BR102020013240A8 - Ligantes binucleantes fenólicos, compostos metálicos binucleares, composição médico-veterinária, processos de síntese de ligantes binucleantes, processo de síntese de compostos binucleares, e uso - Google Patents
Ligantes binucleantes fenólicos, compostos metálicos binucleares, composição médico-veterinária, processos de síntese de ligantes binucleantes, processo de síntese de compostos binucleares, e usoInfo
- Publication number
- BR102020013240A8 BR102020013240A8 BR102020013240A BR102020013240A BR102020013240A8 BR 102020013240 A8 BR102020013240 A8 BR 102020013240A8 BR 102020013240 A BR102020013240 A BR 102020013240A BR 102020013240 A BR102020013240 A BR 102020013240A BR 102020013240 A8 BR102020013240 A8 BR 102020013240A8
- Authority
- BR
- Brazil
- Prior art keywords
- binucleant
- binuclear
- ligands
- phenolic
- medical
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 5
- 230000015572 biosynthetic process Effects 0.000 title abstract 4
- 238000003786 synthesis reaction Methods 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 3
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- GYHGFFPPDZYKOG-UHFFFAOYSA-N N-[[2-hydroxy-3-[[(2-hydroxyphenyl)methyl-(pyridin-2-ylmethyl)amino]methyl]-5-methylphenyl]methylideneamino]pyridine-4-carboxamide Chemical compound CC(C=C1CN(CC(C=CC=C2)=C2O)CC2=NC=CC=C2)=CC(C=NNC(C2=CC=NC=C2)=O)=C1O GYHGFFPPDZYKOG-UHFFFAOYSA-N 0.000 abstract 1
- UEHRFCLGCVOZAO-UHFFFAOYSA-N N-[[3-[bis(pyridin-2-ylmethylamino)methyl]-2-hydroxy-5-methylphenyl]methylideneamino]pyridine-4-carboxamide Chemical compound CC(C=C1C(NCC2=NC=CC=C2)NCC2=NC=CC=C2)=CC(C=NNC(C2=CC=NC=C2)=O)=C1O UEHRFCLGCVOZAO-UHFFFAOYSA-N 0.000 abstract 1
- 244000053095 fungal pathogen Species 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 150000002736 metal compounds Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/86—Hydrazides; Thio or imino analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic System
- C07F1/08—Copper compounds
Abstract
ligantes binucleantes fenólicos, compostos metálicos binucleares, composição médico-veterinária, processos de síntese de ligantes binucleantes, processo de síntese de compostos binucleares, método de tratamento de neoplasias e doenças fúngicas e uso. a presente invenção trata de novas metalodrogas contendo um centro de coordenação binuclear de cobre(ii) e os ligantes binucleantes não-simétricos 2-hidroxi-3-{[(2-hidroxibenzil)(2-piridilmetil)amino]-metil}-5-metilbenzaldeído isonicotinoíl hidrazona (h3l1) ou 2-hidroxi-3-{bis[(2-piridilmetil)amino]-metil}-5-metilbenzaldeído isonicotinoíl hidrazona (h2l2) adequadas para o tratamento de neoplasias envolvendo tumores sólidos e/ou leucemias, bem como doenças de natureza oportunista, tais como as doenças causadas por fungos patogênicos.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR102020013240A BR102020013240A8 (pt) | 2020-06-26 | 2020-06-26 | Ligantes binucleantes fenólicos, compostos metálicos binucleares, composição médico-veterinária, processos de síntese de ligantes binucleantes, processo de síntese de compostos binucleares, e uso |
PCT/BR2021/050266 WO2021258173A1 (pt) | 2020-06-26 | 2021-06-21 | Ligantes binucleântes fenólicos, compostos metálicos binucleâres, composição médico-veterinária, processos de síntese de ligantes binucleântes, processo de síntese de compostos binucleâres, método de tratamento de neoplasias e doenças fúngicas e uso |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR102020013240A BR102020013240A8 (pt) | 2020-06-26 | 2020-06-26 | Ligantes binucleantes fenólicos, compostos metálicos binucleares, composição médico-veterinária, processos de síntese de ligantes binucleantes, processo de síntese de compostos binucleares, e uso |
Publications (2)
Publication Number | Publication Date |
---|---|
BR102020013240A2 BR102020013240A2 (pt) | 2022-01-11 |
BR102020013240A8 true BR102020013240A8 (pt) | 2023-10-24 |
Family
ID=79282352
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR102020013240A BR102020013240A8 (pt) | 2020-06-26 | 2020-06-26 | Ligantes binucleantes fenólicos, compostos metálicos binucleares, composição médico-veterinária, processos de síntese de ligantes binucleantes, processo de síntese de compostos binucleares, e uso |
Country Status (2)
Country | Link |
---|---|
BR (1) | BR102020013240A8 (pt) |
WO (1) | WO2021258173A1 (pt) |
-
2020
- 2020-06-26 BR BR102020013240A patent/BR102020013240A8/pt unknown
-
2021
- 2021-06-21 WO PCT/BR2021/050266 patent/WO2021258173A1/pt active Application Filing
Also Published As
Publication number | Publication date |
---|---|
BR102020013240A2 (pt) | 2022-01-11 |
WO2021258173A1 (pt) | 2021-12-30 |
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Free format text: REFERENTE A RPI 2662 DE 11/01/2022, QUANTO AO ITEM (54). |