BR112014019134A8 - MULTIDIMENSIONAL METHOD FOR SIMULTANEOUSLY ANALYZING SEVERAL ANALYTES IN A SAMPLE SOLUTION - Google Patents

MULTIDIMENSIONAL METHOD FOR SIMULTANEOUSLY ANALYZING SEVERAL ANALYTES IN A SAMPLE SOLUTION

Info

Publication number
BR112014019134A8
BR112014019134A8 BR112014019134A BR112014019134A BR112014019134A8 BR 112014019134 A8 BR112014019134 A8 BR 112014019134A8 BR 112014019134 A BR112014019134 A BR 112014019134A BR 112014019134 A BR112014019134 A BR 112014019134A BR 112014019134 A8 BR112014019134 A8 BR 112014019134A8
Authority
BR
Brazil
Prior art keywords
analytes
sample solution
immune complexes
simultaneously analyzing
analyzing several
Prior art date
Application number
BR112014019134A
Other languages
Portuguese (pt)
Other versions
BR112014019134A2 (en
Inventor
E Regnier Fred
B Herold Nicholas
W Meyer Kevin
Original Assignee
Perfinity Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perfinity Biosciences Inc filed Critical Perfinity Biosciences Inc
Publication of BR112014019134A2 publication Critical patent/BR112014019134A2/pt
Publication of BR112014019134A8 publication Critical patent/BR112014019134A8/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

MÉTODO MULTIDIMENSIONAL PARA ANALISAR SIMULTANEAMENTE VÁRIOS ANALITOS EM UMA SOLUÇÃO DE AMOSTRA Um método multidimensional é provido para analisar simultaneamente vários analitos em uma amostra de solução, o método incluindo:Adicionar seletores de afinidade a uma solução de amostra que contém os analitos a serem medidos, os seletores de afinidade tendo uma afinidade para um ou mais dos analitos na solução de amostra; permitir que os complexos imunes se formem entre os seletores de afinidade e os analitos; parcialmente ou totalmente dividir os complexos imunes formados a partir de substâncias do tipo não analito na solução de amostra em uma primeira dimensão de separação utilizando uma técnica de adsorção seletiva; dissociar os complexos imunes divididos; separar os analitos e os seletores de afinidade dos complexos imunes dissociados um do outro em uma segunda dimensão de separação utilizando uma técnica de adsorção seletiva; e dividir dos analitos de acordo com as suas razões de massa-para-carga.MULTIDIMENSIONAL METHOD FOR SIMULTANEOUSLY ANALYZING SEVERAL ANALYTES IN A SAMPLE SOLUTION A multidimensional method is provided for simultaneously analyzing several analytes in a sample solution, the method including: Adding affinity selectors to a sample solution containing the analytes to be measured, the affinity selectors having an affinity for one or more of the analytes in the sample solution; allowing immune complexes to form between affinity selectors and analytes; partially or fully splitting the immune complexes formed from non-analyte-type substances in the sample solution in a first separation dimension using a selective adsorption technique; dissociate the divided immune complexes; separating the analytes and affinity selectors of the dissociated immune complexes from each other in a second separation dimension using a selective adsorption technique; and dividing the analytes according to their mass-to-charge ratios.

BR112014019134A 2012-02-02 2013-01-30 MULTIDIMENSIONAL METHOD FOR SIMULTANEOUSLY ANALYZING SEVERAL ANALYTES IN A SAMPLE SOLUTION BR112014019134A8 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261594193P 2012-02-02 2012-02-02
PCT/US2013/023727 WO2013116260A1 (en) 2012-02-02 2013-01-30 Selector based recognition and quantification system and method for multiple analytes in a single analysis

Publications (2)

Publication Number Publication Date
BR112014019134A2 BR112014019134A2 (en) 2017-06-20
BR112014019134A8 true BR112014019134A8 (en) 2017-07-11

Family

ID=48905766

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014019134A BR112014019134A8 (en) 2012-02-02 2013-01-30 MULTIDIMENSIONAL METHOD FOR SIMULTANEOUSLY ANALYZING SEVERAL ANALYTES IN A SAMPLE SOLUTION

Country Status (12)

Country Link
EP (1) EP2820425A1 (en)
JP (1) JP2015505619A (en)
KR (1) KR20140137353A (en)
CN (1) CN104160278A (en)
AU (1) AU2013215305A1 (en)
BR (1) BR112014019134A8 (en)
CA (1) CA2863635A1 (en)
IL (1) IL233897A0 (en)
IN (1) IN2014DN06899A (en)
RU (1) RU2014135576A (en)
SG (1) SG11201404526PA (en)
WO (1) WO2013116260A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015084748A1 (en) * 2013-12-03 2015-06-11 Perfinity Biosciences, Inc A single reactor for simplified sample preparation workflows
WO2016118489A1 (en) * 2015-01-19 2016-07-28 Siscapa Assay Technologies, Inc. Combined analysis of small molecules and proteins by mass spectrometry
KR20210002673A (en) * 2018-04-30 2021-01-08 바이오테지 에이비 Protein quantitative analysis
WO2019229058A1 (en) * 2018-05-29 2019-12-05 Capsenze Biosystems Ab Method and system for providing antibody fragments suitable for online quality control
KR102198342B1 (en) * 2019-05-22 2021-01-04 연세대학교 산학협력단 Method of screening antibody and antibody screening system using the same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5061790A (en) * 1989-07-10 1991-10-29 Molecular Diagnostics, Inc. Oxidative denaturation of protein analytes
US6303325B1 (en) * 1998-05-29 2001-10-16 Dade Behring Inc. Method for detecting analytes
AU2002341862C1 (en) * 2001-09-27 2009-01-29 Purdue Research Foundation Controlling isotope effects during fractionation of analytes
US20090269780A1 (en) * 2008-04-23 2009-10-29 Luminex Corporation Method for Creating a Standard for Multiple Analytes Found in a Starting Material of Biological Origin
CN103154735B (en) * 2009-05-11 2018-10-02 连接Dx股份有限公司 Method and composition for testing and analyzing object
US8455202B2 (en) * 2010-03-10 2013-06-04 Perfinity Biosciences, Inc. Affinity selector based recognition and quantification system and method for multiple analytes in a single analysis

Also Published As

Publication number Publication date
KR20140137353A (en) 2014-12-02
JP2015505619A (en) 2015-02-23
BR112014019134A2 (en) 2017-06-20
EP2820425A1 (en) 2015-01-07
IN2014DN06899A (en) 2015-05-15
CN104160278A (en) 2014-11-19
CA2863635A1 (en) 2013-08-08
SG11201404526PA (en) 2014-11-27
AU2013215305A1 (en) 2014-08-28
WO2013116260A1 (en) 2013-08-08
IL233897A0 (en) 2014-09-30
RU2014135576A (en) 2016-03-27

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]