BR112012028290A2 - desintoxicação de acetato derivado de biomassa via conversão metabólica em etanol, acetona, isopropanol ou acetato de etila - Google Patents

desintoxicação de acetato derivado de biomassa via conversão metabólica em etanol, acetona, isopropanol ou acetato de etila

Info

Publication number
BR112012028290A2
BR112012028290A2 BR112012028290A BR112012028290A BR112012028290A2 BR 112012028290 A2 BR112012028290 A2 BR 112012028290A2 BR 112012028290 A BR112012028290 A BR 112012028290A BR 112012028290 A BR112012028290 A BR 112012028290A BR 112012028290 A2 BR112012028290 A2 BR 112012028290A2
Authority
BR
Brazil
Prior art keywords
acetate
isopropanol
acetone
ethanol
conversion
Prior art date
Application number
BR112012028290A
Other languages
English (en)
Other versions
BR112012028290B1 (pt
Inventor
Aaron Argyros
Alan Benjamin Gilbert
Allan C Froehlich
Arthur J Shaw Iv
David A Hogsett
Hans Van Dijken
Haowen Xu
John E Mcbride
Steve Licht
Vineet B Rajgarhia
William Ryan Sillers
Original Assignee
Mascoma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mascoma Corp filed Critical Mascoma Corp
Publication of BR112012028290A2 publication Critical patent/BR112012028290A2/pt
Publication of BR112012028290B1 publication Critical patent/BR112012028290B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • C12N1/185—Saccharomyces isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0067—Oxidoreductases (1.) acting on hydrogen as donor (1.12)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06—Ethanol, i.e. non-beverage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06—Ethanol, i.e. non-beverage
    • C12P7/08—Ethanol, i.e. non-beverage produced as by-product or from waste or cellulosic material substrate
    • C12P7/10—Ethanol, i.e. non-beverage produced as by-product or from waste or cellulosic material substrate substrate containing cellulosic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C12P7/28—Acetone-containing products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01012—Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) (1.2.1.12)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y112/00—Oxidoreductases acting on hydrogen as donor (1.12)
    • C12Y112/99—Oxidoreductases acting on hydrogen as donor (1.12) with other acceptors (1.12.99)
    • C12Y112/99006—Hydrogenase (acceptor) (1.12.99.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/85—Saccharomyces
    • C12R2001/865—Saccharomyces cerevisiae
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Botany (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

desintoxicação de acetato derivado de biomassa via conversão metabólica em etanol, acetona, isopropanol ou acetato de etila. a presente invenção fornece novas vias metabólicas para desintoxicar acetato derivado de biomassa via conversão metabólica em etanol, acetona, isopropanol ou acetato de etila. mais especificamente, a invenção fornece um micro-organismo recombinante compreendendo uma ou mais enzimas nativas e/ou heterólogas que funcionam em uma ou mais vias metabólicas construídas para obter: (1) conversão de acetato em etanol; (2) conversão de acetato em acetona; (3) conversão de acetato em isopropanol; ou (4) conversão de acetato em acetato de etila; em que uma ou mais enzimas nativas e/ou heterólogas são ativadas, suprarreguladas ou infrarreguladas. a invenção também fornece novos organismos adaptados para crescer na presença de compostos inibitórios, incluindo, mas não limitados a acetato.
BR112012028290-5A 2010-05-05 2011-05-05 levedura recombinante, processo para converter biomassa em etanol e meio de fermentação compreendendo dita levedura BR112012028290B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US33165710P 2010-05-05 2010-05-05
US61/331,657 2010-05-05
US35113310P 2010-06-03 2010-06-03
US61/351,133 2010-06-03
PCT/US2011/035416 WO2011140386A2 (en) 2010-05-05 2011-05-05 Detoxification of biomass derived acetate via metabolic conversion to ethanol, acetone, isopropanol, or ethyl acetate

Publications (2)

Publication Number Publication Date
BR112012028290A2 true BR112012028290A2 (pt) 2015-09-22
BR112012028290B1 BR112012028290B1 (pt) 2021-02-02

Family

ID=44279261

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012028290-5A BR112012028290B1 (pt) 2010-05-05 2011-05-05 levedura recombinante, processo para converter biomassa em etanol e meio de fermentação compreendendo dita levedura

Country Status (4)

Country Link
US (1) US9605269B2 (pt)
BR (1) BR112012028290B1 (pt)
CA (1) CA2798452C (pt)
WO (1) WO2011140386A2 (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108315272A (zh) 2008-11-21 2018-07-24 拉勒曼德匈牙利流动性管理有限责任公司 用于使用纤维素进行同时糖化和发酵的表达纤维素酶的酵母
BR112012028290B1 (pt) * 2010-05-05 2021-02-02 Lallemand Hungary Liquidity Management Llc. levedura recombinante, processo para converter biomassa em etanol e meio de fermentação compreendendo dita levedura
WO2012019175A2 (en) 2010-08-06 2012-02-09 Mascoma Corporation Production of malonyl-coa drived products via anaerobic pathways
WO2012088467A2 (en) 2010-12-22 2012-06-28 Mascoma Corporation Genetically modified clostridium thermocellum engineered to ferment xylose
BR122019017739B1 (pt) * 2011-04-05 2021-06-22 Lallemand Hungary Liquidity Management Llc Micro-organismo recombinante compreendendo uma deleção de enzimas nativas que atuam para produzir glicerol e/ou regular a síntese de glicerol e vias metabólicas sintéticas para converter uma fonte de carboidrato a etanol
WO2013061941A1 (ja) 2011-10-24 2013-05-02 トヨタ自動車株式会社 組換え酵母を用いたエタノールの製造方法
CN104126011B (zh) 2011-11-30 2017-07-11 帝斯曼知识产权资产管理有限公司 由乙酸和甘油生产乙醇的工程化酵母菌株
CA2857498A1 (en) * 2011-11-30 2013-09-26 Mascoma Corporation Engineering an increase in ethanol production by altering cofactor specificity
US9085781B2 (en) 2012-07-23 2015-07-21 Edeniq, Inc. Acetate resistance in yeast based on introduction of a mutant HAA1 allele
WO2014035458A1 (en) 2012-08-29 2014-03-06 Mascoma Corporation Expression of enzymes in yeast for lignocellulose derived oligomer cbp
CA2889890C (en) * 2012-11-09 2023-03-28 Lallemand Hungary Liquidity Management Llc Method for acetate consumption during ethanolic fermentation of cellulosic feedstocks
WO2014133092A1 (ja) * 2013-02-27 2014-09-04 トヨタ自動車株式会社 組換え酵母を用いたエタノールの製造方法
CN105209600A (zh) 2013-03-15 2015-12-30 拉勒曼德匈牙利流动管理有限责任公司 通过代谢工程化的酵母菌株调节由玉米生产乙醇期间的氮代谢的方法
EP3033413B2 (en) 2013-08-15 2023-05-10 Lallemand Hungary Liquidity Management LLC Methods for the improvement of product yield and production in a microorganism through glycerol recycling
WO2015041940A2 (en) * 2013-09-19 2015-03-26 Shell Oil Company Novel yeast strains
JP6447583B2 (ja) 2016-06-24 2019-01-09 トヨタ自動車株式会社 組換え酵母、及びそれを用いたエタノールの製造方法
CA3047889A1 (en) * 2016-12-22 2018-06-28 Lallemand Hungary Liquidity Management Llc Sulfite tolerance in recombinant yeast host cells
JP6879111B2 (ja) 2017-08-02 2021-06-02 トヨタ自動車株式会社 組換え酵母及びこれを用いたエタノールの製造方法
KR20200135469A (ko) * 2018-03-27 2020-12-02 바스프 에스이 자일로스 대사 효모
WO2021104672A1 (en) 2019-11-29 2021-06-03 Lallemand Hungary Liquidity Management Llc Yeast expressing heterologous glucoamylase
US20210163995A1 (en) 2019-11-29 2021-06-03 Lallemand Hungary Liquidity Management Llc Process for displacing an exogenous enzyme
EP4085146A1 (en) * 2020-02-21 2022-11-09 Braskem, S.A. Production of ethanol with one or more co-products in yeast
CN116783289A (zh) * 2020-09-01 2023-09-19 丹麦技术大学 用于生产挥发性化合物的方法和细胞
CN113774093B (zh) * 2021-10-11 2024-06-18 徐州工程学院 一种3-羟基丙酸的补料发酵生产方法
WO2023170628A1 (en) 2022-03-09 2023-09-14 Lallemand Hungary Liquidity Management Llc Bacterial and archaeal alpha-amylases

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69931162T2 (de) * 1998-07-10 2007-03-29 Fluxome Sciences As Metabolisch veränderte mikrobiellen zelle mit veränderten metabolitherstellung
CN1955299A (zh) * 2000-11-22 2007-05-02 内特尔沃克公司 合成有机产物的方法和材料
WO2004085627A1 (en) * 2003-03-26 2004-10-07 Forskarpatent I Syd Ab New saccharomyces cerevisiae strains utilizing xylose
SE0400815D0 (sv) * 2004-03-26 2004-03-26 Forskarpatent I Syd Ab Traits in recombinant xylose-growing saccharomyces cerevisiae strains using genome-wide transcription analysis
CN101914462B (zh) 2004-07-16 2013-04-24 Dsm知识产权资产有限公司 发酵木糖的真核细胞的代谢工程
US7846712B2 (en) 2006-06-01 2010-12-07 Alliance For Sustainable Energy, Llc L-arabinose fermenting yeast
US20080293086A1 (en) * 2006-09-18 2008-11-27 Cobalt Technologies, Inc. A Delaware Corporation Real time monitoring of microbial enzymatic pathways
WO2008052595A1 (en) * 2006-10-31 2008-05-08 Metabolic Explorer Process for the biological production of 1,3-propanediol from glycerol with high yield
EP2102327A4 (en) * 2006-12-01 2010-01-06 Gevo Inc MANIPULATED MICROORGANISMS FOR THE MANUFACTURE OF N-BUTANOL AND CORRESPONDING METHODS
US20080293125A1 (en) 2007-04-18 2008-11-27 Gevo, Inc. Engineered microorganisms for producing isopropanol
WO2009012210A2 (en) * 2007-07-13 2009-01-22 Regents Of The University Of Minnesota Ethanol-producing microorganisms and methods of using
WO2009013160A2 (en) 2007-07-23 2009-01-29 Dsm Ip Assets B.V. Butanol production in a eukaryotic cell
WO2009013159A2 (en) * 2007-07-23 2009-01-29 Dsm Ip Assets B.V. Acetyl-coa producing enzymes in yeast
WO2009043012A1 (en) * 2007-09-27 2009-04-02 Mascoma Corporation Progressive fermentation of lignocellulosis biomass
EP2060632A1 (en) * 2007-10-29 2009-05-20 Technische Universität Berlin Method of modifying a yeast cell for the production of ethanol
EP2225373A4 (en) * 2007-12-13 2014-04-30 Glycos Biotechnologies Inc MICROBIAL CONVERSION OF OILS AND FATTY ACIDS IN HIGH-VALUE CHEMICALS
DE102008004253B4 (de) 2008-01-14 2011-07-28 Butalco Gmbh Gesteigerte Produktion von Acetyl-Coenzym A
US8163516B2 (en) * 2008-02-08 2012-04-24 Algenol Biofuels Inc. Selection of ADH in genetically modified cyanobacteria for the production of ethanol
EP2255004B1 (en) * 2008-02-20 2014-04-30 Nagarjuna Fertilizers And Chemicals Limited Genetically transformed microorganism for biomass fermentation
CA3081506A1 (en) 2008-03-05 2009-09-11 Genomatica, Inc. Long chain alcohol-producing organisms
WO2009137804A1 (en) * 2008-05-09 2009-11-12 University Of Georgia Research Foundation, Inc. Yeast cells and mehtods for increasing ethanol production
CA2724036C (en) 2008-05-11 2018-09-25 Mascoma Corporation Construction of protrophic/celluloytic yeast strains expressing tethered and secreted cellulases
CA3021166C (en) 2008-05-11 2024-01-09 Universiteit Stellenbosch Heterologous expression of fungal cellobiohydrolases in yeast
CA2729924C (en) 2008-07-07 2018-05-29 Mascoma Corporation Isolation and characterization of schizochytrium aggregatum cellobiohydrolase i (cbh 1)
WO2010005551A2 (en) 2008-07-07 2010-01-14 Mascoma Corporation Heterologous expression of termite cellulases in yeast
BRPI0916598A2 (pt) * 2008-07-28 2017-05-30 Qteros Inc métodos e composições para aumentar a produção de produtos em micro-organismos
US20120094343A1 (en) 2008-11-12 2012-04-19 Mascoma Corporation Gene Knockout Mesophilic and Thermophilic Organisms, and Methods of Use Thereof
CN108315272A (zh) 2008-11-21 2018-07-24 拉勒曼德匈牙利流动性管理有限责任公司 用于使用纤维素进行同时糖化和发酵的表达纤维素酶的酵母
WO2010075529A2 (en) 2008-12-23 2010-07-01 Mascoma Corporation Heterologous biomass degrading enzyme expression in thermoanaerobacterium saccharolyticum
WO2010075504A2 (en) * 2008-12-23 2010-07-01 Gevo, Inc. Engineered microorganisms for the production of one or more target compounds
EP2277989A1 (en) * 2009-07-24 2011-01-26 Technische Universiteit Delft Fermentative glycerol-free ethanol production
NZ624392A (en) * 2009-08-21 2015-12-24 Lallemand Hungary Liquidity Man Llc Production of propanols, alcohols, and polyols in consolidated bioprocessing organisms
WO2011066356A1 (en) * 2009-11-24 2011-06-03 Gevo, Inc. Methods of increasing dihydroxy acid dehydratase activity to improve production of fuels, chemicals, and amino acids
CA2784903A1 (en) * 2009-12-29 2011-07-28 Butamax(Tm) Advanced Biofuels Llc Alcohol dehydrogenases (adh) useful for fermentive production of lower alkyl alcohols
BR112012028290B1 (pt) * 2010-05-05 2021-02-02 Lallemand Hungary Liquidity Management Llc. levedura recombinante, processo para converter biomassa em etanol e meio de fermentação compreendendo dita levedura
US20130071904A1 (en) * 2010-05-28 2013-03-21 Yoram Barak Acetate-resistant yeast strain for the production of a fermentation product
BR112012031362A2 (pt) 2010-06-03 2015-10-13 Mascoma Corp levedura expressando enzimas sacarolíticas para bioprocessamento consolidado usando amido e celulose
BR112012031639A2 (pt) * 2010-06-11 2015-11-24 Regentes Of The University Of California vias sintéticas para a síntese de biocombustíveis
WO2012019175A2 (en) * 2010-08-06 2012-02-09 Mascoma Corporation Production of malonyl-coa drived products via anaerobic pathways
BR122019017739B1 (pt) 2011-04-05 2021-06-22 Lallemand Hungary Liquidity Management Llc Micro-organismo recombinante compreendendo uma deleção de enzimas nativas que atuam para produzir glicerol e/ou regular a síntese de glicerol e vias metabólicas sintéticas para converter uma fonte de carboidrato a etanol
US8663970B1 (en) * 2012-09-11 2014-03-04 National Chung Cheng University Recombinant thermotolerant yeast with a substitute heat shock protein 104 promoter
MY195138A (en) * 2012-10-15 2023-01-11 Genomatica Inc Microorganisms and Methods for Production of Specific Length Fatty Alcohols and Related Compounds
CA2889890C (en) * 2012-11-09 2023-03-28 Lallemand Hungary Liquidity Management Llc Method for acetate consumption during ethanolic fermentation of cellulosic feedstocks
WO2015041940A2 (en) * 2013-09-19 2015-03-26 Shell Oil Company Novel yeast strains

Also Published As

Publication number Publication date
CA2798452A1 (en) 2011-11-10
WO2011140386A2 (en) 2011-11-10
WO2011140386A3 (en) 2012-01-05
CA2798452C (en) 2019-09-03
US20130273555A1 (en) 2013-10-17
US9605269B2 (en) 2017-03-28
BR112012028290B1 (pt) 2021-02-02

Similar Documents

Publication Publication Date Title
BR112012028290A2 (pt) desintoxicação de acetato derivado de biomassa via conversão metabólica em etanol, acetona, isopropanol ou acetato de etila
BR112015010134A2 (pt) Processo para consumo de acetato durante a fermentação etanólica de matérias-primas celulósicas
BR112016025331A2 (pt) composições antimicrobianas
EA201201648A1 (ru) Стимуляторы sgc
PH12015501470A1 (en) Compositions and methods for the control of nematodes and soil borne diseases
BR112014014652A2 (pt) microrganismos modificados e métodos de fazer butadieno usando os mesmos
BR112017004744A2 (pt) corpo vegetal enxertado e método para a produção do mesmo
BR112014027227A2 (pt) modificação alvejada de malato desidrogenase
BR112015018783A2 (pt) mistura íntima seca, composição, método de preparação de uma mistura íntima seca e método de aumento da germinação, crescimento, metabolismo e/ou atividade enzimática de esporos bacterianos
PH12016500478A1 (en) Isolated strain of clonostachys rosea for use as a biological control agent
BR112012021771A2 (pt) métodos de uso de inibidores de contransportadores de sódio-glicose 1 e 2.
BRPI0712816B8 (pt) compostos de pirrolpirimidina e seus usos
WO2011163500A3 (en) Methods and compositions for reducing body odor
TN2011000482A1 (en) Organic compounds and their uses
WO2012047733A3 (en) Treatment of acne by conditioned media
MX2012014904A (es) Metodos de tratamiento utilizando inhibidores de tlr7 y/o tlr9.
BR112013000275A2 (pt) derivados de tetraidro-pirido-pirimidina
CO6640205A2 (es) Microorganismos y metodos para la biosintesis de p-toluato y tereftalato
BR112016006048A8 (pt) composições antimicrobianas
UY29416A1 (es) Derivados de ácido pirimidincarboxílico y su uso
BR112016016539A2 (pt) micro-organismos recombinantes enriquecidos com carboidratos
UA107204C2 (uk) Протигрибкова композиція, що містить грибковий організм pythium oligandrum
UA107687C2 (ru) Комбинированная композиция, которая в качестве активных ингредиентов содержит l-карнитин или пропионил-l-карнитин, троксерутин, диосмин и гесперидин, для предотвращения и/или лечения хронических заболеваний вен.
MY182946A (en) Production of organic acids by fermentation at low ph
SG10201804952QA (en) Glucosylceramide synthase inhibitors

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: LALLEMAND HUNGARY LIQUIDITY MANAGEMENT LLC. (HU)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B25G Requested change of headquarter approved

Owner name: LALLEMAND HUNGARY LIQUIDITY MANAGEMENT LLC. (HU)

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 05/05/2011, OBSERVADAS AS CONDICOES LEGAIS.