4 - ((4- (tert- 4- (2 - butyl) phenyl) (methyl) amino) - 185 (trifluoromethoxy) benz 588 2-fluoro-5-methylphenyl) -N-yl) phenyl) -N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide N '- (2 -chloro-5-methyl- N '- (4 - ((4- (tert- 4- (2-butyl) phenyl) (methyl) amino) - 186 (trifluoromethyl) benzi 589 2-chloro-5-methylphenyl) - N- lo) phenyl) -N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide N '- (4 - ((2,6- N' - (4- (N- (4- (tert-difluorophenyl) amino) - butyl) phenyl) methylsulfonami 187 2,5-dimethylphenyl) -N- 590 da) -2-chloro-5-methylphenyl) - ethyl-N- N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-4 - ((2,6-N '- (2-chloro-5-methyl-4 - ((2-difluorophenyl) amino) - methyl-4- (perfluoropropan-188 591 5-methylphenyl) -N-ethyl- 2- il) phenyl) amino) phenyl) -N- N-methylformimidamide ethyl-N-methylformimidamide N '- (4 - ((2,6-N' - (2,5-dichloro-4 - ((2- dif fluorophenyl) (methyl) fluorophenyl) amino) phenyl) - 189 amino) -2,5- 592 N-ethyl-N-dimethylphenyl) -N-ethyl-methylformimidamide N-methylformimidamide

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N '- (2-chloro-4 - ((2,6- N' - (4 - ((4- (tert-difluorophenyl) (methyl) butyl) phenyl) amino) -2,5- 190 amino) -5 -methylphenyl) - 593 dichlorophenyl) -N-ethyl-N- N-ethyl-N-methylformimidamide methylformimidamide N '- (4 - ((2-chloro-6- N' - (2,5-dichloro-4 - (( 4- fluorophenyl) amino) - fluorophenyl) amino) phenyl) - 191 2,5-dimethylphenyl) -N- 594 N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-4 - ((2 - N '- (2,5-dichloro-4 - (((4-chloro-6-methoxyphenyl) amino) phenyl) - 192 fluorophenyl) amino) -5- 595 N-ethyl-N-methylphenyl) -N-ethyl- N- methylformimidamide methylformimidamide N '- (4 - ((2-chloro-6- N' - (2,5-dichloro-4 - ((4-fluorophenyl) (methyl) am (trifluoromethoxy) phenyl) ami 193 ino) - 2,5- 596 no) phenyl) -N-ethyl-N-dimethylphenyl) -N-ethyl-methylformimidamide N-methylformimidamide N '- (2,5-dimethyl-4 N' - (2,5-dichloro-4 - (((2- ((4- (pentafluoro-16-fluoro-3- 194 sulfanyl) phenyl) amino) 597 (trifluoromethyl) phenyl) amin phenyl) -N-ethyl-N- o) phenyl) -N-ethyl- N- methylformimidamide methylformimidamide N '- (2,5-dimethyl-4- (4- N' - (2,5-dichloro-4 - ((2- methyl-3-fluoro-5- 195 ( trifluoromethyl) benzi 598 methylphenyl) amino) phenyl) -N- lo) phenyl) -N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide

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N-ethyl-N '- (2-fluoro-4 - (((2- N' - (4- (4-chloro-3-methoxy-4-fluorobenzyl) -2,5-196 599 methylphenyl) amino) -5 - dimethylphenyl) -N-ethyl-methylphenyl) -N- N-methylformimidamide methylformimidamide N '- (4- (3,5- N-ethyl-N' - (2-fluoro-4 - ((2- bis (trifluoromethyl) be methoxy-4- 197 nzyl) -2,5- 600 methylphenyl) (methyl) amino) - dimethylphenyl) -N-ethyl-5-methylphenyl) -N- N-methylformimidamide methylformimidamide N '- (4- (3- ( 1- N '- (2-chloro-5-methyl-4-cyanoethyl) benzyl) - (methyl (2-methyl-4- 198 2,5-dimethylphenyl) -N- 601 (perfluoropropan-2-ethyl-N- il) phenyl) amino) phenyl) -N-methylformimidamide ethyl-N-methylformimidamide N '- (2-chloro-5-methyl-4- (N-N' - (4- (4-chloro-3- (2- methyl-4-methylbenzyl) -2,5- (perfluoropropan-2- 199 602 dimethylphenyl) -N-ethyl-yl) phenyl) methylsulfonamide) N-methylformimidamide phenyl) -N-ethyl-N-methylformimidamide N-ethyl-N ' - (4- (4- N-ethyl-N '- (5-fluoro-2-fluoro-3-methyl-4- (methyl (2-200 methylbenzyl) -2,5- 603 ((trifluoromethyl) thio) phenyl dimethylphenyl) -N-) amino) phenyl) -N- methylformimidamide methylformimidamide N '- (4- (2-chloro-4- N' - ( 2,5-dichloro-4- (4-fluorobenzyl) -2,5- 201 604 chlorobenzyl) phenyl) -N-ethyl-dimethylphenyl) -N-ethyl- N-methylformimidamide N-methylformimidamide

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N '- (4- (3- (dimethylamino) benzyl N' - (2,5-dichloro-4- (4- 202) -2,5-dimethylphenyl) - 605 fluorobenzyl) phenyl) -N- N-ethyl- N- ethyl-N-methylformimidamide methylformimidamide N '- (4- (2,3-N' - (2,5-dichloro-4- (4-dimethylbenzyl) -2,5- 203 606 cyanobenzyl) phenyl) -N- ethyl-dimethylphenyl) -N-ethyl- N-methylformimidamide N-methylformimidamide N '- (4- (3,4-N' - (2,5-dichloro-4-dimethylbenzyl) -2,5- (pyridine-3- 204 607 dimethylphenyl) -N-ethyl-ylmethyl) phenyl) -N-ethyl-N- N-methylformimidamide methylformimidamide N '- (4- (3,5-N' - (2,5-dichloro-4- (2- dimethylbenzyl) -2,5- (trifluoromethoxy) benzyl) f 205 608 dimethylphenyl) -N-ethyl-enyl) -N-ethyl-N- N-methylformimidamide methylformimidamide N '- (4- (2- N' - (2, 5-dichloro-4- (3-cyanobenzyl) -2,5- 206 609 cyanobenzyl) phenyl) -N-ethyl-dimethylphenyl) -N-ethyl- N-methylformimidamide N-methylformimidamide N '- (2,5-dimethyl- 4- (2- N '- (2,5-dichloro-4- (2- (trifluoromethoxy) benz 207 610 cyanobenzyl) phenyl) -N-ethyl-yl) phenyl) -N-ethyl-N-N-methylformimidamide methylformimidamide N '- (2,5-dimethyl-4- (4- N' - (2,5-dichloro-4- (4- (trif fluoromethoxy) benz (trifluoromethyl) benzyl) fe 208 611 yl) phenyl) -N-ethyl-N-nyl) -N-ethyl-N-methylformimidamide methylformimidamide

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Compound name Compound name No.

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N '- (4 - ((2,6-dichloro-4- N' - (2,5-dichloro-4- (4- (trifluoromethyl) phenyl (trifluoromethoxy) benzyl) f 209 612) amino) -2,5 - enyl) -N-ethyl-N-dimethylphenyl) -N-ethyl-methylformimidamide N-methylformimidamide N '- (4- (3-chloro-2- N' - (2,5-dichloro-4- (2-fluorobenzyl ) -2,5- (trifluoromethyl) benzyl) fe 210 613 dimethylphenyl) -N-ethyl-nyl) -N-ethyl-N- N-methylformimidamide methylformimidamide N '- (2,5-dimethyl-4- ((2- N '- (2,5-dichloro-4- (3,5- (trifluoromethoxy) pheni 211 614 dimethylbenzyl) phenyl) -N- 1) amino) phenyl) -N- ethyl-N-methylformimidamide ethyl-N-methylformimidamide N '- (2-chloro-5-methyl-4 - ((2- N' - (2,5-dichloro-4- (4- (trifluoromethoxy) phenyl fluoro-3- 212 615 l) amino) phenyl) -N - methylbenzyl) phenyl) -N-ethyl-ethyl-N- N-methylformimidamide methylformimidamide N '- (2-chloro-5-methyl-4 - ((3- N' - (2,5-dichloro-4 - (( 4- (trifluoromethoxy) phenyl fluorophenyl) (methyl) amino) f 213 616 l) amino) phenyl) -N- enyl) -N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide

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Compound name Compound name No.

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N '- (2,5-dimethyl-4- ((4- N' - (2,5-dichloro-4- (ethyl (4- (trifluoromethoxy) pheni (trifluoromethoxy) phenyl) ami 214 617 l) amino) phenyl ) -N- no) phenyl) -N-ethyl-N- ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-5-methyl-4 - ((4- N' - (2,5-dichloro-4 - (((2- (trifluoromethoxy) phenyl fluorophenyl) (methyl) amino) f 215 618 l) amino) phenyl) -N- enyl) -N-ethyl-N- ethyl-N-methylformimidamide methylformimidamide N '- (2,5 -dimethyl-4- (methyl (2- N '- (4 - ((4- (tert- (trifluoromethoxy) phenyl butyl) phenyl) (methyl) amino) - 216 619 l) amino) phenyl) -N- 2, 5-dichlorophenyl) -N-ethyl-ethyl-N- N-methylformimidamide methylformimidamide N '- (2-chloro-5-methyl- 4- (methyl (2- N' - (2,5-dichloro-4 - (( 4- (trifluoromethoxy) pheni methoxyphenyl) (methyl) amino) f 217 620 l) amino) phenyl) -N-enyl) -N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide N '- (2,5-dimethyl- 4- N '- (2,5-dichloro-4 - ((2- (methyl (4-fluoro-5- (trifluoromethoxy) pheni 218 621 methylphenyl) (methyl) amino) fe 1) amino) phenyl) -N- nil) -N-ethyl-N- ethyl-N-methylformimidamide methylformimidamide

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Compound name Compound name No.

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N '- (2-chloro-5-methyl- N-ethyl-N' - (4 - ((4- 4- (methyl (4- (1,1,1,3,3,3-hexafluoro-2- (trifluoromethoxy) pheni methoxypropan-2-yl) -2- 219 622 l) amino) phenyl) -N-methylphenyl) (methyl) amino) -ethyl-N-2,5-dimethylphenyl) -N- methylformimidamide methylformimidamide N'- (2-chloro-5-methyl- N-ethyl-N '- (2-fluoro-5- 4- (methyl (3-methyl-4 - ((2- (trifluoromethoxy) pheni 220 623 ((trifluoromethyl) thio)) phenyl l) amino) phenyl) -N-) amino) phenyl) -N- ethyl-N- methylformimidamide methylformimidamide N-ethyl-N '- (2-fluoro-5- N-ethyl-N' - (4 - (( 2-methyl-4 - ((4-fluorophenyl) amino) - 221 624 ((trifluoromethyl) thio) phenyl 2,5-dimethylphenyl) -N-) amino) phenyl) -N- methylformimidamide methylformimidamide N '- (2-chlorine -4- (4- N-ethyl-N '- (2-fluoro-5-fluoro-3-methyl-4 - (((3-222 methylbenzyl) -5- 625 (((trifluoromethyl) thio) phenyl methylphenyl) -N -ethyl-N-) amino) phenyl) -N- methylformimidamide methylformimidamide N-ethyl-N '- (2-fluoro-5- N' - (2-chloro-4- (4- methyl-4- (methyl (2 - chloro-3-methylbenzyl) - 223 626 ((trifluoromethyl) thio) phenyl 5-methylphenyl) -N-ethyl-) amino) phenyl) -N- N-methylformimidamide methylformimidamide

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N '- (2-chloro-5-methyl- N-ethyl-N' - (2-fluoro-5- 4- (4-methyl-4- (methyl (4- 224 (trifluoromethoxy) benz 627 ((trifluoromethyl)) thio) phenyl yl) phenyl) -N-ethyl-N-) amino) phenyl) -N- methylformimidamide methylformimidamide N '- (2-chloro-5-methyl- N' - (2,5-dichloro-4- (ethyl (4- 4- (2-fluorophenyl) amino) phenyl) - 225 methylbenzyl) phenyl) -N- 628 N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-4- (3- N '- (2,5-dichloro-4-chloro-2- (methyl (4-226 fluorobenzyl) -5- 629 (trifluoromethoxy) phenyl) ami methylphenyl) -N-ethyl-N- no) phenyl) -N-ethyl -N- methylformimidamide methylformimidamide N '- (2-chloro-5-methyl- N-ethyl-N' - (2-fluoro-5- 4- (3-methyl-4- (p- 227 (trifluoromethoxy) benz 630 tolylamino ) phenyl) -N-yl) phenyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-4- (2- N-ethyl-N' - (2-fluoro-4 - ((4- chloro-3-methoxyphenyl) (methyl) amino) - 228 fluorobenzyl) -5- 631 5-methylphenyl) -N-methylphenyl) -N-ethyl-N-methylformimidamide methylformimidamide

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N '- (2-chloro-4- (3-chloro-2-fluoro-5- N-ethyl-N' - (2-fluoro-5- (trifluoromethyl) benzyl methyl-4- (methyl (p- 229 632 lo) -5-methylphenyl) -N-tolyl) amino) phenyl) -N- ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-4 - ((2,6-dichloro-4- N' - (2 -chloro-5-methyl-4- (N- (trifluoromethyl) phenyl phenylmethylsulfonamide) pheni 230 633) amino) -5- l) -N, N-methylphenyl) -N-ethyl-N-dimethylformimidamide methylformimidamide N-ethyl-N '- (4 - ((4- N' - (4- (1,1,1,3,3,3-hexafluoro-2- (cyano (phenyl) methyl) - hydroxypropan-2-yl) -2- 231 2,5-dimethylphenyl) -N- 634 methylphenyl) amino) -2,5-ethyl-N-dimethylphenyl) -N- methylformimidamide methylformimidamide N '- (2,5-dichloro-4- (4- N' - (2 -chloro-4- (2,3-chloro-3-dichlorobenzyl) -5- 232 635 (trifluoromethyl) benzyl) f methylphenyl) -N-ethyl-N-nyl) -N-ethyl-N-methylformimidamide methylformimidamide N'- (2-chloro-4- (3,5-N '- (2,5-dichloro-4- (4-difluorobenzyl) -5-fluoro-2- 233 636 methylphenyl) -N-ethyl-N-methylbenzyl) phenyl ) -N-ethyl-methylformimidamide N-methylformimidamide

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N '- (2-chloro-4- (3,5-N' - (2,5-dichloro-4- (2,4-dimethylbenzyl) -5- 234 637 difluorobenzyl) phenyl) -N-methylphenyl) -N -ethyl-N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-5-methyl-4 - ((4- (pentafluoro- N' - (2,5-dichloro-4- (2,3-l6 - 235 638 dimethylbenzyl) phenyl) -N-sulfanyl) phenyl) amino) ethyl-N-methylformimidamide phenyl) -N-ethyl-N-methylformimidamide N '- (2-chloro-4 - ((2-chloro-6- N '- (2,5-dichloro-4- (2-fluorophenyl) (methyl) am chloro-3- 236 639 ino) -5-methylphenyl) -N-fluorobenzyl) phenyl) -N-ethyl-N-ethyl-N -methylformimidamide methylformimidamide N '- (2,5-dimethyl-4- (methyl (4- N' - (2,5-dichloro-4- (2,3- (pentafluoro-16- 237 640 dichlorobenzyl) phenyl) -N - sulfanyl) phenyl) amino) ethyl-N-methylformimidamide phenyl) -N-ethyl-N-methylformimidamide N '- (2-chloro-5-methyl- 4- (methyl (4- N' - (2,5-dichloro -4- (3,4- (pentafluoro-16- 238 641 difluorobenzyl) phenyl) -N-sulfanyl) phenyl) amino) ethyl-N-methylformimidamide phenyl) -N-ethyl-N-methylformimidamide

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N '- (4- (2-chloro-3- N' - (2,5-dichloro-4- (3-fluorobenzyl) -2,5-fluoro-5- 239 642 dimethylphenyl) -N-ethyl-methoxybenzyl) phenyl) -N- N-methylformimidamide ethyl-N-methylformimidamide N '- (2,5-dimethyl-4- N' - (2,5-dichloro-4- (2- (pyridine-3-fluoro-4- 240 ylmethyl) phenyl) -N- 643 (trifluoromethyl) benzyl) fe ethyl-N-nyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (4- (3,5- N' - (2,5-dichloro- 4- (3-difluorobenzyl) -2,5-chloro-2- 241 644 dimethylphenyl) -N-ethyl-fluorobenzyl) phenyl) -N- N-methylformimidamide ethyl-N-methylformimidamide N '- (2,5-dichloro- 4- (4- N '- (4- (2,3-fluoro-3-dichlorobenzyl) -2,5- 242 645 (trifluoromethyl) benzyl) fe dimethylphenyl) -N-ethyl-nyl) -N-ethyl-N - N-methylformimidamide methylformimidamide N '- (4- (3-chloro-2-fluoro-5- N' - (2,5-dichloro-4- (2- (trifluoromethyl) benzyl chloro-4- 243 646 lo) - 2,5-fluorobenzyl) phenyl) -N-dimethylphenyl) -N-ethyl-ethyl-N-methylformimidamide N-methylformimidamide N '- (4- (3-chloro-5- N' - (2,5-dichloro-4 - (2-fluorobenzyl) -2,5-chloro-5- 244 647 dimethylphenyl) -N-ethyl-fluorobenzyl) phenyl) -N- N- methylformimidamide ethyl-N-methylformimidamide

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N '- (2-chloro-5-methyl- N' - (2,5-dichloro-4- (4- 4- (methyl (3-chloro-3- 245 (methylthio) phenyl) amino 648 (trifluoromethoxy) benzyl ) f) phenyl) -N-ethyl-N-enyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (2,5-dimethyl-4- ((2- N' - (2-chloro-4- ( 2,4- ((trifluoromethyl) thio) dimethylbenzyl) -5- 246 649 phenyl) amino) phenyl) -N-methylphenyl) -N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-5 -methyl- 4 - ((2- N '- (2-chloro-4- (2-fluoro-4- ((trifluoromethyl) thio) (trifluoromethyl) benzyl) - 247 650 phenyl) amino) phenyl) -N- 5 -methylphenyl) -N-ethyl-N- ethyl-N- methylformimidamide methylformimidamide N '- (4 - ((3- ((difluoromethyl) thio) f N' - (4- (2-bromobenzyl) -2- 248 enyl) amino) -2,5- 651 chloro-5-methylphenyl) -N-dimethylphenyl) -N-ethyl-ethyl-N-methylformimidamide N-methylformimidamide N '- (2,5-dimethyl-4-ethyl 5 - ((5 -chloro-4- ((4- ((((ethyl (methyl) amino) methyl ((trifluoromethyl) thio) 249 652 no) amino) -2-phenyl) amino) phenyl) -N- methylphenyl) amino) -2- ethyl-N- (isopropylthio) benzoate methylformimidamide

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N '- (2-chloro-5-methyl-4 - ((4- N' - (4 - ((2- ((trifluoromethyl) thio) bromophenyl) (methoxy) methyl) - 250 653 phenyl) amino) phenyl) -N- 2,5-dimethylphenyl) -N, N- ethyl-N- dimethylformimidamide methylformimidamide N '- (2,5-dimethyl-4- (methyl (2- N' - (4- ((trifluoromethyl) thio) ( methoxy (phenyl) methyl) -2,5- 251 654 phenyl) amino) phenyl) -N-dimethylphenyl) -N, N-ethyl-N-dimethylformimidamide methylformimidamide N '- (2-chloro-5-methyl- 4- ( methyl (2- N '- (4- (2-bromobenzyl) -2,5- ((trifluoromethyl) thio) 252 655 dichlorophenyl) -N-ethyl-N-phenyl) amino) phenyl) -N- methylformimidamide ethyl-N - methylformimidamide N '- (2,5-dimethyl-4- (methyl (4- N' - (2,5-dichloro-4- (3- ((trifluoromethyl) thio) chloro-4- 253 656 phenyl) amino) phenyl) -N- fluorobenzyl) phenyl) -N- ethyl-N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-5-methyl- 4- (methyl (4- N' - (2,5-dichloro -4- (2- ((trifluoromethyl) thio) cyclopropylbenzyl) phenyl) - 254 657 phenyl) amino) phenyl) -N- N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide

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N '- (2-chloro-4- (4- N' - (2,5-dichloro-4- (2-chloro-3-fluoro-6- (trifluoromethyl) benzyl 255 658 (trifluoromethyl) benzyl) -5-methylphenyl) -N- nyl) -N-ethyl-N- ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-4- (3-fluoro-4- N' - (2,5-dichloro- 4- (2,6- (trifluoromethyl) benzi 256 659 dichlorobenzyl) phenyl) -N- lo) -5-methylphenyl) -N- ethyl-N-methylformimidamide ethyl-N-methylformimidamide N '- (2-chloro-4- (3,4- N '- (2,5-dichloro-4- (3-difluorobenzyl) -5- 257 660 methoxybenzyl) phenyl) -N-methylphenyl) -N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-4- (3- N' - (2,5-dichloro-4- (4-fluoro-4- ((trifluoromethyl) thio) benzi 258 methylbenzyl) -5- 661 lo) phenyl) - N-ethyl-N-methylphenyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-4- (3- N' - (2,5-dichloro-4- (2- fluoro-5-chloro -6- 259 methylbenzyl) -5- 662 fluorobenzyl) phenyl) -N-methylphenyl) -N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide N '- (2,5-dichloro-4- (3- N'- (2,5-dichloro-4- (4-methylbenzyl) phenyl) -N- 260 663 methoxybenzyl) phenyl) -N- ethyl-N-ethyl -N-methylformimidamide methylformimidamide

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N '- (4- (4-chloro-3- N-ethyl-N' - (4- (3-fluoro-4- (trifluoromethyl) benzyl methoxybenzyl) -2,5- 261 lo) -2,5- 664 dimethylphenyl) -N- dimethylphenyl) -N-ethyl-methylformimidamide N-methylformimidamide N '- (4- (2-chloro-5- N-ethyl-N' - (4- (3-methoxy-5-fluorobenzyl) -2 , 5- (trifluoromethyl) benzyl) - 262 665 dimethylphenyl) -N-ethyl-2,5-dimethylphenyl) -N- N-methylformimidamide methylformimidamide N-ethyl-N '- (4- (3- N' - (4- (5-chloro-2-fluoro-4-fluorobenzyl) -2,5- 263 methylbenzyl) -2,5- 666 dimethylphenyl) -N-ethyl-N-dimethylphenyl) -N- methylformimidamide methylformimidamide N '- (4- ( 4-chloro-3- N '- (2-chloro-4 - (((4-chloro-2- (trifluoromethoxy) benz fluorophenyl) amino) -5- 264 yl) -2,5- 667 methylphenyl) -N-ethyl -N- dimethylphenyl) -N-ethyl-methylformimidamide N-methylformimidamide N '- (4- (3,4- N' - (2-chloro-4 - ((2,4-difluorobenzyl) -2,5- difluorophenyl) amino) -5- 265 668 dimethylphenyl) -N-ethyl-methylphenyl) -N-ethyl-N- N-methylformimidamide methylformimidamide N '- (4 - ((3- ((difluoromethyl) thio) f N' - (2- chlorine-4 - (((2-fluoroenyl) (methyl) amino) - 6-methylphenyl) amino) -5- 266 669 2,5-dimethylphenyl) -N-methylphenyl) -N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide

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N '- (2,5-dimethyl-4- ((3-N' - (2-chloro-4 - (((2-fluoro- ((trifluoromethyl) thio) 3-methylphenyl) amino) -5- 267 670 phenyl ) amino) phenyl) -N- methylphenyl) -N-ethyl-N- ethyl-N-methylformimidamide methylformimidamide N '- (2,5-dimethyl-4-N' - (2-chloro-4 - ((3-fluoro - (((4- 5-methylphenyl) amino) -5- 268 (methylthio) phenyl) amino 671 methylphenyl) -N-ethyl-N-) phenyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chlorine -5-methyl- N '- (2-chloro-4 - ((3-fluoro-4 - ((4-4-methylphenyl) amino) -5- 269 (methylthio) phenyl) amino 672 methylphenyl) -N-ethyl -N-) phenyl) -N-ethyl-N- methylformimidamide methylformimidamide N '- (2,5-dimethyl-4- (methyl (3- N' - (2-chloro-4 - ((2-fluoro- (( trifluoromethyl) thio) 4-methylphenyl) amino) -5- 270 673 phenyl) amino) phenyl) -N-methylphenyl) -N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-5-methyl - 4- (methyl (3- N- (4- (4-fluorobenzyl) -2,5- ((trifluoromethyl) thio) dimethylphenyl) -1- 271 674 phenyl) amino) phenyl) -N- methylpyrrolidin-2-formate ethyl-N- imine methylformimidamide

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N '- (2,5-dimethyl-4- N-ethyl-N' - (2-fluoro-5- (methyl (4-methyl-4- (4- 272 (methylthio) phenyl) amino 675 (trifluoromethyl) benzyl ) fe) phenyl) -N-ethyl-N-nyl) -N-methylformimidamide methylformimidamide N '- (2-chloro-5-methyl- N' - (4- (3-chloro-2- 4- (methyl (4 - fluorobenzyl) -2-fluoro-5- 273 (methylthio) phenyl) amino 676 methylphenyl) -N-ethyl-N-) phenyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (2,5-dimethyl-4 - N-ethyl-N '- (2-fluoro-4- (3- ((3- (pentafluoro-16-fluoro-5-methoxybenzyl) -5- 274 sulfanyl) phenyl) amino) 677 methylphenyl) -N- phenyl ) -N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-5-methyl-4 - ((3- (pentafluoro- N-ethyl-N' - (2-fluoro-4- (3- l6- fluoro-4-methoxybenzyl) -5- 275 678 sulfanyl) phenyl) amino) methylphenyl) -N-phenyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (2,5-dimethyl-4- (methyl (3- N '- (2,5-dimethyl-4- (2- (pentafluoro-16-phenyl-1,3-dithiolan-2- 276 679 sulfanyl) phenyl) amino) yl) phenyl) -N, N-phenyl) - N-ethyl-N-dimethylformimidamide methylformimidamide

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N '- (2-chloro-5-methyl- 4- (methyl (3- N' - (2-chloro-4 - ((4- (pentafluoro-16-chlorophenyl) (methoxy) methyl) - 277 680 sulfanyl) phenyl) amino) 5-methylphenyl) -N, N- phenyl) -N-ethyl-N-dimethylformimidamide methylformimidamide N '- (4 - ((3,5-ethyl 5 - ((4- bis (trifluoromethyl) fe (( (ethyl (methyl) amino) methyl 278 nil) amino) -2,5- 681 no) amino) -2,5-dimethylphenyl) -N-ethyl-dimethylphenyl) amino) -2- N-methylformimidamide (isopropylthio) benzoate N '- (4 - ((3,5-ethyl 5 - ((2,5-dichloro-4-bis (trifluoromethyl) fe ((((ethyl (methyl) amino) methyl 279 nil) amino) -2-chloro-5 - 682 no) amino) phenyl) amino) -2- methylphenyl) -N-ethyl-N- (isopropylthio) benzoate methylformimidamide N '- (2-chloro-5-methyl-ethyl 5 - ((4- 4 - (( 3- ((((ethyl (methyl) amino) methyl ((trifluoromethyl) thio) 280 683 no) amino) -2-fluoro-5-phenyl) amino) phenyl) -N-methylphenyl) amino) -2-ethyl-N - (isopropylthio) benzoate methylformimidamide N '- (2,5-dichloro-4- (4-N-ethyl-N' - (4 - (((3-fluoro-5-methylbenzyl) phenyl) -N-methylphenyl) amino) -2,5- 281 684 ethyl-N-dimethylphenyl) -N- methylformimidamide methylformimidamide N '- (2,5-dichloride o-4- (3-N-ethyl-N '- (4 - ((2-fluoro-3-fluorobenzyl) phenyl) - methylphenyl) amino) -2,5- 282 685 N-ethyl-N-dimethylphenyl) - N- methylformimidamide methylformimidamide

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N '- (2,5-dichloro-4- (2- N-ethyl-N' - (4 - (((2-fluoro-4-fluorobenzyl) phenyl) -methylphenyl) amino) -2,5- 283 686 N -ethyl-N-dimethylphenyl) -N- methylformimidamide methylformimidamide N '- (2,5-dichloro-4- (2- N' - (4 - ((2,4-chlorobenzyl) phenyl) -N- difluorophenyl) amino) -2.5- 284 687 ethyl-N-dimethylphenyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (2,5-dichloro-4- (2- N-ethyl-N' - (4 - ((3 -fluoro-4-methylbenzyl) phenyl) -N- methylphenyl) amino) -2,5- 285 688 ethyl-N-dimethylphenyl) -N- methylformimidamide methylformimidamide N '- (2,5-dichloro-4- (3- N '- (4 - ((4-chloro-2-chlorobenzyl) phenyl) -N-fluorophenyl) amino) -2,5- 286 689 ethyl-N-dimethylphenyl) -N-ethyl-N-methylformimidamide methylformimidamide N' - ( 2-chloro-4 - ((4- N-ethyl-N '- (2-fluoro-4- (4- (dimethylamino) phenyl) to fluorobenzyl) -5- 287 mino) -5-methylphenyl) - 690 methylphenyl) -N- N-ethyl-N- methylformimidamide methylformimidamide N '- (4 - ((4- N-ethyl-N' - (2-fluoro-4- (4- (dimethylamino) phenyl) to fluoro-2-methylbenzyl) -5- 288 mino) -2,5- 691 methylphenyl) -N- dimethylphenyl) -N-ethyl-methylformimidamide N-methylf ormimidamide

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N '- (2-chloro-4 - ((3- N-ethyl-N' - (2-fluoro-4- (3- ((difluoromethyl) thio) methoxy-5- 289 enyl) amino) -5- 692 (trifluoromethyl) benzyl) -methylphenyl) -N-ethyl-N-5-methylphenyl) -N-methylformimidamide methylformimidamide N '- (2-chloro-4 - ((3-N-ethyl-N' - (2-fluoro -4- (2- ((difluoromethyl) thio) f fluoro-3-methylbenzyl) -5- 290 enyl) (methyl) amino) -5- 693 methylphenyl) -N-methylphenyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (4 - ((3- N' - (2,5-dimethyl-4- (2- (m- (difluoromethoxy) phenyl tolyl) -1,3-dithiolan-2- 291) amino) -2, 5- 694 yl) phenyl) -N-ethyl-N-dimethylphenyl) -N-ethyl-methylformimidamide N-methylformimidamide N '- (4 - ((3- N-ethyl-N' - (4- (2- (3 - (difluoromethoxy) phenyl fluorophenyl) -1,3-dithiolan- 292) (methyl) amino) -2,5- 695 2-yl) -2,5-dimethylphenyl) -N-dimethylphenyl) -N-ethyl-methylformimidamide N -methylformimidamide N '- (2-chloro-4 - ((3- (difluoromethoxy) phenyl N' - (4- (4-cyanobenzyl) -2- 293) amino) -5- 696 fluoro-5-methylphenyl) -N - methylphenyl) -N-ethyl-N- ethyl-N-methylformimidamide methylformimidamide N '- (4 - ((4- N-ethyl-N' - (2-fluoro-4- (3- (diflu oromethoxy) phenyl fluoro-5-294) amino) -2,5- 697 (trifluoromethyl) benzyl) -dimethylphenyl) -N-ethyl-5-methylphenyl) -N- N-methylformimidamide methylformimidamide

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N '- (4 - ((4- N-ethyl-N' - (2-fluoro-4- (2- (difluoromethoxy) phenyl fluoro-5-methylbenzyl) -5- 295) (methyl) amino) -2, 5- 698 methylphenyl) -N- dimethylphenyl) -N-ethyl-methylformimidamide N-methylformimidamide N '- (2-chloro-4 - ((4- methyl 4 - (((4- (difluoromethoxy) phenyl (((ethyl (methyl (methyl ) amino) methyl 296) amino) -5- 699 no) amino) -2,5-methylphenyl) -N-ethyl-N-dimethylphenyl) amino) -3-methylformimidamide methylbenzoate N '- (2-chloro-4- ( (4- methyl 4 - ((2,5-dichloro-4- (difluoromethoxy) phenyl ((((ethyl (methyl) amino) methyl 297) (methyl) amino) -5- 700 no) amino) phenyl) amino) - 3-methylphenyl) -N-ethyl-N-methylbenzoate methylformimidamide N '- (4 - ((2,5-methyl 4 - ((4-difluorophenyl) amino) - (((ethyl (methyl) amino) methyl 298 2, 5-dimethylphenyl) -N- 701 no) amino) -2-fluoro-5-ethyl-N-methylphenyl) amino) -3-methylformimidamide methylbenzoate N '- (2-chloro-4 - ((2,5- N' - (4 - ((3,4-difluorophenyl) amino) - difluorophenyl) amino) -2,5- 299 702 5-methylphenyl) -N-ethyl-dimethylphenyl) -N-ethyl-N- N-methylformimidamide methylformimidamide N ' - (4 - ((3,5-bis (trifluoromethyl) fe N '- - (4 - ((3,5-nil) (me tyl) amino) - difluorophenyl) amino) -2,5- 300 703 2,5-dimethylphenyl) -N-dimethylphenyl) -N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide

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N '- (4 - ((3,5-bis (trifluoromethyl) fe N' - (2,5-dichloro-4 - ((3,4-nyl) (methyl) amino) -2-difluorophenyl) amino) phenyl ) 301 704 chloro-5-methylphenyl) - -N-ethyl-N- N-ethyl-N-methylformimidamide methylformimidamide N '- (2,5-dimethyl-4- N' - (2,5-dichloro-4- ( (3,5- ((5-methyl-2-difluorophenyl) amino) phenyl) 302 (trifluoromethyl) phenyl 705 -N-ethyl-N-) amino) phenyl) -N-ethyl-methylformimidamide N-methylformimidamide N '- ( 4 - ((2,5-N '- (2,5-dichloro-4 - ((2,5-difluorophenyl) (methyl) dimethylphenyl) amino) phenyl) - 303 amino) -2,5- 706 N-ethyl -N- dimethylphenyl) -N-ethyl-methylformimidamide N-methylformimidamide N '- (2-chloro-4 - ((2,5-N' - (4 - ((3,4-difluorophenyl) (methyl) difluorophenyl) amino ) -5- 304 amino) -5-methylphenyl) - 707 fluoro-2-methylphenyl) -N- N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide N '- (2,5-dimethyl-4- N'- (4- (2,3- (methyl (5-methyl-2-difluorobenzyl) -2-fluoro-305 (trifluoromethyl) phenyl 708 5-methylphenyl) -N-ethyl-N-) amino) phenyl) -N-ethyl - methylformimidamide N-methylformimidamide

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N '- (4 - ((4-chloro-2- N' - (2,5-dichloro-4 - ((5- (trifluoromethyl) phenyl chloro-2- 306) amino) -2,5- 709 methylphenyl) amino) phenyl) -N- dimethylphenyl) -N-ethyl-ethyl-N-methylformimidamide N-methylformimidamide N '- (2-chloro-4 - ((4-chloro-2- N' - (4 - ((4- (trifluoromethyl) phenyl chlorophenyl) (methyl) amino) - 307 710) amino) -5- 2,5-dimethylphenyl) -N, N-methylphenyl) -N-ethyl-N-dimethylformimidamide methylformimidamide N '- (4 - (( 4-chloro-2- N '- (4- (2,3- (trifluoromethyl) phenyl difluorobenzyl) -2.5-308) (methyl) amino) -2.5-711 dimethylphenyl) -N-ethyl-N- dimethylphenyl) -N-ethyl-methylformimidamide N-methylformimidamide N '- (2-chloro-4 - (((4-chloro-2-N-ethyl-N' - (4- (2-fluoro-3- (trifluoromethyl)) phenyl methylbenzyl) -2,5-309 712) (methyl) amino) -5-dimethylphenyl) -N-methylphenyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (4- (2,6- N-ethyl-N '- (4- (2-fluoro-5-dichlorobenzyl) -2,5- methylbenzyl) -2,5- 310 713 dimethylphenyl) -N-ethyl-dimethylphenyl) -N- N-methylformimidamide methylformimidamide N' - (4- (2- N-ethyl-N '- (4- (2-fluoro-3-bromobenzyl) -2,5-methoxybenzyl) -2,5 - 311 714 dimethylphenyl) -N-ethyl-dimethylphenyl) -N- N-methylformimidamide methylformimidamide

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N '- (4- (2-chloro-6- N' - (2-chloro-4 - (((5-chloro-2-fluorobenzyl) -2,5-methylphenyl) amino) -5- 312 715 dimethylphenyl) - N-ethyl-methylphenyl) -N-ethyl-N- N-methylformimidamide methylformimidamide N-ethyl-N '- (4- (3-methyl 4 - (((5-chloro-4-fluoro-5- (((ethyl ( methyl) amino) methyl 313 methoxybenzyl) -2.5- 716 no) amino) -2-dimethylphenyl) -N-methylphenyl) amino) -3-methylformimidamide methylbenzoate N-ethyl-N '- (4- (5- N' - (2-chloro-4 - ((2-chloro-5-fluoro-2-methylphenyl) amino) -5- 314 methylbenzyl) -2,5- 717 methylphenyl) -N-ethyl-N-dimethylphenyl) -N- methylformimidamide methylformimidamide N-ethyl-N '- (4- (3-fluoro-4- N' - (4 - ((2-chloro-5- (trifluoromethyl) benzyl methylphenyl) amino) -2,5- 315 718 lo) -2,5-dimethylphenyl) -N-ethyl-N-dimethylphenyl) -N- methylformimidamide methylformimidamide N '- (4- (2-chloro-5- N' - (4 - (((5-chloro-2- (trifluoromethyl ) benzyl methylphenyl) amino) -2,5- 316 lo) -2,5- 719 dimethylphenyl) -N-ethyl-N-dimethylphenyl) -N-ethyl-methylformimidamide N-methylformimidamide N '- (4- (2.5 - N '- (2,5-dichloro-4 - ((2-dichlorobenzyl) -2,5-chloro-5- 317 720 dimethylphenyl) -N -ethyl-methylphenyl) amino) phenyl) -N- N-methylformimidamide ethyl-N-methylformimidamide

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N '- (4- (2,4-N' - (2,5-dichloro-4 - ((2-difluorobenzyl) -2,5-fluoro-4- 318 721 dimethylphenyl) -N-ethyl-methylphenyl) amino ) phenyl) -N- N-methylformimidamide ethyl-N-methylformimidamide N '- (4- (2,4-N' - (4 - ((3-chloro-2-dichlorobenzyl) -2,5-fluorophenyl) amino) -2.5- 319 722 dimethylphenyl) -N-ethyl-dimethylphenyl) -N-ethyl-N- N-methylformimidamide methylformimidamide N-ethyl-N '- (4 - (((2-fluoro-6- N-ethyl-N '- (4- (2-methylphenyl) amino) -2,5- 320 fluorobenzyl) phenyl) - 723 dimethylphenyl) -N- N-methylformimidamide methylformimidamide N' - (4- (2- N '- (4 - (( 4-chloro-3-chlorobenzyl) phenyl) -N- (trifluoromethyl) phenyl) amin 321 724 ethyl-N- o) -2,5-dimethylphenyl) -N-methylformimidamide ethyl-N-methylformimidamide N '- (2-chlorine -4- (5- N '- (2,5-dichloro-4 - (((2-fluoro-2-fluoro-6- 322 methylbenzyl) -5- 725 methylphenyl) amino) phenyl) -N- methylphenyl) -N -ethyl-N- ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-4- (2,5-N' - (2,5-dichloro-4 - ((2-dichlorobenzyl) -5-fluoro-3 - 323 726 methylphenyl) -N-ethyl-N-methylphenyl) amino) phenyl) -N-methylformimidamide ethyl-N-methylformimi damide N '- (2-chloro-4- (4- N' - (2,5-dimethyl-4- (2-fluoro-2-methylbenzyl) phenyl) -N-ethyl-324 methylbenzyl) -5- 727 N -methylphenyl hydrochloride) -N-ethyl-N-methylformimidamide methylformimidamide

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N '- (2-chloro-4- (2- N' - (4 - ((4-chloro-5-chlorophenyl) (methyl) amino) - (trifluoromethyl) benzi 325 728 2,5-dimethylphenyl) -N- ethyl-lo) -5-methylphenyl) -N- N-ethyl-hydrochloride-N-methylformimidamide methylformimidamide N '- (2-chloro-4- (3- N' - (4- (2- (3-fluorophenyl) - fluoro-5- 1,3-dithiolan-2-yl) -2,5- 326 methoxybenzyl) -5- 729 dimethylphenyl) -N, N-methylphenyl) -N-ethyl-N-dimethylformimidamide methylformimidamide N '- (2- chloro-4- (2,3-N-ethyl-N '- (4- (3-fluoro-2-dimethylbenzyl) -5-methoxybenzyl) -2,5- 327 730 methylphenyl) -N-ethyl-N-dimethylphenyl ) -N- methylformimidamide methylformimidamide N-ethyl-N '- (5-fluoro- N-ethyl-N' - (4- (4-fluoro-2- 2-methyl-4- (3-methylbenzyl) -2,5 - 328 731 methylbenzyl) phenyl) -N- dimethylphenyl) -N- methylformimidamide methylformimidamide N-ethyl-N '- (5-fluoro- N' - (4- (5-chloro-2- 4- (3-fluorobenzyl) - 2- fluorobenzyl) -2-fluoro-5- 329 732 methylphenyl) -N- methylphenyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (4- (3- N-ethyl-N' - (2-fluoro- 5- chlorobenzyl) -5-methyl-4- (2-methyl-5- 330 fluoro-2-methylphenyl) - 733 (trifluorome tyl) benzyl) fe N-ethyl-N-nyl) -N-methylformimidamide methylformimidamide

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N '- (4- (2- N' - (4 - ((5-chloro-2-chlorobenzyl) -5-fluorophenyl) amino) -2,5- 331 fluoro-2-methylphenyl) - 734 dimethylphenyl) -N -ethyl-N- N-ethyl-N-methylformimidamide methylformimidamide N-ethyl-N '- (5-fluoro- N' - (4 - (((3-chloro-5- 2-methyl-4- (4-fluorophenyl) amino) -2,5- 332 735 methylbenzyl) phenyl) -N-dimethylphenyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-4- (3- N' - (4 - ((4- chloro-3-chloro-5-fluorophenyl) amino) -2,5- 333 fluorobenzyl) -5- 736 dimethylphenyl) -N-ethyl-N-methylphenyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (2- chloro-4- (4-chloro-3- N '- (2,5-dichloro-4 - (((5- (trifluoromethoxy) benz fluoro-2- 334 737 yl) -5-methylphenyl) -N- methylphenyl) amino ) phenyl) -N- ethyl-N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-4- (2- N' - (4 - (((2,5-chloro-5-dimethylphenyl) amino) - 2- 335 fluorobenzyl) -5- 738 fluoro-5-methylphenyl) -N-methylphenyl) -N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-4- (2,4- N' - (4 - ((3,5-dichlorobenzyl) -5-difluorophenyl) amino) -2- 336 739 methylphenyl) -N-ethyl-N-fluid ro-5-methylphenyl) -N- methylformimidamide ethyl-N-methylformimidamide

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N '- (2-chloro-4- (2,4-N' - (4 - ((2,4-difluorobenzyl) -5-difluorophenyl) amino) -2- 337 740 methylphenyl) -N-ethyl-N- fluoro-5-methylphenyl) -N- methylformimidamide ethyl-N-methylformimidamide N '- (2-chloro-4- (4- fluoro-3- N' - (4- (2-chlorobenzyl) -2,5- (trifluoromethyl ) benzi 338 741 dimethylphenyl) -N, N- lo) -5-methylphenyl) -N- dimethylformimidamide ethyl-N-methylformimidamide N-ethyl-N '- (5-fluoro-4 - (((3 N' - (2 , 5-dichloro-4- (3-fluoro-5- (trifluoromethoxy) benz 339 742 methylphenyl) amino) -2-yl) phenyl) -N-ethyl-N-methylphenyl) -N- methylformimidamide methylformimidamide N '- (2 , 5-dichloro-4- (3- N '- (4 - ((5-chloro-2- (trifluoromethyl) benzyl methylphenyl) amino) -5- 340 743 lo) phenyl) -N-ethyl-N-fluoro- 2-methylphenyl) -N- methylformimidamide ethyl-N-methylformimidamide N '- (2-chloro-4- (2- N' - (4 - (((3,4-chloro-6-difluorophenyl) amino) -2- 341 fluorobenzyl) -5- 744 fluoro-5-methylphenyl) -N-methylphenyl) -N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide N-ethyl-N '- (5-fluoro- N' - (4 - (( 5-chloro-2- 4- (2-fluorobenzyl) -2-methylphenyl) (methyl) amino) - 342 745 methylphenyl) -N- 5-fluoro-2-methylphenyl) -N- methylformimidamide ethyl-N-methylformimidamide

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N-ethyl-N '- (5-fluoro- N' - (4 - ((2,5-2-methyl-4- (2-dimethylphenyl) amino) -5- 343 746 methylbenzyl) phenyl) -N- fluoro -2-methylphenyl) -N- methylformimidamide ethyl-N-methylformimidamide N '- (2-chloro-5-methyl- N' - (4 - ((2-chloro-5- 4- (methyl (2-methylphenyl) amino ) -2- 344 (methylthio) phenyl) amino 747 fluoro-5-methylphenyl) -N-) phenyl) -N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-4 - ((3 - N '- (4 - ((5-chloro-2- (difluoromethoxy) phenyl methylphenyl) amino) -2- 345) (methyl) amino) -5- 748 fluoro-5-methylphenyl) -N- methylphenyl) -N -ethyl-N- ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-5-methyl- N' - (2,5-dichloro-4 - ((3- 4 - ((2- fluoro-5- 346 (methylthio) phenyl) amino 749 methylphenyl) amino) phenyl) -N-) phenyl) -N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide N '- (2,5-dimethyl-4- N' - (2, 5-dichloro-4 - ((3- (pyridine-2-fluoro-4- 347 ylamino) phenyl) -N- 750 methylphenyl) amino) phenyl) -N- ethyl-N-ethyl-N-methylformimidamide methylformimidamide N'- (2-chloro-5-methyl- N '- (2,5-dichloro-4 - ((2,4- 4- (methyl (pyridine-2-difluorophenyl) amino) phen il) 348 il) amino) phenyl) -N- 751 -N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide

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N '- (2,5-dimethyl-4- N' - (2,5-dichloro-4 - ((4- (methyl (pyridine-2-chloro-2- 349 yl) amino) phenyl) -N- 752 fluorophenyl) amino) phenyl) - ethyl-N- N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-4- N' - (2,5-dichloro-4 - ((4- (cyano (4- chloro-3- (trifluoromethyl) phenyl 350 753 fluorophenyl) amino) phenyl) -) methyl) -5- N-ethyl-N-methylphenyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-4- N '- (2,5-dichloro-4 - ((5- (cyano (3-chloro-2- (trifluoromethyl) phenyl 351 754 fluorophenyl) amino) phenyl) -) methyl) -5- N-ethyl-N- methylphenyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-4- N' - (2,5-dichloro-4 - ((3- (cyano (4-chloro-5- 352 fluorophenyl) methyl ) -5- 755 fluorophenyl) amino) phenyl) -methylphenyl) -N-ethyl-N- N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-4 - ((3- N' - (2.5 -dichloro-4 - ((3-chloro-4-chloro-2-fluorophenyl) (cyano) me 353 756 fluorophenyl) amino) phenyl) - tyl) -5-methylphenyl) -N- N-ethyl-N- ethyl- N- methylformimidamide methylformimidamide

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N '- (2-chloro-4- N' - (4 - ((3,5- (cyano (p-difluorophenyl) amino) -5- 354 tolyl) methyl) -5- 757 fluoro-2-methylphenyl) - N- methylphenyl) -N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-4 - ((2- N' - (4 - ((2-chloro-5-chlorophenyl)) (cyano) met methylphenyl) amino) -5- 355 yl) -5-methylphenyl) -N- 758 fluoro-2-methylphenyl) -N- ethyl-N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-4- ( (4- N '- (4 - ((3,5-chlorophenyl) (cyano) met difluorophenyl) (methyl) amino 356 yl) -5-methylphenyl) -N- 759) -5-fluoro-2-methylphenyl) - ethyl-N- N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-4- N' - (4 - ((2-chloro-5- (cyano (3-methylphenyl) (methyl) amino) - 357 fluorophenyl) methyl) -5- 760 5-fluoro-2-methylphenyl) -N-methylphenyl) -N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide N '- (4 - ((2-chloro-4- N- ethyl-N '- (2-fluoro-4 - ((2- (trifluoromethyl) phenyl fluoro-4- 358) amino) -2,5- 761 methylphenyl) amino) -5-dimethylphenyl) -N-ethyl-methylphenyl) -N- N-methylformimidamide methylformimidamide

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N '- (2-chloro-4 - ((2- N-ethyl-N' - (2-fluoro-4 - (((2-chloro-4-fluoro-6- (trifluoromethyl) phenyl 359 762 methylphenyl) amino)) -5-) amino) -5- methylphenyl) -N- methylphenyl) -N-ethyl-N-methylformimidamide methylformimidamide N '- (4 - ((2-chloro-4- N-ethyl-N' - (2-fluoro -4 - ((2- (trifluoromethyl) phenyl fluoro-3- 360) (methyl) amino) -2,5- 763 methylphenyl) amino) -5-dimethylphenyl) -N-ethyl-methylphenyl) -N- N-methylformimidamide methylformimidamide N '- (2-chloro-4 - ((2- N-ethyl-N' - (2-fluoro-4 - (((3-chloro-4-fluoro-5- (trifluoromethyl) phenyl 361 764 methylphenyl) amino ) -5-) (methyl) amino) -5-methylphenyl) -N-methylphenyl) -N-ethyl-N-methylformimidamide methylformimidamide N-ethyl-N '- (2-fluoro-4 - ((3- N'- (2-chloro-4- (2,6-fluoro-4-dichlorobenzyl) -5- 362 765 methylphenyl) amino) -5-methylphenyl) -N-ethyl-N-methylphenyl) -N- methylformimidamide methylformimidamide N-ethyl- N '- (5-fluoro- N' - (4 - ((4-chloro-2- 2-methyl-4- (3-fluorophenyl) amino) -2- 363 (trifluoromethyl) benzi 766 fluoro-5-methylphenyl) -N- lo) phenyl) -N- ethyl-N-methylformimidamide methylformimidamide

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N-ethyl-N '- (5-fluoro- N-ethyl-N' - (5-fluoro-4 - ((2- 2-methyl-4- (3-fluoro-3- 364 (trifluoromethoxy) benz 767 methylphenyl ) amino) -2-yl) phenyl) -N- methylphenyl) -N- methylformimidamide methylformimidamide N '- (2-cyclopropyl-4- N' - (4 - (((3-chloro-5- (3-fluorobenzyl) - 5-fluorophenyl) amino) -2- 365 768 methylphenyl) -N-ethyl-N-fluoro-5-methylphenyl) -N-methylformimidamide ethyl-N-methylformimidamide N '- (2-cyclopropyl-5- N' - (4 - (((5-chloro-2-methyl-4- (3-fluorophenyl) amino) -2- 366 methylbenzyl) phenyl) -N- 769 fluoro-5-methylphenyl) -N- ethyl-N-ethyl-N-methylformimidamide methylformimidamide N '- (4- (3- N' - (5-chloro-4 - (((4-chlorobenzyl) -2-fluorophenyl) amino) -2- 367 cyclopropyl-5- 770 methylphenyl) -N-ethyl-N - methylphenyl) -N-ethyl-N- methylformimidamide methylformimidamide N-ethyl-N '- (4- (3- N' - (5-chloro-4 - (((3-fluoro-5-fluorophenyl) amino) -2- 368 methylbenzyl) -2,5- 771 methylphenyl) -N-ethyl-N-dimethylphenyl) -N- methylformimidamide methylformimidamide N-ethyl-N '- (4- (2-fluoro-4- N' - (5-chloro- 4 - ((2- (trifluoromethyl) benzyl fluorophenyl) amino) -2- 369 772 lo) -2.5 - methylphenyl) -N-ethyl-N-dimethylphenyl) -N- methylformimidamide methylformimidamide

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N '- (2,5-dimethyl-4- N' - (4 - ((4- (tert- ((2-butyl) phenyl) amino) -5- 370 (methylthio) phenyl) amino 773 chloro-2- methylphenyl) -N-) phenyl) -N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide N '- (2-chloro-5-methyl-N' - (5-chloro-4 - ((4- 4- ( pyridine-2- (dimethylamino) phenyl) amino) 371 ylamino) phenyl) -N- 774 -2-methylphenyl) -N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide N-ethyl-N '- (4 - (( 4- fluoro-3- (1,1,2,2- N '- (5-chloro-4 - ((4-tetrafluoroethoxy) pheni methoxyphenyl) amino) -2- 372 775 l) amino) -2,5- methylphenyl) -N-ethyl-N-dimethylphenyl) -N- methylformimidamide methylformimidamide N '- (2-chloro-4 - (((4-fluoro-3- (1,1,2,2- N' - (5-chloro -2-methyl-4- (p-tetrafluoroethoxy) pheni 373 776 tolylamino) phenyl) -N-ethyl-1) amino) -5- N-methylformimidamide methylphenyl) -N-ethyl-N-methylformimidamide N-ethyl-N ' - (4 - ((4- N '- (5-chloro-4 - ((2,3-fluoro-3- (1,1,2,2-dihydrobenzo [b] [1,4] dioxin tetrafluoroethoxy)) pheni 374 777 -6-yl) amino) -2- l) (methyl) amino) -2,5-methylphenyl) -N-ethyl-N-dimethylphenyl) -N-methylformimidamide methylformimidamide

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N '- (2-chloro-4- (N- (2- N' - (4-fluorophenyl) methylsulf (benzo [d] [1,3] dioxol-5- 375 onamide) -5- 778 ylamino) -5 -chloro-2-methylphenyl) -N-ethyl-N-methylphenyl) -N-ethyl-N-methylformimidamide methylformimidamide N- (5-chloro-4-N '- (5-chloro-2-methyl-4 - (( 1- ((((ethyl (methyl) amino) m oxo-2,3-dihydro-1H-inden- 376 ethylene) amino) -2- 779 5-yl) amino) phenyl) -N-ethyl-methylphenyl) -N - (2-N-methylformimidamide fluorophenyl) acetamide N '- (2-chloro-4 - (((2- N' - (5-chloro-2-methyl-4 - (((5-fluorophenyl) (methyl) amoxo- 5,6,7,8- 377 ino) -5-methylphenyl) - 780 tetrahydronaphthalene-2-N, N-yl) amino) phenyl) -N-ethyl-N-dimethylformimidamide methylformimidamide N '- (2-chloro-4 - N '- (2-chloro-4- (2- (ethyl (2-cyanobenzyl) -5- 378 fluorophenyl) amino) -5- 781 methylphenyl) -N, N-methylphenyl) -N-ethyl-N-dimethylformimidamide methylformimidamide 5-chloro-N- (2- N '- (4 - (((2-fluorophenyl) -N, 2-cyanophenyl) amino) -2,5- 379 dimethyl-4- 782 dimethylphenyl) -N-ethyl-N - (((morpholinethylene) methylformimidamide mino) aniline N '- ((2-chloro-4 - ((2-N-ethyl-N' - (2-methoxy-5-fluorophenyl) (methyl) am methyl -4- (methyl (m-380 ino) -5-methylphenyl) -N- 783 tolyl) amino) phenyl) -N- isopropylformimidamid methylformimidamide a

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Compound name Compound name No.

At the.

N '- (2-chloro-4 - ((2- N-ethyl-N' - (4- (2-fluorophenyl) (methyl) am fluorobenzyl) -2-methoxy-5- 381 784 ino) -5-methylphenyl ) -N- methylphenyl) -N- methylformimidamide methylformimidamide 5-chloro-N- (2-fluorophenyl) -N, 2- N '- (4- (2-chlorobenzyl) -5- 382 dimethyl-4- 785 methoxy-2 -methylphenyl) -N- ((thiomorpholinomethylen ethyl-N-methylformimidamide o) amino) aniline N-ethyl-N '- (5-fluoro-4 - ((4-fluoro-3- N-ethyl-N' - (2 -methoxy-5- (1,1,2,2- methyl-4 - ((2-383 tetrafluoroethoxy) pheni 786 (trifluoromethyl) phenyl) amin l) amino) -2- o) phenyl) -N- methylphenyl) - N-methylformimidamide methylformimidamide N-ethyl-N '- (5-fluoro-4 - ((4-fluoro-3- N-ethyl-N' - (2-methoxy-5- (1,1,2,2-methyl -4- (3- 384 tetrafluoroethoxy) pheni 787 (trifluoromethyl) benzyl) fe l) (methyl) amino) -2-nyl) -N-methylformimidamide methylphenyl) -N- methylformimidamide N '- (2-chloro-4- ( 2,6- N-ethyl-N '- (2-methoxy-5-difluorobenzyl) -5-methyl-4- (3- 385 788 methylphenyl) -N-ethyl-N- (trifluoromethoxy) benzyl) f methylformimidamide enyl) -N-methylformimidamide

Sir

Sir

Compound name Compound name No.

At the.

N '- (2-chloro-5-methyl- N-ethyl-N' - (5-methoxy-4- (4- 4- (pyridine-3-methoxybenzyl) -2- 386 ylmethyl) phenyl) -N- 789 methylphenyl) -N- ethyl-N-methylformimidamide methylformimidamide N- (5-chloro-4-N-ethyl-N '- (2-methoxy-5- ((((ethyl (methyl) amino) m methyl-4 - (( 3- 387 ethylene) amino) -2- 790 (trifluoromethoxy) phenyl) ami methylphenyl) -N- (2-no) phenyl) -N-chlorophenyl) acetamide methylformimidamide N '- (2-chloro-4- (N- ( 2- N-ethyl-N '- (2-methoxy-5-chlorophenyl) methylsulfo methyl-4- (methyl (4-388 namide) -5- 791 (trifluoromethyl) phenyl) amin methylphenyl) -N-ethyl-N- o) phenyl) -N- methylformimidamide methylformimidamide N-ethyl-N '- (2-fluoro- N' - (4 - ((2- 5-methyl-4- (3-bromophenyl) (methyl) amino) - 389 ( trifluoromethyl) benzi 792 2-methoxy-5-methylphenyl) -N- lo) phenyl) -N- ethyl-N-methylformimidamide methylformimidamide N-ethyl-N '- (2-fluoro- N-ethyl-N' - (2- methoxy-4- (3- 5-methyl-4- (3-methoxybenzyl) -5- 390 (trifluoromethoxy) benz 793 methylphenyl) -N-yl) phenyl) -N-methylformimidamide methylformimidamide N-ethyl-N '- (2 -fluoro- 5-methyl-4- (2- N '- (2-chloro-5-methoxy-4- (3- 391 (trifluor omethoxy) benz 794 nitrobenzyl) phenyl) -N-ethyl-yl) phenyl) -N- N-methylformimidamide methylformimidamide

Sir

Sir

Compound name Compound name No.

At the.

N '- (4- (3- N' - (2-chloro-4- (3-chlorobenzyl) -2-cyanobenzyl) -5- 392 fluoro-5-methylphenyl) - 795 methoxyphenyl) -N-ethyl-N- N-ethyl-N-methylformimidamide methylformimidamide N-ethyl-N '- (2-fluoro- N' - (2-chloro-5-methoxy-4- (m- 4- (3-fluorobenzyl) -5- 393 796 tolylamino ) phenyl) -N-ethyl-methylphenyl) -N- N-methylformimidamide methylformimidamide N-ethyl-N '- (2-fluoro- N-ethyl-N' - (2-methoxy-4 - ((3- 5-methyl -4- (3-methoxyphenyl) amino) -5- 394 797 methylbenzyl) phenyl) -N-methylphenyl) -N- methylformimidamide methylformimidamide N-ethyl-N '- (2-fluoro- N-ethyl-N' - (2 -methoxy-5- 5-methyl-4- (4-methyl-4- (methyl (o-395 798 methylbenzyl) phenyl) -N-tolyl) amino) phenyl) -N- methylformimidamide methylformimidamide N-ethyl-N'- (2-fluoro- N-ethyl-N '- (4- (3-fluoro-5- 5-methyl-4- (2- (trifluoromethyl) benzyl) - 396 799 methylbenzyl) phenyl) -N- 5-methoxy- 2-methylphenyl) -N- methylformimidamide methylformimidamide N '- (4- (2- N' - (4- (2-chloro-4-chlorobenzyl) -2-fluorobenzyl) -5-methoxy-2- 397 fluoro-5- methylphenyl) - 800 methylphenyl) -N-ethyl-N- N-ethyl-N-methylformimidamide methylformimidam acid N-ethyl-N '- (2-fluoro- N' - (4- (2-cyanobenzyl) -5- 4- (2-fluorobenzyl) -5- 398 801 methoxy-2-methylphenyl) -N- methylphenyl) -N- ethyl-N-methylformimidamide methylformimidamide

Mr. Mr. Name of the compound Name of the compound No. No. N '- (2,5-dimethyl-4 N' - (4 - ((2,6- ((methylimino) (o- difluorophenyl) (methyl) amino 399 tolyl) methyl) phenyl) -N-802) -2-methoxy-5-methylphenyl) - ethyl-N- N-ethyl-N-methylformimidamide methylformimidamide N '- (4 - ((((4- (difluoromethyl) thio ) f N '- (4- (3,5-dimethylbenzyl) - 400 enyl) amino) -2,5- 803 2-methoxy-5-methylphenyl) -N-dimethylphenyl) -N-ethyl-ethyl-N-methylformimidamide N-methylformimidamide N '- (2-chloro-4 - ((4- ((difluoromethyl) thio) f N' - (4- (2-cyanobenzyl) -2- 401 enyl) amino) -5- 804 methoxy-5 -methylphenyl) -N- methylphenyl) -N-ethyl-N- ethyl-N-methylformimidamide methylformimidamide N '- (4 - ((4- ((difluoromethyl) thio) f N' - (5-chloro-2-methyl- 4- (2-enyl) (methyl) amino) - (trifluoromethoxy) benzyl) f 402 805 2,5-dimethylphenyl) -N- enyl) -N-ethyl-N-ethyl-N-methylformimidamide methylformimidamide N '- (2 -chloro-4 - (((4- N '- (5-chloro-2-methoxy-4- (4- ((difluoromethyl) thio) f (trifluoromethoxy) benzyl) f 403 enyl) (methyl) amino) -5- 806 enyl) -N-ethyl-N-methylphenyl) -N-ethyl-N-methylformimidamide methylformimidamide

[0165] * Compound names were generated using Chemdraw Professional 17.1

[0166] As described in this document, those of the compounds of Formula (I) show a fungicidal activity in relation to diseases caused by phytopathogenic fungi, in particular, by the pathogens of rust diseases such as Phakopsora pachyrhizi and Puccinia triticina that attack agricultural crops important, such as soy and wheat, respectively. Examples of biological tests (IN-VIVO TEST) Example A: Phakopsora pachyrhizi test on soybeans

[0167] The compounds were dissolved in 2% dimethylsulfoxide / acetone and mixed with water to the calibrated spray volume of 50 ml, and then were poured into the spray bottles for other applications.

[0168] To test the preventive activity of the compounds, healthy and young soybean plants, grown in the greenhouse, were sprayed with the preparation of the active compound, at the indicated application rates, inside spray booths using hollow cone jets. One day after treatment, the plants were inoculated with a spore suspension containing 2.1 x 10 6 of the Phakopsora pachyrhizi inoculum. The inoculated plants were kept in the greenhouse at 25º C of temperature and 90% relative humidity for the expression of the disease.

[0169] The visual assessment of the performance of the compound in the treated plants was carried out by classifying the severity of the disease (on a scale of 0-100%) at 3, 7, 10 and 15 days after application. The effectiveness (% control) of the compounds was calculated by comparing the classification of the disease under treatment with the control without treatment. The sprayed plants were also evaluated for the compatibility of the plants with the compost, by registering symptoms such as necrosis, chlorosis and dwarfism.

[0170] The compounds 1 2 3 5 6 8 9 10 11 12 13 15 17 18 20 24 27 32 33 35 39 42 44 45 46 47 48 51 52 53 55 56 57 59 60 62 63 65 66 68 69 70 71 72 73 75 76 79 82 94 95 96 98 100 108 110 111 113 116 117 118 122 141 142 143 153 156 158 164 172 176 177 179 180 184 185 187 189 190 191 196 197 200 203 206 216 226 241 247 256 259 260 261 264 269 270 272 276 278 279 282 283 285 288 292 293 309 318 321 322 323 324 326 327 328 330 331 332 333 335 337 340 341 342 343 344 345 348 349 357 358 359 363 365 366 368 372 373 374 375 379 383 384 389 392 396 397 401 408 412 413 424 425 437 468 469 475 477 478 483 485 487 488 489 490 491 492 498 499 504 518 523 528 529 531 533 540 542 543 549 550 554 556 559 560 561 563 564 565 575 573 577 578 581 588 591 592 597 609 613 616 618 619 620 621 623 624 625 626 631 635 636 637 641 645 646 647 648 649 651 652 653 654 657 658 660 661 662 664 665 667 670 671 675 677 678 679 686 687 690 692 693 694 696 697 698 704 705 708 710 711 713 714 715 716 717 718 721 723 724 726 727 728 729 730 732 733 737 739 740 741 747 748 749 751 754 758 759 761 762 763 764 765 766 767 768 769 775 at 500 ppm showed> 90% of the control in these tests compared to the untreated test, which showed extensive development of the disease. Example B: Puccinia graminis test on wheat

[0171] The compounds were dissolved in 2% dimethyl sulfoxide / acetone and mixed with water to the calibrated spray volume of 50 ml. This 50 ml spray solution was then poured into the spray bottles for other applications.

[0172] To test the preventive activity of the compounds, healthy and young wheat plants, grown in the greenhouse, were sprayed with the preparation of the active compound, at the indicated application rates, inside spray booths using hollow cone jets. One day after treatment, the plants were inoculated with a spore suspension (tween 20 water solution) containing 6x106 Puccinia graminis inoculum. The inoculated plants were kept in the greenhouse at 18-20º C of temperature and 90-95% relative humidity for the expression of the disease.

[0173] Visual assessment of the performance of the compound in the treated plants was carried out by classifying the severity of the disease (on a scale of 0-100%) at 3, 7, 10 and 15 days after application. The effectiveness (% control) of the compounds was calculated by comparing the classification of the disease under treatment with the control without treatment. The sprayed plants were also evaluated for phytotoxic effects of the compound, registering symptoms such as necrosis, chlorosis and growth retardation.

[0174] Compounds 88 90 102 103 106 at 500 ppm showed> 90% of the control in these tests compared to the untreated test, which showed extensive disease development.

[0175] Having described the invention with reference to certain preferred aspects, other aspects will become evident to an expert from the consideration of the specification.

It will be evident to experts that it is possible to make many modifications, both in materials and methods, without departing from the scope of the invention.

Claims (12)

1. Use of a 4-substituted phenylamidine compound of Formula (I) Formula (I) in which, R1 is selected from the group consisting of hydrogen, CN, S (O) nR ″, OR ″, C1-C12 -alkyl, C1-C12-alkoxy, C1-C12-alkylthio, C2-C12-alkenyl, C2-C12-alkynyl, C1-C12-haloalkyl, C2-C12-haloalkenyl, C1-C12-haloalkoxy, C1-C12-haloalkylthio , C3-C8-cycloalkyl, C4-C8-cycloalkenyl and C5-C8-cycloalkyl; wherein one or more carbon atoms in the cyclic ring system can be replaced by hetero atoms selected from the group consisting of N, O, and S (O) n; R2 and R3 are independently selected from the group consisting of hydrogen, CN, S (O) nR ″, OR ′, (C = O) -R ″, C1-C12-alkyl, C2-C12-alkenyl, C2- C12-alkynyl, C1-C12-haloalkyl, C2-C12-haloalkenyl, C2-C12-haloalkynyl, C3-C8-cycloalkyl, C4-C8-cycloalkenyl, C5- C8-cycloalkynyl, C6-C18-aryl and C7-C19- aralkyl; wherein one or more carbon atoms in the cyclic ring system can be replaced by hetero atoms selected from the group consisting of N, O, and S (O) n; or R1 and R2, R2 and R3 or R1 and R3 together with the atoms to which they are attached, or together with other atoms selected from the group consisting of C, N, O, S and which optionally include from 1 to 3 members rings selected from the group consisting of C (= O), C (= S), S (O) m and SiR′2 can form a four to seven-membered non-aromatic ring, which in turn can be replaced by one or more X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN, or CONR′2; each group of R1, R2, and R3 can be optionally substituted by one or more groups selected from the group consisting of X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN, or CONR′2; R4, R5, R6 and R7 are independently selected from the group consisting of hydrogen, X, CN, SCN, SF5, S (O) nR ″, SiR′3, OR ″, NR′R ″, (C = O ) -R ″, CR′═NR ″, C1- C12-alkyl, C2-C12-alkenyl, C2-C12-alkynyl, C1-C12-haloalkyl, C2-C12-haloalkenyl, C2-C12-haloalkynyl, C1- C12 -haloalkoxy, C1-C12-haloalkylthio, C3-C8-cycloalkyl, C4-C8-cycloalkenyl, C5-C8-cycloalkynyl, C3-C8-cycloalkyloxy, C3-C8-cycloalkylthio, C6-C18-aryl and C7- C19-aral ; wherein one or more carbon atoms in the cyclic ring system can be replaced by hetero atoms selected from the group consisting of N, O, and S (O) n; and all the groups mentioned above can optionally be replaced by one or more groups selected from the group consisting of X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN, or CONR ′ two; or R4 and R7 or R5 and R6 together with the atom to which they are attached, or together with other atoms selected from the group consisting of C, N, O, S and which optionally include from 1 to 3 ring members selected from from the group consisting of C (= O), C (= S), S (O) m and SiR′2 can form a four to seven membered ring, which in turn can be replaced by one or more X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN, or CONR′2; each group of R4, R5, R6 and R7 can optionally be replaced by one or more groups selected from the group consisting of X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN , or CONR′2; L represents CR8R9 or NR10; R8 and R9 are independently selected from the group consisting of hydrogen, X, CN, SCN, S (O) nR ″, OS (O) nR ″, SiR′3, OSiR′3, NR′R ″, NR ′ S (O) nR ″, (C = O) -R ″, CR ′ = NR ″, C1-C12-alkyl, C2-C12-alkenyl, C2-C12-alkynyl, C1-C12-alkoxy, C2-C12- alkenyloxy, C2-C12-alkynyloxy, C1-C12-haloalkyl, C2-C12-haloalkenyl, C2-C12-haloalkynyl, C1-C12-haloalkoxy, C1-C12-haloalkylthio, C3-C8-cycloalkyl, C4-C8-cycle C5-C8-cycloalkynyl, C3-C8-cycloalkyloxy, C3-C8-cycloalkylthio, C6-C18-aryl and C7-C19-aralkyl; wherein one or more carbon atoms in the cyclic ring system can be replaced by hetero atoms selected from the group consisting of N, O, and S (O) n; and all the groups mentioned above can be replaced by one or more groups selected from the group consisting of X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN, or CONR′2 ; or R8 and R9 together with the atom to which they are attached or together with other atoms selected from the group consisting of C, N, O, S and which optionally include from 1 to 3 ring members selected from the group consisting of in C (= O), C (= S), S (O) m and SiR′2 can form a three to seven membered ring, which in turn can be replaced by one or more X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN, or CONR′2; or R8 and R9, together with the atom to which they are attached, can form a group of = C (R′R ′ ″), = S, = NR ′ ″; R10 is selected from the group consisting of hydrogen, CN, SCN, S (O) nR ″, SiR′3, NR′R ″, (C = O) -R ″, CR ′ = NR ″, C1-C12 -alkyl, C2-C12-alkenyl, C2-C12-alkynyl, C1-C12-haloalkyl, C2-C12-haloalkenyl, C2-C12-haloalkynyl, C3-C8-cycloalkyl, C4-C8-cycloalkenyl, C5- C8-cycloalkynyl , C6-C18-aryl and C7-C19-aralkyl; wherein one or more carbon atoms in the cyclic ring system can be replaced by hetero atoms selected from the group consisting of N, O, and S (O) n; and all the groups mentioned above can be replaced by one or more groups selected from the group consisting of X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN, or CONR′2 ; A is selected from the group consisting of fused or unfused C6-C18-aryl and C5-C18-heteroaryl; wherein one or more heteroatoms selected from N, O, S and one or more carbon atoms are optionally substituted by C (= O), C (= S), S (O) m and SiR′2; which are optionally substituted by one or more groups of R11; R11 is selected from the group consisting of hydrogen, X, CN, SCN, SF5, R ″, OR ′ ′, NO2, NR′′2, SiR′3, (C = O) -R ″, S (O ) nR ″, OS (O) nR ″, NR′S (O) nR ″, OSiR′3, C1-C8- alkyl-S (O) nR ″, C1-C8-alkyl- (C = O) -R ″, CR ′ = NR ″, S (O) nC6-C18-aryl, S (O) nC7-C19-aralkyl, S (O) nC7-C19-alkaryl, C1-C12-alkyl, C2-C12-alkenyl, C2-C12-alkynyl, C1-C12-haloalkyl, C2-C12-haloalkenyl, C2-C12-haloalkynyl, C1-C12- alkoxy, C1-C12-alkylthio, C1-C12-holoalkoxy, C1-C12-haloalkylthio, C3-12-cycloalkyl, C4-C8-cycloalkenyl, C5-C8-cycloalkyl, C3-C8-cycloalkyloxy, C3-C8-cycloalkylalkyl, C7-C19-aralkyl, C5-C12-bicyclic alkyl and C7-C12-bicyclic alkenyl; wherein one or more carbon atoms in the cyclic ring system can be replaced by hetero atoms selected from the group consisting of N, O, and S (O) n; and all the groups mentioned above can be replaced by one or more groups selected from the group consisting of X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN, or CONR′2 ; or two R11 together with the atom to which they are attached or together with other atoms selected from the group consisting of C, N, O, S and which optionally include from 1 to 3 ring members selected from the group consisting of C (= O), C (= S), S (O) m and SiR′2 can form a four to ten membered ring, which in turn can be replaced by one or more X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN, or CONR′2; each group of R8, R9, R10 and R11 can be optionally substituted by one or more groups selected from the group consisting of X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN , or CONR′2; X represents halogen; R ′ is selected from the groups consisting of hydrogen, straight or branched chain C1-C12-alkyl and C3-10-cyclic alkyl; each group of R ′ is optionally replaced by one or more X; R ″ is selected from the groups consisting of hydrogen, NR′2, OR ′, straight or branched C1-C12-alkyl, C1-C12-haloalkyl, C3-C8-cyclic alkyl, each group of R ″ is optionally substituted by one or more groups selected from the group consisting of X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN, or CONR′2; and C6-C18-aryl which is optionally substituted by one or more R ′; R ′ ″ is selected from the groups consisting of hydrogen, R ″, CN, OR ′, (C = O) -R ′, COOR ′, CONR′2, straight or branched C1-C12-alkyl, C2 -C12- alkenyl, C2-C12-alkynyl, C3-C8-cyclic alkyl, C4-C8-cyclic alkenyl, C5-C8-cyclic alkynyl, C6-C18-aryl and C7-C19-aralkyl; wherein one or more carbon atoms in the cyclic ring system can be replaced by hetero atoms selected from the group consisting of N, O, and S (O) n; and all the groups mentioned above can be replaced by one or more groups selected from the group consisting of X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN, or CONR′2 ; R ′ and R ′ ″ together with the atom to which they are attached or together with other atoms selected from the group consisting of C, N, O, S and which optionally include from 1 to 3 ring members selected from the group consisting of C (= O), C (= S), S (O) m and SiR′2 can form a three to six membered ring, which in turn can be replaced by one or more X, R ′, OR ′, SR ′, NR′2, SiR′3, COOR ′, CN, or CONR′2; m and n represent integers where n = 0, 1 or 2; and m = 1 or 2; or its agronomically acceptable salts, metal complexes, structural isomers / isomers, stereoisomers, diastereoisomers, enantiomers, tautomers or N-oxides, to control or prevent diseases caused by pathogens of rust diseases in agricultural and / or horticultural crops. The use of a compound of Formula (I) according to Claim 1, wherein said compound of Formula (I) is selected from N '- (2,5-dimethyl-4- (phenylamino) phenyl ) -N-ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4- (methyl (phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-5- methyl-4- (phenylamino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-5-methyl-4- (methyl (phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (4-benzyl-2,5-dimethylphenyl) -N-ethyl- N-methylformimidamide, N' - (2,5-dimethyl-4- (N-phenylmethylsulfonamide) phenyl) -N-ethyl-N-methylformimidamide , N '- (2,5-dimethyl-4- (methyl (2-methyl-4- (perfluoropropan-2-yl) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N' - (4- ((4-chlorophenyl) (methyl) amino) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (4 - ((3-chlorophenyl) (methyl) amino) -2,5-dimethylphenyl ) -N-ethyl-N-methylformimidamide, N '- (4 - ((3,4-dichlorophenyl) (methyl) amino) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N' - (2 -chloro-5-methyl-4- (methyl (3,4,5-trifluorophenyl) amino) phenyl) - N-ethyl-N-methylformimidamide, N '- (2-chloro-5-methyl-4- (methyl (m-tolyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro- 4 - ((3,4- dichlorophenyl) (methyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4 - ((3-methoxyphenyl) (methyl) amino) -5-methylphenyl) -N- ethyl-N-methylformimidamide, N-ethyl-N '- (4- (methoxy (phenyl) methyl) -2,5-dimethylphenyl) -N-methylformimidamide, N' - (2-chloro-5-methyl-4- ( methyl (4- (trifluoromethyl) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-5-methyl-4- (methyl (p-tolyl) amino) phenyl) -N- ethyl-N-methylformimidamide, N '- (2-chloro-4 - ((2-methoxyphenyl) (methyl) amino) -5-methylphenyl) -N-ethyl- N-methylformimidamide, N' - (2-chloro-5 -methyl-4- (N-phenylmethylsulfonamide) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4 - ((2-chlorophenyl) (methyl) amino) -5-methylphenyl) -N- ethyl-N-methylformimidamide, N '- (2-chloro-4 - ((4-chlorophenyl) (methyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-4 - (((4-methoxyphenyl) (methyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (4- (3,5-dichlorobenzyl) -2,5-dimethylphenyl) -N-ethyl -N-methylformimidamide, N '- (4- (4- bromobenzyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N' - (4- (3,4-dichlorobenzyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4- (3-methylbenzyl) phenyl) -N-ethyl-N-methylformimidamide , N '- (4- (4-chlorobenzyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N' - (2,5-dimethyl-4- (4- (methylthio) benzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4 - ((4-methoxy-3-methylphenyl) (methyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-4 - ((3,4-dimethoxyphenyl) (methyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4 - ((3,5 - dimethoxyphenyl) (methyl) amino) -5-methylphenyl) -N-ethyl-N- methylformimidamide, N '- (2,5-dimethyl-4- (4-methylbenzyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (4- (3-chlorobenzyl) -2,5-dimethylphenyl) -N -ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4- (4- (methylsulfonyl) benzyl) phenyl) -N-ethyl- N-methylformimidamide, N' - (2,5-dimethyl-4- (methyl (m-tolyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N'- (4 - (((3-methoxyphenyl) (methyl) amino) -2,5-dimethylphenyl) -N - methylformimidamide, N '- (2,5-dimethyl-4- (methyl (p-tolyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N'- (4 - ((4-methoxyphenyl ) (methyl) amino) -2,5-dimethylphenyl) -N-methylformimidamide, N-ethyl-N '- (4 - (((3-methoxyphenyl) amino) - 2,5-dimethylphenyl) -N-methylformimidamide, N' - (2,5-dimethyl-4- (m-tolylamino) phenyl) -N-ethyl-N-methylformimidamide, N-ethyl- N '- (4 - (((4-methylphenyl) (methyl) amino) -2, 5-dimethylphenyl) -N- methylformimidamide, N '- (4- (3-bromobenzyl) -2-chloro-5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (4- (3-bromobenzyl) - 2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N '- (4- (2-fluorobenzyl) -2,5-dimethylphenyl) -N- methylformimi damida, N '- (2-chloro-4- (2-fluorobenzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-4- (2-chlorobenzyl) -5-methylphenyl ) -N-ethyl-N-methylformimidamide, N'- (4- (2-chlorobenzyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4- ( 4- (methylsulfinyl) benzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (4 - ((4- (tert-butyl) phenyl) (methyl) amino) -2,5-dimethylphenyl) -N- ethyl-N-methylformimidamide, N '- (4 - ((4- (tert-butyl) phenyl) amino) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N' - (4 - ((2 -chlorophenyl) amino) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (4 - (((2-chlorophenyl) (methyl) amino) -2,5-dimethylphenyl) -N-ethyl- N- methylformimidamide, N '- (2-chloro-4 - ((2-chlorophenyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-4- (3,4-dichlorobenzyl ) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4- (3,5-dichlorobenzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - ( 4- (4- bromobenzyl) -2-chloro-5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4- (2- (methylthio) benzyl) phenyl) -N- ethyl-N-methylformimidamide, N'- (2,5-dimethyl-4- (2- (methylsulfinyl) benzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4- ( 2- (methylsulfonyl) benzyl) phenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N '- (4 - (((2-fluorophenyl) (methyl) amino) -2,5-dimethylphenyl) -N-methylformimidamide , N '- (2-chloro-4 - ((2-fluorophenyl) (methyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N' - (4 - ((3- fluorophenyl) (methyl) amino) -2,5-dimethylphenyl) -N- methylformimidamide, N-ethyl-N '- (4 - ((4-fluorophenyl) (methyl) amino) -2,5-dimethylphenyl) -N- methylformimidamide, N '- (4- (2,5-dimethylbenzyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N' - (4- (3-bro mo- 2-fluorobenzyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (4- (3-chloro-4-fluorobenzyl) -2,5-dimethylphenyl) -N-ethyl-N -methylformimidamide, N-ethyl-N '- (4- (3-fluorobenzyl) -2,5-dimethylphenyl) -N-methylformimidamide, N'- (2-chloro-4- (3-fluorobenzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4- ((methylimino) (phenyl) methyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (2,5-dimethyl -4- (2-methylbenzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4- (2-phenyl-1,3-dithiolan-2-yl) phenyl) -N -ethyl-N- methylformimidamide, N '- (4 - ((4-chlorophenyl) amino) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N' - (4- ((4-fluorophenyl) amino) -2,5-dimethylphenyl) -N- methylformimidamide, N- (4- (3-chloro-4-fluorobenzyl) -2,5-dimethylphenyl) -1-morpholinomimimine, N- (4- (3-chloro-4- fluorobenzyl) -2,5-dimethylphenyl) -1- (piperidin-1-yl) metanimine, N- (4- (3-bromo-2-fluorobenzyl) -2,5-dimethylphenyl) -1-morpholinomethine, N- ( 4- (3-bromo-2-fluorobenzyl) -2,5-dimethylphenyl) -1- (piperidin-1-yl) metanimine, N- (2-chloro-4- (3-fluorobenzyl) -5-methylphenyl) - 1-morpholinometanimin, N- (2-chloro-4- (3-fluorobenzyl) -5-methylphenyl) -1- (piperidin-1-yl) metanimin, N- (2-chloro-4- (2-chlorobenzyl) - 5-methylphenyl) -1-morpholinomethimine, N-ethyl- N '- (4 - ((2-methoxyphenyl) amino) -2,5-dimethylphenyl) -N- methylformimidamide, N-ethyl-N' - (4- ( (3-fluorophenyl) amino) - 2,5-dimethylphenyl) -N-methylformimidamide, N '- (2-chloro-4 - ((2-fluorophenyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide , N '- (2-chloro-4 - ((3-chlorophenyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidam acid, N- (3-chlorophenyl) - N, 2,5-trimethyl-4 - ((morpholinomethylene) amino) aniline, N '- (2-chloro-4 - ((3-chlorophenyl) (methyl) amino) - 5-methylphenyl) -N-ethyl- N-methylformimidamide, N- (3-chlorophenyl) -N, 2,5-trimethyl-4- ((piperidin-1-ylmethylene) amino) aniline, N '- (4- ( (3-chlorophenyl) (methyl) amino) -2,5-dimethylphenyl) -N- cyanoformimidamide, N-allyl-N '- (4 - ((3-chlorophenyl) (methyl) amino) -2,5-dimethylphenyl) -N- methylformimidamide, N '- (4 - ((3-chlorophenyl) (methyl) amino) -2,5-dimethylphenyl) -N-isopropyl-N-methylformimidamide, N' - (4 - ((2-bromophenyl) amino) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (4 - ((3-chlorophenyl) amino) -2,5- dimethylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N '- (4- ((4-methoxyphenyl) amino) -2,5-dimethylphenyl) -N-methylformimidamide, N' - (2-chloro-5 -methyl-4- (3-methylbenzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-5-methyl-4- (4-methylbenzyl) phenyl) -N-ethyl-N-methylformimidamide , N '- (2,5-dimethyl-4 - ((2- (trifluoromethyl) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N' - (2,5-dimethyl-4- (methyl ( 2- (trifluoromethyl) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N '- (4- (3-methoxybenzyl) -2,5-dimethylphenyl) -N-methylformimidamide, N'- (2,5-dimethyl-4- (3- (trifluoromethyl) benzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (4- (3-cyanobenzyl) -2,5-dimethylphenyl) -N-ethyl -N- methylformimidamide, N '- (4- (4-cyanobenzyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N' - (2,5-dimethyl- 4- (3-nitrobenzyl) phenyl ) -N-ethyl-N-methylformimidamide, N'- (2,5-dimethyl-4- (2-nitrobenzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4- (3- (trifluoromethoxy) benzyl) phenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N '- (4- (3-fluoro-5- (trif fluoromethyl) benzyl) -2,5-dimethylphenyl) -N-methylformimidamide, N '- (2,5-dimethyl-4- (2-methyl-5- (trifluoromethyl) benzyl) phenyl) -N-ethyl-N-methylformimidamide , N-ethyl-N '- (4- (4-methoxybenzyl) -2,5-dimethylphenyl) -N-methylformimidamide, N' - (2,5-dimethyl-4 - ((4- (trifluoromethyl) phenyl) amino ) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4 - ((3- (trifluoromethoxy) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N' - ( 2,5-dimethyl-4- (methyl (4- (trifluoromethyl) phenyl) amino) phenyl) -N-ethyl-N- methylformimidamide, N '- (2,5-dimethyl-4- (methyl (3- (trifluoromethoxy) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N' - (2,5-dimethyl-4- ( (3- (methylthio) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (4 - ((2-bromophenyl) (methyl) amino) -2,5-dimethylphenyl) -N- ethyl- N-methylformimidamide, N- (4- (2-fluorobenzyl) -2,5-dimethylphenyl) -1-morpholinomethimine, N- (4- (4-fluorobenzyl) - 2,5-dimethylphenyl) -1-morpholinomimine, N- ethyl-N '- (4- (4-fluorobenzyl) -2,5-dimethylphenyl) -N-methylformimidamide, N- (4- (2-fluorobenzyl) -2,5-dimethylphenyl) -1- (piperidin-1- il) metanimin, N- (4- (2-chlorobenzyl) -2,5-dimethylphenyl) -1- (piperidin-1-yl) metanimin, N- (4- (4-fluorobenzyl) -2,5-dimethylphenyl) -1- (piperidin-1-yl) metanimine, N '- (4- (2-fluorobenzyl) -2,5-dimethylphenyl) -N-methoxy-N-methylformimidamide, N' - (4- (2-chlorobenzyl) -2,5-dimethylphenyl) -N-methoxy-N-methylformimidamide, N- (4- (2-chlorobenzyl) -2,5-dimethylphenyl) -1-morpholinomimimine, N- cyano-N '- (4- (2 -fluorobenzyl) -2,5-dimethylphenyl) formimidamide, N '- (4- (2-chlorobenzyl) -2,5-dimethyl nil) -N-cyanoformimidamide, N '- (4- (2-fluorobenzyl) - 2,5-dimethylphenyl) -N-isopropylformimidamide, N' - (4- (2-chlorobenzyl) -2,5-dimethylphenyl) -N -isopropylformimidamide, N '- (2-chloro-4- (4-cyanobenzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-4- (4-methoxybenzyl) -5- methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4- (3-methoxybenzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-5- methyl-4- (3-nitrobenzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4- (3-cyanobenzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N -ethyl-N '- (4 - ((2-methoxyphenyl) (methyl) amino) -2,5-dimethylphenyl) -N- methylformimidamide, N '- (2,5-dimethyl-4- (methyl (3- (methylthio) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-5-methyl-4 - (((3- (methylthio) phenyl) amino) phenyl) -N- ethyl-N-methylformimidamide, N '- (2-chloro-5-methyl-4- (m-tolylamino) phenyl) -N-ethyl-N -methylformimidamide, N '- (2-chloro-4 - ((3-methoxyphenyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-5-methyl-4- ( o-tolylamino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4 - ((4-chlorophenyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N'- (2,5-dimethyl-4- (o-tolylamino) phenyl) - N-ethyl-N-methylformimidamide, N '- (2-chloro-4 - ((4-methoxyphenyl) amino) -5-methylphenyl) -N -ethyl-N-methylformimidamide, N '- (2-chloro-5-methyl-4- (methyl (o-tolyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N' - (4 - ((2 - bromophenyl) amino) -2-chloro-5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (4 - ((2-bromophenyl) (methyl) amino) -2-chloro-5-methylphenyl) - N-ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4- (methyl (o-tolyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-4- ((2-methoxy phenyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-5-methyl-4 - ((2- (trifluoromethyl) phenyl) amino) phenyl) -N-ethyl- N-methylformimidamide, N '- (2-chloro-5-methyl-4- (methyl (2- (trifluoromethyl) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-5 -methyl-4 - ((4- (trifluoromethyl) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4 - ((3-fluorophenyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4 - ((4-fluorophenyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-4 - (((3-fluorophenyl) (methyl) amino) -5-methylphenyl) -N-ethyl-N- methylformimidamide, N '- (2-chloro-4 - ((4-fluorophenyl) (methyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (4-benzyl-2-chloro-5 -methylphenyl) -N- ethyl-N-methylformimidamide, N '- (2-chloro-5-methyl-4- (2-nitrobenzyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro- 4- (4-fluorobenzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-5-methyl-4- (4- ((trifluoromethyl) thio) benzyl) phenyl) -N -ethyl-N-methylformimidamide, N '- (2-chloro-4- (3-chlorobenzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-4- (4-chlorobenzyl ) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N'- (2-chloro-5-methyl-4- (3- (trifluoromethyl) benzyl) phenyl) -N- ethyl-N-methylformimidamide, N ' - (4- (2-fluorobenzyl) -2,5-dimethylphenyl) -N-isopropyl-N-methylformimidamide, N '- (4- (2-chlorobenzyl) -2,5-dimethylphenyl) -N-isopropyl-N- methylformimidamide, N-allyl-N '- (4- (2-fluorobenzyl) -2,5-dimethylphenyl) -N-methylformimidamide, N-allyl-N' - (4- (2-chlorobenzyl) -2,5-dimethylphenyl ) -N-methylformimidamide, N- (4- (2-fluorobenzyl) -2,5-dimethylphenyl) -1- thiomorpholin ometanimine, N- (4- (2-chlorobenzyl) -2,5-dimethylphenyl) -1-thiomorpholinometanimine, N- (cyclopropylmethyl) -N '- (4- (2-fluorobenzyl) -2,5-dimethylphenyl) -N -methylformimidamide, N- (cyclopropylmethyl) - N '- (4- (2-fluorobenzyl) -2,5-dimethylphenyl) -N- isopropylformimidamide, N' - (4- (2-chlorobenzyl) -2,5-dimethylphenyl) -N- (cyclopropylmethyl) -N- isopropylformimidamide, N '- (4- (2-chlorobenzyl) -2,5-dimethylphenyl) -N-cyano-N- (cyanomethyl) formimidamide, N-cyano- N- (cyanomethyl) -N '- (4- (2-fluorobenzyl) -2,5-dimethylphenyl) formimidamide, N' - (2,5-dimethyl-4- (4- ((trifluoromethyl) thio) benzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4- (2- (trifluoromethyl) benzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4- (4- (trifluoromethyl) benzyl) phenyl) -N-ethyl- N-methylformimidamide, N' - (2,5-dimethyl-4 - ((3- (trifluoromethyl) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-5-methyl-4 - (((3- (trifluoromethyl) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide , N '- (2-chloro-5-methyl-4- (methyl (3- (trifluoromethyl) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N' - (2,5-dimethyl-4- (methyl (3- (trifluoromethyl) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4- (4-chloro-3-fluorobenzyl) - 5-methylphenyl) -N- ethyl-N-methylformimidamide, N '- (4- (3,5-bis (trifluoromethyl) benzyl) -2-chloro-5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-5 -methyl-4- (4-methyl-3- (trifluoromethyl) benzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4- (3-fluoro-5- (trifluoromethyl) benzyl) -5- methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4- (2-chloro-4-fluorobenz il) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4- (2-cyanobenzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2 -chloro-5-methyl-4- (4- (trifluoromethyl) benzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-5-methyl-4- (2- (trifluoromethoxy) benzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-5-methyl-4- (2- (trifluoromethyl) benzyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (4- ((2,6-difluorophenyl) amino) -2,5-dimethylphenyl) -N-ethyl- N-methylformimidamide, N '- (2-chloro-4 - ((2,6-difluorophenyl) amino) -5-methylphenyl ) -N-ethyl-N- methylformimidamide, N '- (4 - ((2,6-difluorophenyl) (methyl) amino) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-4 - ((2 , 6-difluorophenyl) (methyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (4 - (((2-chloro-6-fluorophenyl) amino) - 2,5-dimethylphenyl) - N-ethyl-N-methylformimidamide, N '- (2-chloro-4 - ((2-chloro-6-fluorophenyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (4- ((2-chloro-6-fluorophenyl) (methyl) amino) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4 - ((4- (pentafluoro- 16-sulfanyl) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4- (4-methyl-3- (trifluoromethyl) benzyl) phenyl) -N-ethyl- N-methylformimidamide, N '- (4- (4-chloro-3-fluorobenzyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N' - (4- (3,5-bis (trifluoromethyl) benzyl) - 2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (4- (3- (1-cyanoethyl) benzyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (4- (4-chloro-3-methylbenzyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N' - (4- (4- flu oro-3-methylbenzyl) -2,5-dimethylphenyl) -N-methylformimidamide, N '- (4- (2-chloro-4-fluorobenzyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (4- (3- (dimethylamino) benzyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N' - (4- (2,3-dimethylbenzyl) -2,5-dimethylphenyl) - N-ethyl-N-methylformimidamide, N '- (4- (3,4-dimethylbenzyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N' - (4- (3,5-dimethylbenzyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (4- (2-cyanobenzyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N' - (2,5 -dimethyl-4- (2- (trifluoromethoxy) benzyl) phenyl) -N- ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4- (4- (trifluoromethoxy) benzyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (4 - ((2,6-dichloro -4- (trifluoromethyl) phenyl) amino) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (4- (3-chloro-2-fluorobenzyl) -2,5-dimethylphenyl) -N -ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4 - ((2- (trifluoromethoxy) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-5 -methyl-4 - ((2- (trifluoromethoxy) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-5-methyl-4 - ((3- (trifluoromethoxy) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4 - ((4- (trifluoromethoxy) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N'- (2-chloro-5-methyl-4 - (((4- (trifluoromethoxy) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4- (methyl (2- (trifluoromethoxy) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-5-methyl-4- (methyl (2- (trifluoromethoxy) phenyl) amino) phenyl) -N-ethyl -N- methylformimidamide, N '- (2,5-dimethyl-4- (methyl (4- (trifluoromethoxy) phenyl) amino) pheni l) -N-ethyl-N-methylformimidamide, N '- (2-chloro-5-methyl-4- (methyl (4- (trifluoromethoxy) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-5-methyl-4- (methyl (3- (trifluoromethoxy) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N '- (4 - ((2-fluorophenyl ) amino) - 2,5-dimethylphenyl) -N-methylformimidamide, N '- (2-chloro-4- (4-fluoro-3-methylbenzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-4- (4-chloro-3-methylbenzyl) - 5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-5- methyl-4- (4- (trifluoromethoxy) benzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-5-methyl-4- (2-methylbenzyl) phenyl) -N-ethyl-N -methylformimidamide, N '- (2-chloro-4- (3-chloro-2-fluorobenzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-5-methyl-4- (3- (trifluoromethoxy) benzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4- (2-chloro-3-fluorobenzyl) - 5-methylphenyl) -N-ethyl-N- methylformimidamide, N '- (2-chloro-4- (3-chloro-2-fluoro-5- (trifluoromethyl) benzyl) -5-methylphenyl) - N-ethyl-N-methylformimidamide, N' - (2-chloro- 4 - ((2,6-dichloro-4- (trifluoromethyl) phenyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (4- (cyano (phenyl) methyl) -2,5 - dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4- (2,3-dichlorobenzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2-chlorine -4- (3,5-difluorobenzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4- (3,5-dimethylbenzyl) -5-methylphenyl) -N-ethyl -N- methylformimidamide, N '- (2-chloro-5-methyl-4 - ((4- (pentafluoro-16-sulfanyl) phenyl) amino) phenyl) -N-ethyl-N -methylformimidamide, N '- (2-chloro-4 - ((2-chloro-6-fluorophenyl) (methyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2,5- dimethyl-4- (methyl (4- (pentafluoro-16-sulfanyl) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-5-methyl-4- (methyl (4- (pentafluoro-16-sulfanyl) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (4- (2-chloro-3-fluorobenzyl) -2,5-dimethylphenyl) -N-ethyl-N -methylformimidamide, N '- (2,5-dimethyl- 4- (pyridine-3-ylmethyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (4- (3,5-difluorobenzyl) -2,5 -dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (4- (2,3-dichlorobenzyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N' - (4- (3- chlorine- 2-fluoro-5- (trifluoromethyl) benzyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (4- (3-chloro-5-fluorobenzyl) - 2,5-dimethylphenyl) - N-ethyl-N-methylformimidamide, N '- (2-chloro-5-methyl-4- (methyl (3- (methylthio) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N' - (2 , 5-dimethyl-4 - ((2- ((trifluoromethyl) thio) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-5-methyl-4 - ((2- ((trifluoromethyl) thio) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (4 - (((((difluoromethyl) thio) phenyl) amino) -2,5-dimethylphenyl) -N -ethyl- N-methylformimidamide, N '- (2,5-dimethyl-4 - ((4- ((trifluoromethyl) thio) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N' - (2- chloro-5-methyl-4 - ((4- ((trifluoromethyl) thio) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4- (methyl (2- ((trifluoromethyl) thio) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-5-methyl-4- (methyl (2- ((trifluoromethyl) thio) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4- (methyl (4- ((trifluoromethyl) thio) phenyl) amino) phenyl) -N-ethyl -N- methylformimidamide, N '- (2-chloro-5-methyl-4- (methyl (4- ((trifluoromethyl) thio) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N' - (2 -chloro-4- (4-chloro-3- (trifluoromethyl) benzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4- (3-fluoro-4- (trifluoromethyl ) benzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4- (3,4-difluorobenzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-4- (3-fluoro-4-methylbenzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4- (3-fluoro-5-methylbenzyl) - 5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro- 4- (3-methylbenzyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (4- (4- chloro-3- (trifluoromethyl) benzyl) -2,5-dimethylphenyl) -N- ethyl-N-methylformimidamide, N '- (4- (2-chloro-5-fluorobenzyl) - 2,5-dimethylphenyl) -N- ethyl-N-methylformimidamide, N-ethyl-N'- (4- (3-fluoro-4-methylbenzyl) -2,5-dimethylphenyl) -N-methylformimidamide, N '- (4- (4-chloro-3- (trifluoromethoxy) benzyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (4- (3,4-difluorobenzyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (4 - ((3- ((difluoromethyl) thio) phenyl) (methyl) amino) -2,5-dimethylphenyl) - N-ethyl-N-methylformimidamide, N' - (2,5-dimethyl-4 - (((3- ((trifluoromethyl) thio) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4 - ((4- (methylthio) phenyl) amino) phenyl ) -N-ethyl-N-methylformimidamide, N '- (2-chloro-5-methyl-4 - ((4- (methylthio) phenyl) amino) phenyl) -N- ethyl-N-methylformimidamide, N' - ( 2,5-dimethyl-4- (methyl (3- ((trifluoromethyl) thio) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-5- methyl-4- (methyl (3- ((trifluoromethyl) thio) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4- (methyl (4- (methylthio) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-5-methyl-4- (methyl (4- (methylthio) phenyl) amino) phenyl) -N-ethyl-N- methylformimidamide, N '- (2,5-dimethyl-4 - ((3- (pentafluoro-16-sulfanyl) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-5- methyl-4 - (((3- (pentafluoro-16-sulfanyl) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4- (methyl (3- (pentafluoro- 16-sulfanyl) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-5-methyl-4- (methyl (3- (pentafluoro-16-sulfanyl) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N' - (4 - ((3 , 5-bis (trifluoromethyl) phenyl) amino) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (4 - (((3,5-bis (trifluoromethyl) phenyl) amino) -2- chloro-5-methylphenyl) -N- ethyl-N-methylformimidamide, N '- (2-chloro-5-methyl-4 - ((3- ((trifluoromethyl) thio) phenyl) amino) phenyl) -N-ethyl- N- methylformimidamide, N '- (2,5-dichloro-4- (4-methylbenzyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (2,5-dichloro-4- (3-fluorobenzyl) phenyl ) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4- (2-fluorobenzyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (2,5-dichloro-4- (2-chlorobenzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4- (2-methylbenzyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (2, 5- dichloro-4- (3-chlorobenzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4 - ((4- (dimethylamino) phenyl) amino) -5-methylphenyl) -N -ethyl-N- methylformimidamide, N '- (4 - ((4- (dimethylamino) phenyl) amino) - 2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N' - (2-clo ro- 4 - ((3 - ((difluoromethyl) thio) phenyl) amino) -5-methylphenyl) -N- ethyl-N-methylformimidamide, N '- (2-chloro-4 - ((3- ((difluoromethyl) thio) phenyl) (methyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (4 - ((3- (difluoromethoxy) phenyl) amino) -2,5-dimethylphenyl) -N- ethyl-N-methylformimidamide, N '- (4 - ((3- (difluoromethoxy) phenyl) (methyl) amino) -2,5-dimethylphenyl) -N- ethyl-N-methylformimidamide, N' - (2-chloro- 4 - ((3- (difluoromethoxy) phenyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (4 - ((4- (difluoromethoxy) phenyl) amino) - 2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (4 - ((4- (difluoromethoxy) phenyl) (methyl) amino) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide , N '- (2-chloro-4 - ((4- (difluoromethoxy) phenyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-4 - ((4- (difluoromethoxy) phenyl) (methyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (4 - (((2,5-difluorophenyl) amino) -2,5-dimethylphenyl) -N- ethyl-N-methylformimidamide, N '- (2-chloro-4- ((2,5-difluorophenyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (4 - ((3, 5- bis (trifluoromethyl) phenyl) (methyl) amino) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (4 - ((3,5-bis (trifluoromethyl) phenyl) (methyl) amino) -2-chloro-5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4- ((5-methyl-2- (trifluoromethyl) phenyl) amino) phenyl) - N-ethyl-N-methylformimidamide, N '- (4 - ((2,5-difluorophenyl) (methyl) amino) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N' - (2-chlorine -4 - ((2,5-difluorophenyl) (methyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4- (methyl (5-methyl-2- (trifluoromethyl) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (4 - (((4-chloro-2- (trifluoromethyl) phenyl) amino) -2 , 5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4 - ((4-chloro-2- (trifluoromethyl) phenyl) amino) -5-methylphenyl) -N-ethyl-N - methylformimidamide, N '- (4 - ((4-chloro-2- (trifluoromethyl) phenyl) (methyl) amino) -2,5-dimethylphenyl) -N- ethyl-N-methylformimidamide, N' - (2-chlorine -4 - (((4-chloro-2- (trifluoromethyl) phenyl) (methyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (4- (2,6-dichlorobenzyl) -2 , 5- dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (4- (2-bromobenzyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N' - (4- (2-chloro-6 -fluorobenzyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N '- (4- (3-fluoro-5-methoxybenzyl) - 2,5-dimethylphenyl) -N-methylformimidamide, N-ethyl-N '- (4- (5-fluoro-2-methylbenzyl) -2,5-dimethylphenyl) -N-methylformimidamide, N-ethyl-N' - (4- (3-fluoro-4- (trifluoromethyl ) benzyl) -2,5-dimethylphenyl) -N-methylformimidamide, N '- (4- (2-chloro-5- (trifluoromethyl) benzyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (4- (2,5-dichlorobenzyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N' - (4- (2,4-difluorobenzyl) -2,5-dimethylphenyl) -N -ethyl-N- methylformimidamide, N '- (4- (2,4-dichlorobenzyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N' - (4- (2-fluorobenzyl ) phenyl) -N-methylformimidamide, N '- (4- (2-chlorobenzyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-4- (5-fluoro-2-methylbenzyl) - 5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4- (2,5-dichlorobenzyl) -5-met ylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4- (4-fluoro-2-methylbenzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2- chloro-4- (2-chloro-5- (trifluoromethyl) benzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4- (3-fluoro-5-methoxybenzyl) - 5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4- (2,3-dimethylbenzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N' - (5-fluoro-2-methyl-4- (3-methylbenzyl) phenyl) -N-methylformimidamide, N-ethyl-N '- (5-fluoro-4- (3-fluorobenzyl) -2-methylphenyl) -N - methylformimidamide, N '- (4- (3-chlorobenzyl) -5-fluoro-2- methylphenyl) -N-ethyl-N-methylformimidamide, N '- (4- (2-chlorobenzyl) -5-fluoro-2-methylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N' - (5- fluoro-2-methyl-4- (4-methylbenzyl) phenyl) -N-methylformimidamide, N '- (2-chloro-4- (3-chloro-5-fluorobenzyl) -5-methylphenyl) -N-ethyl-N - methylformimidamide, N '- (2-chloro-4- (4-chloro-3- (trifluoromethoxy) benzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-4- ( 2-chloro-5-fluorobenzyl) - 5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4- (2,4-dichlorobenzyl) -5-methylphenyl) -N-ethyl-N - methylformimidamide, N '- (2-chloro-4- (2,4-difluorobenzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-4- (4- fluoro-3 - (trifluoromethyl) benzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4- (3- (trifluoromethoxy) benzyl) phenyl) -N-ethyl-N-methylformimidamide , N '- (2,5-dichloro-4- (3- (trifluoromethyl) benzyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-4- (2-chloro-6-fluorobenzyl ) -5-methylphenyl) -N- ethyl-N-methylformimidamide, N-ethyl-N '- (5-fluoro-4- (2-fluorobenzyl) -2- methylphenyl) -N-methylformimidamide, N-ethyl- N '- (5-fluoro-2-methyl-4- (2-methylbenzyl) phenyl) -N-methylformimidamide, N' - (2-chloro-5-methyl-4 - (methyl (2- (methylthio) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4 - ((3- (difluoromethoxy) phenyl) (methyl) amino) -5 - methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-5-methyl-4 - ((2- (methylthio) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N' - (2,5-dimethyl-4- (pyridine-2-ylamino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-5-methyl-4- (methyl (pyridine-2-yl ) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4- (methyl (pyridine-2- il) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4- (cyano (4- (trifluoromethyl) phenyl) methyl) -5-methylphenyl) -N-ethyl- N-methylformimidamide , N '- (2-chloro-4- (cyano (3- (trifluoromethyl) phenyl) methyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-4- (cyano ( 4-fluorophenyl) methyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4 - ((3-chloro-4-fluorophenyl) (cyano) methyl) -5-methylphenyl) -N-ethyl-N- methylformimidamide, N '- (2-chloro-4- (cyano (p-tolyl) methyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro- 4 - (((2-chlorophenyl) (cyano) methyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4 - ((4-chlorophenyl) (cyano) methyl) -5 -methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4- (cyano (3-fluorophenyl) methyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (4 - (((2-chloro-4- (trifluoromethyl) phenyl) amino) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4 - ((2-chloro-4- (trifluoromethyl) phenyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (4 - ((2-chloro-4- (trifluoromethyl) phen il) (methyl) amino) -2,5-dimethylphenyl) -N- ethyl-N-methylformimidamide, N '- (2-chloro-4 - ((2-chloro-4- (trifluoromethyl) phenyl) (methyl) amino ) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4- (2,6-dichlorobenzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl- N '- (5-fluoro-2-methyl-4- (3- (trifluoromethyl) benzyl) phenyl) -N-methylformimidamide, N-ethyl-N' - (5-fluoro-2-methyl-4- (3- (trifluoromethoxy) benzyl) phenyl) -N-methylformimidamide, N'- (2-cyclopropyl-4- (3-fluorobenzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-cyclopropyl-5 -methyl-4- (3- methylbenzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (4- (3-chlorobenzyl) -2-cyclopropyl-5-methylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N' - ( 4- (3-fluoro-5-methylbenzyl) - 2,5-dimethylphenyl) -N-methylformimidamide, N-ethyl-N '- (4- (2-fluoro-4- (trifluoromethyl) benzyl) -2,5- dimethylphenyl) -N- methylformimidamide, N '- (2,5-dimethyl-4 - ((2- (methylthio) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-5 -methyl-4- (pyridine-2-ylamino) phenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N '- (4 - ((4-fluoro-3- (1,1,2,2- tetrafluoroethoxy) phenyl) amino) -2,5-dimethylphenyl) -N-methylformimidamide, N '- (2-chloro-4 - ((4-fluoro-3- (1,1,2,2-tetrafluoroethoxy) phenyl) amino ) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N '- (4 - ((4-fluoro-3- (1,1,2,2-tetrafluoroethoxy) phenyl) (methyl) amino ) -2,5-dimethylphenyl) -N- methylformimidamide, N '- (2-chloro-4- (N- (2-fluorophenyl) methylsulfonamide) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N- ( 5-chloro-4- ((((ethyl (methyl) amino) methylene) amino) -2-methylphenyl) -N- (2-fluorophenyl) acetamide, N '- (2-chloro-4 - ((2- f fluorophenyl) (methyl) amino) -5-methylphenyl) -N, N-dimethylformimidamide, N '- (2-chloro-4- (ethyl (2-fluorophenyl) amino) -5-methylphenyl) -N-ethyl-N- methylformimidamide, 5-chloro-N- (2-fluorophenyl) -N, 2-dimethyl-4 - ((morpholinomethylene) amino) aniline, N '- (2-chloro-4 - ((2-fluorophenyl) (methyl) amino ) -5-methylphenyl) -N- isopropylformimidamide, N '- (2-chloro-4 - ((2-fluorophenyl) (methyl) amino) -5-methylphenyl) -N- methylformimidamide, 5-chloro-N- (2 -fluorophenyl) -N, 2-dimethyl- 4 - ((thiomorpholinomethylene) amino) aniline, N-ethyl-N '- (5-fluoro-4 - ((4-fluoro-3- (1,1,2,2 - tetrafluoroethoxy) phenyl) amino) -2-methylphenyl) -N-methylformimidamide, N-ethyl-N '- (5-fluoro-4 - (((4-fluoro-3- (1,1,2,2-tetrafluoroethoxy) phenyl ) (methyl) amino) -2-methylphenyl) -N-methylformimidamide, N '- (2-chloro-4- (2,6-difluorobenzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N'- (2-chloro-5-methyl-4- (pyridine-3-ylmethyl) phenyl) -N-ethyl-N-methylformimidamide, N- (5-chloro-4- ((((ethyl (methyl) amino) methylene) amino) ) -2-methylphenyl) -N- (2-chlorophenyl) acetamide, N '- (2-chloro-4- (N- (2-chlorophenyl) methylsulfonamide) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N '- (2-fluoro-5-methyl-4- (3- (trifluoromethyl) benzyl) phenyl) -N-methylformimidamide, N-ethyl-N' - (2-fluoro-5-methyl-4 - (3- (trifluoromethoxy) benzyl) phenyl) -N-methylformimidamide, N-ethyl-N '- (2-fluoro-5-methyl-4- (2- (trifluoromethoxy) benzyl) phenyl) -N-methylformimidamide, N '- (4- (3-chlorobenzyl) -2-fluoro-5-methylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N' - (2-fluoro-4- (3-fluorobenzyl) - 5- methylphenyl) -N-methylformimidamide, N-ethyl-N '- (2-fluoro-5-methyl-4- (3-methylbenzyl) phenyl) - N-methylformimidamide, N-ethyl- N '- (2-fluoro-5-methyl-4- (4-methylbenzyl) phenyl) -N-methylformimidamide, N-ethyl-N' - (2-fluoro-5-methyl- 4- (2-methylbenzyl) phenyl) -N-methylformimidamide, N '- (4- (2-chlorobenzyl) -2-fluoro-5-methylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N'- (2-fluoro-4- (2-fluorobenzyl) - 5-methylphenyl) -N-methylformimidamide, N '- (2,5-dimethyl-4- ((methylimino) (o-tolyl) methyl) phenyl) -N- ethyl-N-methylformimidamide, N '- (4 - ((4- ((difluoromethyl) thio) phenyl) amino) -2,5-dimethylphenyl) -N-ethyl- N-methylformimidamide, N' - (2-chloro- 4 - ((4- ((difluoromethyl) thio) phenyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (4 - ((4- ((difluoromethyl) thio) phenyl) (methyl) amino) -2, 5-dimethylphenyl) - N-ethyl-N-methylformimidamide, N '- (2-chloro-4 - ((4- ((difluoromethyl) thio) phenyl) (methyl) amino) -5-methylphenyl) -N-ethyl- N-methylformimidamide, N '- (2-chloro-4- (ethyl (phenyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N- (5-chloro-4- (((ethyl (methyl ) amino) methylene) amino) -2-methylphenyl) -N- phenylacetamide, N '- (2-chloro-4 - ((2- ((difluoromethyl) thio) phenyl) amino) -5-methylphenyl) -N-ethyl -N- methylformimidamide, N '- (2-chloro-4 - ((2- ((difluoromethyl) thio) phenyl) (methyl) amino) -5-methylphenyl) -N- ethyl-N-methylformimidamide, N' - ( 2-chloro-4- (ethyl (3-methoxyphenyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4 - ((3- (difluoromethoxy) -4-fluorophenyl ) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4- (N- (3-methoxyphenyl) methylsulfonamide) -5-methylphenyl) -N-ethyl-N-methylformimidamide , N '- (4 - ((3- (difluoromethoxy) -4-fluorophenyl) amino) -2,5-dimethylphenyl) -N-ethyl-N- me tilformimidamide, N '- (2-chloro-4 - ((3- (difluoromethoxy) -4-fluorophenyl) (methyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (4- ( (3- (difluoromethoxy) -4-fluorophenyl) (methyl) amino) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (4 - (((2,5-dimethylphenyl) amino) -2 , 5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4- ((2,5-dimethylphenyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N- (5-chloro-4- ((((ethyl (methyl) amino) methylene) amino) -2-methylphenyl) -N- (2- chlorophenyl) propionamide, N-ethyl-N '- (5-fluoro-4 - ((4-methoxyphenyl) amino) -2-methylphenyl) -N-methylformimidamide, N-ethyl-N' - (5-fluoro-4- ((4-methoxyphenyl) (methyl) amino) -2-methylphenyl) -N-methylformimidamide, N '- (2-chloro-4- (2-fluoro-6- (trifluoromethyl) benzyl) -5-methylphenyl) -N -ethyl-N-methylformimidamide, N '- (2-cyclopropyl-4- (2-fluorobenzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2-cyclopropyl-5-methyl-4- (4-methylbenzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (4- (2-chlorobenzyl) -2-cyclopropyl-5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2 -cyclopropyl- 5-methyl-4- (3- (trifluoromethoxy) benzyl) phenyl) -N-ethyl-N-methylformimidamide, N- (5-chloro-4- ((((ethyl (methyl) amino) methylene) amino) -2-methylphenyl) -N- (2-fluorophenyl) propionamide, N '- (2-chloro-4- (N- (4-fluoro-3- (1,1,2,2-tetrafluoroethoxy) phenyl) methylsulfonamide) -5- methylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N '- (2-fluoro-4- (4-methylbenzyl) -5- (trifluoromethyl) phenyl) -N- methylformimidamide, N' - ( 4- (2-chlorobenzyl) -2-fluoro-5- (trifluoromethyl) phenyl) -N-ethyl- N-methylformimidamide, N-ethyl- N '- (2-fluoro-4- (2-fluorobenzyl) -5- (trifluoromethyl) phenyl) -N-methylformimidamide, N-ethyl-N' - (2-fluoro-4- (2-methylbenzyl) - 5- (trifluoromethyl) phenyl) -N-methylformimidamide, N '- (4- (3-chlorobenzyl) -2-fluoro-5- (trifluoromethyl) phenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N '- (2-fluoro-4- (3-fluorobenzyl) - 5- (trifluoromethyl) phenyl) -N-methylformimidamide, N-ethyl-N'- (2-fluoro-4- (3-methylbenzyl ) -5- (trifluoromethyl) phenyl) -N- methylformimidamide, N-ethyl-N '- (2-fluoro-5- (trifluoromethyl) - 4- (3- (trifluoromethyl) benzyl) phenyl) -N-methylformimidamide, N -ethyl-N '- (2-fluoro-4- (3- (trifluoromethoxy) benzyl) -5- (trifluoromethyl) phenyl) -N-methylformimidamide, N' - (5-chloro-4- (cyano (5-fluoro-2-methylphenyl) methyl) -2-methylphenyl) -N-ethyl-N-methylformimidamide, methyl 2- (2-chloro-4- ((((ethyl (methyl) amino) methylene) amino) -5-methylphenyl) -2- (3-chlorophenyl) acetate, N '- (4- (1- (4-bromophenyl) vinyl) -5-chloro-2-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dimethyl- 4 - ((3- (1,1,2,2-tetrafluoroethoxy) phenyl) amino) phenyl) -N-ethyl- N-methylformimidamide, N' - (2,5-dimethyl -4- (methyl (3- (1,1,2,2- tetrafluoroethoxy) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N '- (4 - ((2-fluoro- 5-methylphenyl) amino) -2,5-dimethylphenyl) -N-methylformimidamide, N-ethyl-N '- (5-fluoro-4 - ((2-fluorophenyl) amino) -2-methylphenyl) - N-methylformimidamide, N-ethyl-N '- (4 - ((2-fluoro-5-methylphenyl) (methyl) amino) -2,5-dimethylphenyl) -N-methylformimidamide, N' - (2-chloro-4 - ((2 -fluoro-5-methylphenyl) (methyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N '- (5-fluoro-2-methyl-4- (phenylamino) phenyl) - N-methylformimidamide, N '- (4 - ((2-chlorophenyl) amino) -5-fluoro-2-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (4 - ((4- (tert-butyl) ) phenyl) am ino) -5-fluoro-2-methylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl- N '- (5-fluoro-2-methyl-4- (m-tolylamino) phenyl) -N- methylformimidamide, N- (5-chloro-4- ((((ethyl (methyl) amino) methylene) amino) -2-methylphenyl) -N- phenylpropionamide, N- (5-chloro-4- (((ethyl (methyl) amino) methylene) amino) -2-methylphenyl) -N- (3-methoxyphenyl) acetamide, N '- (2-chloro-4 - ((4-fluoro-3-methoxyphenyl) amino) -5-methylphenyl) -N-ethyl -N- methylformimidamide, N-ethyl-N '- (4 - (((4-fluoro-3-methoxyphenyl) amino) -2,5-dimethylphenyl) -N-methylformimidamide, N-ethyl-N' - (4- ( (4-fluoro-3-methoxyphenyl) (methyl) amino) -2,5- dimethylphenyl) -N-methylformimidamide, N '- (4 - ((2- ((difluoromethyl) thio) phenyl) amino) -2,5-dimethylphenyl) -N-ethyl- N-methylformimidamide, N' - (4- ( (2- ((difluoromethyl) thio) phenyl) (methyl) amino) -2,5-dimethylphenyl) - N-ethyl-N-methylformimidamide, N '- (2-chloro-4 - ((4-fluoro-3- methoxyphenyl) (methyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-bromo-6-fluoro-3-methyl-4- (phenylamino) phenyl) -N-ethyl-N -methylformimidamide, N '- (2-chloro-5-methyl-4 - (((5-oxo-5,6,7,8-tetrahydronaphthalene-2-yl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-5-methyl-4 - (((1-methylindoline-5-yl) amino) phenyl) -N-ethyl-N-methylformimidamide, 2- (2-chloro-5-ethyl-4- ((((ethyl (methyl) amino) methylene) amino) phenyl) -2- (3-fluorophenyl) -N, N-dimethylpropanamide, 2- (2-chloro-4- ((((ethyl (methyl) amino) methylene) amino) -5-methylphenyl) -2- (3-fluorophenyl) -N, N-dimethylpropanamide, 2- (2-chloro-4- ((((ethyl (methyl) amino) methylene) amino) -5-methylphenyl) - 2- (5-fluoro-2-methylphenyl) -N, N-dimethylacetamide, N '- (5-chloro-4- ((4-chloro-3-fluorophenyl) (cyano) methyl) -2-methylphenyl) -N -ethyl - N-methylformimidamide, N '- (2,5-difluoro-4- (2-fluorobenzyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (4- (3-chlorobenzyl) -2,5-difluorophenyl ) -N-ethyl-N-methylformimidamide, N '- (2,5-difluoro-4- (3-methylbenzyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (2,5-difluoro-4- (4-methylbenzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (4- (2-chlorobenzyl) -5-cyano-2-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (5 -cyano-4- (2-fluorobenzyl) -2-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (5-cyano-2-methyl-4- (2-methylbenzyl) phenyl) -N-ethyl- N- methylformimidamide, N '- (4- (3-chlorobenzyl) -5-cyano-2- methylphenyl) -N-ethyl-N-methylformimidamide, N '- (5-cyano-4- (3-fluorobenzyl) -2-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (5-cyano-2- methyl-4- (3-methylbenzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (5-cyano-2-methyl-4- (4-methylbenzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (4- (2-chlorobenzyl) -2,5-difluorophenyl) -N-ethyl-N-methylformimidamide, N' - (2,5-difluoro-4- (2-methylbenzyl) phenyl) -N-ethyl -N-methylformimidamide, N '- (5-chloro-4- (2-chlorobenzyl) -2-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (5-chloro-4- (2-fluorobenzyl) - 2-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (5-chloro-2-methyl-4- (2-methylbenzyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (5-chlorine -4- (3-chlorobenzyl) -2-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (5-chloro-4- (3-fluorobenzyl) -2-methylphenyl) -N-ethyl-N-methylformimidamide , N '- (5-chloro-2-methyl-4- (3-methylbenzyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (5-chloro-2-methyl-4- (4-methylbenzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (4- (2-chlorobenzyl) -2-cyclopropyl-5- (trifluoromethyl) phenyl) -N-ethyl-Nm ethylformimidamide, N '- (2-cyclopropyl-4- (3-methylbenzyl) -5- (trifluoromethyl) phenyl) -N- ethyl-N-methylformimidamide, N' - (2-cyclopropyl-4- (4-methylbenzyl) - 5- (trifluoromethyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (4- (3-chlorobenzyl) -2-cyclopropyl-5- (trifluoromethyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (2-cyclopropyl-4- (3-fluorobenzyl) -5- (trifluoromethyl) phenyl) -N- ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4 - ((5-oxo- 5, 6,7,8-tetrahydronaphthalene-2-yl) amino) phenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N '- (5-fluoro-2-methyl-4- (methyl (phenyl) amino) phenyl) -N-methylformimidamide, N '- (4 - ((4- (tert-butyl) phenyl) (methyl) amino) -5-fluoro-2-methylphenyl) -N- ethyl-N-methylformimidamide, N-ethyl-N '- (5-fluoro-2-methyl-4- (methyl (m-tolyl) amino) phenyl) -N-methylformimidamide, N' - (2-cyclopropyl-4- (2-methylbenzyl) -5- (trifluoromethyl) phenyl) -N- ethyl-N-methylformimidamide, N '- (2,5-difluoro-4- (3-fluorobenzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4- (cyano (3- (trifluoromethyl) phenyl) methyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N-methyl-N' - ( 5-methyl-4- (2-methylbenzyl) -2- (methylsulfonyl) phenyl) formimidamide, N-ethyl-N-methyl-N '- (5-methyl-4- (4-methylbenzyl) -2- (methylsulfonyl) phenyl) formimidamide, N '- (4- (3-chlorobenzyl) - 5-methyl-2- (methylsulfonyl) phenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N' - (4- (3-fluorobenzyl ) -5-methyl- 2- (methylsulfonyl) phenyl) -N-methylformimidamide, N-ethyl-N-methyl-N '- (5-methyl-4- (3-methylbenzyl) -2- (methylsulfonyl) phenyl) formimidamide , N-ethyl-N '- (4- (2-fluorobenzyl) -5-methyl-2- (methylsulfonyl) phenyl) -N-methylformimidamide, N' - (4- (2-chlorobenzyl) -5-methyl-2 - (methylsulfonyl) phenyl) -N-ethyl-N-methylformimidamide, N-ethyl- N-methyl-N '- (5- methyl-2- (methylsulfonyl) -4- (3- (trifluoromethyl) benzyl) phenyl) formimidamide, N-ethyl-N-methyl-N '- (5-methyl-2- (methylsulfonyl) -4- (3- ( trifluoromethoxy) benzyl) phenyl) formimidamide, N '- (2-chloro-4 - ((2-fluoro-5-methylphenyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2, 5-dimethyl-4 - ((1-methylindoline-5-yl) amino) phenyl) -N-ethyl-N-methylformimidamide, 2- (4-chloro-3-fluorophenyl) -2- (2-chloro-4- ((((ethyl (methyl) amino) methylene) amino) -5-methylphenyl) -N, N-dimethylpropanamide, 2- (4-chloro-3-fluorophenyl) -2- (2-chloro-5-ethyl-4- ((((ethyl (methyl) amino) methylene) amino) phenyl) -N, N- dimethylpropanamide, 2- (5-chloro-4- ((((ethyl (methyl) amino) methylene) amino) -2-methylphenyl) -2- (3-fluorophenyl) -N, N-dimethylacetamide, 2- (5-chlorine -4- ((((ethyl (methyl) amino) methylene) amino) -2-methylphenyl) -2- (3-fluorophenyl) -N, N-dimethylpropanamide, N '- (2-chloro-4- (1- ( 3-fluorophenyl) vinyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4 - ((2,3-dihydro-1H-inden-4-yl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (4- ((2,3-dihydro-1H-inden-4-yl) amino) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide , N '- (2-chloro-4 - ((2,3-dihydro-1H-inden-4-yl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2,5 -dichloro-4 - ((2,3-dihydro-1H- inden-4-yl) (methyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (4 - ((2,3-dihydro -1H-inden-4-yl) (methyl) amino) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (4- (cyano (3- (trifluoromethyl) phenyl) methyl) -2 , 5-dimethylphenyl) -N, N-dimethylformimidamide, N '- (4- (cyano (3- (trifluoromethyl) phenyl) methyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N' - ( 2-chloro-5-methyl-4- (N-phenylethyls) ulfonamide) phenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4- (N- (3-methoxyphenyl) ethylsulfonamide) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N'- (2-chloro-5-methyl-4 - (((1-methyl-1,2,3,4-tetrahydroquinolin-6-yl) amino) phenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N ' - (2-fluoro-5-methyl-4- (phenylamino) phenyl) -N-methylformimidamide, N '- (2-chloro-4- (N- (4-methoxyphenyl) methylsulfonamide) -5-methylphenyl) -N- ethyl-N-methylformimidamide, N-ethyl-N '- (2-fluoro-4 - ((2-methoxyphenyl) amino) -5-methylphenyl) -N-methylformimidamide, N' - (2-chloro-5-methyl- 4- (methyl (5-oxo- 5,6,7,8-tetrahydronaphthalene-2-yl) amino) phenyl) -N-ethyl-N- methylformimidamide, N '- (2-chloro-5-methyl-4- (methyl (6-methyl-5-oxo-5,6,7,8-tetrahydronaphthalene-2-yl) amino) phenyl) -N-ethyl- N- methylformimidamide, N-ethyl-N '- (4- (methoxy (o-tolyl) methyl) - 2,5-dimethylphenyl) -N-methylformimidamide, N' - (2-chloro-5-methyl-4- ( (5,6,7,8-tetrahydronaphthalene-1-yl) amino) phenyl) -N- ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4 - ((5,6,7,8- tetrahydronaphthalene-1-yl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dimethyl-4- (3- (trifluoromethyl) benzyl) phenyl) -N, N-dimethylformimidamide, N' - (4- (1- (4-bromophenyl) -2,2,2-trifluoro-1-hydroxyethyl) -2-chloro-5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (4- ( 1- (4-bromophenyl) -2,2,2-trifluoro-1 - ((trimethylsilyl) oxy) ethyl) - 2-chloro-5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2- chloro-4- (methoxy (o-tolyl) methyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (4 - (((4-bromophenyl) (methylimino) methyl) -2-chloro-5 -methylphenyl) -N-ethyl- N-methylformimidamide, N '- (2-chloro-4 - ((4-chlorophenyl) (methoxy) methyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl -N '- (4- ( (2-fluorophenyl) amino) -5-methyl-2- (methylsulfonyl) phenyl) -N-methylformimidamide, N '- (2-chloro-4 - ((4-chlorophenyl) (methylimino) methyl) -5-methylphenyl) -N- ethyl-N-methylformimidamide, N-ethyl-N-methyl-N '- (5-methyl-2- (methylsulfonyl) -4- (p-tolylamino) phenyl) formimidamide, N' - (4- (( 4- (tert-butyl) phenyl) amino) -5-methyl-2- (methylsulfonyl) phenyl) -N-ethyl-N-methylformimidamide, N-ethyl- N '- (2-fluoro-4 - ((2- fluorophenyl) amino) -5-methylphenyl) -N- methylformimidamide, N-ethyl-N '- (2-fluoro-4 - ((2-methoxyphenyl) (methyl) amino) -5-methylphenyl) -N-methylformimidamide, N -ethyl-N '- (2-fluoro-4 - ((2-fluorophenyl) (methyl) amino) -5-methylphenyl) -N- methylformimidamide, N '- (2-chloro-4- (N- (4-methoxyphenyl) ethylsulfonamide) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N- (5-chloro-4- (((ethyl ( methyl) amino) methylene) amino) -2-methylphenyl) -N- (4-methoxyphenyl) acetamide, N-ethyl-N '- (2-fluoro-5-methyl-4- (methyl (phenyl) amino) phenyl) -N-methylformimidamide, N '- (2-chloro-4- (ethyl (2-methoxyphenyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-4- (N - (2-methoxyphenyl) methylsulfonamide) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N- (5-chloro-4- ((((ethyl (methyl) amino) methylene) amino) -2-methylphenyl) - N- (2-methoxyphenyl) acetamide, N '- (4 - ((2-bromophenyl) (methylimino) methyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro- 5-methyl-4- ((methylimino) (phenyl) methyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (4 - ((2-bromophenyl) (methoxy) methyl) - 2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N-methyl-N '- (5-methyl-2- (methylsulfonyl) -4- (phenylamino) phenyl) formimidamide, N-ethyl-N' - (4- ((3-methoxyphenyl) amino) -5-methyl-2- (methylsulfonyl) phenyl) -N-methylformimidamide, N-ethyl- N '- (4 - ((2-fluorophenyl) (methyl) amino) -5-methyl-2- (methylsulfonyl) phenyl) - N-methylformimidamide, N-ethyl-N-methyl-N' - (5-methyl- 4- (methyl (p-tolyl) amino) -2- (methylsulfonyl) phenyl) formimidamide, N '- (4 - ((2-chlorophenyl) amino) -2-fluoro-5- (trifluoromethyl) phenyl) -N- ethyl-N-methylformimidamide, N '- (4- ((3-chlorophenyl) amino) -2-fluoro-5- (trifluoromethyl) phenyl) -N- ethyl-N-methylformimidamide, N' - (4 - ((4 -chlorophenyl) amino) -2-fluoro-5- (trifluoromethyl) phenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N-methyl-N '- (5-methyl-4- (methyl (phenyl) amino) -2- (methylsulfonyl) phenyl) formimidamide, N '- (4 - ((2-chlorophenyl) (methyl) amino) -2-fluoro-5- (trifluoromethyl) phenyl) -N-ethyl -N-methylformimidamide, N '- (4- ((3-chlorophenyl) (methyl) amino) -2-fluoro-5- (trifluoromethyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (4- ( (4-chlorophenyl) (methyl) amino) -2-fluoro-5- (trifluoromethyl) phenyl) -N-ethyl-N-methylformimidamide, N'- (2,5-dichloro-4- (cyano (3-fluoro- 4-methylphenyl) methyl) phenyl) -N- ethyl-N-methylformimidamide, N '- (2,5-dichloro-4- (phenylamino) phenyl) -N-ethyl-N-methylformimidamide, N' - (2,5 - dichloro-4- (p-tolylamino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4 - ((2-chlorophenyl) amino) phenyl) -N-ethyl-N- methylformimidamide, N '- (2,5-dichloro-4 - ((4-chlorophenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N'- (2,5-dichloro-4 - ((4-chlorophenyl ) (methyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4 - ((4-chlorophenyl) (ethyl) amino) phenyl) -N-ethyl-N-methylformimidamide , N '- (2,5-dichloro-4- (methyl (phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N' - (2,5-dichloro-4 - ((3- m ethoxyphenyl) (methyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4 - ((2-chlorophenyl) (methyl) amino) phenyl) -N-ethyl-N- methylformimidamide, N '- (2,5-dichloro-4 - ((3-methoxyphenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N' - (5-fluoro-4 - ((4 - fluorophenyl) amino) -2-methylphenyl) -N-methylformimidamide, N-ethyl-N '- (5-fluoro-4 - ((2-methoxyphenyl) amino) -2-methylphenyl) -N- methylformimidamide, N-ethyl -N '- (5-fluoro-2-methyl-4 - (((2- ((trifluoromethyl) thio) phenyl) amino) phenyl) -N-methylformimidamide, N' - (4 - ((4-chlorophenyl) (methyl ) amino) -5-fluoro-2-methylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl- N '- (5-fluoro-4 - ((4-fluorophenyl) (methyl) amino) -2-methylphenyl) - N-methylformimidamide, N' - (4 - ((4-chlorophenyl) amino) -5-fluoro- 2-methylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N '- (5-fluoro-4 - ((2-methoxyphenyl) (methyl) amino) -2-methylphenyl) -N- methylformimidamide, N- ethyl-N '- (2-fluoro-4 - (((3-fluorophenyl) amino) -5-methylphenyl) -N-methylformimidamide, N-ethyl-N' - (2-fluoro-4 - ((4-fluorophenyl) amino) -5-methylphenyl) -N- methylformimidamide, N-ethyl-N '- (2-fluoro-4 - ((3-methoxyphenyl) amino) -5-methylphenyl) -N-methylformimidamide, N-ethyl-N' - (2-fluoro-4 - ((3-fluorophenyl) (methyl) amino) -5-methylphenyl) -N-methylformimidamide, N-ethyl-N '- (2-fluoro-4- ((4-fluorophenyl) ( methyl) amino) -5-methylphenyl) -N- methylformimidamide, N-ethyl-N '- (2-fluoro-4 - ((3-methoxyphenyl) (methyl) amino) -5-methylphenyl) -N- methylformimidamide, N '- (4 - ((4- (tert-butyl) phenyl) amino) -2-fluoro-5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (4- ((4- (tert-butyl) ) phenyl) amino) -2-chloro-5-methylphenyl) -N-ethyl- N-methylformimidamide, N '- (4 - ((4- (tert-butyl) phenyl) (methyl) amino) -2-fluoro- 5- methylphenyl) -N-ethyl-N-methylformimidamide, N '- (4 - ((4- (tert-butyl) phenyl) (methyl) amino) -2-chloro-5-methylphenyl) -N-ethyl-N-methylformimidamide , N '- (4- (N- (4- (tert-butyl) phenyl) methylsulfonamide) -2-chloro-5-methylphenyl) -N-ethyl- N-methylformimidamide, N' - (2-chloro-5- methyl-4 - (((2-methyl-4- (perfluoropropan-2-yl) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4 - ((2- fluorophenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N'- (4 - ((4- (tert-butyl) phenyl) amino) -2,5-dichlorophenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4 - ((4-fluorophenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N'- (2,5-dichloro-4 - ((4-methoxyphenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4 - ((4- (trifluoromethoxy) phenyl) amino ) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4 - ((2-fluoro-3- (trifluoromethyl) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4 - (((2-fluoro-5-methylphenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N' - (2-fluoro-4- ( (2-methoxy-4-methylphenyl) amino) -5-methylphenyl) -N-methylformimidamide, N-ethyl-N '- (2-fluoro-4- ((2-methoxy-4-methylphenyl) (methyl) amino) -5-methylphenyl) -N- methylformimidamide, N '- (2-chloro-5-methyl-4- (methyl (2-methyl-4- (perfluoropropan-2-yl) phenyl) amino) phenyl) -N-ethyl -N- methylformimidamide, N '- (2-chloro-5-methyl-4- (N- (2-methyl-4- (perfluoropropan-2-yl) phenyl) methylsulfonamide) phenyl) -N-ethyl- N-methylformimidamide , N-ethyl-N '- (5-fluoro-2-methyl-4- (methyl (2 - ((trifluoromethyl) thio) phenyl) amino) phenyl) -N-methylformimidamide, N' - (2,5-dichloro -4- (4-chlorobenzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4- (4-fluorobenzyl) phenyl) -N-ethyl-N-methylformim idamide, N '- (2,5-dichloro-4- (4-cyanobenzyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (2,5-dichloro-4- (pyridine-3-ylmethyl) phenyl ) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4- (2- (trifluoromethoxy) benzyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (2,5-dichloro -4- (3-cyanobenzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4- (2-cyanobenzyl) phenyl) -N-ethyl-N-methylformimidamide, N'- (2,5-dichloro-4- (4- (trifluoromethyl) benzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4- (4- (trifluoromethoxy) benzyl) phenyl) -N- ethyl-N-methylformimidamide, N '- (2,5-dichloro-4- (2- (trifluoromethyl) benzyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (2,5-dichloro-4- ( 3,5-dimethylbenzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4- (4-fluoro-3-methylbenzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4 - ((4-fluorophenyl) (methyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N' - (2,5-dichloro-4- (ethyl (4- (trifluoromethoxy) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4 - ((2-fluorophenyl) (methyl) amino) phenyl) -N-ethyl-N- methylformimidamide, N '- (4 - ((4- (tert-butyl) phenyl) (methyl) amino) -2,5-dichlorophenyl) -N-ethyl-N-methylformimidamide, N' - (2,5-dichloro- 4 - (((4-methoxyphenyl) (methyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4 - (((2-fluoro-5-methylphenyl) (methyl) amino ) phenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N '- (4 - ((4- (1,1,1,3,3,3-hexafluoro-2-methoxypropan-2-yl) - 2-methylphenyl) (methyl) amino) -2,5-dimethylphenyl) -N-methylformimidamide, N-ethyl-N '- (2-fluoro-5-methyl-4 - ((2- ((trifluoromethyl) thio) phenyl ) amino) phenyl) -N - methylformimidamide, N-ethyl-N '- (2-fluoro-5-methyl-4 - ((4- ((trifluoromethyl) thio) phenyl) amino) phenyl) -N- methylformimidamide, N-ethyl-N' - ( 2-fluoro-5-methyl-4 - ((3- ((trifluoromethyl) thio) phenyl) amino) phenyl) -N-methylformimidamide, N-ethyl-N '- (2-fluoro-5-methyl-4- ( methyl (2- ((trifluoromethyl) thio) phenyl) amino) phenyl) -N-methylformimidamide, N-ethyl-N '- (2-fluoro-5-methyl-4- (methyl (4- ((trifluoromethyl) thio)) phenyl) amino) phenyl) -N- methylformimidamide, N '- (2,5-dichloro-4- (ethyl (4-fluorophenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N'- (2,5-dichloro-4- (methyl (4- (trifluoromethoxy) phenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N '- (2-fluoro-5-methyl-4- (p-tolylamino) phenyl) -N-methylformimidamide, N-ethyl-N '- (2-fluoro-4 - ((4-methoxyphenyl) (methyl) amino) -5-methylphenyl) -N-methylformimidamide, N-ethyl -N '- (2-fluoro-5-methyl-4- (methyl (p-tolyl) amino) phenyl) -N-methylformimidamide, N' - (2-chloro-5-methyl-4- (N-phenylmethylsulfonamide) phenyl) -N, N-dimethylformimidamide, N-ethyl-N '- (4 - ((4- (1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl) -2-methylphenyl ) amino) -2,5-dimethylphenyl) -N-methylformimidamide, N '- (2,5-dichloro-4- (4-chloro-3- (trifluoromethyl) benzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4- (4-fluoro-2-methylbenzyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (2,5-dichloro-4- (2,4-difluorobenzyl ) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4- (2,3-dimethylbenzyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (2,5- dichloro-4- (2-chloro-3-fluorobenzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4- (2,3-dichlorobenzyl) phenyl) -N-ethyl- N-met ilformimidamide, N '- (2,5-dichloro-4- (3,4-difluorobenzyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (2,5-dichloro-4- (3-fluoro-5 - methoxybenzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4- (2-fluoro-4- (trifluoromethyl) benzyl) phenyl) -N- ethyl-N-methylformimidamide, N '- (2,5-dichloro-4- (3-chloro-2-fluorobenzyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (2,5-dichloro-4- (4-fluoro-3- (trifluoromethyl) benzyl) phenyl) -N- ethyl-N-methylformimidamide, N '- (2,5-dichloro-4- (2-chloro-4-fluorobenzyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (2,5-dichloro-4- (2-chloro-5-fluorobenzyl) phenyl) -N-ethyl-N- methylformimidamide, N '- (2,5-dichloro-4- (4-chloro-3- (trifluoromethoxy) benzyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (2-chloro-4- (2, 4-dimethylbenzyl) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4- (2-fluoro-4- (trifluoromethyl) benzyl) -5-methylphenyl) -N-ethyl- N- methylformimidamide, N '- (4- (2-bromobenzyl) -2-chloro-5-methylphenyl) -N-ethyl-N-methylformimidamide, ethyl 5 - (((5-chloro-4 - (((ethyl (methyl ) amino) methylene) amino) -2-methylphenyl) amino) - 2- (isopropylthio) benzoate, N '- (4 - ((2-bromophenyl) (methoxy) methyl) -2,5-dimethylphenyl) -N, N - dimethylformimidamide, N '- (4- (methoxy (phenyl) methyl) -2,5-dimethylphenyl) -N, N-dimethylformimidamide, N' - (4- (2- bromobenzyl) -2,5-dichlorophenyl) -N -ethyl-N-methylformimidamide, N '- (2,5-dichloro-4- (3-chloro-4-fluorobenzyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (2,5-dichloro-4 - (2-cyclopropylbenzyl) phenyl) -N-ethyl-N-methylformimidamide, N'- (2,5-dichloro-4- (2-fluoro-6- (trifluoromethyl) benzyl) phenyl) - N-ethyl-N- methylformimidamide, N '- (2,5-dichloro-4- (2,6-dichlorobenzyl) phenyl) -N-ethyl-N-methylformimi damida, N '- (2,5-dichloro-4- (3-methoxybenzyl) phenyl) -N-ethyl-N-methylformimidamide, N' - (2,5-dichloro-4- (4- ((trifluoromethyl) thio ) benzyl) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4- (2-chloro-6-fluorobenzyl) phenyl) -N-ethyl-N-methylformimidamide, N' - ( 2,5- dichloro-4- (4-methoxybenzyl) phenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N '- (4- (3-fluoro-4-methoxybenzyl) - 2,5-dimethylphenyl) -N-methylformimidamide, N-ethyl-N '- (4- (3-methoxy-5- (trifluoromethyl) benzyl) -2,5-dimethylphenyl) -N- methylformimidamide, N' - (4- (5-chloro- 2-fluorobenzyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4- ((4-chloro-2-fluorophenyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4 - ((2,4-difluorophenyl) amino) -5-methylphenyl ) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4 - ((2-fluoro-6-methylphenyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - ( 2-chloro-4 - ((2-fluoro-3-methylphenyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4 - ((3-fluoro-5- methylphenyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (2-chloro-4 - ((3-fluoro-4-methylphenyl) amino) -5-methylphenyl) -N-ethyl- N- methylformimidamide, N '- (2-chloro-4 - ((2-fluoro-4-methylphenyl) amino) -5-methylphenyl) -N-ethyl-N-methylformimidamide, N- (4- (4-fluorobenzyl) -2,5-dimethylphenyl) -1-methylpyrrolidin-2-imine formate, N-ethyl- N '- (2-fluoro-5-methyl-4- (4- (trifluoromethyl) benzyl) phenyl) -N- methylformimidamide , N '- (4- (3-chloro-2-fluorobenzyl) -2-fluoro-5-methylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl- N' - (2-fluoro-4- (3 -fluoro-5-methoxybenzyl) -5-methylphenyl) -N- methylformimidamide, N-ethyl-N '- (2-fluoro-4- (3-fluoro-4-methoxybenzyl) -5-m ethylphenyl) -N-methylformimidamide, N '- (2,5-dimethyl-4- (2-phenyl-1,3-dithiolan-2-yl) phenyl) -N, N-dimethylformimidamide, N' - (2-chlorine -4 - (((4-chlorophenyl) (methoxy) methyl) -5-methylphenyl) -N, N-dimethylformimidamide, ethyl 5 - ((4- (((((methyl) methyl) methylene) amino) -2,5 - dimethylphenyl) amino) -2- (isopropylthio) benzoate, ethyl 5 - ((2,5-dichloro-4 - (((ethyl (methyl) amino) methylene) amino) phenyl) amino) - 2- (isopropylthio) benzoate , ethyl 5 - ((4- ((((ethyl (methyl) amino) methylene) amino) -2-fluoro-5- methylphenyl) amino) -2- (isopropylthio) benzoate, N-ethyl-N '- (4- ((3-fluoro-5-methylphenyl) amino) -2,5-dimethylphenyl) -N- methylformimidamide, N-ethyl- N '- (4 - ((2-fluoro-3-methylphenyl) amino) -2,5-dimethylphenyl) -N-methylformimidamide, N-ethyl-N' - (4 - ((2-fluoro-4-methylphenyl) amino) -2,5-dimethylphenyl) -N-methylformimidamide, N '- (4 - ((2,4-difluorophenyl) amino) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl- N '- (4 - ((3-fluoro-4-methylphenyl) amino) -2,5-dimethylphenyl) -N-methylformimidamide, N' - (4 - (((4-chloro-2-fluorophenyl) amino) -2 , 5-dimethylphenyl) -N- ethyl-N-methylformimidamide, N-ethyl-N '- (2-fluoro-4- (4-fluorobenzyl) -5-methylphenyl) -N-methylformimidamide, N-ethyl- N'- (2-fluoro-4- (4-fluoro-2-methylbenzyl) -5-methylphenyl) -N-methylformimidamide, N-ethyl-N '- (2-fluoro-4- (3-methoxy-5- (trifluoromethyl)) benzyl) -5-methylphenyl) -N- methylformimidamide, N-ethyl-N '- (2-fluoro-4- (2-fluoro-3-methylbenzyl) -5-methylphenyl) -N-methylformimidamide, N' - (2 , 5-dimethyl-4- (2- (m-tolyl) -1,3-dithiolan-2-yl) phenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N '- (4- (2- (3- fluorophenyl) -1,3- dithiolan-2-yl) -2,5-dimethylphenyl) -N-methylformimidamide, N'- (4- (4-cyanobenzyl) -2-fluoro-5-methylphenyl) -N-ethyl- N-methylformimidamide, N-ethyl-N '- (2-fluoro-4- (3-fluoro-5- (trifluoromethyl) benzyl) -5-methylphenyl) -N-methylformimidamide, N-ethyl-N' - (2- fluoro-4- (2-fluoro-5-methylbenzyl) -5-methylphenyl) -N-methylformimidamide, methyl 4- ((4 - (((ethyl (methyl) amino) methylene) amino) -2,5-dimethylphenyl) amino) -3-methylbenzoate, methyl 4 - (((2,5-dichloro-4 - ((((ethyl (methyl) amino) methylene) amino) phenyl) amino) -3-methylbenzoate, methyl 4 - ((4- ( ((ethyl (methyl) amino) methylene) amino) -2-fluoro-5- methylphenyl) amino) -3-methylbenzoate, N '- (4 - ((3,4-difluorophenyl) amino) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N' - (4 - ((3 , 5-difluorophenyl) amino) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4 - ((3,4-difluorophenyl) amino) phenyl) -N- ethyl-N-methylformimidamide, N '- (2,5-dichloro-4 - ((3,5-difluorophenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N'- (2,5-dichloro-4 - (((2,5-dimethylphenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (4 - ((3,4-difluorophenyl) amino) -5-fluoro-2-methylphenyl) -N- ethyl-N-methylformimidamide, N '- (4- (2,3-difluorobenzyl) -2-fluoro-5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (2,5-dichloro-4- ( (5-chloro-2-methylphenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (4- ((4-chlorophenyl) (methyl) amino) -2,5-dimethylphenyl) -N, N - dimethylformimidamide, N '- (4- (2,3-difluorobenzyl) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N' - (4- (2-fluoro-3-methylbenzyl ) -2,5-dimethylphenyl) -N- methylformimidamide, N-ethyl-N '- (4- (2-fluoro-5-methylbenzyl) - 2,5-dimethylphenyl) -N-methylformimi damida, N-ethyl-N '- (4- (2-fluoro-3-methoxybenzyl) -2,5-dimethylphenyl) -N-methylformimidamide, N' - (2-chloro-4 - ((5-chloro-2 - methylphenyl) amino) -5-methylphenyl) -N-ethyl-N- methylformimidamide, methyl 4 - ((5-chloro-4- ((((ethyl (methyl) amino) methylene) amino) -2-methylphenyl) amino) -3- methylbenzoate, N '- (2-chloro-4 - (((2-chloro-5-methylphenyl) amino) - 5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (4 - ((2 -chloro- 5-methylphenyl) amino) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (4 - ((5-chloro-2-methylphenyl) amino) - 2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4 - ((2-chloro-5-methylphenyl) amino) phenyl) -N-ethyl-N- methylformimidamide, N '- (2,5-dichloro-4 - ((2-fluoro-4-methylphenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N' - (4- ((3-chloro-2 -fluorophenyl) amino) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N '- (4 - (((2-fluoro-6-methylphenyl) amino) -2,5-dimethylphenyl) -N-methylformimidamide, N '- (4 - ((4-chloro-3- (trifluoromethyl) phenyl) amino) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N' - (2,5- dichloro- 4 - ((2-fluoro-6-methylphenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4 - ((2-fluoro-3-methylphenyl) amino ) phenyl) -N-ethyl-N-methylformimidamide, N'- (2,5-dimethyl-4- (2-methylbenzyl) phenyl) -N-ethyl-N-methylformimidamide hydrochloride, N '- (4 - (( 4-chlorophenyl) (methyl) amino) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (4- (2- (3-fluorophenyl) -1,3-dithiolan-2- il) -2,5-dimethylphenyl) -N, N-dimethylformimidamide, N-ethyl-N '- (4- (3-fluoro-2-methoxybenzyl) -2,5-dimethylphenyl) -N-methylformimidamide, N-ethyl -N '- (4- (4-fluoro-2-methylbenzyl) - 2,5-dimethylphenyl) -N-methylformimidamide, N' - (4- (5-chloro-2-fluorobenz il) -2-fluoro-5-methylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N '- (2-fluoro-5-methyl-4- (2-methyl-5- (trifluoromethyl) benzyl) phenyl) -N-methylformimidamide, N'- (4 - (((5-chloro-2-fluorophenyl) amino) -2,5-dimethylphenyl) -N-ethyl- N-methylformimidamide, N '- (4 - ((3 -chloro-5-fluorophenyl) amino) - 2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (4 - (((4-chloro-3-fluorophenyl) amino) -2,5-dimethylphenyl) -N-ethyl-N-methylformimidamide, N '- (2,5-dichloro-4 - ((5-fluoro-2-methylphenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N' - (4- ((2,5-dimethylphenyl) amino) -2-fluoro-5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (4 - (((3,5-difluorophenyl) amino) -2-fluoro-5 -methylphenyl) -N-ethyl-N-methylformimidamide, N '- (4- ((2,4-difluorophenyl) amino) -2-fluoro-5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (4- (2-chlorobenzyl) -2,5-dimethylphenyl) -N, N -dimethylformimidamide, N-ethyl-N '- (5-fluoro-4 - (((3-fluoro-5-methylphenyl) amino) -2-methylphenyl) -N- methylformimidamide, N' - (4 - ((5-chlorine -2-methylphenyl) amino) -5-fluoro-2-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (4- ((3,4-difluorophenyl) amino) -2-fluoro-5-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (4 - ((5-chloro-2-methylphenyl) (methyl) amino) -5-fluoro-2-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (4 - ((2,5-dimethylphenyl) amino) -5-fluoro-2-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (4- ((2-chloro-5-methylphenyl) amino) -2-fluoro-5-methylphenyl) -N- ethyl-N-methylformimidamide, N '- (4 - ((5-chloro-2-methylphenyl) amino) -2-fluoro-5-methylphenyl) -N-ethyl- N- methylformimidamide, N '- (2,5-dichloro-4 - (((3-fluoro-5-methylphenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N'- (2,5-dichloro-4 - (((3-fluoro-4-methylphenyl) amino) phenyl) -N-ethyl- N-methylformimidamide, N '- (2,5-dichloro-4 - ((2,4-difluorophenyl) amino) phenyl) -N -ethyl-N-methylformimidamide, N'- (2,5-dichloro-4 - (((4-chloro-2-fluorophenyl) amino) phenyl) -N-ethyl- N-methylformimidamide, N '- (2,5- dichloro-4 - ((4-chloro-3-fluorophenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N'- (2,5-dichloro-4 - ((5-chloro-2-fluorophenyl) amino ) phenyl) -N-ethyl- N-methylformimidamide, N '- (2,5-dichloro-4 - ((3-chloro-5-fluorophenyl) amino) phenyl) -N-ethyl-N-methylformimidamide, N'- (2,5-dichloro-4 - ((3-chloro-2-fluorophenyl) amino) phenyl) -N-ethyl- N-methylformimidamide, N '- (4 - ((3,5-difluorophenyl) amino) -5 - fluoro-2-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (4- ((2-chloro-5-methylphenyl) amino) -5-fluoro-2-methylphenyl) -N- ethyl-N- methylformimidamide, N '- (4 - ((3,5- difluorophenyl) (methyl) amino) -5-fluoro-2-methylphenyl) -N-ethyl- N-methylformimidamide, N '- (4 - (((2-chloro-5-methylphenyl) (methyl) amino) -5-fluoro -2-methylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N '- (2-fluoro-4 - (((2-fluoro-4-methylphenyl) amino) -5-methylphenyl) -N-methylformimidamide, N-ethyl-N '- (2-fluoro-4 - (((2-fluoro-6-methylphenyl) amino) -5-methylphenyl) -N-methylformimidamide, N-ethyl-N' - (2-fluoro-4- ((2-fluoro-3-methylphenyl) amino) -5-methylphenyl) -N-methylformimidamide, N-ethyl-N '- (2-fluoro-4 - (((3-fluoro-5-methylphenyl) amino) -5 -methylphenyl) -N-methylformimidamide, N- ethyl-N '- (2-fluoro-4 - (((3-fluoro-4-methylphenyl) amino) -5-methylphenyl) -N-methylformimidamide, N' - (4- ((4-chloro-2-fluorophenyl) amino) -2-fluoro-5-methylphenyl) -N-ethyl-N-methylformimidamide, N-ethyl-N '- (5-fluoro-4 - ((2-fluoro- 3-methylphenyl) amino) -2-methylphenyl) -N-methylformimidamide, N'- (4 - ((3-chloro-5-fluorophenyl) amino) -2-fluoro-5-methylphenyl) -N- ethyl-N- methylformimidamide, N '- (4 - ((5-chloro-2-fluorophenyl) amino) -2-fluoro-5-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (5- chloro-4 - ((4-fluorophenyl) amino) -2-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (5-chloro-4 - ((3-fluorophenyl) amino) -2-methylphenyl) - N-ethyl-N-methylformimidamide, N '- (5-chloro-4 - ((2-fluorophenyl) amino) -2-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (4 - ((4- (tert-butyl) phenyl) amino) -5-chloro-2-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (5-chloro-4 - ((4- (dimethylamino) phenyl) amino) -2 -methylphenyl) -N-ethyl-N-methylformimidamide, N '- (5-chloro-4 - ((4-methoxyphenyl) amino) -2-methylphenyl) -N-ethyl-N-methylformimidamide, N' - (5- chloro-2-methyl-4- (p-tolylamino) phenyl) -N-ethyl-N-methylformimidamide, N '- (5-chloro-4 - ((2,3-dihydrobenzo [b] [1,4] dioxin -6-yl) amino) - 2-methylphenyl) -N-ethyl-N-methylformimidamide, N '- (4- (benzo [d] [1,3] dioxol-5-ylamino) -5-chloro-2-methylphenyl) -N- ethyl-N -methylformimidamide, N '- (5-chloro-2-methyl-4 - (((1-oxo- 2,3-dihydro-1H-inden-5-yl) amino) phenyl) -N-ethyl-N-methylformimidamide, N '- (5-chloro-2-methyl-4 - (((5-oxo-5,6,7,8-tetrahydronaphthalene-2-yl) amino) phenyl) -N-ethyl-N-methylformimidamide, N'- (2-chloro-4- (2-cyanobenzyl) -5-methylphenyl) -N, N-dimethylformimidamide, N '- (4 - ((2-cyanophenyl) amino) -2,5-dimethylphenyl) -N-ethyl- N- methylformimidamide, N-ethyl-N '- (4- (2-fluorobenzyl) -2-methoxy-5-methylphenyl) -N-methylformimidamide, N' - (2-chloro-5-methoxy-4- (m- tolylamino) phenyl) -N-ethyl-N-methylformimidamide, N-ethyl- N '- (5-methoxy-4- (4-methoxybenzyl) -2-methylphenyl) -N- methylformimidamide, N' - (2-chloro- 4- (3-cyanobenzyl) -5-methoxyphenyl) -N-ethyl-N-methylformimidamide or its salts, structural isomers / isomers, stereoisomers, diastereoisomers, enantiomers, tautomers or agronomically acceptable N-oxides. The use of a compound of Formula (I) according to Claim 1, to control or prevent pathogenic rust diseases selected from Cronartium ribicola (white pine rust); Gymnosporangium juniperi-virginianae (cedar apple rust); Hemilea vastatrix (coffee rust); Phakopsora meibomiae and Phakopsora pachyrhizi (soybean rust); Puccinia coronata (rust of oats and ryegrass); Puccinia graminis (Kentucky wheat and grass stem rust or black grain rust); Puccinia hemerocallidis (rust Dailily); Puccinia persistens subspecies trithycin (wheat rust or 'brown or red rust'); Puccinia sorghi (rust on corn); Puccinia striiformis (‘yellow rust’ on cereals); Uromyces appendiculatus (bean rust); Uromyces phaseoli (bean rust); Puccinia melanocephala ('brown rust' on sugar cane) or Puccinia kuehnii ('orange rust' on sugar cane). The use of a compound of Formula (I) according to Claim 3, wherein said rust pathogen is selected from Cronartium ribicola; Gymnosporangium juniperi-virginianae; Hemilea vastatrix; Phakopsora meibomiae, Phakopsora pachyrhizi; Puccinia coronata; Puccinia graminis; Phercinia hemerocallidis; Puccinia persistens subspecies trithycin; Puccinia sorghi; Puccinia striiformis; Uromyces appendiculatus; Uromyces phaseoli; Puccinia melanocephala or Puccinia kuehni. The use of a compound of Formula (I) according to Claim 3, wherein said rust pathogen is selected from Phakopsora pachyrhizi, Phakopsora meibomiae or Puccinia graminis. The use of a compound of Formula (I) according to Claim 1, wherein said compound is formulated in a composition with one or more inert vehicles. The use of a compound of Formula (I) according to Claim 6, wherein said composition can additionally comprise one or more compatible active compounds selected from fungicides, insecticides, nematicides, acaricides, biopesticides, herbicides, regulators of plant growth, antibiotics, fertilizers and or their mixtures. 8. The use of a compound of Formula (I) according to the Claim 6, wherein the concentration of the compound of Formula (I) in said composition ranges from 1 to 90% by weight relative to the total weight of the composition, preferably from 5 to 50% by weight relative to the total weight of the composition. The use of a compound of Formula (I) according to Claim 1, wherein said agricultural crops are selected from cereals, corn, rice, soybeans and other legumes, fruits and fruit trees, nuts and trees of nuts, citrus and citrus trees, vegetable plants, cucurbits, oil plants, tobacco, coffee, tea, cocoa, beet, sugar cane, cotton, potatoes, tomatoes, onions, peppers and other vegetables and ornamentals. A method of controlling or preventing plant infestation by pathogens of rust diseases in agricultural and / or horticultural crops wherein said compound of Formula (I) according to Claim 1 is applied to plants, parts thereof or their location. A method of controlling or preventing plant infestation by pathogens of rust diseases in agricultural and / or horticultural crops, wherein said compound of Formula (I) according to Claim 1 is applied to the seeds of the plants. A method of controlling or preventing pathogens from rust diseases in agricultural and / or horticultural crops using said compound of Formula (I) according to Claim 1, which consists of applying effective dosages of the compound in amounts that vary from 1 gr to 5 kg per hectare of agricultural and / or horticultural crops.