BR112014023423A2 - terapia de combinação - Google Patents
terapia de combinaçãoInfo
- Publication number
- BR112014023423A2 BR112014023423A2 BR112014023423A BR112014023423A BR112014023423A2 BR 112014023423 A2 BR112014023423 A2 BR 112014023423A2 BR 112014023423 A BR112014023423 A BR 112014023423A BR 112014023423 A BR112014023423 A BR 112014023423A BR 112014023423 A2 BR112014023423 A2 BR 112014023423A2
- Authority
- BR
- Brazil
- Prior art keywords
- combination
- combination therapy
- treating cancer
- pharmaceutical
- fluorophenylamino
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
Abstract
resumo patente de invenção: "terapia de combinação". a presente invenção refere-se a uma combinação farmacêutica compreendendo o composto inibidor de mek ácido 6-(4-bromo-2-fluorfenilamino)-7-flúor-3-metil-3h-benzoimidazol-5-carboxílico (2-hidroxietioxi)-amida ou um sal farmaceuticamente aceitável do mesmo e o anticorpo a inibidor de igf1r, uma composição farmacêutica compreendendo essa combinação; métodos para tratar câncer compreendendo administração de uma quantidade terapeuticamente eficaz dessa combinação a um indivíduo em necessidade da mesma e usos dessa combinação para o tratamento de câncer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261613046P | 2012-03-20 | 2012-03-20 | |
US201361763767P | 2013-02-12 | 2013-02-12 | |
PCT/US2013/030781 WO2013142182A2 (en) | 2012-03-20 | 2013-03-13 | Combination therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014023423A2 true BR112014023423A2 (pt) | 2017-07-11 |
Family
ID=48083597
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014023423A BR112014023423A2 (pt) | 2012-03-20 | 2013-03-13 | terapia de combinação |
Country Status (12)
Country | Link |
---|---|
US (1) | US8961970B2 (pt) |
EP (1) | EP2827901B1 (pt) |
JP (1) | JP2015512388A (pt) |
KR (1) | KR102088469B1 (pt) |
CN (1) | CN104487089B (pt) |
AU (1) | AU2013235596B9 (pt) |
BR (1) | BR112014023423A2 (pt) |
CA (1) | CA2868000C (pt) |
ES (1) | ES2641864T3 (pt) |
MX (1) | MX359770B (pt) |
RU (1) | RU2677245C2 (pt) |
WO (1) | WO2013142182A2 (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
AU2015240465B2 (en) | 2014-04-04 | 2020-02-27 | Del Mar Pharmaceuticals | Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer |
CN105566225A (zh) * | 2015-02-16 | 2016-05-11 | 苏州晶云药物科技有限公司 | 一种口服丝裂原活化蛋白激酶抑制剂的晶型及其制备方法 |
US20190008859A1 (en) | 2015-08-21 | 2019-01-10 | Acerta Pharma B.V. | Therapeutic Combinations of a MEK Inhibitor and a BTK Inhibitor |
US10779980B2 (en) | 2016-04-27 | 2020-09-22 | Synerz Medical, Inc. | Intragastric device for treating obesity |
TW201938165A (zh) * | 2017-12-18 | 2019-10-01 | 美商輝瑞股份有限公司 | 治療癌症的方法及組合療法 |
WO2019139970A1 (en) * | 2018-01-09 | 2019-07-18 | Duke University | Topical administration of mek inhibiting agents for the treatment of skin disorders |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6695842B2 (en) | 1997-10-27 | 2004-02-24 | St. Francis Medical Technologies, Inc. | Interspinous process distraction system and method with positionable wing and method |
TWI343377B (en) * | 2002-03-13 | 2011-06-11 | Array Biopharma Inc | N3 alkylated benzimidazole derivatives as mek inhibitors |
US20040209930A1 (en) * | 2002-10-02 | 2004-10-21 | Carboni Joan M. | Synergistic methods and compositions for treating cancer |
CA2528961A1 (en) * | 2003-06-09 | 2005-01-06 | Samuel Waksal | Methods of inhibiting receptor tyrosine kinases with an extracellular antagonist and an intracellular antagonist |
MY146381A (en) * | 2004-12-22 | 2012-08-15 | Amgen Inc | Compositions and methods relating relating to anti-igf-1 receptor antibodies |
TW200900070A (en) | 2007-02-27 | 2009-01-01 | Osi Pharm Inc | Combination cancer therapy |
MX2009009379A (es) * | 2007-03-02 | 2009-09-14 | Amgen Inc | Metodos y composiciones para tratar enfermedades tumorales. |
AU2012212075A1 (en) * | 2011-02-02 | 2013-07-18 | Amgen Inc. | Methods and compositons relating to inhibition of IGF-1R |
-
2013
- 2013-03-13 CN CN201380015467.7A patent/CN104487089B/zh active Active
- 2013-03-13 KR KR1020147028944A patent/KR102088469B1/ko active IP Right Grant
- 2013-03-13 RU RU2014142057A patent/RU2677245C2/ru active
- 2013-03-13 MX MX2014011270A patent/MX359770B/es active IP Right Grant
- 2013-03-13 AU AU2013235596A patent/AU2013235596B9/en active Active
- 2013-03-13 ES ES13715486.0T patent/ES2641864T3/es active Active
- 2013-03-13 EP EP13715486.0A patent/EP2827901B1/en active Active
- 2013-03-13 WO PCT/US2013/030781 patent/WO2013142182A2/en active Application Filing
- 2013-03-13 JP JP2015501748A patent/JP2015512388A/ja active Pending
- 2013-03-13 BR BR112014023423A patent/BR112014023423A2/pt not_active Application Discontinuation
- 2013-03-13 US US13/799,706 patent/US8961970B2/en active Active
- 2013-03-13 CA CA2868000A patent/CA2868000C/en active Active
Also Published As
Publication number | Publication date |
---|---|
CA2868000A1 (en) | 2013-09-26 |
US20130273061A1 (en) | 2013-10-17 |
WO2013142182A3 (en) | 2013-11-14 |
AU2013235596A1 (en) | 2014-10-02 |
JP2015512388A (ja) | 2015-04-27 |
CA2868000C (en) | 2019-02-26 |
KR102088469B1 (ko) | 2020-03-17 |
AU2013235596B9 (en) | 2017-12-14 |
RU2014142057A (ru) | 2016-05-20 |
CN104487089A (zh) | 2015-04-01 |
MX2014011270A (es) | 2015-03-09 |
EP2827901A2 (en) | 2015-01-28 |
ES2641864T3 (es) | 2017-11-14 |
RU2677245C2 (ru) | 2019-01-16 |
MX359770B (es) | 2018-10-10 |
AU2013235596B2 (en) | 2017-11-23 |
WO2013142182A2 (en) | 2013-09-26 |
CN104487089B (zh) | 2018-08-28 |
EP2827901B1 (en) | 2017-09-06 |
US8961970B2 (en) | 2015-02-24 |
KR20140146114A (ko) | 2014-12-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112014023423A2 (pt) | terapia de combinação | |
BR112015029491A2 (pt) | derivados de imidazopirrolidinona e seu uso no tratamento de doença | |
BR112015029512A2 (pt) | derivados de pirazolopirrolidina e seu uso no tratamento de doenças | |
BR112014015955A8 (pt) | uso terapêutico subcutâneo de inibidor de dpp-4 | |
EA201101507A1 (ru) | Способы лечения солидных опухолей | |
BR112014016163A2 (pt) | piridoftalazinonas tetra ou penta-cíclicas fundidas como inibidores de parp | |
BR112014010420A2 (pt) | inibidores de pak para o tratamento de distúrbios proliferativos celulares | |
EA201590371A1 (ru) | 1,4-дизамещенные аналоги пиридазина и способы лечения связанных с дефицитом smn состояний | |
BR112015010396A2 (pt) | terapia de combinação | |
BR112013030894A2 (pt) | moduladores do sistema imune | |
BR112014004504A2 (pt) | "composto como inibidor de c-kit cinase, seu uso, composição farmacêutica, e medicamento para o tratamento de uma doença mediada por uma cinase" | |
MX2014002171A (es) | Tratamientos de combinacion para hepatitis c. | |
BR112012033738A2 (pt) | método para o tratamento de transtorno bipolar | |
BR112015015477A2 (pt) | derivados de 2,3-di-hidro-isoindol-1-ona e métodos de uso dos mesmos como inibidores de btk | |
BR112016007946A2 (pt) | combinação farmacêutica, usos da mesma, de plinabulina e de composição, kits ou mistura e método para tratar e/ou prevenir câncer | |
BR112014008036A2 (pt) | tratamento de rinite | |
BR112015029401A8 (pt) | derivados de pirazolo-pirrolidin-4-ona, seus usos, e composição e combinação farmacêuticas | |
BR112014001600A2 (pt) | composto inibidor do trajeto de sinalização notch | |
BR112014017985A8 (pt) | Combinação de um inibidor de rtk com um antiestrogênio e uso da mesma para o tratamento de cancer | |
BR112016027043A8 (pt) | combinação, composição farmacêutica compreendendo glucocorticoide e edo-s101, kit e uso no tratamento de câncer | |
MY165902A (en) | Substituted pyridine derivatives as fabi inhibitors | |
BR112013033831A2 (pt) | composição farmacêutica oftalmológica tópica que contém regorafenib | |
BR112014010729A2 (pt) | métodos para tratamento de ataques de gota | |
BR112019005456A2 (pt) | composição farmacêutica e método para tratamento de esteatose hepática não alcoólica | |
BR112014010938A2 (pt) | compostos de 5-(piridin-2-il-amino)-pirazina-2-carbonitrila e seu uso terapêutico |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B25A | Requested transfer of rights approved |
Owner name: AMGEN INC (US) , NOVARTIS AG (CH) |
|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B12B | Appeal against refusal [chapter 12.2 patent gazette] |