BR112015007001A2 - nanoinvólucros de sílica degradável para a captura de imagem/terapia por ultrassom - Google Patents

nanoinvólucros de sílica degradável para a captura de imagem/terapia por ultrassom

Info

Publication number
BR112015007001A2
BR112015007001A2 BR112015007001A BR112015007001A BR112015007001A2 BR 112015007001 A2 BR112015007001 A2 BR 112015007001A2 BR 112015007001 A BR112015007001 A BR 112015007001A BR 112015007001 A BR112015007001 A BR 112015007001A BR 112015007001 A2 BR112015007001 A2 BR 112015007001A2
Authority
BR
Brazil
Prior art keywords
imaging
nanoinvolvers
ultrasound therapy
degradable
degradable silica
Prior art date
Application number
BR112015007001A
Other languages
English (en)
Inventor
Liberman Alexander
C Kummel Andrew
N Ta Casey
F Mattrey Robert
blair Sarah
C Trogler William
Wu Zhe
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of BR112015007001A2 publication Critical patent/BR112015007001A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A61K41/0033—Sonodynamic cancer therapy with sonochemically active agents or sonosensitizers, having their cytotoxic effects enhanced through application of ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B33/00—Silicon; Compounds thereof
    • C01B33/113—Silicon oxides; Hydrates thereof
    • C01B33/12—Silica; Hydrates thereof, e.g. lepidoic silicic acid
    • C01B33/18—Preparation of finely divided silica neither in sol nor in gel form; After-treatment thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Acoustics & Sound (AREA)
  • Radiology & Medical Imaging (AREA)
  • Oncology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Medical Informatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Silicon Compounds (AREA)
  • Manufacturing & Machinery (AREA)

Abstract

resumo “nanoinvólucros de sílica degradável para a captura de imagem/terapia por ultrassom” a presente invenção refere-se a métodos usando nanoinvólucros de sílica degradáveis para marcação com ultrassom intraoperatória local; detecção do tumor através de injeção sistêmica; e remoção de tumores ultrassônica intensificada por nanoinvólucro. 1/1
BR112015007001A 2012-09-28 2013-09-27 nanoinvólucros de sílica degradável para a captura de imagem/terapia por ultrassom BR112015007001A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261707794P 2012-09-28 2012-09-28
US201361845727P 2013-07-12 2013-07-12
PCT/US2013/062436 WO2014052911A1 (en) 2012-09-28 2013-09-27 Degradable silica nanoshells for ultrasonic imaging/therapy

Publications (1)

Publication Number Publication Date
BR112015007001A2 true BR112015007001A2 (pt) 2017-07-04

Family

ID=50389036

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015007001A BR112015007001A2 (pt) 2012-09-28 2013-09-27 nanoinvólucros de sílica degradável para a captura de imagem/terapia por ultrassom

Country Status (8)

Country Link
US (2) US20150273061A1 (pt)
EP (1) EP2900598A4 (pt)
JP (1) JP2016505475A (pt)
KR (1) KR20150063097A (pt)
CN (1) CN104822626A (pt)
AU (1) AU2013323203B2 (pt)
BR (1) BR112015007001A2 (pt)
WO (1) WO2014052911A1 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8440229B2 (en) * 2007-08-14 2013-05-14 The Regents Of The University Of California Hollow silica nanospheres and methods of making same
AU2015243218B2 (en) * 2014-04-11 2019-03-21 Covidien Lp Tagged surgical instruments and methods therefor
CN104288792B (zh) * 2014-10-31 2017-07-07 苏州大学 具有超声造影和光热治疗性能的制剂、其制备方法与应用
WO2016149711A1 (en) * 2015-03-19 2016-09-22 The Regents Of The University Of California Silica nanostructures, large-scale fabrication methods, and applications thereof
CN104958324A (zh) * 2015-05-29 2015-10-07 黄波 一种溶瘤病毒制剂及其制备方法
CN107198777A (zh) * 2016-04-01 2017-09-26 依生生物制药(新加坡)私人有限公司 用于治疗癌症的含有聚核苷酸的药物组合物
WO2018045222A1 (en) * 2016-08-31 2018-03-08 The Regents Of The University Of California Ultrasound responsive micro-composite markers
CN106902098B (zh) * 2017-02-18 2020-07-03 华中科技大学 一种抗肿瘤植入膜及其制备方法
CA3058898C (en) * 2017-04-07 2022-08-30 View Point Medical, Inc. Multi-mode imaging markers
EP3624777A4 (en) 2017-05-19 2021-03-10 Cornell University FUNCTIONALIZED NANOPARTICLE AND METHOD FOR MANUFACTURING AND USING THEREOF
US10941270B2 (en) 2018-03-09 2021-03-09 John Nguyen Ta Biodegradation of polymer using surface chemistry
CN108478816A (zh) * 2018-04-24 2018-09-04 上海交通大学医学院附属瑞金医院 铁掺杂的二氧化硅空心纳米球、复合材料、制备方法及应用
US20210284542A1 (en) * 2018-07-03 2021-09-16 King Abdullah University Of Science And Technology Recyclable and/or reusable polymer templates for producing hollow silica particles
CN110064063B (zh) * 2019-03-15 2021-11-19 徐州医科大学 一种双层疏水-亲水改性中空纳米硅球、其制备方法及应用
WO2021041560A1 (en) * 2019-08-28 2021-03-04 View Point Medical, Inc. Ultrasound marker detection, markers and associated systems, methods and articles
US11882992B2 (en) 2019-11-27 2024-01-30 View Point Medical, Inc. Composite tissue markers detectable via multiple detection modalities including radiopaque element
US11903767B2 (en) 2019-11-27 2024-02-20 View Point Medical, Inc. Composite tissue markers detectable via multiple detection modalities
CN112190752A (zh) * 2020-10-21 2021-01-08 西北师范大学 一种用于肿瘤栓塞的多功能高分子复合材料及其制备方法
CN113353939B (zh) * 2021-05-25 2023-09-08 中国科学院上海硅酸盐研究所 一种带隙可调、降解性可控的二维氢硅烯纳米材料及其制备方法和应用
CN115227833B (zh) * 2022-07-29 2023-03-21 西安交通大学医学院第一附属医院 一种氟化二氧化硅载药纳米粒及其制备方法、用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8440229B2 (en) * 2007-08-14 2013-05-14 The Regents Of The University Of California Hollow silica nanospheres and methods of making same
EP2233437A4 (en) * 2007-12-06 2016-07-27 Univ Tokushima NANOFUNCTIONAL SILICA PARTICLES AND METHOD FOR THE PRODUCTION THEREOF
US20120045515A1 (en) * 2009-02-04 2012-02-23 Ye Liu Hollow silica particle with a polymer thereon
GB2473814B (en) * 2009-09-16 2014-06-11 Spheritech Ltd Hollow particulate support
JP5614968B2 (ja) * 2009-10-22 2014-10-29 株式会社Adeka 疎水性コアシェルシリカ粒子、中空シリカ粒子およびこれらの製造方法
US20130034609A1 (en) * 2010-02-09 2013-02-07 Agency For Science, Technology And Research Smart polymers functionalized hollow silica vesicles
WO2012009448A2 (en) * 2010-07-13 2012-01-19 The Regents Of The University Of California Cationic polymer coated mesoporous silica nanoparticles and uses thereof
US9427410B2 (en) * 2010-10-08 2016-08-30 The University Of North Carolina At Chapel Hill Formulation of acoustically activatable particles having low vaporization energy and methods for using same
CN102327622B (zh) * 2011-09-08 2014-08-06 上海交通大学 一种利用介孔二氧化硅纳米颗粒装载siRNA的方法
CN102489270B (zh) * 2011-11-15 2015-05-20 天津科技大学 ε-聚赖氨酸硅纳米颗粒的制备方法

Also Published As

Publication number Publication date
AU2013323203A1 (en) 2015-04-09
CN104822626A (zh) 2015-08-05
US20180099050A1 (en) 2018-04-12
EP2900598A1 (en) 2015-08-05
KR20150063097A (ko) 2015-06-08
EP2900598A4 (en) 2016-06-15
US20150273061A1 (en) 2015-10-01
JP2016505475A (ja) 2016-02-25
AU2013323203B2 (en) 2017-04-13
WO2014052911A1 (en) 2014-04-03

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Legal Events

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B08F Application fees: dismissal - article 86 of industrial property law
B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)