BR112012012131A2 - uso de agonistas de receptores adrenérgicos alfa-2 para tratar ou prevenir psoríase - Google Patents

uso de agonistas de receptores adrenérgicos alfa-2 para tratar ou prevenir psoríase

Info

Publication number
BR112012012131A2
BR112012012131A2 BR112012012131A BR112012012131A BR112012012131A2 BR 112012012131 A2 BR112012012131 A2 BR 112012012131A2 BR 112012012131 A BR112012012131 A BR 112012012131A BR 112012012131 A BR112012012131 A BR 112012012131A BR 112012012131 A2 BR112012012131 A2 BR 112012012131A2
Authority
BR
Brazil
Prior art keywords
alpha
treat
adrenergic receptor
receptor agonists
psoriasis
Prior art date
Application number
BR112012012131A
Other languages
English (en)
Inventor
A Dejovin Jacke
Original Assignee
Galderma Laboratories Lp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Laboratories Lp filed Critical Galderma Laboratories Lp
Publication of BR112012012131A2 publication Critical patent/BR112012012131A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

uso de agonista de receptores adrenérgicos alfa-2 para tratar ou prevenir psoríase. a presente invenção refere-se a método e kits para tratar ou prevenir psoríare ou um sintoma associado a ela em uma indivíduo. os métodos envolvem aplicações tópicas no indivíduo de uma quantidade terapeuticamente eficaz de um agonista de receptores <224>2, tal como brimonidina.
BR112012012131A 2009-11-19 2010-11-18 uso de agonistas de receptores adrenérgicos alfa-2 para tratar ou prevenir psoríase BR112012012131A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/621,942 US8394800B2 (en) 2009-11-19 2009-11-19 Method for treating psoriasis
PCT/US2010/057184 WO2011075267A1 (en) 2009-11-19 2010-11-18 Use of alpha 2 adrenergic receptor agonists for treating or preventing psoriasis

Publications (1)

Publication Number Publication Date
BR112012012131A2 true BR112012012131A2 (pt) 2019-09-24

Family

ID=43729952

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012012131A BR112012012131A2 (pt) 2009-11-19 2010-11-18 uso de agonistas de receptores adrenérgicos alfa-2 para tratar ou prevenir psoríase

Country Status (14)

Country Link
US (2) US8394800B2 (pt)
EP (1) EP2501373B1 (pt)
JP (1) JP5680660B2 (pt)
KR (2) KR101374907B1 (pt)
CN (1) CN102844025B (pt)
AU (1) AU2010332233C1 (pt)
BR (1) BR112012012131A2 (pt)
CA (1) CA2781112C (pt)
ES (1) ES2532527T3 (pt)
HK (1) HK1175698A1 (pt)
MX (1) MX2012005790A (pt)
NZ (1) NZ600333A (pt)
RU (1) RU2538729C2 (pt)
WO (1) WO2011075267A1 (pt)

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RU2012125249A (ru) 2013-12-27
AU2010332233C1 (en) 2013-12-19
KR20120129878A (ko) 2012-11-28
EP2501373A1 (en) 2012-09-26
CA2781112C (en) 2015-01-06
MX2012005790A (es) 2012-09-28
CN102844025A (zh) 2012-12-26
US9072739B2 (en) 2015-07-07
CA2781112A1 (en) 2011-06-23
NZ600333A (en) 2014-05-30
US20110118267A1 (en) 2011-05-19
RU2538729C2 (ru) 2015-01-10
WO2011075267A1 (en) 2011-06-23
CN102844025B (zh) 2014-11-19
JP2013511534A (ja) 2013-04-04
EP2501373B1 (en) 2015-02-25
HK1175698A1 (en) 2013-07-12
AU2010332233A1 (en) 2012-06-14
US8394800B2 (en) 2013-03-12
ES2532527T3 (es) 2015-03-27
JP5680660B2 (ja) 2015-03-04
KR101374907B1 (ko) 2014-03-14
KR20130106439A (ko) 2013-09-27
US20130184283A1 (en) 2013-07-18

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