BR0308322A - Use of an interferon beta (ifnb) polypeptide variant, and methods for treating or preventing stroke or stroke and ischemic attack in a primate - Google Patents
Use of an interferon beta (ifnb) polypeptide variant, and methods for treating or preventing stroke or stroke and ischemic attack in a primateInfo
- Publication number
- BR0308322A BR0308322A BR0308322-5A BR0308322A BR0308322A BR 0308322 A BR0308322 A BR 0308322A BR 0308322 A BR0308322 A BR 0308322A BR 0308322 A BR0308322 A BR 0308322A
- Authority
- BR
- Brazil
- Prior art keywords
- stroke
- interferon beta
- primate
- ifnb
- ischemic attack
- Prior art date
Links
Landscapes
- Peptides Or Proteins (AREA)
Abstract
"USO DE UMA VARIANTE DE POLIPEPTìDEO DE INTERFERON BETA (IFNB), E, MéTODOS PARA TRATAR OU PREVENIR DERRAME OU ACIDENTE CEREBROVASCULAR (AVC) E ATAQUE ISQUêMICO EM UM PRIMATA". A presente invenção diz respeito ao uso de polipeptídeos semelhantes ao interferon beta para o tratamento de derrame ou ataque isquêmico transitório em um primata, preferivelmente em um ser humano. Mais particularmente, os polipeptídeos semelhantes ao interferon beta diferem da seq³ência de aminoácido do IFNB humano do tipo selvagem (SEQ ID NO:2) em que pelo menos um sítio de glicosilação, preferivelmente pelo menos um sítio de N-glicosilação in vivo foi íntroduzido. Opcionalmente os polipeptídeos semelhantes ao interferon beta são PEGuilados"USE OF AN INTERFERON BETA (IFNB) POLYPEPTIDE VARIANT, AND METHODS TO TREAT OR PREVENT STROKE OR CEREBREVASCULAR ACCIDENT AND ISCHEMIC ATTACK IN A PRIMATE". The present invention relates to the use of interferon beta-like polypeptides for the treatment of stroke or transient ischemic attack in a primate, preferably in a human. More particularly, interferon beta-like polypeptides differ from the amino acid sequence of wild-type human IFNB (SEQ ID NO: 2) in which at least one glycosylation site, preferably at least one in vivo N-glycosylation site has been introduced. Optionally interferon beta-like polypeptides are PEGylated
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200200037 | 2002-03-12 | ||
| PCT/DK2003/000127 WO2003075944A2 (en) | 2002-03-12 | 2003-02-28 | Interferon beta-like molecules for treatment of stroke |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0308322A true BR0308322A (en) | 2004-12-21 |
Family
ID=33560701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0308322-5A BR0308322A (en) | 2002-03-12 | 2003-02-28 | Use of an interferon beta (ifnb) polypeptide variant, and methods for treating or preventing stroke or stroke and ischemic attack in a primate |
Country Status (1)
| Country | Link |
|---|---|
| BR (1) | BR0308322A (en) |
-
2003
- 2003-02-28 BR BR0308322-5A patent/BR0308322A/en not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired |