BR0312602A - Método para modular os nìveis de um produto metabólico ou biossintético em uma planta, vetor, célula geneticamente modificada, planta geneticamente modificada, sementes ou outro material reprodutivo, produto, e sistema biorreator - Google Patents

Método para modular os nìveis de um produto metabólico ou biossintético em uma planta, vetor, célula geneticamente modificada, planta geneticamente modificada, sementes ou outro material reprodutivo, produto, e sistema biorreator

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Publication number
BR0312602A
BR0312602A BR0312602-1A BR0312602A BR0312602A BR 0312602 A BR0312602 A BR 0312602A BR 0312602 A BR0312602 A BR 0312602A BR 0312602 A BR0312602 A BR 0312602A
Authority
BR
Brazil
Prior art keywords
plant
genetically modified
product
plants
metabolic
Prior art date
Application number
BR0312602-1A
Other languages
English (en)
Inventor
Stevens Michael Brumley
Matthew Peter Punell
Barrie Fong Chong
Lars Arved Petrasovits
Lars Keld Nielsen
Richard Bruce Mcqualter
Original Assignee
Of Sugar Experiment Stations B
Univ Queensland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Of Sugar Experiment Stations B, Univ Queensland filed Critical Of Sugar Experiment Stations B
Publication of BR0312602A publication Critical patent/BR0312602A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"MéTODO PARA MODULAR OS NìVEIS DE UM PRODUTO METABóLICO OU BIOSSINTéTICO EM UMA PLANTA, VETOR, CéLULA GENETICAMENTE MODIFICADA, PLANTA GENETICAMENTE MODIFICADA, SEMENTES OU OUTRO MATERIAL REPRODUTIVO, PRODUTO, E, SISTEMA BIORREATOR". A presente invenção refere-se em geral ao uso de plantas como biorreatores para a produção de moléculas possuindo propriedades úteis tais como inter alia polímeros, metabólitos, proteínas, fármacos e nutracêuticos. Mais particularmente, a presente invenção contempla o uso de gramíneas, e ainda mais particularmente de gramíneas C4, tal como cana-de-açúcar, para a produção de uma variedade de produtos tais como, por exemplo, poli(hidróxialcanoatos), PHBA, vanilina, indigo, ácido adípico, 2-fenil-etanol, 1,3propanodiol, sorbitol, polimeros de frutano e ácido lático bem como outros produtos incluindo, inter alia, outros plásticos, sedas, carboidratos, proteínas nutracêuticas e terapêuticas e anticorpos. A presente invenção refere-se adicionalmente às plantas transgênicas e, em particular, às plantas gramineas C4 transgênicas, capazes de produzir os compostos citados acima e outros produtos, e aos métodos para gerar tais plantas. A capacidade de utilizar a taxa de crescimento elevada e a fixação de carbono eficiente de gramineas C4 é vantajosa, pelo fato de que evita as penalidades de crescimento significativas observadas em outras plantas, e os resultados de rendimentos altos de produto desejado sem necessariamente causar efeitos deletérios concomitantes sobre as plantas individuais. Em adição, a gramínea C4, cana-de-açúcar, é particularmente vantajosa, visto que em adição às características comuns de todas as gramíneas C4, esta planta acumula sacarose. Esta armazenagem de sacarose proporciona um pronto fornecimento de energia e de compostos baseados em carbono o que pode adicionalmente evitar quaisquer efeitos deletérios sobre o crescimento da planta associada com a produção do produto. A presente invenção proporciona, portanto, um sistema biorreator compreendendo uma planta geneticamente modificada projetada para produzir produtos biossintéticos ou metabólicos específicos de interesse.
BR0312602-1A 2002-07-11 2003-07-11 Método para modular os nìveis de um produto metabólico ou biossintético em uma planta, vetor, célula geneticamente modificada, planta geneticamente modificada, sementes ou outro material reprodutivo, produto, e sistema biorreator BR0312602A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39486902P 2002-07-11 2002-07-11
PCT/AU2003/000903 WO2004006657A1 (en) 2002-07-11 2003-07-11 Transgenic plants used as a bioreactor system

Publications (1)

Publication Number Publication Date
BR0312602A true BR0312602A (pt) 2005-05-24

Family

ID=30115783

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0312602-1A BR0312602A (pt) 2002-07-11 2003-07-11 Método para modular os nìveis de um produto metabólico ou biossintético em uma planta, vetor, célula geneticamente modificada, planta geneticamente modificada, sementes ou outro material reprodutivo, produto, e sistema biorreator

Country Status (5)

Country Link
US (2) US7754943B2 (pt)
AU (2) AU2003243831B2 (pt)
BR (1) BR0312602A (pt)
WO (1) WO2004006657A1 (pt)
ZA (1) ZA200500213B (pt)

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US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
ES2707786T3 (es) 2004-01-16 2019-04-05 Pfenex Inc Expresión de proteínas de mamífero en Pseudomonas fluorescens
AU2005269527B2 (en) 2004-07-26 2011-12-01 Pfenex Inc. Process for improved protein expression by strain engineering
EP2157184B1 (en) 2007-04-19 2020-11-18 Laboratorios Minkab, S.A. de C.V. Process for producing vanilin from microorganisms immobilized by surface culture
CA2685326A1 (en) 2007-04-27 2008-11-06 Dow Global Technologies Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
WO2010057271A1 (en) * 2008-11-21 2010-05-27 Sugar Industry Innovation Pty Ltd Polyhydroxyalkanoate production in plant peroxisomes
AU2010221135A1 (en) * 2009-03-05 2011-09-29 Metabolix, Inc. Propagation of transgenic plants
EP2462221B1 (en) 2009-08-05 2017-02-22 Genomatica, Inc. Semi-synthetic terephthalic acid via microorganisms that produce muconic acid
DK2512402T3 (en) * 2009-12-15 2015-04-20 Corticalis As DEBRIDATION PASTA
WO2012048298A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
WO2014169106A1 (en) * 2013-04-11 2014-10-16 Washington State University Modified plants for producing aroma/fine/specialty chemicals
EP3068867B1 (en) 2013-11-16 2018-04-18 Terumo BCT, Inc. Expanding cells in a bioreactor
WO2015148704A1 (en) 2014-03-25 2015-10-01 Terumo Bct, Inc. Passive replacement of media
CN106715676A (zh) 2014-09-26 2017-05-24 泰尔茂比司特公司 按计划供养
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
WO2018184028A2 (en) 2017-03-31 2018-10-04 Terumo Bct, Inc. Cell expansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
CN107586752B (zh) * 2017-08-04 2019-12-24 江南大学 一种工程菌及其应用
US12037592B2 (en) * 2019-02-20 2024-07-16 The Regents Of The University Of California Plants and methods for producing muconic acid
CN111850054A (zh) * 2020-06-28 2020-10-30 营口理工学院 一种菌株的应用及菌株转化粗甘油生产乙醇的方法
JP2024511064A (ja) 2021-03-23 2024-03-12 テルモ ビーシーティー、インコーポレーテッド 細胞捕獲及び増殖
CN114672497B (zh) * 2022-04-25 2023-07-18 山东农业大学 马铃薯StPHB3基因在提高马铃薯块茎品质中的应用
CN117084168A (zh) * 2023-06-13 2023-11-21 武汉生物工程学院 一种景天科多肉植物通用的组织培养方法

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US6091002A (en) * 1996-03-13 2000-07-18 Monsanto Company Polyhydroxyalkanoates of narrow molecular weight distribution prepared in transgenic plants
WO2000052183A1 (en) * 1999-03-05 2000-09-08 Monsanto Technology Llc Multigene expression vectors for the biosynthesis of products via multienzyme biological pathways
US6475734B1 (en) * 1999-09-29 2002-11-05 Pioneer Hi-Bred International, Inc. Polyhydroxyalkanoate synthase genes
AU7741200A (en) 1999-09-29 2001-04-30 E.I. Du Pont De Nemours And Company Production of polyhydroxyalkanoate in plants

Also Published As

Publication number Publication date
AU2008234960A1 (en) 2008-11-13
AU2003243831A1 (en) 2004-02-02
US20060259998A1 (en) 2006-11-16
US20110252507A1 (en) 2011-10-13
WO2004006657A1 (en) 2004-01-22
AU2003243831B2 (en) 2008-07-24
US7754943B2 (en) 2010-07-13
ZA200500213B (en) 2006-02-22

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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