BR0308091A - Processes for the synthesis of 5'-deoxy-5'-chloroadenosine and 5'-deoxy-5'-methylthioadenosine - Google Patents
Processes for the synthesis of 5'-deoxy-5'-chloroadenosine and 5'-deoxy-5'-methylthioadenosineInfo
- Publication number
- BR0308091A BR0308091A BR0308091-9A BR0308091A BR0308091A BR 0308091 A BR0308091 A BR 0308091A BR 0308091 A BR0308091 A BR 0308091A BR 0308091 A BR0308091 A BR 0308091A
- Authority
- BR
- Brazil
- Prior art keywords
- chloroadenosine
- deoxy
- synthesis
- methylthioadenosine
- processes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C1/00—Making non-ferrous alloys
- C22C1/08—Alloys with open or closed pores
- C22C1/083—Foaming process in molten metal other than by powder metallurgy
- C22C1/086—Gas foaming process
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Metallurgy (AREA)
- Mechanical Engineering (AREA)
- Materials Engineering (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"PROCESSOS PARA A SìNTESE DE 5<39>-DESóXI-5<39>CLOROADENOSINA E 5<39>-DESóXI-5<39>-METILTIOADENOSINA". A presente invenção refere-se a um processo para preparar in situ cloroadenosina, em que adenosina em um solvente não-aquoso é feita reagir com um cloreto de tionila e uma piridina para formar uma solução reacional; o solvente não-aquoso é trocado por um álcool inferior, e é adicionada uma base à solução reacional; e a cloroadenosina resultante é filtrada, lavada e seca. Adicionalmente, é descrito um processo em duas etapas para a síntese de metiltioadenosina utilizando a cloroadenosina preparada in situ."PROCESSES FOR THE SYNTHESIS OF 5 <39> -DESOXY-5 <39> CHLOROADENOSIN AND 5 <39> -DESOXY-5 <39> -METHYLTHYOADENOSINE". The present invention relates to a process for preparing chloroadenosine in situ, wherein adenosine in a non-aqueous solvent is reacted with a thionyl chloride and a pyridine to form a reaction solution; the non-aqueous solvent is exchanged for a lower alcohol, and a base is added to the reaction solution; and the resulting chloroadenosine is filtered, washed and dried. Additionally, a two-step process for the synthesis of methylthioadenosine using chloroadenosine prepared in situ is described.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36128402P | 2002-03-04 | 2002-03-04 | |
| PCT/IB2003/000595 WO2003074541A1 (en) | 2002-03-04 | 2003-02-17 | Processes for the synthesis of 5’-deoxy-5’ chloroadenosine and 5’-deoxy-5’methylthioadenosine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0308091A true BR0308091A (en) | 2004-12-21 |
Family
ID=27789105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0308091-9A BR0308091A (en) | 2002-03-04 | 2003-02-17 | Processes for the synthesis of 5'-deoxy-5'-chloroadenosine and 5'-deoxy-5'-methylthioadenosine |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20030181713A1 (en) |
| EP (1) | EP1483279A1 (en) |
| KR (1) | KR20040094761A (en) |
| CN (1) | CN1639182A (en) |
| AR (1) | AR038716A1 (en) |
| AU (1) | AU2003206011A1 (en) |
| BR (1) | BR0308091A (en) |
| CA (1) | CA2477729A1 (en) |
| GT (1) | GT200300047A (en) |
| HN (1) | HN2003000082A (en) |
| IL (1) | IL163778A0 (en) |
| MX (1) | MXPA04008550A (en) |
| PA (1) | PA8567901A1 (en) |
| PE (1) | PE20031002A1 (en) |
| PL (1) | PL370863A1 (en) |
| RU (1) | RU2004126699A (en) |
| SV (1) | SV2004001491A (en) |
| TW (1) | TW200304826A (en) |
| UY (1) | UY27693A1 (en) |
| WO (1) | WO2003074541A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014163150A1 (en) * | 2013-04-05 | 2014-10-09 | ライオン株式会社 | Composition for internal use |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4373122A (en) * | 1981-01-26 | 1983-02-08 | W. H. Brady Co. | Capacitance switch |
| US4454122A (en) * | 1981-04-27 | 1984-06-12 | Bioresearch S.R.L. | Adenosine derivatives of anti-inflammatory and analgesic activity, and therapeutic compositions which contain them as their active principle |
| US4373097A (en) * | 1981-04-27 | 1983-02-08 | Bioresearch S.R.L. | Process for preparing adenosine derivatives of anti-inflammatory and analgesic activity |
| JPS61171423A (en) * | 1985-01-24 | 1986-08-02 | Advance Res & Dev Co Ltd | Drug for alleviating dental caries and periodontosis |
| US6492349B1 (en) * | 1993-03-31 | 2002-12-10 | Nutramax Laboratories, Inc. | Aminosugar and glycosaminoglycan composition for the treatment and repair of connective tissue |
| US5872104A (en) * | 1994-12-27 | 1999-02-16 | Oridigm Corporation | Combinations and methods for reducing antimicrobial resistance |
-
2003
- 2003-02-14 US US10/367,361 patent/US20030181713A1/en not_active Abandoned
- 2003-02-17 CA CA002477729A patent/CA2477729A1/en not_active Abandoned
- 2003-02-17 WO PCT/IB2003/000595 patent/WO2003074541A1/en not_active Application Discontinuation
- 2003-02-17 CN CNA03805177XA patent/CN1639182A/en active Pending
- 2003-02-17 MX MXPA04008550A patent/MXPA04008550A/en not_active Application Discontinuation
- 2003-02-17 PL PL03370863A patent/PL370863A1/en not_active Application Discontinuation
- 2003-02-17 BR BR0308091-9A patent/BR0308091A/en not_active Application Discontinuation
- 2003-02-17 AU AU2003206011A patent/AU2003206011A1/en not_active Abandoned
- 2003-02-17 KR KR10-2004-7013733A patent/KR20040094761A/en not_active Application Discontinuation
- 2003-02-17 RU RU2004126699/04A patent/RU2004126699A/en not_active Application Discontinuation
- 2003-02-17 EP EP03702894A patent/EP1483279A1/en not_active Withdrawn
- 2003-02-17 IL IL16377803A patent/IL163778A0/en unknown
- 2003-02-27 PE PE2003000193A patent/PE20031002A1/en not_active Application Discontinuation
- 2003-02-27 PA PA20038567901A patent/PA8567901A1/en unknown
- 2003-02-28 UY UY27693A patent/UY27693A1/en not_active Application Discontinuation
- 2003-03-03 AR ARP030100701A patent/AR038716A1/en not_active Application Discontinuation
- 2003-03-03 HN HN2003000082A patent/HN2003000082A/en unknown
- 2003-03-03 TW TW092104403A patent/TW200304826A/en unknown
- 2003-03-03 SV SV2003001491A patent/SV2004001491A/en not_active Application Discontinuation
- 2003-03-04 GT GT200300047A patent/GT200300047A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA04008550A (en) | 2004-12-06 |
| EP1483279A1 (en) | 2004-12-08 |
| CN1639182A (en) | 2005-07-13 |
| PE20031002A1 (en) | 2003-11-29 |
| HN2003000082A (en) | 2004-05-05 |
| SV2004001491A (en) | 2004-05-07 |
| RU2004126699A (en) | 2005-04-10 |
| PA8567901A1 (en) | 2003-11-12 |
| KR20040094761A (en) | 2004-11-10 |
| AU2003206011A1 (en) | 2003-09-16 |
| CA2477729A1 (en) | 2003-09-12 |
| TW200304826A (en) | 2003-10-16 |
| AR038716A1 (en) | 2005-01-26 |
| UY27693A1 (en) | 2003-10-31 |
| GT200300047A (en) | 2003-10-10 |
| US20030181713A1 (en) | 2003-09-25 |
| WO2003074541A1 (en) | 2003-09-12 |
| IL163778A0 (en) | 2005-12-18 |
| PL370863A1 (en) | 2005-05-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR0211169A (en) | Process for preparing amidine derivatives | |
| HUP0203485A2 (en) | Purine derivatives | |
| BRPI0407967A (en) | One-step process for the preparation of anticonvulsant derivatives | |
| BR0002089A (en) | Synthesis of nucleoside analogues | |
| BRPI0518758A2 (en) | acetamide compounds as fungicides | |
| BR0211699A (en) | Process for preparing a modified clay, modified clay, and polymer clay nanocomposite | |
| BR0314106A (en) | Hashed polypeptides, especially hashed erythropoietin | |
| EP1874792A4 (en) | Activators for oligonucleotide and phosphoramidite synthesis | |
| DE3789526D1 (en) | Isomaltamines and their N-acyl derivatives, processes for their preparation and their use. | |
| BRPI0415209A (en) | tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | |
| BR0005488A (en) | Process for the preparation of vinyl carbonate, and the use of it | |
| ECSP10010058A (en) | DERIVATIVES OF QUINAZOLINADIONA, ITS PREPARATION AND ITS THERAPEUTIC APPLICATIONS | |
| BRPI0416534A (en) | multiparticulate compositions with improved stability | |
| BR0007638A (en) | Process for post-genomic determination of macromolecular atomic structures | |
| WO2003038117A3 (en) | Enhanced in vitro nucleic acid synthesis using nucleoside monophosphates | |
| BRPI0507979A (en) | process for preparing a compound | |
| BRPI0409471A (en) | process for the preparation of unsubstituted 2-cyanopyrrolidines | |
| BR0308091A (en) | Processes for the synthesis of 5'-deoxy-5'-chloroadenosine and 5'-deoxy-5'-methylthioadenosine | |
| BRPI0606197A2 (en) | production process of a compound | |
| BR0315494B1 (en) | Dispersed Ink and the Process for Dispersed Ink Production | |
| BR0206806A (en) | Method for carbamoylation of alcohols | |
| BR0012205A (en) | Dinucleotide crystals | |
| ITMI20021365A1 (en) | PROCESS TO PREPARE ACYLFLUORIDE | |
| BRPI0411652A (en) | process for the preparation of non-peptide substituted spirobenzoazepine derivatives | |
| Kodama et al. | Synthesis of a 1′-α-phenylselenouridine derivative as a synthetic precursor for various 1′-modified nucleosides, via enolization at the 1′-position of 3′, 5′-O-TIPDS-2′-ketouridine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |