BR112014009858A2 - processo para rápida identificação e preparação de formas cristalinas - Google Patents
processo para rápida identificação e preparação de formas cristalinasInfo
- Publication number
- BR112014009858A2 BR112014009858A2 BR112014009858A BR112014009858A BR112014009858A2 BR 112014009858 A2 BR112014009858 A2 BR 112014009858A2 BR 112014009858 A BR112014009858 A BR 112014009858A BR 112014009858 A BR112014009858 A BR 112014009858A BR 112014009858 A2 BR112014009858 A2 BR 112014009858A2
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- rapid identification
- organic compound
- steps
- crystalline forms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0004—Crystallisation cooling by heat exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0018—Evaporation of components of the mixture to be separated
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
- B01D9/0054—Use of anti-solvent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0077—Screening for crystallisation conditions or for crystal forms
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
- C30B29/54—Organic compounds
- C30B29/56—Tartrates
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
- C30B7/02—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions by evaporation of the solvent
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
- C30B7/08—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions by cooling of the solution
Landscapes
- Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
abstract disclosed is a method of rapid identification and preparation of a crystalline form of an organic compound by using sub-gram level of said organic compound, comprising the steps of temperature-cycled slurrying, cooling, antisolvent addition and solvent evaporation as the major crystallization steps. ______________________ tradução do resumo resumo patente de invenção: "processo para rápida identificação e preparação de formas cristalinas". descreve-se um método de rápida identificação e preparação de uma forma cristalina de um composto orgânico usando nível sub-grama do dito composto orgânico, compreendendo as etapas de suspenção do ciclo de temperatura, arrefecimento, adição de antisolvente e evaporação do solvente, como os principais passos para cristalização.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161550760P | 2011-10-24 | 2011-10-24 | |
PCT/US2012/061491 WO2013062971A1 (en) | 2011-10-24 | 2012-10-23 | Process for rapid identification and preparation of crystalline forms |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014009858A2 true BR112014009858A2 (pt) | 2017-04-18 |
Family
ID=47178924
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014009858A BR112014009858A2 (pt) | 2011-10-24 | 2012-10-23 | processo para rápida identificação e preparação de formas cristalinas |
Country Status (9)
Country | Link |
---|---|
US (1) | US9321717B2 (pt) |
EP (1) | EP2771086A1 (pt) |
JP (1) | JP2014534439A (pt) |
KR (1) | KR20140108222A (pt) |
AU (1) | AU2012329037A1 (pt) |
BR (1) | BR112014009858A2 (pt) |
CA (1) | CA2853497A1 (pt) |
RU (1) | RU2014120016A (pt) |
WO (1) | WO2013062971A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11282700B2 (en) | 2019-04-17 | 2022-03-22 | University Of Kentucky Research Foundation | Method for manufacturing perovskite-based devices in ambient air |
CN110283131A (zh) * | 2019-06-28 | 2019-09-27 | 鲁南制药集团股份有限公司 | 一种吉非替尼与香草酸共晶甲醇溶剂合物及其制备方法 |
JP2024500966A (ja) * | 2020-12-22 | 2024-01-10 | エルジー・ケム・リミテッド | メラノコルチン受容体アゴニスト化合物の結晶形iおよびその製造方法 |
KR20220090457A (ko) * | 2020-12-22 | 2022-06-29 | 주식회사 엘지화학 | 멜라노코르틴 수용체 작용제 화합물의 결정형 ⅱ 및 이의 제조방법 |
CN113373499B (zh) * | 2021-05-21 | 2023-08-15 | 湖北理工学院 | 一种观赏性花饰化学艺术晶体的制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009059605A1 (en) * | 2007-11-08 | 2009-05-14 | University Of Copenhagen | Small scale solid state screening |
US20120190127A1 (en) * | 2009-06-15 | 2012-07-26 | Brandeis University | Systems and methods for determining process conditions in confined volumes |
WO2011046915A1 (en) * | 2009-10-12 | 2011-04-21 | R.P. Scherer Technologies, Llc | Apparatus for crystallization and method therefor |
-
2012
- 2012-10-23 JP JP2014538878A patent/JP2014534439A/ja active Pending
- 2012-10-23 KR KR1020147013800A patent/KR20140108222A/ko not_active Application Discontinuation
- 2012-10-23 CA CA2853497A patent/CA2853497A1/en not_active Abandoned
- 2012-10-23 BR BR112014009858A patent/BR112014009858A2/pt not_active Application Discontinuation
- 2012-10-23 RU RU2014120016/05A patent/RU2014120016A/ru not_active Application Discontinuation
- 2012-10-23 AU AU2012329037A patent/AU2012329037A1/en not_active Abandoned
- 2012-10-23 EP EP12787238.0A patent/EP2771086A1/en not_active Withdrawn
- 2012-10-23 WO PCT/US2012/061491 patent/WO2013062971A1/en active Application Filing
- 2012-10-23 US US13/658,540 patent/US9321717B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
KR20140108222A (ko) | 2014-09-05 |
WO2013062971A1 (en) | 2013-05-02 |
AU2012329037A1 (en) | 2014-05-22 |
US9321717B2 (en) | 2016-04-26 |
RU2014120016A (ru) | 2015-12-10 |
JP2014534439A (ja) | 2014-12-18 |
US20130144077A1 (en) | 2013-06-06 |
EP2771086A1 (en) | 2014-09-03 |
CA2853497A1 (en) | 2013-05-02 |
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Legal Events
Date | Code | Title | Description |
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B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |