BR0312821A - 4-(4-metil-piperazin-1-il-metil)-n-[(4-metil-3-(4-piridin-3-i l)-pirimidin-2-il-amino)-fenil]-benzamida para tratar câncer anaplásico da tireóide - Google Patents
4-(4-metil-piperazin-1-il-metil)-n-[(4-metil-3-(4-piridin-3-i l)-pirimidin-2-il-amino)-fenil]-benzamida para tratar câncer anaplásico da tireóideInfo
- Publication number
- BR0312821A BR0312821A BR0312821-0A BR0312821A BR0312821A BR 0312821 A BR0312821 A BR 0312821A BR 0312821 A BR0312821 A BR 0312821A BR 0312821 A BR0312821 A BR 0312821A
- Authority
- BR
- Brazil
- Prior art keywords
- methyl
- piperazin
- benzamide
- pyrimidin
- pyridin
- Prior art date
Links
- -1 4-methyl-piperazin-1-yl-methyl Chemical group 0.000 title abstract 3
- 208000001446 Anaplastic Thyroid Carcinoma Diseases 0.000 title abstract 2
- 206010002240 Anaplastic thyroid cancer Diseases 0.000 title 1
- 208000019179 thyroid gland undifferentiated (anaplastic) carcinoma Diseases 0.000 title 1
- 241001024304 Mino Species 0.000 abstract 1
- 208000024770 Thyroid neoplasm Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000002510 thyroid cancer Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"4-(4-METIL-PIPERAZIN-1-IL-METIL)-N-[(4-METIL-3(4-PIRIDIN-3-I L)-PIRIMIDIN-2-IL-AMINO)-FENIL]-BENZAMIDA PARA TRATAR CâNCER ANAPLáSICO DA TIREóIDE". A invenção refere-se ao uso de 4-(4-metil-piperazin-1-il-metil)-N[(4-metil-3-(4-piridin-3-il)-pirimidin-2-il-a mino)-fenil]-benzamida da seguinte fórmula: ou um seu sal farmaceuticamente aceitável para a fabricação de um medicamento para o tratamento de cânceres anaplásicos da tireóide.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39841002P | 2002-07-24 | 2002-07-24 | |
| US45455703P | 2003-03-14 | 2003-03-14 | |
| PCT/IB2003/001985 WO2004009088A1 (en) | 2002-07-24 | 2003-05-23 | 4-(4-methylpiperazin-1-ylmethyl)-n-[4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide for treating anaplastic thyroid cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0312821A true BR0312821A (pt) | 2005-04-19 |
Family
ID=30773082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0312821-0A BR0312821A (pt) | 2002-07-24 | 2003-05-23 | 4-(4-metil-piperazin-1-il-metil)-n-[(4-metil-3-(4-piridin-3-i l)-pirimidin-2-il-amino)-fenil]-benzamida para tratar câncer anaplásico da tireóide |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20060106026A1 (pt) |
| EP (1) | EP1551408A1 (pt) |
| JP (1) | JP2005533838A (pt) |
| CN (1) | CN1671389A (pt) |
| AU (1) | AU2003232376A1 (pt) |
| BR (1) | BR0312821A (pt) |
| CA (1) | CA2498982A1 (pt) |
| WO (1) | WO2004009088A1 (pt) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4141219A1 (de) * | 1991-12-13 | 1993-06-17 | Basf Ag | Verfahren zur herstellung von tetrahydropyrancarbonsaeureestern |
| CO4940418A1 (es) * | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
| ITMI992711A1 (it) * | 1999-12-27 | 2001-06-27 | Novartis Ag | Composti organici |
| US20030185831A1 (en) * | 2001-11-30 | 2003-10-02 | Schering Corporation | Methods of treating cancer using an FPT inhibitor and antineoplastic |
-
2003
- 2003-05-23 EP EP03765220A patent/EP1551408A1/en not_active Withdrawn
- 2003-05-23 CN CNA038173751A patent/CN1671389A/zh active Pending
- 2003-05-23 JP JP2004522386A patent/JP2005533838A/ja active Pending
- 2003-05-23 CA CA002498982A patent/CA2498982A1/en not_active Abandoned
- 2003-05-23 WO PCT/IB2003/001985 patent/WO2004009088A1/en active Application Filing
- 2003-05-23 AU AU2003232376A patent/AU2003232376A1/en not_active Abandoned
- 2003-05-23 BR BR0312821-0A patent/BR0312821A/pt not_active IP Right Cessation
- 2003-05-23 US US10/521,929 patent/US20060106026A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2498982A1 (en) | 2004-01-29 |
| EP1551408A1 (en) | 2005-07-13 |
| JP2005533838A (ja) | 2005-11-10 |
| AU2003232376A1 (en) | 2004-02-09 |
| US20060106026A1 (en) | 2006-05-18 |
| WO2004009088A1 (en) | 2004-01-29 |
| CN1671389A (zh) | 2005-09-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 8A E 9A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2157 DE 08/05/2012. |