BR112013004428B1 - microeletrodo resistente a deslocamento, feixe de eletrodo e matriz de eletrodo - Google Patents
microeletrodo resistente a deslocamento, feixe de eletrodo e matriz de eletrodo Download PDFInfo
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- BR112013004428B1 BR112013004428B1 BR112013004428-4A BR112013004428A BR112013004428B1 BR 112013004428 B1 BR112013004428 B1 BR 112013004428B1 BR 112013004428 A BR112013004428 A BR 112013004428A BR 112013004428 B1 BR112013004428 B1 BR 112013004428B1
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- A—HUMAN NECESSITIES
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- A61N1/0526—Head electrodes
- A61N1/0529—Electrodes for brain stimulation
- A61N1/0536—Preventing neurodegenerative response or inflammatory reaction
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- A—HUMAN NECESSITIES
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- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
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- A—HUMAN NECESSITIES
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- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
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- A—HUMAN NECESSITIES
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- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
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- A61N1/372—Arrangements in connection with the implantation of stimulators
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1000862 | 2010-08-25 | ||
| SE1000862-1 | 2010-08-25 | ||
| PCT/EP2011/064641 WO2012025596A2 (en) | 2010-08-25 | 2011-08-25 | Displacement resistant microelectrode, microelectrode bundle and microelectrode array |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112013004428A2 BR112013004428A2 (pt) | 2016-05-31 |
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Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130211485A1 (en) * | 2012-02-13 | 2013-08-15 | Agency For Science, Technology And Research | Probe Device and a Method of Fabricating the Same |
| AU2013277814B2 (en) * | 2012-06-21 | 2015-09-24 | Neuronano Ab | Medical microelectrode, method for its manufacture, and use thereof |
| US10933218B2 (en) * | 2013-07-30 | 2021-03-02 | Massachusetts Institute Of Technology | Systems and methods for delivering chemical and electrical stimulation across one or more neural circuits |
| CN103445790B (zh) * | 2013-09-09 | 2016-03-23 | 重庆西南医院 | 一种动物听觉检测电极定位装置 |
| US11583233B2 (en) * | 2013-12-20 | 2023-02-21 | Neuronano Ab | Medical device comprising an electrode and a light source |
| AU2016272173A1 (en) | 2015-06-05 | 2017-12-14 | Neuronano Ab | Method and system for improving stimulation of excitable tissue |
| CN107921260B (zh) | 2015-07-10 | 2022-02-25 | 神经毫微股份公司 | 用于改善对可兴奋组织的刺激的方法和系统 |
| US10172558B2 (en) * | 2015-09-10 | 2019-01-08 | University Of Utah Research Foundation | Structure and methodology for a shadow mask having hollow high aspect ratio projections |
| CN108472483A (zh) * | 2015-11-30 | 2018-08-31 | 神经毫微股份公司 | 避免出血的微电极 |
| US20190060518A1 (en) * | 2016-02-26 | 2019-02-28 | Neuronano Ab | Method of providing an implantation site in soft tissue |
| CN106646048B (zh) * | 2016-12-23 | 2019-11-12 | 深圳市中科先见医疗科技有限公司 | 一种微电极阵列的制备方法 |
| EP3630270B1 (en) | 2017-05-29 | 2025-07-16 | Neuronano AB | Microelectrode identification |
| AU2018366155B2 (en) | 2017-11-09 | 2024-08-01 | Neuronano Ab | Positional stabilization of tissue-implanted medical devices |
| KR20210103494A (ko) | 2018-12-13 | 2021-08-23 | 뉴웨이브 메디컬, 인코포레이티드 | 에너지 전달 장치 및 관련 시스템 |
| WO2020141997A1 (en) * | 2019-01-04 | 2020-07-09 | Neuronano Ab | Probe for implantation into nervous tissue comprising a microelectrode or a set of microelectrodes |
| WO2020163310A1 (en) * | 2019-02-04 | 2020-08-13 | Rutgers, The State University Of New Jersey | Device for tissue electrotransfer using a microelectrode |
| CN109908467B (zh) * | 2019-04-25 | 2024-04-30 | 北京品驰医疗设备有限公司 | 神经电刺激电极组件及其制备方法 |
| CN112869747B (zh) * | 2019-11-29 | 2022-11-25 | 清华大学 | 微电极及其制作和使用方法、塞类装置和微电极系统 |
| US12171995B1 (en) * | 2021-10-07 | 2024-12-24 | Paradromics, Inc. | Methods for improved biocompatibility for human implanted medical devices |
| CN115999015A (zh) * | 2022-12-15 | 2023-04-25 | 厦门大学深圳研究院 | 一种基于ipmc的主动弯曲导管 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3724467A (en) | 1971-04-23 | 1973-04-03 | Avery Labor Inc | Electrode implant for the neuro-stimulation of the spinal cord |
| US3822708A (en) | 1972-12-07 | 1974-07-09 | Clinical Technology Corp | Electrical spinal cord stimulating device and method for management of pain |
| US3995560A (en) | 1975-08-12 | 1976-12-07 | Charles Mackintosh | Rail obstruction sensing means for a rail transportation system |
| US4379462A (en) | 1980-10-29 | 1983-04-12 | Neuromed, Inc. | Multi-electrode catheter assembly for spinal cord stimulation |
| US4427483A (en) * | 1981-12-01 | 1984-01-24 | The Research Foundation Of State University Of New York | Microelectrode fabricting apparatus |
| US4573481A (en) | 1984-06-25 | 1986-03-04 | Huntington Institute Of Applied Research | Implantable electrode array |
| US4852573A (en) | 1987-12-04 | 1989-08-01 | Kennedy Philip R | Implantable neural electrode |
| US4920979A (en) | 1988-10-12 | 1990-05-01 | Huntington Medical Research Institute | Bidirectional helical electrode for nerve stimulation |
| US5031621A (en) | 1989-12-06 | 1991-07-16 | Grandjean Pierre A | Nerve electrode with biological substrate |
| US5215008A (en) | 1991-10-24 | 1993-06-01 | Kartovaara Ilkka K | Calendering machine for testing paper |
| US5417719A (en) | 1993-08-25 | 1995-05-23 | Medtronic, Inc. | Method of using a spinal cord stimulation lead |
| US5501703A (en) | 1994-01-24 | 1996-03-26 | Medtronic, Inc. | Multichannel apparatus for epidural spinal cord stimulator |
| US5741319A (en) | 1995-01-27 | 1998-04-21 | Medtronic, Inc. | Biocompatible medical lead |
| DE19529371C3 (de) | 1995-08-10 | 2003-05-28 | Nmi Univ Tuebingen | Mikroelektroden-Anordnung |
| US5957958A (en) | 1997-01-15 | 1999-09-28 | Advanced Bionics Corporation | Implantable electrode arrays |
| US6421566B1 (en) | 1998-04-30 | 2002-07-16 | Medtronic, Inc. | Selective dorsal column stimulation in SCS, using conditioning pulses |
| US6253110B1 (en) | 1999-04-27 | 2001-06-26 | Medtronic Inc | Method for tissue stimulation and fabrication of low polarization implantable stimulation electrode |
| US7099718B1 (en) | 2001-05-29 | 2006-08-29 | Advanced Bionics Corporation | Neural stimulation lead fixation |
| EP1401513A4 (en) * | 2001-05-30 | 2007-09-12 | Innersea Technology | Implantable devices having a liquid crystal polymer substrate |
| US7041492B2 (en) | 2001-06-20 | 2006-05-09 | Matsushita Electric Industrial Co., Ltd. | Extracellular recording electrode |
| US7146221B2 (en) | 2001-11-16 | 2006-12-05 | The Regents Of The University Of California | Flexible electrode array for artifical vision |
| US20030105505A1 (en) | 2001-12-05 | 2003-06-05 | Pianca Anne M. | Medical leads with superior handling characteristics |
| US6993392B2 (en) | 2002-03-14 | 2006-01-31 | Duke University | Miniaturized high-density multichannel electrode array for long-term neuronal recordings |
| US7393446B2 (en) | 2004-03-05 | 2008-07-01 | Frank E. Towsley | Cellular metal structure |
| ES2390824T3 (es) | 2005-10-06 | 2012-11-16 | Neuronano Ab | Haz portador de electrodos |
| CN101583309B (zh) * | 2005-10-07 | 2012-07-04 | 神经连结科技公司 | 模块化多通道微电极阵列及其制造方法 |
| US20070197892A1 (en) | 2006-02-23 | 2007-08-23 | Medtrode Inc. | Non-planar multi-channel electrode array |
| US7853303B2 (en) | 2006-11-16 | 2010-12-14 | National Research Council Of Canada | Neurological probe and method of using same |
| CA2676021C (en) | 2007-01-23 | 2013-12-31 | Neuronano Ab | Dissociating multi-channel electrode |
| EA017163B1 (ru) * | 2007-12-10 | 2012-10-30 | Неуронано Аб | Медицинский электрод, пучок электродов и массив из пучков электродов |
| US8886279B2 (en) * | 2008-06-03 | 2014-11-11 | University Of Utah Research Foundation | High aspect ratio microelectrode arrays enabled to have customizable lengths and methods of making the same |
| GB0817597D0 (en) * | 2008-09-26 | 2008-11-05 | Univ Newcastle | Electrode |
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| HK1184090A1 (zh) | 2014-01-17 |
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| EA022775B1 (ru) | 2016-02-29 |
| EP2612691A1 (en) | 2013-07-10 |
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| PL2612691T3 (pl) | 2015-04-30 |
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| SG187918A1 (en) | 2013-04-30 |
| DK2608839T3 (en) | 2015-04-20 |
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