BR102020006848A2 - LONG-TERM LIQUID COMPOUND FOR PREVENTION AGAINST ECTOPARASITES AND CULICIDAES - Google Patents
LONG-TERM LIQUID COMPOUND FOR PREVENTION AGAINST ECTOPARASITES AND CULICIDAES Download PDFInfo
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- BR102020006848A2 BR102020006848A2 BR102020006848-2A BR102020006848A BR102020006848A2 BR 102020006848 A2 BR102020006848 A2 BR 102020006848A2 BR 102020006848 A BR102020006848 A BR 102020006848A BR 102020006848 A2 BR102020006848 A2 BR 102020006848A2
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- culicidaes
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 25
- 239000007788 liquid Substances 0.000 title claims abstract description 16
- 230000002265 prevention Effects 0.000 title claims abstract description 15
- 244000078703 ectoparasite Species 0.000 title claims abstract description 13
- 230000007774 longterm Effects 0.000 title claims description 11
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- 238000009472 formulation Methods 0.000 claims abstract description 14
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- WVDDGKGOMKODPV-UHFFFAOYSA-N hydroxymethyl benzene Natural products OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 11
- 239000002253 acid Substances 0.000 claims description 5
- 235000019445 benzyl alcohol Nutrition 0.000 claims description 5
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- 229940075582 sorbic acid Drugs 0.000 claims description 5
- 229940049964 oleate Drugs 0.000 claims description 4
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 4
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- 231100000252 nontoxic Toxicity 0.000 abstract description 6
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- VZRKEAFHFMSHCD-UHFFFAOYSA-N Ethyl 3-(N-butylacetamido)propionate Chemical compound CCCCN(C(C)=O)CCC(=O)OCC VZRKEAFHFMSHCD-UHFFFAOYSA-N 0.000 abstract description 4
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- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 description 4
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- 230000007059 acute toxicity Effects 0.000 description 2
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- VEHPJKVTJQSSKL-UHFFFAOYSA-N azadirachtin Natural products O1C2(C)C(C3(C=COC3O3)O)CC3C21C1(C)C(O)C(OCC2(OC(C)=O)C(CC3OC(=O)C(C)=CC)OC(C)=O)C2C32COC(C(=O)OC)(O)C12 VEHPJKVTJQSSKL-UHFFFAOYSA-N 0.000 description 2
- FTNJWQUOZFUQQJ-NDAWSKJSSA-N azadirachtin A Chemical compound C([C@@H]([C@]1(C=CO[C@H]1O1)O)[C@]2(C)O3)[C@H]1[C@]23[C@]1(C)[C@H](O)[C@H](OC[C@@]2([C@@H](C[C@@H]3OC(=O)C(\C)=C\C)OC(C)=O)C(=O)OC)[C@@H]2[C@]32CO[C@@](C(=O)OC)(O)[C@@H]12 FTNJWQUOZFUQQJ-NDAWSKJSSA-N 0.000 description 2
- FTNJWQUOZFUQQJ-IRYYUVNJSA-N azadirachtin A Natural products C([C@@H]([C@]1(C=CO[C@H]1O1)O)[C@]2(C)O3)[C@H]1[C@]23[C@]1(C)[C@H](O)[C@H](OC[C@@]2([C@@H](C[C@@H]3OC(=O)C(\C)=C/C)OC(C)=O)C(=O)OC)[C@@H]2[C@]32CO[C@@](C(=O)OC)(O)[C@@H]12 FTNJWQUOZFUQQJ-IRYYUVNJSA-N 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 229940000635 beta-alanine Drugs 0.000 description 2
- 239000003974 emollient agent Substances 0.000 description 2
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- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- AXMPPCGZGUAUBS-UHFFFAOYSA-N ethyl 2-(hexanoylamino)propanoate Chemical compound CCCCCC(=O)NC(C)C(=O)OCC AXMPPCGZGUAUBS-UHFFFAOYSA-N 0.000 description 1
- 239000010642 eucalyptus oil Substances 0.000 description 1
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- 150000002500 ions Chemical class 0.000 description 1
- 239000000171 lavandula angustifolia l. flower oil Substances 0.000 description 1
- -1 limonoid compounds Chemical class 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/26—Meliaceae [Chinaberry or Mahogany family], e.g. mahogany, langsat or neem
Abstract
composto líquido de longa duração para prevenção contra ectoparasitas e culicidaes. trata-se de um composto para prevenção contra ectoparasitas e culicidaes, pertencente ao campo de aplicação das substâncias elaboradas, para aplicação sobre a pele e pelo de animais, tendo sido desenvolvido para proteger de picadas de insetos, principalmente de mosquitos, pernilongos, pulgas, carrapatos, piolhos, vespas e afins, cuja formulação compreende as substâncias ativas azadirachta indica seed oil e "ethyl butylacetylaminopropionate", associadas a outros componentes e em quantidades específicas, destacando-se também pelo fato de ser atóxico aos animais de sangue quente e manter os efeitos da proteção por aproximadamente doze horas de duração, compreendido por uma fórmula, que está citada no descritivo. o produto ora tratado integra o rol dos produtos destinados ao uso veterinário.Long-lasting liquid compound for prevention against ectoparasites and culicidae. it is a compound for prevention against ectoparasites and culicidae insects, belonging to the field of application of the substances prepared, for application on the skin and fur of animals, having been developed to protect against insect bites, mainly mosquitoes, mosquitoes, fleas, ticks, lice, wasps and the like, whose formulation comprises the active substances azadirachta indica seed oil and "ethyl butylacetylaminopropionate", associated with other components and in specific quantities, also standing out for the fact that it is non-toxic to warm-blooded animals and maintains protective effects lasting approximately twelve hours, comprised of a formula, which is mentioned in the description. The product discussed here is part of the list of products intended for veterinary use.
Description
[001] Trata-se o presente relatório descritivo do pedido de patente de invenção de um COMPOSTO LÍQUIDO DE LONGA DURAÇÃO PARA PREVENÇÃO CONTRA ECTOPARASITAS E CULICIDAES, pertencente ao campo de aplicação das substâncias químicas elaboradas para uso veterinário, com aplicação sobre a pele e pelo de animais, tendo sido desenvolvido para proteger de picadas de insetos, principalmente de mosquitos, pernilongos, pulgas, carrapatos, piolhos, vespas e afins.[001] This is the present descriptive report of the patent application for the invention of a LONG-TERM LIQUID COMPOUND FOR THE PREVENTION AGAINST ECTOPARASITES AND CULICIDAES, belonging to the field of application of chemical substances prepared for veterinary use, with application on the skin and hair of animals, having been developed to protect from insect bites, mainly mosquitoes, mosquitoes, fleas, ticks, lice, wasps and the like.
[002] Dito composto foi idealizado e desenvolvido a partir da mistura de determinados ingredientes e em quantidades especificamente elaboradas, para o alcance ideal dos efeitos esperados.[002] Said compound was conceived and developed from the mixture of certain ingredients and in amounts specifically elaborated, for the ideal reach of the expected effects.
[003] Sua formulação compreende as substâncias ativas "Azadirachta Indica Seed Oil", o óleo de Neem ou Nim, é uma substância vegetal extraída das sementes da árvore Neem Indiano (Azadirachta Indica) rico em compostos limonóides com conhecida ação repelente sobre insetos, e "Ethyl Butylacetylaminopropionate", o Butilacetilaminopropionato de Etila, um ativo repelente de insetos, onde sua estrutura química é baseada em uma substância natural (beta-alanina), estas, associadas a outros componentes e em quantidades específicas.[003] Its formulation comprises the active substances "Azadirachta Indica Seed Oil", Neem or Neem oil, is a plant substance extracted from the seeds of the Indian Neem tree (Azadirachta Indica) rich in limonoid compounds with known repellent action on insects, and "Ethyl Butylacetylaminopropionate", Ethyl Butylacetylaminopropionate, an active insect repellent, where its chemical structure is based on a natural substance (beta-alanine), these, associated with other components and in specific amounts.
[004] O mencionado produto destaca-se dos demais conhecidos e existentes no mercado em razão de apresentar uma peculiar composição, apresentar um amplo espectro de proteção, pelo fato de ser atóxico aos animais de sangue quente e manter os efeitos da proteção prolongada por aproximadamente doze horas de duração. Indicado para uso veterinário, abrangendo todos os tipos de animais, tais como caninos, felinos, equinos, bovinos, caprinos, entre outros. Sendo para uso tópico, devendo ser aplicado sobre a pele e pelo dos animais.[004] The aforementioned product stands out from the others known and existing on the market due to its peculiar composition, a broad spectrum of protection, as it is non-toxic to warm-blooded animals and maintains the effects of prolonged protection for approximately twelve hours long. Indicated for veterinary use, covering all types of animals, such as canines, felines, horses, cattle, goats, among others. For topical use, it should be applied to the skin and fur of animals.
[005] Os repelentes foram definidos como uma classe de substâncias que fazem com que o inseto, após ter identificado o seu hospedeiro, altere seu curso de vôo de tal forma a passar longe do seu objetivo inicial. São geralmente substâncias aplicadas sobre a pele que desencorajam por sua composição a aproximação de insetos. COMPOSTO LÍQUIDO DE LONGA DURAÇÃO PARA PREVENÇÃO CONTRA ECTOPARASITAS E CULICIDAES teve sua eficácia comprovada em testes laboratoriais e de campo. Além disso, sua segurança foi provada em extensivos estudos toxicológicos, e é uma alternativa segura e eficaz em relação as demais opções disponíveis no mercado.[005] Repellents have been defined as a class of substances that cause the insect, after having identified its host, to alter its flight course in such a way as to pass away from its initial objective. These are generally substances applied to the skin that, due to their composition, discourage the approach of insects. LONG-LASTING LIQUID COMPOUND FOR PREVENTION AGAINST ECTPOPARASITES AND CULICIDAES had its effectiveness proven in laboratory and field tests. Furthermore, its safety has been proven in extensive toxicological studies, and it is a safe and effective alternative to other options available on the market.
[006] Como é do conhecimento geral, a expansão geográfica de doenças transmitidas por insetos que picam os animais e o aumento da frequência dos casos tornam cada vez mais urgente à implantação de campanhas de combate às estas doenças. Entre as alternativas mais ecológicas, eficientes e de baixo custo para alcançar este objetivo, está à utilização dos compostos repelentes como preventivo.[006] As is well known, the geographic expansion of diseases transmitted by insects that bite animals and the increase in the frequency of cases make it increasingly urgent to implement campaigns to combat these diseases. Among the most ecological, efficient and low-cost alternatives to achieve this goal is the use of repellent compounds as a preventive.
[007] Os insetos podem se tornar um problema ou até uma ameaça ao homem e aos animais, podendo causar infecções e transmitir doenças muito perigosas. Algumas doenças graves transmitidas por insetos são a Malária, a Dengue, a Febre Amarela, a Erliquiose, o Calazar, e a Encefalite.[007] Insects can become a problem or even a threat to man and animals, causing infections and transmitting very dangerous diseases. Some serious diseases transmitted by insects are Malaria, Dengue, Yellow Fever, Ehrlichiosis, Calazar, and Encephalitis.
[008] O uso de inseticidas é uma das principais armas que temos para evitar problemas com os insetos, porém o seu uso é limitado por uma série de razões, dentre as quais destacam-se o perfil toxicológico da maioria das substâncias que têm este tipo de ação e a dificuldade do uso constante. Por estas razões, as medidas defensivas são preferidas pela maioria das pessoas.[008] The use of insecticides is one of the main weapons we have to avoid problems with insects, but their use is limited for a number of reasons, among which the toxicological profile of most substances that have this type stand out. of action and the difficulty of constant use. For these reasons, defensive measures are preferred by most people.
[009] Entretanto, nem sempre podemos evitar o uso dos compostos repelentes e, por isso, é necessário escolher um produto adequado que, além da eficácia, tenha excelentes características toxicológicas e, preferencialmente, não seja desagradável de ser usado, tanto por seu odor quanto por seu toque. Os chamados "repelentes de insetos" são substâncias químicas que têm o propósito de evitar que o inseto aterrisse sobre a pele. Assim, sem entrar em contato, ele não pode causar danos.[009] However, we cannot always avoid the use of repellent compounds and, therefore, it is necessary to choose a suitable product that, in addition to efficacy, has excellent toxicological characteristics and, preferably, is not unpleasant to be used, both due to its odor as for your touch. So-called "insect repellants" are chemical substances that are designed to prevent the insect from landing on the skin. So, without contacting him, he cannot do any harm.
[010] Dethier definiu os repelentes como sendo uma classe de substâncias capazes de fazer com que os insetos, após identificarem o seu alvo, alterem o seu caminho de voo. Essa definição descreve também a diferença fundamental entre os repelentes e os inseticidas que, como o próprio nome diz, mata os insetos.[010] Dethier defined repellants as a class of substances capable of causing insects, after identifying their target, to alter their flight path. This definition also describes the fundamental difference between repellents and insecticides which, as the name implies, kill insects.
[011] Nesse mesmo aspecto, o estado da técnica revela que para se tentar evitar ou minimizar os riscos de picadas de insetos em animais, as opções mais comuns são:
Os Óleos de Citronela, Eucalipto e Lavanda veem sendo usado há décadas como repelentes naturais. Porém são produtos de baixa eficácia e com um tempo de ação relativamente curto. Além disso, são potencialmente irritantes e não são raros os casos de eczemas de contato causados em animais por estes produtos.[011] In this same aspect, the state of the art reveals that to try to avoid or minimize the risks of insect bites in animals, the most common options are:
Citronella, Eucalyptus and Lavender Oils have been used for decades as natural repellents. However, they are products of low efficacy and with a relatively short action time. In addition, they are potentially irritating and contact eczema caused by these products in animals is not rare.
[012] Os demais compostos repelentes para uso veterinário disponíveis no mercado não garantem ser eficazes contra as várias espécies de insetos, não apresentam segurança toxicológica para os animais que realizam o uso, por apresentarem certa toxicidade. Não são raros os relatos de incidentes com os produtos, principalmente com animais atópicos, que apresentam dermatites crônicas e peles sensíveis. Além disso, suas propriedades cosméticas não são agradáveis.[012] The other repellent compounds for veterinary use available on the market do not guarantee to be effective against the various species of insects, they do not present toxicological safety for the animals that perform the use, as they present certain toxicity. Reports of incidents with the products are not rare, especially with atopic animals, which have chronic dermatitis and sensitive skin. Also, its cosmetic properties are not pleasant.
[013] O COMPOSTO LÍQUIDO DE LONGA DURAÇÃO PARA PREVENÇÃO CONTRA ECTOPARASITAS E CULICIDAES é uma alternativa aos produtos anteriores, pois tem ampla eficácia e proteção garantida por até 12 horas, é efetivo contra ectoparasitas e culicidaes, diversos tipos de mosquitos (Anopheles gambiae, Anopheles funestus, Aedes aegypti, Aedes albopictus), piolhos (Pediculushumanus), carrapatos (Ixodes scapularis, Ixodes ricinus), moscas (Stomoxys calcitrans, Simulidae, Tabanidae, Musca domestica), vespas (Polistes galliens) e abelhas (Apis mellifera).[013] The LONG-TERM LIQUID COMPOUND FOR PREVENTION AGAINST ECTOPARASITES AND CULICIDAES is an alternative to the previous products, as it has broad efficacy and protection guaranteed for up to 12 hours, it is effective against ectoparasites and Culicidaes, various types of mosquitoes (Anopheles gambiae, Anopheles funestus, Aedes aegypti, Aedes albopictus), lice (Pediculushumanus), ticks (Ixodes scapularis, Ixodes ricinus), flies (Stomoxys calcitrans, Simulidae, Tabanidae, Musca domestica), wasps (Polistes galliens) and bees (Apis).
[014] O composto em tema tem sua eficácia comprovada em testes laboratoriais e de campo. Além disso, sua segurança foi provada em extensivos estudos toxicológicos (toxicidade aguda, irritação aguda, sensibilização, exposição repetida, genotoxicidade, reprotoxicidade, ADME (absorção, distribuição, metabolismo e excreção. Apresentando um nível de toxicidade aguda muito baixa, sendo considerado como praticamente atóxico e tem amplo espectro de ação. Considerado seguro para os animais, pessoas, incluindo gestantes e lactantes, e crianças.[014] The compound in subject has its effectiveness proven in laboratory and field tests. Furthermore, its safety has been proven in extensive toxicological studies (acute toxicity, acute irritation, sensitization, repeated exposure, genotoxicity, reprotoxicity, ADME (absorption, distribution, metabolism and excretion. Presenting a very low level of acute toxicity, being considered as practically non-toxic and has a broad spectrum of action.Considered safe for animals, people, including pregnant and lactating women, and children.
[015] O COMPOSTO LÍQUIDO DE LONGA DURAÇÃO PARA PREVENÇÃO CONTRA ECTOPARASITAS E CULICIDAES é atóxico, inodoro, transparente, elevada estabilidade, amplo espectro de ação, ativo inclusive contra Aedes aegypti e Clogmia Albipunctata (mosquito palha), sendo este o mosquito transmissor da doença Leismaniose Visceral, popularmente conhecida como Calazar.[015] LONG-TERM LIQUID COMPOUND FOR PREVENTION AGAINST ECTOPARASITES AND CULICIDAES is non-toxic, odorless, transparent, high stability, broad spectrum of action, active even against Aedes aegypti and Clogmia Albipunctata (straw mosquito), which is the mosquito that transmits the disease Visceral Leismaniasis, popularly known as Calazar.
[016] Dentre as suas propriedades podemos citar, a segurança e longa duração, sendo repelente natural atóxico, com proteção contra insetos, carrapatos, piolhos, vespas, abelhas e borrachudos, seguro para uso veterinário, seguro para pessoas que irão realizar suas aplicações nos animais, como também para gestantes, lactantes e crianças que possam realizar contato com o mesmo.[016] Among its properties we can mention, safety and long-lasting, being a non-toxic natural repellent, with protection against insects, ticks, lice, wasps, bees and black flies, safe for veterinary use, safe for people who will carry out their applications in animals, as well as for pregnant women, lactating women and children who may make contact with it.
[017] Com mecanismo de ação que afugenta os insetos, carrapatos, piolhos, pulgas, vespas, abelhas, entre outras, prevenindo picadas. O composto proposto, pode auxiliar no combate às doenças transmitidas por insetos, não como cura e sim como repelente, evitando a transmissão da doença através da picada.[017] With action mechanism that scares away insects, ticks, lice, fleas, wasps, bees, among others, preventing stings. The proposed compound can help fight diseases transmitted by insects, not as a cure but as a repellent, preventing the transmission of disease through the bite.
[018] Os resultados de um estudo de campo com a formulação, realizado em 10 pessoas, mostrou que o composto tem a capacidade de oferecer proteção de até 12 horas. Durante o ensaio, os carrapatos foram colocados na parte superior do braço (já com o produto aplicado) e enquanto o os carrapatos não atravessaram a área coberta com a formulação repelente respectiva, o produto foi eficaz. 100% dos voluntários foram protegidos durante o tempo de exposição. Cada formulação testada cumpriu a alegação "Até 12 horas de proteção", o que confirma a repelência duradoura contra carrapatos.[018] The results of a field study with the formulation, carried out in 10 people, showed that the compound has the ability to offer protection for up to 12 hours. During the test, the ticks were placed on the upper arm (already with the product applied) and while the ticks did not cross the area covered with the respective repellent formulation, the product was effective. 100% of volunteers were protected during the exposure time. Each formulation tested fulfilled the claim "Up to 12 hours of protection", which confirms long-lasting repellency against ticks.
[019] Os resultados de um estudo de campo com 10 pessoas, mostrou que o composto em questão foi eficaz contra as picadas do mosquito Aedes, Anófeles, Culex, entre outros. Cumpriu os requisitos para transportar a distinção de "proteção de até 10 horas", o que confirma o efeito repelente contra mosquitos ser duradoura.[019] The results of a field study with 10 people, showed that the compound in question was effective against the bites of mosquitoes Aedes, Anopheles, Culex, among others. It fulfilled the requirements to carry the distinction of "protection of up to 10 hours", which confirms the repellent effect against mosquitoes to be long-lasting.
[020] O COMPOSTO LÍQUIDO DE LONGA DURAÇÃO PARA PREVENÇÃO CONTRA ECTOPARASITAS E CULICIDAES tem em sua formulação os seguintes componentes, que são:
1 - Água Deionizada (ou Água desmineralizada) utilizada na formulação como veículo, com todos os sais minerais removidos, sendo própria para ser utilizada em processos químicos. Água pura livre de íons, minerais, metais e outros contaminantes.
2 - Ethyl Butylacetylaminopropionate (ou Butilacetilaminopropionato de etila) é um ativo repelente de alta performance e sua estrutura química é baseada em uma substância natural (beta-alanina). É um repelente altamente eficaz e seguro. Oferece proteção de longa duração e pode ser aplicado em animais adultos e filhotes, humanos, incluindo gestantes e lactantes, crianças.
3 - Azadirachta Indica Seed Oil, o óleo de Neem, utilizado na composição do produto como ativo repelente, é um óleo virgem e orgânico, extraído das sementes (amêndoas) e obtido através da prensagem das sementes em processo à frio, afim de preservar e manter as suas propriedades em níveis mais elevados possíveis. Apresentando aspectos de cor levemente amarelada, odor característico.
Azadirachta Indica Seed Oil (ou Óleo de Neem) é composto pelo ativo Azadirachtina, substância encontrada principalmente nas sementes, e em menor quantidade na casca e nas folhas do nim, é o principal composto responsável pelos efeitos de repelência aos insetos (SCHMUTTERER, 1990; MORDUE & NISBET, 2000).
Os efeitos da azadiractina sobre insetos incluem repelência, deterrência alimentar, interrupção do crescimento, interferência na metamorfose, esterilidade e anormalidades anatômicas (SCHMUTTERER, 1990; MORDUE & NISBET, 2000; MARTINEZ & EMDEN, 2001).
Produtos derivados do nim têm vantagem de ser praticamente não tóxicos aos animais, homens e ser rapidamente degradados no solo e nas plantas (ISMAN, 2006). Esses compostos têm grande potencial no controle de pragas, apresentam toxicidade extremamente baixa aos vertebrados, sendo praticamente inócuos, causando baixo impacto ao ambiente.
4 - Alcohol (ou álcool de cereais), é utilizado na formulação como solvente, é um produto de alta pureza, a característica organoléptica do álcool de cereais é singular, facilmente detectada pela maciez e palatabilidade. Ou seja, trata-se de um produto suave ao consumidor final, utiliza-se nos processos onde necessita-se de um álcool etílico a 96°GL de alta pureza e odor suave.
5 - Polyglyceryl Oleate (ou poliglicerol) é incorporado a formulação com a função de solubilizador e emulsificante. Extraído de fontes vegetais. Livre de PEG de óleos naturais e emolientes lipofílicos. Apresenta propriedades solubilizantes para óleos naturais e graxos. Também, emolientes hidrofóbicos ativos ou preservativos solubilizados em água ou formulações baseadas em água.
6 - Benzyl Alcohol (ou álcool benzílico) é empregado na formulação como agente preservante/conservante. Líquido eficaz no controle de bactérias e fungos.
7 - Benzoil Acid (ou ácido benzoico) é utilizado na formulação como agente preservante, é um composto aromático classificado como ácido carboxílico. Este ácido fraco e seus sais são usados como conservante e ocorre naturalmente em certas plantas. Ativo no controle de bactérias e fungos.
8 - Sorbic Acid (ou ácido sórbico) é usado na formulação como preservante é um composto orgânico encontrado na natureza e utilizado como conservante. É um sólido incolor, pouco solúvel na água e facilmente sublimável. Enérgico no controle de bactérias e fungos.[020] LONG-TERM LIQUID COMPOUND FOR PREVENTION AGAINST ECTPOPARASITES AND CULICIDAES has in its formulation the following components, which are:
1 - Deionized Water (or Demineralized Water) used in the formulation as a vehicle, with all mineral salts removed, being suitable for use in chemical processes. Pure water free of ions, minerals, metals and other contaminants.
2 - Ethyl Butylacetylaminopropionate (or Ethyl Butylacetylaminopropionate) is a high-performance repellent active and its chemical structure is based on a natural substance (beta-alanine). It is a highly effective and safe repellent. Offers long-lasting protection and can be applied to adult animals and puppies, humans, including pregnant and lactating women, children.
3 - Azadirachta Indica Seed Oil, Neem oil, used in the composition of the product as a repellent active, is a virgin and organic oil, extracted from seeds (almonds) and obtained by pressing the seeds in a cold process, in order to preserve and keep its properties at the highest possible levels. Presenting aspects of slightly yellowish color, characteristic odor.
Azadirachta Indica Seed Oil (or Neem Oil) is composed of the active Azadirachtin, a substance found mainly in seeds, and in smaller amounts in the neem bark and leaves, it is the main compound responsible for the insect repellency effects (SCHMUTTERER, 1990; MORDUE & NISBET, 2000).
The effects of azadirachtin on insects include repellency, food deterrence, growth interruption, interference with metamorphosis, sterility and anatomical abnormalities (SCHMUTTERER, 1990; MORDUE & NISBET, 2000; MARTINEZ & EMDEN, 2001).
Neem-derived products have the advantage of being practically non-toxic to animals, humans and being rapidly degraded in soil and plants (ISMAN, 2006). These compounds have great potential in pest control, have extremely low toxicity to vertebrates, being practically innocuous, causing a low impact on the environment.
4 - Alcohol (or grain alcohol), used in the formulation as a solvent, is a product of high purity, the organoleptic characteristic of grain alcohol is unique, easily detected by its softness and palatability. In other words, it is a mild product for the final consumer, it is used in processes where an ethyl alcohol at 96°GL of high purity and a mild odor is needed.
5 - Polyglyceryl Oleate (or polyglycerol) is incorporated into the formulation as a solubilizer and emulsifier. Extracted from plant sources. PEG-free of natural oils and lipophilic emollients. It has solubilizing properties for natural and fatty oils. Also, active hydrophobic emollients or water-solubilized preservatives or water-based formulations.
6 - Benzyl Alcohol (or benzyl alcohol) is used in the formulation as a preservative/preservative agent. Effective liquid in controlling bacteria and fungi.
7 - Benzoil Acid (or benzoic acid) is used in the formulation as a preserving agent, it is an aromatic compound classified as carboxylic acid. This weak acid and its salts are used as a preservative and occur naturally in certain plants. Active in the control of bacteria and fungi.
8 - Sorbic Acid (or sorbic acid) is used in the formulation as a preservative, it is an organic compound found in nature and used as a preservative. It is a colorless solid, sparingly soluble in water and easily sublimable. Energetic in controlling bacteria and fungi.
[021] Em relação a sua fórmula, os aspectos característicos quantitativos e qualitativos do COMPOSTO LÍQUIDO DE LONGA DURAÇÃO PARA PREVENÇÃO CONTRA ECTOPARASITAS E
CULICIDAES são:
- - Aqua..........................................................68,40%
- - Ethyl Butylacetylaminopropionate..................25,00%
- - Azadirachta Indica Seed Oil.............................2,00%
- - Alcohol........................................................2,00%
- - Polyglyceryl Oleate........................................2,00%
- - Benzyl Alcohol...............................................0,20%
- - Benzoil Acid..................................................0,20%
- - Sorbic Acid...................................................0,20%
CULICITIES are:
- - Aqua...................................................... ..........68.40%
- - Ethyl Butylacetylaminopropionate.....................25.00%
- - Azadirachta Indica Seed Oil................................ 2.00%
- - Alcohol...................................................... ........2.00%
- - Polyglyceryl Oleate.......................................... 2.00%
- - Benzyl Alcohol...................................................... 0.20%
- - Benzoil Acid..................................................... ...0.20%
- - Sorbic Acid................................................... ....0.20%
[022] A fórmula foi desenvolvida depois de anos de trabalho e também de vários testes que foram feitos em laboratório e em campo. O COMPOSTO LÍQUIDO DE LONGA DURAÇÃO PARA PREVENÇÃO CONTRA ECTOPARASITAS E CULICIDAES é um repelente para uso tópico em animais como caninos, felinos, equinos, bovinos e caprinos, de alta qualidade biológica, que atua na proteção dos animais contra picadas de insetos, tais como mosquitos, pernilongos, pulgas, carrapatos, piolhos, vespas e afins, evitando a proliferação e infestação de doenças transmitidas por tais insetos. A ação do repelente tem sido comprovada em testes laboratoriais e de campo.[022] The formula was developed after years of work and also several tests that were done in the laboratory and in the field. LONG-LASTING LIQUID COMPOUND FOR PREVENTION AGAINST ECTOPARASITES AND CULICIDAES is a repellent for topical use in animals such as canines, felines, horses, cattle and goats, of high biological quality, which protects animals against insect bites, such as mosquitoes , mosquitoes, fleas, ticks, lice, wasps and the like, preventing the proliferation and infestation of diseases transmitted by such insects. The repellent action has been proven in laboratory and field tests.
[023] O objeto da presente patente de invenção consiste em um COMPOSTO LÍQUIDO DE LONGA DURAÇÃO PARA PREVENÇÃO CONTRA ECTOPARASITAS E CULICIDAES completo, pois utiliza fórmula balanceada de tais produtos citados na apresentação da solução.[023] The object of this invention patent consists of a LONG-TERM LIQUID COMPOUND FOR PREVENTION AGAINST ECTOPARASITES AND CULICIDAES complete, as it uses a balanced formula of such products mentioned in the presentation of the solution.
[024] Assim o COMPOSTO LÍQUIDO DE LONGA DURAÇÃO PARA PREVENÇÃO CONTRA ECTOPARASITAS E CULICIDAES tem sua eficiência comprovada, melhor que os convencionais, por promover uma eficaz e longa proteção aos animais, apresentar um amplo espectro de proteção, contra insetos, principalmente de mosquitos, pernilongos, pulgas, carrapatos, piolhos, vespas e afins.[024] Thus, the LONG-TERM LIQUID COMPOUND FOR PREVENTION AGAINST ECTOPARASITES AND CULICIDAES has its proven efficiency, better than conventional ones, for promoting an effective and long-lasting protection to animals, presenting a broad spectrum of protection against insects, especially mosquitoes, mosquitoes, fleas, ticks, lice, wasps and the like.
[025] O efeito repelente persistente durante várias horas, também em condições climáticas pouco favoráveis, máxima tolerância pela pele e mucosa, ausência de propriedades tóxicas que não devem penetrar na pele. Com viabilidade econômica e também baixa toxidade, pois não utiliza nenhum tipo de produto químico ou tóxico que possa comprometer a saúde e o equilíbrio de animais de sangue quente, de pessoas e do meio ambiente.[025] Persistent repellent effect for several hours, also in unfavorable weather conditions, maximum tolerance for the skin and mucosa, absence of toxic properties that should not penetrate the skin. With economic feasibility and also low toxicity, as it does not use any type of chemical or toxic product that could compromise the health and balance of warm-blooded animals, people and the environment.
[026] Ressalte-se que enquanto o pedido de patente em questão foi descrito com referência a modalidade pretendida, nada impede que o produto venha a ter suas características quantitativas e qualitativas diversificadas ou alteradas, mantendo ou até melhorando o desempenho alcançado, logicamente sem que se distancie do espírito e escopo do quanto ora explanado. Sua disponibilização no mercado poderá ocorrer também sob as mais variadas apresentações, seja em líquido (spray, loções, gotas, etc.), ou semipastosos (pomadas, cremes, pastas, etc.)[026] It should be noted that while the patent application in question was described with reference to the intended modality, nothing prevents the product from having its quantitative and qualitative characteristics diversified or altered, maintaining or even improving the performance achieved, logically without distance yourself from the spirit and scope of what is now explained. Its availability on the market may also take place under the most varied presentations, whether in liquid (spray, lotions, drops, etc.) or semi-paste (ointments, creams, pastes, etc.)
Claims (3)
compreender a seguinte formulação:
- - Aqua..........................................................68,40%
- - Ethyl Butylacetylaminopropionate..................25,00%
- - Azadirachta Indica Seed Oil.............................2,00%
- - Alcohol.......................................................2,00%
- - Polyglyceryl Oleate........................................2,00%
- - Benzyl Alcohol...............................................0,20%
- - Benzoil Acid..................................................0,20%
- - Sorbic Acid...................................................0,20%
understand the following formulation:
- - Aqua...................................................... ..........68.40%
- - Ethyl Butylacetylaminopropionate.....................25.00%
- - Azadirachta Indica Seed Oil................................ 2.00%
- - Alcohol...................................................... .......2.00%
- - Polyglyceryl Oleate.......................................... 2.00%
- - Benzyl Alcohol...................................................... 0.20%
- - Benzoil Acid..................................................... ...0.20%
- - Sorbic Acid................................................... ....0.20%
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| BR102020006848-2A BR102020006848A2 (en) | 2020-04-04 | 2020-04-04 | LONG-TERM LIQUID COMPOUND FOR PREVENTION AGAINST ECTOPARASITES AND CULICIDAES |
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| Application Number | Priority Date | Filing Date | Title |
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| BR102020006848-2A BR102020006848A2 (en) | 2020-04-04 | 2020-04-04 | LONG-TERM LIQUID COMPOUND FOR PREVENTION AGAINST ECTOPARASITES AND CULICIDAES |
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