BR0311538A - Pyrazolopyrimidines - Google Patents

Pyrazolopyrimidines

Info

Publication number
BR0311538A
BR0311538A BR0311538-0A BR0311538A BR0311538A BR 0311538 A BR0311538 A BR 0311538A BR 0311538 A BR0311538 A BR 0311538A BR 0311538 A BR0311538 A BR 0311538A
Authority
BR
Brazil
Prior art keywords
halo
optionally substituted
new
cycloalkyl
dihydroxy
Prior art date
Application number
BR0311538-0A
Other languages
Portuguese (pt)
Inventor
Olaf Gebauer
Nico Joerg Greul
Herbert Gayer
Bernd-Wieland Kr Ger
Hans-Ludwig Elbe
Ralf Dunkel
Oliver Guth
Arnd Voerste
Stefan Hillebrand
Stefan Herrmann
Ulrich Heinemann
Ronald Ebbert
Karl-Heinz Kuck
Peter Loesel
Ulrike Wachendorff-Neumann
Astrid Mauler-Machnik
Original Assignee
Bayer Cropscience Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Cropscience Ag filed Critical Bayer Cropscience Ag
Publication of BR0311538A publication Critical patent/BR0311538A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

7-Amino-6-aryl-pyrazolo-(1,5-a)-pyrimidine derivatives (I) are new. Also new are halo-, hydroxy- or dihydroxy-pyrazolopyrimidine derivative intermediates (II). Pyrazolopyrimidines of formula (I) and their acid addition salts (in the case where R1 = amino) are new. R1 = NH2 or OH or alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, alkenyloxy, alkynyloxy, cycloalkoxy, mono- or dialkylamino, alkenylamino, alkynylamino, cycloalkylamino, N-cycloalkyl-N-alkylamino, alkylideneamino or heterocyclyl (all optionally substituted); R2 = H or alkyl, alkenyl, alkynyl or cycloalkyl (all optionally substituted); or NR1R2 = optionally substituted heterocycle; R3 = optionally substituted aryl; X1 = H or halo; X2 = halo, CN, NO2, haloalkyl, CHO, alkoxycarbonyl, alkylcarbonyl, hydroxyiminoalkyl or alkoxyiminoalkyl. Independent claims are also included for: (1) preparation of (I); (2) new halo-, hydroxy- or dihydroxy-pyrazolopyrimidine derivative intermediates of formula (II); and (3) preparation of (II). Q1 = halo and Q2 = X1; or Q1 = OH and Q2 = H or OH.
BR0311538-0A 2002-05-29 2003-05-16 Pyrazolopyrimidines BR0311538A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10223917A DE10223917A1 (en) 2002-05-29 2002-05-29 New 7-amino-6-aryl-pyrazolo-(1,5-a)-pyrimidine derivatives, useful as pesticides, e.g. insecticides, acaricides, nematocides, bactericides or especially fungicides for protection of plants or materials
PCT/EP2003/005159 WO2004000844A1 (en) 2002-05-29 2003-05-16 Pyrazolopyrimidines and the use thereof for controlling harmful organisms

Publications (1)

Publication Number Publication Date
BR0311538A true BR0311538A (en) 2005-03-01

Family

ID=29432434

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0311538-0A BR0311538A (en) 2002-05-29 2003-05-16 Pyrazolopyrimidines

Country Status (20)

Country Link
US (1) US20060089499A1 (en)
EP (1) EP1513843B1 (en)
JP (1) JP2005533070A (en)
KR (1) KR20050004234A (en)
CN (1) CN1671709A (en)
AT (1) ATE366253T1 (en)
AU (1) AU2003240258A1 (en)
BR (1) BR0311538A (en)
CA (1) CA2487544A1 (en)
DE (2) DE10223917A1 (en)
DK (1) DK1513843T3 (en)
ES (1) ES2289300T3 (en)
IL (1) IL165348A0 (en)
MX (1) MXPA04011824A (en)
PL (1) PL373467A1 (en)
PT (1) PT1513843E (en)
RU (1) RU2331643C2 (en)
UA (1) UA77546C2 (en)
WO (1) WO2004000844A1 (en)
ZA (1) ZA200409618B (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8580782B2 (en) 2002-09-04 2013-11-12 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
US7205308B2 (en) 2002-09-04 2007-04-17 Schering Corporation Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
US7084271B2 (en) 2002-09-04 2006-08-01 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
TW200413377A (en) 2002-09-04 2004-08-01 Schering Corp Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7196078B2 (en) 2002-09-04 2007-03-27 Schering Corpoartion Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
CA2497544C (en) 2002-09-04 2010-11-02 Schering Corporation Pyrazolo[1,5-a]pyrimidines compounds as cyclin dependent kinase inhibitors
MXPA05002570A (en) 2002-09-04 2005-09-08 Schering Corp Pyrazolopyrimidines as cyclin dependent kinase inhibitors.
US7161003B1 (en) 2002-09-04 2007-01-09 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7119200B2 (en) 2002-09-04 2006-10-10 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US8673924B2 (en) 2002-09-04 2014-03-18 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
CA2516824A1 (en) 2003-02-28 2004-09-10 Teijin Pharma Limited Pyrazolo[1,5-a]pyrimidine derivatives
EP1608652A1 (en) * 2003-03-31 2005-12-28 Vernalis (Cambridge) Limited Pyrazolopyrimidine compounds and their use in medicine
CA2527136A1 (en) * 2003-06-03 2004-12-09 Basf Aktiengesellschaft Substituted pyrazolopyrimidines, methods for the production thereof, use of the same for controlling pathogenic fungi, and agents containing said compounds
JP2007506665A (en) * 2003-06-27 2007-03-22 バイエル・クロツプサイエンス・アクチエンゲゼルシヤフト Pyrazolopyrimidine
DE10357567A1 (en) * 2003-12-10 2005-07-07 Bayer Cropscience Ag pyrazolopyrimidine
DE10357568A1 (en) * 2003-12-10 2005-07-07 Bayer Cropscience Ag pyrazolopyrimidine
DE10357565A1 (en) * 2003-12-10 2005-07-07 Bayer Cropscience Ag pyrazolopyrimidine
DE102004008807A1 (en) * 2004-02-20 2005-09-08 Bayer Cropscience Ag pyrazolopyrimidine
EP1720879A2 (en) * 2004-02-25 2006-11-15 Basf Aktiengesellschaft Azolopyrimidine compounds and use thereof for combating parasitic fungi
DE102005007534A1 (en) * 2005-02-17 2006-08-31 Bayer Cropscience Ag pyrazolopyrimidine
US20080146839A1 (en) * 2005-03-18 2008-06-19 Basf Aktiengesellschaft Method for Producing 5-Halo-2,4,6-Trifluoroisophthalic Acid
JP2007008864A (en) * 2005-06-30 2007-01-18 Bayer Cropscience Ag Pyrazolopyrimidine derivative and germicide for use in agriculture and gardening
MX2008000708A (en) * 2005-07-27 2008-03-18 Basf Ag Fungicidal 5-methyl-6-phenylpyrazolopyrimidin-7-ylamines.
WO2007012600A1 (en) * 2005-07-27 2007-02-01 Basf Aktiengesellschaft Fungicidal 5-alkyl-6-phenylpyrazolopyrimidin-7-ylamines
EP1931676B1 (en) 2005-10-06 2011-11-16 Schering Corporation Pyrazolopyrimidines as protein kinase inhibitors
WO2007101859A1 (en) * 2006-03-07 2007-09-13 Basf Se Substituted pyrazolopyrimidines, method for the production thereof and use thereof for controlling parasitic fungi and agents containing the latter
WO2007101804A1 (en) * 2006-03-07 2007-09-13 Basf Se Substituted pyrazolopyrimidines, methods for the production thereof and use thereof for controlling parasitic fungi and agents comprising the same
DE102006039255A1 (en) * 2006-08-17 2008-02-21 Bayer Cropscience Ag Insecticidal heterocyclic carboxylic acid derivatives
WO2008046856A2 (en) * 2006-10-18 2008-04-24 Basf Se Fungicidal compositions
US20100087640A1 (en) * 2007-01-11 2010-04-08 Basf Se Method for production of aryl-substituted annelated pyrimidines
EP3849981B1 (en) 2018-09-10 2023-02-01 Eli Lilly and Company Pyrazolo[1,5-a]pyrimidine-3-carboxamide derivatives useful in the treatment of psoriasis and systemic lupus erythematosus
CN110016036B (en) * 2019-05-16 2022-06-03 辽宁大学 Pyrazolo [1,5-a ] pyrimidine compound and preparation method and application thereof
AR121251A1 (en) 2020-02-12 2022-05-04 Lilly Co Eli 7-(METHYLAMINO)PYRAZOLE[1,5-A]PYRIMIDINE-3-CARBOXAMIDE COMPOUNDS
BR112022026083A2 (en) * 2020-06-26 2023-01-17 Nihon Nohyaku Co Ltd ARILTETRAHYDROPYRIDAZINE DERIVATIVE OR SALT THEREOF, INSECTICIDAL AGENT CONTAINING THE COMPOUND, AND METHOD OF USE THEREOF
CN113287620B (en) * 2021-06-18 2021-11-19 浙江大学 Application of 1H-pyrazolo [3,4-d ] pyrimidine compound in preparation of fusarium graminearum bactericide
AR128103A1 (en) * 2021-12-28 2024-03-27 Nihon Nohyaku Co Ltd DERIVATIVE OF ARYLTETRAHYDROPYRIDAZINE OR SALT THEREOF AND INSECTICIDAL AGENT CONTAINING THE COMPOUND AND METHOD FOR USE IT

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3130633A1 (en) * 1981-08-01 1983-02-17 Basf Ag, 6700 Ludwigshafen 7-AMINO-AZOLO (1,5-A) PYRIMIDINE AND FUNGICIDES CONTAINING THEM
US5817663A (en) * 1996-10-07 1998-10-06 American Cyanamid Company Pentafluorophenylazolopyrimidines
US6156925A (en) * 1998-09-25 2000-12-05 American Cyanamid Company Process for the preparation of halogenated phenylmaloates
US6552026B2 (en) * 1999-06-14 2003-04-22 Basf Aktiengesellschaft 6-phenyl-pyrazolopyrimidines
JP2001019693A (en) * 1999-06-14 2001-01-23 American Cyanamid Co Bactericidal fungicidal 6-phenyl-pyrazolopyrimidine

Also Published As

Publication number Publication date
IL165348A0 (en) 2006-01-15
RU2004139028A (en) 2005-07-10
DE10223917A1 (en) 2003-12-11
ZA200409618B (en) 2006-03-29
CN1671709A (en) 2005-09-21
DK1513843T3 (en) 2007-11-05
CA2487544A1 (en) 2003-12-31
DE50307615D1 (en) 2007-08-16
JP2005533070A (en) 2005-11-04
RU2331643C2 (en) 2008-08-20
US20060089499A1 (en) 2006-04-27
MXPA04011824A (en) 2005-03-31
ES2289300T3 (en) 2008-02-01
WO2004000844A1 (en) 2003-12-31
PL373467A1 (en) 2005-09-05
EP1513843A1 (en) 2005-03-16
EP1513843B1 (en) 2007-07-04
AU2003240258A1 (en) 2004-01-06
ATE366253T1 (en) 2007-07-15
UA77546C2 (en) 2006-12-15
KR20050004234A (en) 2005-01-12
PT1513843E (en) 2007-09-26

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A E 7A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 2064 DE 27/07/2010.