BR102020013240A8 - Ligantes binucleantes fenólicos, compostos metálicos binucleares, composição médico-veterinária, processos de síntese de ligantes binucleantes, processo de síntese de compostos binucleares, e uso - Google Patents

Ligantes binucleantes fenólicos, compostos metálicos binucleares, composição médico-veterinária, processos de síntese de ligantes binucleantes, processo de síntese de compostos binucleares, e uso

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Publication number
BR102020013240A8
BR102020013240A8 BR102020013240A BR102020013240A BR102020013240A8 BR 102020013240 A8 BR102020013240 A8 BR 102020013240A8 BR 102020013240 A BR102020013240 A BR 102020013240A BR 102020013240 A BR102020013240 A BR 102020013240A BR 102020013240 A8 BR102020013240 A8 BR 102020013240A8
Authority
BR
Brazil
Prior art keywords
binucleant
binuclear
ligands
phenolic
medical
Prior art date
Application number
BR102020013240A
Other languages
English (en)
Other versions
BR102020013240A2 (pt
Inventor
Luis Souza Dos Santos André
Paola Rada Arias Jesica
Dias Pereira Marcos
Adrián Rey Nicolás
Dos Santos Moraes Francisco Rafaela
Zeinab Ghasemishahrestani
Original Assignee
Faculdades Catolicas
Univ Federal Do Rio De Janeiro Ufrj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Faculdades Catolicas, Univ Federal Do Rio De Janeiro Ufrj filed Critical Faculdades Catolicas
Priority to BR102020013240A priority Critical patent/BR102020013240A8/pt
Priority to PCT/BR2021/050266 priority patent/WO2021258173A1/pt
Publication of BR102020013240A2 publication Critical patent/BR102020013240A2/pt
Publication of BR102020013240A8 publication Critical patent/BR102020013240A8/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/86—Hydrazides; Thio or imino analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic System
    • C07F1/08—Copper compounds

Abstract

ligantes binucleantes fenólicos, compostos metálicos binucleares, composição médico-veterinária, processos de síntese de ligantes binucleantes, processo de síntese de compostos binucleares, método de tratamento de neoplasias e doenças fúngicas e uso. a presente invenção trata de novas metalodrogas contendo um centro de coordenação binuclear de cobre(ii) e os ligantes binucleantes não-simétricos 2-hidroxi-3-{[(2-hidroxibenzil)(2-piridilmetil)amino]-metil}-5-metilbenzaldeído isonicotinoíl hidrazona (h3l1) ou 2-hidroxi-3-{bis[(2-piridilmetil)amino]-metil}-5-metilbenzaldeído isonicotinoíl hidrazona (h2l2) adequadas para o tratamento de neoplasias envolvendo tumores sólidos e/ou leucemias, bem como doenças de natureza oportunista, tais como as doenças causadas por fungos patogênicos.
BR102020013240A 2020-06-26 2020-06-26 Ligantes binucleantes fenólicos, compostos metálicos binucleares, composição médico-veterinária, processos de síntese de ligantes binucleantes, processo de síntese de compostos binucleares, e uso BR102020013240A8 (pt)

Priority Applications (2)

Application Number Priority Date Filing Date Title
BR102020013240A BR102020013240A8 (pt) 2020-06-26 2020-06-26 Ligantes binucleantes fenólicos, compostos metálicos binucleares, composição médico-veterinária, processos de síntese de ligantes binucleantes, processo de síntese de compostos binucleares, e uso
PCT/BR2021/050266 WO2021258173A1 (pt) 2020-06-26 2021-06-21 Ligantes binucleântes fenólicos, compostos metálicos binucleâres, composição médico-veterinária, processos de síntese de ligantes binucleântes, processo de síntese de compostos binucleâres, método de tratamento de neoplasias e doenças fúngicas e uso

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BR102020013240A BR102020013240A8 (pt) 2020-06-26 2020-06-26 Ligantes binucleantes fenólicos, compostos metálicos binucleares, composição médico-veterinária, processos de síntese de ligantes binucleantes, processo de síntese de compostos binucleares, e uso

Publications (2)

Publication Number Publication Date
BR102020013240A2 BR102020013240A2 (pt) 2022-01-11
BR102020013240A8 true BR102020013240A8 (pt) 2023-10-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
BR102020013240A BR102020013240A8 (pt) 2020-06-26 2020-06-26 Ligantes binucleantes fenólicos, compostos metálicos binucleares, composição médico-veterinária, processos de síntese de ligantes binucleantes, processo de síntese de compostos binucleares, e uso

Country Status (2)

Country Link
BR (1) BR102020013240A8 (pt)
WO (1) WO2021258173A1 (pt)

Also Published As

Publication number Publication date
BR102020013240A2 (pt) 2022-01-11
WO2021258173A1 (pt) 2021-12-30

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Legal Events

Date Code Title Description
B03A Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette]
B03H Publication of an application: rectification [chapter 3.8 patent gazette]

Free format text: REFERENTE A RPI 2662 DE 11/01/2022, QUANTO AO ITEM (54).