BR112018068601A2 - método aprimorado para usar o módulo de biorreator eletroquímico com recuperação do cofator - Google Patents

método aprimorado para usar o módulo de biorreator eletroquímico com recuperação do cofator

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Publication number
BR112018068601A2
BR112018068601A2 BR112018068601A BR112018068601A BR112018068601A2 BR 112018068601 A2 BR112018068601 A2 BR 112018068601A2 BR 112018068601 A BR112018068601 A BR 112018068601A BR 112018068601 A BR112018068601 A BR 112018068601A BR 112018068601 A2 BR112018068601 A2 BR 112018068601A2
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BR
Brazil
Prior art keywords
improved method
phosphorylated
bioreactor module
electrochemical bioreactor
nicotinamide
Prior art date
Application number
BR112018068601A
Other languages
English (en)
Inventor
S Morrison Clifford
R Dodds David
Koffas Mattheos
B Armiger William
Original Assignee
Biocheminsights Inc
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Filing date
Publication date
Application filed by Biocheminsights Inc filed Critical Biocheminsights Inc
Publication of BR112018068601A2 publication Critical patent/BR112018068601A2/pt

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    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/36—Dinucleotides, e.g. nicotineamide-adenine dinucleotide phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • C12N1/16—Yeasts; Culture media therefor
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    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
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    • C12N9/0055—Oxidoreductases (1.) acting on diphenols and related substances as donors (1.10)
    • C12N9/0057—Oxidoreductases (1.) acting on diphenols and related substances as donors (1.10) with oxygen as acceptor (1.10.3)
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    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
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    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/32—Nucleotides having a condensed ring system containing a six-membered ring having two N-atoms in the same ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide
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    • C12Y110/03—Oxidoreductases acting on diphenols and related substances as donors (1.10) with an oxygen as acceptor (1.10.3)
    • C12Y110/03001—Catechol oxidase (1.10.3.1), i.e. tyrosinase
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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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Abstract

a presente invenção revela composição e processo para a utilização de um dispositivo eletroquímico 1 para a redução do estado oxidado de nicotinamida dinucleotídeo adenina de nicotinamida fosforilada ou não fosforilada para o estado reduzido em que produtos indesejados da redução eletroquímica são recuperados como o estado oxidado do dinucleotídeo nicotinamida adenina de nicotinamida fosforilada ou não fosforilada e retornado ao dispositivo eletroquímico para redução.
BR112018068601A 2016-03-14 2017-03-14 método aprimorado para usar o módulo de biorreator eletroquímico com recuperação do cofator BR112018068601A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662308175P 2016-03-14 2016-03-14
PCT/US2017/022241 WO2017160793A1 (en) 2016-03-14 2017-03-14 Improved method for using electrochemical bioreactor module with recovery of cofactor

Publications (1)

Publication Number Publication Date
BR112018068601A2 true BR112018068601A2 (pt) 2019-02-05

Family

ID=59852375

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BR112018068601A BR112018068601A2 (pt) 2016-03-14 2017-03-14 método aprimorado para usar o módulo de biorreator eletroquímico com recuperação do cofator

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Country Link
US (2) US10927395B2 (pt)
EP (1) EP3430155B1 (pt)
CN (1) CN109415746B (pt)
BR (1) BR112018068601A2 (pt)
CA (1) CA3056592A1 (pt)
WO (1) WO2017160793A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112017018025A2 (pt) * 2015-02-23 2018-04-10 Biocheminsights Inc módulo de biorreator eletroquímico e vias metabólicas manipuladas para a produção de 1-butanol com elevada eficiência de carbono
CA3210339A1 (en) * 2021-01-31 2022-08-04 Biocheminsights, Inc. Improved method for regenerating reduced forms of enzyme cofactors
CN113981478B (zh) * 2021-10-09 2024-03-19 河北工业大学 介孔材料固定化酶进行生物电催化二氧化碳还原的方法及应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1207691A (en) 1983-02-09 1986-07-15 Thomas R. Hopkins Regeneration of nad(p) cofactor
US4705704A (en) 1985-10-01 1987-11-10 General Electric Company Novel aminofunctional polysiloxane emulsions for treating textiles
US4800162A (en) 1987-04-01 1989-01-24 Sepracor, Inc. Method for resolution of steroisomers in multiphase and extractive membrane reactors
ATE231652T1 (de) * 1998-07-09 2003-02-15 Univ Michigan State Elektrochemisches verfahren zum erzeugen einer biologischen protontriebkraft und regenerierung des pyridin-nucleotid cofaktors
WO2003006713A1 (en) 2001-05-31 2003-01-23 Michigan Biotechnology Institute Electrode compositions and configurations for electrochemical bioreactor systems
US7410709B2 (en) 2004-06-24 2008-08-12 Purdue Research Foundation Bio-battery
WO2014039767A1 (en) 2012-09-09 2014-03-13 Biocheminsights, Inc. Electrochemical bioreactor module and methods of using the same
WO2016070168A1 (en) 2014-11-02 2016-05-06 Biocheminsights, Inc. Improved electrochemical bioreactor module and use thereof
BR112017018025A2 (pt) * 2015-02-23 2018-04-10 Biocheminsights Inc módulo de biorreator eletroquímico e vias metabólicas manipuladas para a produção de 1-butanol com elevada eficiência de carbono

Also Published As

Publication number Publication date
EP3430155A1 (en) 2019-01-23
US20210171995A1 (en) 2021-06-10
WO2017160793A1 (en) 2017-09-21
US10927395B2 (en) 2021-02-23
CN109415746A (zh) 2019-03-01
CN109415746B (zh) 2023-01-17
CA3056592A1 (en) 2017-09-21
US20190078127A1 (en) 2019-03-14
EP3430155B1 (en) 2022-07-27
EP3430155A4 (en) 2019-08-21

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