BR0318497A - composto de droga antibacteriana compreendendo n-acetil-d-glucosamina - Google Patents
composto de droga antibacteriana compreendendo n-acetil-d-glucosaminaInfo
- Publication number
- BR0318497A BR0318497A BRPI0318497-8A BR0318497A BR0318497A BR 0318497 A BR0318497 A BR 0318497A BR 0318497 A BR0318497 A BR 0318497A BR 0318497 A BR0318497 A BR 0318497A
- Authority
- BR
- Brazil
- Prior art keywords
- glucosamine
- acetyl
- cgcs
- antibiotics
- antibacterial drug
- Prior art date
Links
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 title abstract 4
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 title abstract 4
- 229950006780 n-acetylglucosamine Drugs 0.000 title abstract 4
- 229940124350 antibacterial drug Drugs 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 3
- 229940088710 antibiotic agent Drugs 0.000 abstract 3
- 238000002560 therapeutic procedure Methods 0.000 abstract 3
- 230000001580 bacterial effect Effects 0.000 abstract 2
- 230000003115 biocidal effect Effects 0.000 abstract 2
- 208000017667 Chronic Disease Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000007661 gastrointestinal function Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
"COMPOSTO DE DROGA ANTIBACTERIANA COMPREENDENDO N-ACETIL-D-GLUCOSAMINA". A presente invenção refere-se ao uso da combinação de N-acetil-D-glucosamina e de antibióticos para a preparação de droga antibacteriana. Nas terapias de infecções com antibióticos, os agentes patogênicos podem ser variados para formas mais esguias chamadas células de crescimento críptico (CGCs), as CGCs podem se colonizar e surge a resistência fisiológica à droga. Neste meio-tempo, as colónias normais de bactérias também podem ser mudadas para CGCs pela administração de antibióticos. Estas mudanças resultam em complicações após as terapias, tais como distúrbio de colónias de bactérias no corpo, distúrbio de funções gastrintestinais e outras doenças crónicas. A combinação de antibióticos e N-acetil-D-glucosamina pode prevenir CGC e as complicações após uma terapia com antibióticos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2003/000793 WO2005025582A1 (fr) | 2003-09-18 | 2003-09-18 | Compositions antibacteriennes a base de n-acetyl-d-aminoglycosamine et d'antibiotiques |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0318497A true BR0318497A (pt) | 2006-09-12 |
Family
ID=34280740
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0318497-8A BR0318497A (pt) | 2003-09-18 | 2003-09-18 | composto de droga antibacteriana compreendendo n-acetil-d-glucosamina |
Country Status (5)
Country | Link |
---|---|
US (1) | US20070191291A1 (pt) |
EP (1) | EP1669077A4 (pt) |
AU (1) | AU2003271022A1 (pt) |
BR (1) | BR0318497A (pt) |
WO (1) | WO2005025582A1 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20160279158A1 (en) * | 2013-11-05 | 2016-09-29 | Nestec S.A. | Use of glucosamine-enriched plant compositions |
CN108913768B (zh) * | 2018-07-23 | 2021-10-22 | 广东省实验动物监测所 | 一种同时检测七个氨基糖胺类耐药基因的多重液相基因芯片引物、试剂盒及其分析方法 |
CN111557946A (zh) * | 2020-07-01 | 2020-08-21 | 上海玉曜生物医药科技有限公司 | N-乙酰-d-氨基葡萄糖的新用途及相关产品 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1318592C (en) * | 1988-11-18 | 1993-06-01 | University Of British Columbia | N-acetyl glucosamine as a cytoprotective agent |
US5217962A (en) * | 1992-01-28 | 1993-06-08 | Burton Albert F | Method and composition for treating psoriasis |
US5455240A (en) * | 1994-06-20 | 1995-10-03 | The Rockefeller University | Modulators of pneumococcal adhesion to cellular targets involving the platelet activating factor receptor, and uses thereof |
US6426099B1 (en) * | 1997-12-03 | 2002-07-30 | Renew Life, Inc. | Herbal formulation for rebuilding intestinal bacteria |
US6046179A (en) * | 1998-04-17 | 2000-04-04 | Murch; Simon | Composition for and treatment of inflammatory bowel disease by colon administration of N-acetylglucosamine |
US6037333A (en) * | 1998-05-07 | 2000-03-14 | Trustees Of Tufts College | Microbe-inhibiting compositions |
CN1173706C (zh) * | 2001-02-28 | 2004-11-03 | 中国人民解放军第三军医大学 | N-乙酰-d-氨基葡萄糖在制备治疗宫颈糜烂药物中的应用 |
CN1301112C (zh) * | 2002-07-29 | 2007-02-21 | 中国人民解放军第三军医大学 | 含有n-乙酰-d-氨基葡萄糖的复方抗菌药物 |
-
2003
- 2003-09-18 BR BRPI0318497-8A patent/BR0318497A/pt not_active IP Right Cessation
- 2003-09-18 US US10/572,226 patent/US20070191291A1/en not_active Abandoned
- 2003-09-18 AU AU2003271022A patent/AU2003271022A1/en not_active Abandoned
- 2003-09-18 WO PCT/CN2003/000793 patent/WO2005025582A1/zh active Application Filing
- 2003-09-18 EP EP03750251A patent/EP1669077A4/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
AU2003271022A1 (en) | 2005-04-06 |
EP1669077A4 (en) | 2007-10-03 |
US20070191291A1 (en) | 2007-08-16 |
EP1669077A1 (en) | 2006-06-14 |
WO2005025582A1 (fr) | 2005-03-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE(S). |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012. |