BR102015000922B8 - Compostos a-cetoacílicos de isoniazida, processo de obtenção dos ditos compostos e uso dos compostos no tratamento de tuberculose - Google Patents

Compostos a-cetoacílicos de isoniazida, processo de obtenção dos ditos compostos e uso dos compostos no tratamento de tuberculose

Info

Publication number
BR102015000922B8
BR102015000922B8 BR102015000922A BR102015000922A BR102015000922B8 BR 102015000922 B8 BR102015000922 B8 BR 102015000922B8 BR 102015000922 A BR102015000922 A BR 102015000922A BR 102015000922 A BR102015000922 A BR 102015000922A BR 102015000922 B8 BR102015000922 B8 BR 102015000922B8
Authority
BR
Brazil
Prior art keywords
compounds
obtaining
ketoacylic
isoniazide
tuberculosis
Prior art date
Application number
BR102015000922A
Other languages
English (en)
Other versions
BR102015000922B1 (pt
BR102015000922A2 (pt
Inventor
Boechat Núbia
Silva Castelo Branco Frederico
Original Assignee
Fundacao Oswaldo Cruz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundacao Oswaldo Cruz filed Critical Fundacao Oswaldo Cruz
Priority to BR102015000922A priority Critical patent/BR102015000922B8/pt
Priority to US15/543,937 priority patent/US10065927B2/en
Priority to CN201680010351.8A priority patent/CN107250111B/zh
Priority to PCT/BR2016/000004 priority patent/WO2016112447A1/pt
Publication of BR102015000922A2 publication Critical patent/BR102015000922A2/pt
Publication of BR102015000922B1 publication Critical patent/BR102015000922B1/pt
Publication of BR102015000922B8 publication Critical patent/BR102015000922B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/86—Hydrazides; Thio or imino analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

COMPOSTOS (Alfa)-CETOACÍLICOS DE ISONIAZIDA, PROCESSO DE OBTENÇÃO DOS DITOS COMPOSTOS E USO DOS COMPOSTOS NO TRATAMENTO DE TUBERCULOSE A presente invenção se refere aos compostos da fórmula I Fórmula I onde: R é selecionado dentre H, Me ou Cl e R' é selecionado dentre: H, NH2, NHCOCH3, NHCOCF3 ou NHCOCH2Cl. A invenção proporciona ainda um processo para obtenção dos compostos de fórmula I e seu uso.
BR102015000922A 2015-01-15 2015-01-15 Compostos a-cetoacílicos de isoniazida, processo de obtenção dos ditos compostos e uso dos compostos no tratamento de tuberculose BR102015000922B8 (pt)

Priority Applications (4)

Application Number Priority Date Filing Date Title
BR102015000922A BR102015000922B8 (pt) 2015-01-15 2015-01-15 Compostos a-cetoacílicos de isoniazida, processo de obtenção dos ditos compostos e uso dos compostos no tratamento de tuberculose
US15/543,937 US10065927B2 (en) 2015-01-15 2016-01-14 α-ketoacylic isoniazid compounds, process for producing said compounds, use of the compounds in the treatment of tuberculosis
CN201680010351.8A CN107250111B (zh) 2015-01-15 2016-01-14 α-酮酯酰异烟肼化合物、制备这些化合物的方法、化合物用于治疗结核病的用途
PCT/BR2016/000004 WO2016112447A1 (pt) 2015-01-15 2016-01-14 COMPOSTOS α-CETOACÍLICOS DE ISONIAZIDA, PROCESSO DE OBTENÇÃO DOS DITOS COMPOSTOS, USO DOS COMPOSTOS NO TRATAMENTO DE TUBERCULOSE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BR102015000922A BR102015000922B8 (pt) 2015-01-15 2015-01-15 Compostos a-cetoacílicos de isoniazida, processo de obtenção dos ditos compostos e uso dos compostos no tratamento de tuberculose

Publications (3)

Publication Number Publication Date
BR102015000922A2 BR102015000922A2 (pt) 2016-07-19
BR102015000922B1 BR102015000922B1 (pt) 2022-06-07
BR102015000922B8 true BR102015000922B8 (pt) 2022-07-12

Family

ID=56405066

Family Applications (1)

Application Number Title Priority Date Filing Date
BR102015000922A BR102015000922B8 (pt) 2015-01-15 2015-01-15 Compostos a-cetoacílicos de isoniazida, processo de obtenção dos ditos compostos e uso dos compostos no tratamento de tuberculose

Country Status (4)

Country Link
US (1) US10065927B2 (pt)
CN (1) CN107250111B (pt)
BR (1) BR102015000922B8 (pt)
WO (1) WO2016112447A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR102015000922B8 (pt) * 2015-01-15 2022-07-12 Fundacao Oswaldo Cruz Compostos a-cetoacílicos de isoniazida, processo de obtenção dos ditos compostos e uso dos compostos no tratamento de tuberculose
CN108611358A (zh) * 2018-04-10 2018-10-02 佛山科学技术学院 一种通过合成生物学制备异烟肼烟酰胺腺嘌呤二核苷酸的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001002362A1 (en) * 1999-07-06 2001-01-11 Vertex Pharmaceuticals Incorporated Azo amino acid derivatives for the treatment of neurological diseases
BR102015000922B8 (pt) * 2015-01-15 2022-07-12 Fundacao Oswaldo Cruz Compostos a-cetoacílicos de isoniazida, processo de obtenção dos ditos compostos e uso dos compostos no tratamento de tuberculose

Also Published As

Publication number Publication date
BR102015000922B1 (pt) 2022-06-07
US10065927B2 (en) 2018-09-04
US20170369445A1 (en) 2017-12-28
CN107250111A (zh) 2017-10-13
WO2016112447A1 (pt) 2016-07-21
CN107250111B (zh) 2021-03-23
BR102015000922A2 (pt) 2016-07-19

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Legal Events

Date Code Title Description
B03A Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/01/2015, OBSERVADAS AS CONDICOES LEGAIS

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: REFERENTE A RPI 2683 DE 07/06/2022, QUANTO AO ITEM (72) NOME DO INVENTOR.